Üç Thiazolidine-4-Karboksilik Asit Türevinin Pseudomonas, Acinetobacter, Staphylococcus Aureus ve Escherichia Coli Bakterilerine Karşı Antibakteriyel Özelliklerinin İncelenmesi

Year 2017, Volume: 2 Issue: 4, 1 - 10, 31.12.2017

Hayriye Genç , Mustafa Zengin , Aziz Öğütlü , Oğuz Karabay

https://doi.org/10.26453/otjhs.324573

Abstract

Çok
ilaca dirençli bakterilerin tedavisi, halk sağlığı için artan bir küresel sorundur.
Bu dirence ayak uydurabilmek için yeni ilaç aktif maddelerine ihtiyaç
duyulmaktadır. Tiazolidin-4-karboksilik asitlerin (TCA) doğal olarak oluşan
amino asitlerin çeşitli esas işlevlerini taklit ederek bakteri gelişimini
engelleyebildiği bilinmektedir. Bu nedenle, ikisi yeni olan üç TCA türevinin
sentezlenmesi amaçlanmış ve antibakteriyel aktiviteleri çok ilaca dirençli
(MDR) bakteriler üzerinde araştırılmıştır. Bileşikler (la-c), L-Sistein
hidroklorür ve dihidroksibenzaldehit türevlerinden sentezlendi ve çoklu ilaç
dirençli bakterilere karşı in vitro
aktiviteleri CLSI kriterlerine göre Kirby-Bauer yöntemi ile denendi. 1a-c,
mevcut antibiyotiklere kıyasla S. aureus
gibi Gram pozitif bakterilere ve Pseudomanas,
Acinetobacter ve Escherichia coli
gibi Gram negatif bakterilere karşı önemli antibakteriyel etki sergiledi.
Burada, ılıman şartlar altında yüksek verimle kolaylıkla sentezlenebilen yeni
potansiyel antibakteriyel maddeler bildirilmiştir. Ancak, bu üç bileşiğin daha
ileri araştırmalarının ve in-vitro etkinlik
testlerinin yapılması gerektiği açıktır.

Keywords

Anti-bakteriyel maddeler, ilaç direnci, sistein, tiyazolidin-4-karboksilik asit

Examination of antibacterial properties of three thiazolidine-4-carboxylic acid derivatives against Pseudomonas, Acinetobacter, Staphylococcus aureus, and Escherichia coli

Abstract

Treatment of multi-drug resistant bacteria is a growing problem for global
public health. We need new drugs to keep up with resistant. It is known that
Thiazolidine-4-carboxylic acids (TCA) are able to inhibit bacterial growth by
mimicking various essential functions of naturally occurring amino acids.
Therefore, we aimed to synthesis three TCA derivatives, two of them are novel,
and investigated their antibacterial activities on multi-drug resistant (MDR)
bacteria. Compounds (1a-c) were synthesized from L-Cysteine hydrochloride and
dihydroxybenzaldehyde derivatives and their in vitro activities against
multi-drug resistant bacteria were assayed by the Kirby-Bauer method according
to CLSI criteria. 1a-c exhibited significant antibacterial effect against Gram-positive
bacteria such as S. aureus and Gram-negative bacteria such as Pseudomanas,
Acinetobacter, and Escherichia coli superior to current antibiotics. Here, new
potential antibacterial agents, which can be easily synthesized in high yield under
mild condition, have been reported. But it is clear that further research and
in-vitro activity tests of these three compounds should be performed.

Keywords

Anti-bacterial agents, drug resistance, cysteine, thiazolidine-4-carboxylic acid

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