Kalp Tipi Yağ Asid Bağlayıcı Proteinin Akut Koroner Sendrom Risk Skorları ile İlişkisi

Abstract

Amaç: Kalp tipi yağ asid bağlayıcı protein (H-FABP) düşük moleküler ağırlıklı majör sitoplazmik bir proteindir ve miyokard yaralanmasına cevap olarak hızlı bir şekilde kardiyomiyositlerden salınır. H-FABP'ın akut koroner sendrom (ACS) tanısında kullanılabilirliğini ve koroner arter hastalığının (KAH) prevalansı, şiddeti ve erken teşhisi ile olan ilişkisini araştırdık.
Materyal ve Metod: Bu prospektif gözlemsel çalışmamıza, kliniğimize Şubat 2016 ile Ocak 2017 tarihleri arasında başvuran 18 yaş ve üstü AKS tanılı 110 hasta dahil ettik.Hastaları iki gruba ayırdık: ST yükselmeli olmayan AKS (NSTE-AKS) ve ST yükselmeli AKS (STEMI).H-FABP ve kardiyak troponin I (cTnI) için hastalardan ilk hastaneye başvuru anında ve 6 saat sonra tekrar kan örnekleri alındı. Tüm hastalara koroner anjiografi yapıldı.
Bulgular: Başvuru anında, her iki grupta GRACE (Global Registry of Acute Coronary Events), SYNTAX (The synergy between percutaneous coronary intervention with taxus and cardiac surgery) ve Gensini risk skorları arasında istatistiksel olarak anlamlı bir ilişki bulunmadı (p=0,056, p=0,791, p=0,278). Altıncı saatte bakılan H-FABP düzeyi ile GRACE ve Gensini risk skorları H-FABP pozitif grupta istatistiksel olarak anlamlıydı (p=0,003, p=0,011). Ancak, SYNTAX risk skoru H-FABP pozitif grupta istatistiksel olarak anlamlı değildi (p=0,984).
Sonuç: Çalışmamızda H-FABP ile koroner arter hastalığı risk skorları arasındaki ilişkiyi ve H-FABP'ın AKS tanılı hastalarda tanısında kullanılabileceğini gösterdik.

Keywords

• Kalp tipi yağ asidi bağlayıcı protein,akut koroner sendrom,kardiyak biyobelirteç,inflamasyon,ateroskleroz

The Relationship between Cardiac Fatty Acid Binding Protein and Acute Coronary Syndrome Risk Scores

Abstract

Objective: Heart type fatty acid binding protein (H-FABP) is a low moleculer weight major cytoplasmic protein and released quickly from cardiomyocytes in response to myocardial injury. We searched functionality of H-FABP in diagnosis of acute coronary syndrome (ACS) and prevalence of coronary artery disease, relationship with its severity and early diagnosis.

Materials and Methods: This was a prospective observational study. We took in 110 patients- aged 18 and above-diagnosed ACS between the dates February 2016 and January 2017. The patient population was divided into two groups as ST segment elevation ACS (STEMI, 52 patients) and Non-ST segment elevation ACS (NSTE-ACS, 58 patients). For H-FABP and cardiac troponin I (cTnI) blood samples of the patients were taken both when they first applied to the hospital and six hours later. Coronary angiography was performed to all the patients. 

Results: On admission, it wasn’t found a statistically significant relationship in both groups, GRACE (Global Registry of Acute Coronary Events), SYNTAX (The synergy between percutaneous coronary intervention with taxus and cardiac surgery) and between Gensini Risk skores (p=0.056, p=0.791, p=0.278). The H-FABP level of blood samples looked over six hours later with GRACE and Gensini risk scores were statistically significant in the H-FABP positive group (p=0.003, p=0.011). However SYNTAX risk score in H-FABP positive group was not statistically significant (p=0.984).

Conclusion: In our study, we demonstrated the relationship between H-FABP and coronary artery disease risk scores and that H-FABP can be used in the diagnosis of ACS.

Keywords

• Heart-type fatty acid binding protein,acute coronary syndrome,cardiac biomarker,inflammation,, atherosclerosis

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