Büyük adenomatöz kolorektal poliplerde insan papilloma virüs varlığının araştırılması

Year 2018, , 145 - 154, 30.09.2018

Mehmet Ali Erdğan , Ali Ramazan Benli

https://doi.org/10.26453/otjhs.454432

Abstract

Kolorektal kanser dünya çapında en sık
görülen malignitelerden biridir. Genellikle adenomatöz polip zemini üzerinde
gelişir. İnsan papilloma virüsü (HPV), anogenital enfeksiyonlara neden olur ve
serviks kanseri ile iyi bilinen bir ilişkiye sahiptir. Bununla birlikte, HPV ve
kolorektal polip ve kanser arasındaki ilişkiyi araştıran çalışmalarda çelişkili
sonuçlar vardır. Bu nedenle, kanser potansiyeli yüksek olan kolorektal
adenomatöz poliplerde HPV varlığını değerlendirdik. Çalışmaya, alt
gastrointestinal semptomların taranması veya değerlendirilmesi için total
kolonoskopi uygulanan hastadan ≥1 cm boyutundaki polip alındı. Numuneler,
real-time PCR kullanılarak 25 genotip için tarandı. Real-time PCR kullanılarak
DNA izolasyon analizinde hiçbir örnekte HPV DNA saptanmadı. Sonuç: HPV ile
adenomatöz kolorektal polipler arasında bir ilişkinin olamadığına  inanıyoruz. Bu konuyu açıklığa kavuşturmak
için daha fazla çalışmaya ihtiyaç vardır.

Keywords

Human papilloma virus, Adenomatous polyps, Colorectal cancer

Investigation of presence of human papilloma virus in large adenomatous colorectal polyps

Abstract

Colorectal cancer is one of the most
common malignancies worldwide. It often develops on grounds of adenomatous
polyp. Human papilloma virus (HPV) causes anogenital infections and has
well-known association with cervix cancer. However, there are conflicting
results in the studies investigating relationship between HPV and colorectal
polyps and cancer. Thus, we evaluated presence of HPV in colorectal adenomatous
polyps with high potential for cancer. The study included polyps ≥1 cm in size
from patient who underwent total colonoscopy for screening or evaluation of
lower gastrointestinal symptoms. Samples were screened for 25 genotypes by
using real-time PCR. No HPV DNA was detected in any of samples in DNA isolation
assay by using real-time PCR. We believe that there is no association of
colorectal adenomatous polyps with HPV. Further studies are needed to clarify
this issue.

Keywords

Human papilloma virus, Adenomatous polyps, Colorectal cancer

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