Chronic Effects of Ziprasidone, Aripiprazole, Blonanserin, Cyamemazine, and Nemonapride on Mice Isolated Detrusor Smooth Muscle

Abstract

Objective: Ziprasidone, aripiprazole, blonanserin, cyamemazine, and nemonapride are atypical antipsychotic drugs used for the treatment of schizophrenia. This study aimed to identify the effects of these atypical antipsychotic drugs in mice isolated bladder using the organ bath system

Materials and Methods: The mice were injected intraperitoneally with drugs for 21 days. The effects of drugs were investigated on isoproterenol-induced relaxation responses of carbachol-induced contractions in isolated detrusor strips. The detrusor strips were stimulated with KCl, then tissues were washed for a further 30 min and precontracted with a submaximal concentration of carbachol. After the contraction reached a plateau, cumulative concentration-response curves to isoproterenol were obtained.

Results: We showed that carbachol-induced contractions dose-dependently relaxed by isoproterenol in mice detrusor strips obtained from ziprasidone, aripiprazole, blonanserin, and cyamemazine but not nemonapride treated group. However, none of the drug treatments had any effect KCl responses of mice's bladder.

Conclusion: Ziprasidone, aripiprazole, blonanserin, and cyamemazine but not nemonapride increased the isoproterenol-induced relaxations of the detrusor smooth muscle indicates that it can increase the bladder capacity. We demonstrate that four drugs may represent a potential treatment for overactive bladder. They might be clinically useful for the treatment of overactive bladder in patients that should use antipsychotics. 

Keywords

• Aripiprazole
• blonanserin
• cyamemazine
• nemonapride
• ziprasidone

Ziprasidon, Aripiprazol, Blonanserin, Siyamemazin ve Nemonaprid'in Farelerde İzole Detrusor Düz Kasına Kronik Etkileri

Öz

Amaç: Ziprasidon, aripiprazol, blonanserin, siyamemazin ve nemonaprid şizofreni tedavisinde kullanılan atipik antipsikotik ilaçlardır. Bu çalışmada bu atipik antipsikotik ilaçların organ banyosu kullanılarak farelerde izole edilmiş mesane üzerine etkilerinin belirlenmesi amaçlanmıştır.

Materyal ve Metot: Fareler 21 gün boyunca intraperitoneal ilaç enjeksiyonu uygulandı. İlaçların izole detrusor şeritlerinde karbakolden kaynaklanan kasılmaların izoproterenol kaynaklı gevşeme tepkileri üzerindeki etkileri araştırıldı. Detrüsör şeritleri KCl ile uyarıldı, daha sonra dokular 30 dakika yıkandı ve submaksimal bir karbakol konsantrasyonu ile önceden kastırıldı. Kasılma belli bir platoya ulaştıktan sonra, izoproterenole kümülatif konsantrasyon-yanıt eğrileri elde edildi.

Bulgular: Karbakol kaynaklı kasılmaların ziprasidon, aripiprazol, blonanserin ve siyamemazin ile muamele edilen gruptan elde edilen fare detrusor şeritlerinde izoproterenol ile doza bağlı olarak gevşediğini gösterdik. Bununla birlikte, ilaç tedavilerinin hiçbiri, fare mesanelerinin KCl yanıtlarını etkilememiştir.

Sonuç: Nemonaprid dışında ziprasidon, aripiprazol, blonanserin ve siyamemazin, izoproterenol ile indüklenen detrüsör düz kas gevşemesi görülmesi mesane kapasitesini arttırabileceğini göstermektedir. Dört ilacın aşırı aktif mesane için potansiyel bir tedavi olabileceğini ön görmekteyiz. Bu ilaçlar, antipsikotikleri kullanması gereken hastalarda aşırı aktif mesane tedavisinde klinik olarak yararlı olabilir.  

Anahtar Kelimeler

• Aripiprazol
• blonanserin
• nemonaprid
• siyamemazin
• ziprasidon

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