Sarkoidozlu Hastalarda Sistolik Pulmoner Arter Basıncının Pulmoner Arter Çapı, Yaş, Hastalık Süresi, Hastalığın Evresi ve Akciğer Dışı Tutulumla İlişkisi

Öz

Amaç: Sarkoidozlu hastalarda sistolik pulmoner arter basıncının (sPAB) pulmoner arter çapı (PAÇ), yaş, cinsiyet, hastalık süresi, hastalığın evresi, akciğer dışı tutulum ve spontan remisyon ile olan ilişkilerini araştırmayı amaçladık. Materyal ve Metot: Çalışmaya göğüs hastalıkları kliniğinde 2010-2020 yılları arasında tanı almış ve takip edilmiş 60 sarkoidozlu hasta alındı. Hastaların demografik verileri, klinik seyri, tedavi bilgileri radyolojik ve ekokardiyografik incelemeleri kaydedildi. EKO’ya dayalı ortalama PAB’nın hesaplanmasında sPAB kullanıldı. PAÇ toraks BT konusunda yetkin radyolog tarafından ölçüldü. PAB ile PAÇ ve diğer parametreler arasındaki ilişki araştırıldı. Bulgular: Hastaların sPAB: 29.68±5.73 mmHg, PAÇ:28.20±5.75 mm olarak bulundu. Aralarında anlamlı korelasyon saptandı (r=0.46 p<0.001). PAÇ, PH’u olan hastalarda: 39.7±4.6, olmayanlarda: 27±4.9 (p<0.001) idi. sPAB, ekstrapulmoner tutulumu olmayanlarda: 31.03±6.35, olanlarda: 27.52±3.77 (p=0.01) bulundu. Araştırılan diğer parametrelerle anlamlı ilişki saptanmadı. Sonuç: Sarkoidozlu hastalarda sPAB ve PAÇ arasında orta derecede kuvvetli pozitif yönlü korelasyon saptandı. Aynı zamanda PAÇ, PH olan hastalarda olmayanlara göre anlamlı olarak daha yüksek bulundu. Bu da sarkoidozlu hastalarda toraks BT incelemesi esnasında kolaylıkla ölçülebilen PAÇ’nın sarkoidozla ilişkili pulmoner hipertansiyonu (SİPH) tahmin etmede yol gösterici olabileceğini göstermektedir.

Anahtar Kelimeler

• Pulmoner hipertansiyon
• pulmoner arter çapı
• sarkoidoz
• sistolik pulmoner arter basıncı

The Association of Systolic Pulmonary Artery Pressure with Pulmonary Artery Diameter, Age, Disease Duration, Stage of the Disease, and Extrapulmonary Involvement in Patients with Sarcoidosis

Abstract

Objective: We aimed to investigate the association of systolic pulmonary artery pressure (sPAP), with pulmonary artery diameter (PAD), age, gender, disease duration, disease stages, extrapulmonary involvement, and spontaneous remission in patients with sarcoidosis. Materials and Methods: Diagnosed and followed-up in the chest diseases clinic between 2010-2020, 60 sarcoidosis patients were included. Patients’ demographic data, clinical course, information over treatment, radiological and echocardiographic examinations were recorded. sPAB was utilized to calculate mean PAP based on ECHO. PAD was measured by an experienced radiologist in thoracic CT. Associatons of PAP and PAD with other parameters were investigated. Results: sPAP and PAD were found as 29.68±5.73 mmHg and 28.20±5.75 mm. A significant correlation was detected between them (r=0.46 p<0.001). PADs were 39.7±4.6 and 27±4.9 in patients with and without PH (p<0.001). sPAPs were found as 27.52±3.77 and 31.03±6.35 among those with and without extrapulmonary involvement (p=0.01). No association was found between these parameters and others. Conclusion: A moderately strong positive correlation was detected between sPAP and PAD in sarcoidosis patients. PAD was significantly found higher in patients with PH than those without. This also shows that PAD, which can be easily measured during thoracic CT examination in sarcoidosis patients, can be a guide in predicting sarcoidosis-associated pulmonary hypertension (SAPH).

Keywords

• Pulmonary artery diameter
• pulmonary hypertension
• sarcoidosis
• systolic pulmonary artery pressure

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