Evaluation of Clinical Characteristics, Laboratory, Radiological Findings and Outcomes of Hospitalized Children with Coronavirus Disease 2019

Abstract

Objective: We assessed our knowledge about the epidemiological, clinical characteristics, laboratory/ radiological findings, and outcomes of hospitalized children with COVID-19. Materials and Methods: This retrospective single-center study was conducted on 54 children with COVID-19 who were hospitalized from March 16, 2020, to April 26, 2020, in the Pediatric Department at Sancaktepe Training &Research Hospital Istanbul, Turkey. Results: The median age of our patients was 121.5 months (range 1-214 months), of the 54 hospitalized children, 48.1 % (n=26) were female, and 51.9% (n=28) were male. The most common symptom was cough (n=24, 44.4%). The median duration of hospitalization was five days (range 1-13 days). According to the PCR test results, 24 (44.4%) patients werepositive, and 30 (55.6%) were negative. Among 54 children, white-cell count (WBC), absolute neutrophil count (ANC) were significantly lower, and CRP levels were significantly higher in PCR negative patients. Computed tomography was performed in 26 children, and 19(73.1%) CT scans were consistent with classic/probable/indeterminate COVID-19 predominant patterns. Oxygen requirement was significantly higher in our PCR negative patients. Conclusion: As a result of the low sensitivity of PCR test results, clinicians should consider clinical signs and symptoms in deciding on the diagnosis and treatment of COVID-19.

Keywords

• children
• clinical features
• Covid-19

Coronovirus Hastalığı 2019 Tanısı ile Hastanede Yatan Çocuklarda Klinik, Laboratuar, Radyolojik Bulguların ve Sonuçların Değerlendirilmesi

Öz

Amaç: Çalışmamızda COVID-19 tanısı ile hastanede yatan çocukların epidemiyolojik, klinik özellikleri, laboratuvar / radyolojik bulguları ve sonuçları hakkındaki bilgilerimizi değerlendirdik. Materyal ve Metod: Bu retrospektif tek merkezli çalışma, 16 Mart 2020 - 26 Nisan 2020 tarihleri arasında İstanbul Sancaktepe Eğitim ve Araştırma Hastanesi Pediatri Kliniğinde yatan 54 COVID-19 tanılı çocuk hasta üzerinde gerçekleştirildi. Bulgular: Hastalarımızın ortanca yaşı 121,5 ay (1-214 ay) idi. Hastaneye yatırılan 54 çocuk hastanın % 48,'i (n = 26) kadın, %51,9'u (n = 28) erkekti. En sık görülen semptom öksürüktü (n = 24, % 44,4). Ortalama yatış süresi 5 gündü (1-13 günarasında). PCR test sonuçlarına göre 24 (% 44,4) hasta pozitif, 30 (% 55,6) hasta negatifti. 54 çocukta beyaz küre sayısı (WBC), mutlak nötrofil sayısı (ANC) anlamlı olarak düşüktü ve CRP düzeyleri PCR negative hastalarda anlamlı olarak daha yüksekti. Bilgisayarlı tomografi 26 hastamıza çekildi ve 19 (% 73,1) BT klasik / olası / belirsiz COVID-19 baskın paterni ile uyumlu idi. PCR negative hastalarımızda oksijen gereksinimi anlamlı derecede yüksekti. Sonuç: PCR test sonuçlarının düşük hassasiyetinin bir sonucu olarak, klinisyenler COVID-19'un tanı ve tedavisine karar verirken klinik belirti ve semptomları ön planda düşünmelidir.

Anahtar Kelimeler

• Çocuk
• klinik özellikleri
• Covid-19

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