Fluorescence Reflection on Nails after the Treatment of COVID-19 with Favipiravir

Abstract

Objective: Favipiravir is recommended for treatment of COVID-19 by the Turkey National Treatment Guideline for COVID-19. It has been widely used for COVID-19 infected patients in Turkey. Fluorescence of the nails with certain topical and systemic drugs with Wood’s lamp was and reported in the English literature. This study is designed to determine the fluorescence effect of favipiravir in the nails of COVID-19 patients.

Materials and Methods: Eighty five patients with COVİD-19 infection who were treated with favipiravir and/or hydroxychloroquine and 50 healthy volunteers’ nails were examined by Wood’s lamp. Fluorescence and therapeutic interest were recorded. Data were compared.

Results: Seventy one of the patients (83.5%) had fluorescent nails under UV radiation in the patient group, where no fluorescence was observed in the healthy control group.

Conclusion: Fluorescence of the nails in the patients with confirmed COVID-19 infection who were treated with favipiravir is a common finding. 

Keywords

• COVID-19
• favipiravir
• fluorescence

COVİD-19’un Favipiravir ile Tedavisi Sonrası Tırnaklarda Floresan Yansıma

Öz

Amaç: Favipiravir, COVID-19 Türkiye Ulusal Tedavi Klavuzunda, COVİD-19 tedavisi için önerilmektedir. Türkiye’de COVID-19 ile enfekte hastalarda yaygın olarak kullanılmaktadır. Belli topikal ve sistemik ilaçlar ilaçlarla tırnaklarda Wood lambası ile floresan yansıma bildirilmiştir. Bu çalışma, COVID-19 hastalarının tırnaklarında favipiravirin floresan etkisini belirlemek için tasarlanmıştır.

Materyal ve Metot: Favipiravir ve/veya hidroksiklorokin ile tedavi edilen COVİD-19 enfeksiyonlu 85 hasta ve 50 sağlıklı gönüllünün tırnakları Wood lambası ile incelendi. Floresan yansıma ve ilaç öyküleri kaydedildi. Veriler karşılaştırıldı.

Bulgular: Hasta grubunda, 71 hastada (%83,5) UV radyasyon altında tırnaklarda floresan yansıma mevcuttu. Sağlıklı kontrol grubunda floresans gözlenmedi.

Sonuç: Favipiravir ile tedavi edilen COVİD-19 tespit edilmiş hastaların tırnaklarında floresan yansıma yaygın bir bulgudur. 

Anahtar Kelimeler

• COVID-19
• favipiravir
• floresan

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