Liver Transplantations in Acute Failure; A Single Center Experiences

Abstract

Acute hepatic failure is progressive liver dysfunction. Liver transplantation is an effective treatment option. The aim of this study was to evaluate the living donor liver transplantation due to acute liver failure. Between April 2014 and April 2019 at Medipol University Medical Faculty Hospital Organ Transplantation Department, 13 patients with living donor liver transplantations in acute failure was studied retrospectively. The mean age of the patients was 21.1±20,9 years. Of these patients, nine (69.2%) were female and seven (53.8%) were children (< 18 years old) . Liver transplantation was the most common cause of toxic hepatitis (38.5%). The mean follow-up of the period was 35.1±12.2 months. Complications were seen in five patients (38.5%). Mortality was observed in four patients (30.7%). Overall survival rate was 84.7% and 69,3% in 1 and 5 years, respectively. Living donor liver transplantation appears to be successful in acute failure.

Keywords

• Acute liver failure,liver transplantation,analysis

Akut Yetmezlikte Karaciğer Nakli; Tek Merkez Deneyimi

Öz

Akut karaciğer yetmezliği, ilerleyici karaciğer disfonksiyonudur. Karaciğer nakli, etkin bir tedavi seçeneğidir. Bu çalışmanın amacı akut karaciğer yetmezliği nedeniyle yapılan canlı vericili karaciğer nakillerini değerlendirmektir.  Nisan 2014 ile Nisan 2019 tarihleri arasında, Medipol Üniversitesi Tıp Fakültesi Hastanesi Organ Nakli Bölümü’nde akut karaciğer yetmezliği nedeniyle canlı vericili karaciğer nakli yapılan 13 hasta retrospektif olarak değerlendirildi. Hastaların yaş ortalaması 21,1±20,9 yıldı. Hastaların dokuzu (%69,2) kadın ve yedisi   (%53,8) çocukluk (< 18 yıl) yaş grubunda idi.  En sık toksik hepatit nedeniyle (%38,5) karaciğer nakli yapıldı. Hastaların ortalama takip süresi 35,1±12,2 aydı. Hastaların beşinde (%38,5) komplikasyon gelişti. Hastalardan dördünde (%30,7)  mortalite görüldü. Genel sağkalım oranı 1 ve 5 yıllık sırasıyla % 84,7 ve % 69,3 idi. Akut yetmezlikte yapılan canlı vericili karaciğer nakillerinin başarılı olduğu görünmektedir.

Anahtar Kelimeler

• Akut karaciğer yetmezliği,karaciğer nakli,analiz

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