Autoimmune Hemolytic Anemia Developing Secondary to Epstein-Barr Virus Infection: A case report

Abstract

Infectious mononucleosis (EM) is a disease characterized by irradiation of the Epstein-Barr virus (EBV). The clinical manifestation is characterized by tonsillopharyngitis, lym-phadenopathy and atypical lymphocytosis. We describe a young patient developing hemolytic anemia during follow-up in our clinic due to tonsillopharyngitis secondary to EBV and general condition disorder.

Keywords

• Autoimmune,Hemolytic anemia,Infectious mononucleosis

Epstein-Barr Virus İnfeksiyonuna Sekonder Olarak Gelişen Otoimmun Hemolitik Anemi: Bir Vaka Raporu

Öz

Enfeksiyöz mononükleoz (EM), Epstein-Barr virüsünün (EBV) yayılması ile karakterize bir hastalıktır. Klinik bul-gular tonsillofarenjit, lenfadenopati ve atipik lenfositoz ile karakterizedir. EBV'ye sekonder tonsillofarenjit ve genel durum bozukluğu nedeniyle kliniğimizde takip sırasında hemolitik anemi gelişen genç bir hastayı tanımladık.

Anahtar Kelimeler

• Autoimmune,Hemolytic anemia,Infectious mononucleosis

References

1. 1. Johannsen EC, Schooley RT, Kaye KM. Epstein-Barr virus (infectious mononucleosis). In: Mandell GL, Bennett JE, Dolin R (eds). Principles and Practice of Infectious Diseases. 6th ed. Vol 2. Philadelphia: Elsevier Churchill Livingstone, 2005:1801-20.
2. 2. Arman D. Epstein-Barr virüs. Topçu Wilke A, Söyletir G, Doğanay M (editörler). İnfeksiyon Hastalıkları ve Mikrobiyolojisi. 1. Baskı. İstanbul: Nobel Tıp Kitabevleri, 2002:1197-201.
3. 3. Lennon P, Saunders J, Fenton JE. A longer stay for the kissing disease: epidemiology of bacterial tonsillitis and infectious mononucleosis over a 20- year period. J Laryngol Otol. 2013;7:1-5.
4. 4. Cohen JI. Treatment of infectious mononucleosis: When and how? The Herpes Monitor. 2003;3:1-5.
5. 5. Straus SE, Cohen JI, Tosato G, Meier J. Epstein-Barr virus infections: Biology, pathogenesis and management. Ann Intern Med. 1993;118:45-58.
6. 6. Tynell E, Aurelius E, Brandell A, et al. Acyclovir and prednisolone treatment of acute infectious mononucleosis: A multicenter, double-bind, plasebocontrolled study. J Infect Dis. 1996;174:324-31.
7. 7. H.B. Jenson. Acute complications of Epstein–Barr virus infectious mononucleosis. Curr Opin Pediatr. 12 (2000), pp. 263-268.
8. 8. Zanella A, Barcellini W. Treatment of autoimmune hemolytic anemias. Haematologica. 2014:1457-1554.

9. 9. E. C. Besa, Rapid transient reversal of anemia and long-term effects of maintenance intravenous immunoglobulin for autoimmune hemolytic anemia in patients with lymphoproliferative disorders. The American Journal of Medicine. 1988:691-8.
10. 10. Vouloumanou E.K, Rafailidis P.I, Falagas M.E. Current diagnosis and management of infectious mononucleosis. Curr Opin Hematol. 2012;19(1):14-20.