Abstract
This research aims to correlate status of lipid
profile in the patients diagnosed with cholelithiasis. It is an observational
case control study, completed in the Biochemistry department of Tribhuvan
University and Teaching Hospital (TUTH). Total 100 subjects were
selected and divided in two groups. The
groups consisted of 50 patients with cholelithiasis (group A) and 50 healthy control groups (group B). The research was completed
within a time of eight months commencing from 1st March 2016 to 31st
October 2016. Confirmation of
cholelithiasis was performed with ultrasound studies by
radiologist. Selection of group A and group B were done on basis of
radiological findings. Fasting blood samples for lipid profiles of all subjects
were collected and lipid profile tests done in bio-chemistry lab. Self-designed
form was used for documentation of different parameters of subjects. Triglyceride (TG) and
High-Density Lipids (HDL) were found to be statically significant (p=0.005 and
p=0. 001, respectively). Mean TG level in patients with cholelithiasis (1.9
mmol/l) was found higher than in normal cases (1.45 mmol/l). Mean HDL level in
patients (0.95 mmol/l) was lower than normal cases with (1.05mmol/l). In conclusion, we think that lipid profiles altered in
patients with cholelithiasis.
References
- Njeze GE. Gallstones. Niger J Surg. 2013;19(2):49–55.
- Batajoo H, Hazra NK. Analysis of serum lipid profile in cholelithiasis patients. J Nepal Health Res Counc. 2013;11(23):53-5
- Moghaddam AA, Khorram A, Bonjar MM, Mohammadi M, Ansari H. The prevalence and risk Factors of gallstone among adults in south-east of iran. A Population-Based Study. Glob J Health Sci. 2016;8(4):60–67.
- Apstein MD, Carey MC. Pathogenesis of cholesterol gallstones: A parsimonious hypothesis. Eur J Clin Invest. 1996; 26:343-52.
- Malik AA, Wani ML, Tak SI, Irshad I, Hassan NU. Association of dyslipidemia with cholilithiasis and effect of cholecystectomy on the same. International Journal of Surgery. 2011;9(8):641-42.
- Channa NA, Khand F, Ghanghro AB, Soomro AM. Quantitative analysis of serum lipid profile in gallstone patients and controls. Pak J Anal Environ Chem. 2010;11(1):59-65.
- Weerakoon HTW, Ranasinghe S, Navaratne A, Sivakanesan R, Galketiya KB, Rosairo S. Serum lipid concentrations in patients with cholesterol and pigment gallstones. BMC Res Notes. 2014; 7:548.
- Thijs C, Knipschild P, Brombacher P. Serum lipids and gallstones. A case-control study. Gastroenterology. 1990; 99:943-949.
- Ibrahim M, Sarvepalli S, Stiff GM, Rizk M, Bhatt A, Walsh RM, Hayat U, Garber A, Vargo J, Burke CA. Gallstones: Watch and wait, or intervene? Cleveland Clinic Journal of Medicine. 2018;85(4):323-331.
- Jorgensen T. Gall stones in a Danish population. Relation to weight, physical activity, smoking, coffee consumption, and diabetes mellitus. Gut. 1989; 30:528-534.
Abstract
Bu araştırma, kolelitiazis
tanısı alan hastalarda lipid profili durumunu ilişkilendirmeyi amaçlamaktadır.
Biyokimya Anabilim Dalı'nda tamamlanmış bir gözlemsel vaka kontrol
çalışmasıdır. Toplam 100 denek seçildi ve iki gruba ayrıldı. Gruplar
kolelitiazisli 50 hasta (grup A) ve 50 sağlıklı kontrol gruptan (grup B)
oluşmaktaydı. Araştırma, 1 Mart 2016 ile
31 Ekim 2016 tarihleri arasında sekiz ay içinde tamamlandı. Kolelitiazisin
doğrulanması Radyolog tarafından ultrason çalışmaları ile gerçekleşmiştir. Grup
A ve grup B seçimi radyolojik bulgulara dayanarak yapıldı. Tüm olguların lipit
profilleri için açlık kan örnekleri toplandı ve lipit profil testleri biyokimya
laboratuarında yapıldı. Olguların farklı parametrelerinin belgelenmesi için
öz-tasarımlı form kullanıldı. Trigliserit (TG) ve Yüksek Yoğunluklu Lipidler
(HDL) istatistiksel olarak anlamlı bulundu. (Sırasıyla, p = 0,005 ve p =
0,001). Safra taşı olan hastalarda ortalama TG seviyesi (1,9 mmol / l) normal
olgulardan (1,45 mmol / l) daha yüksek bulundu. Hastalarda ortalama HDL düzeyi
(0,95 mmol / l) normal olgulardan (1,05 mmol / l) düşüktü. Sonuç olarak
kolelitiazisli hastalarda lipit profillerinin değiştiğini düşünmekteyiz.
References
- Njeze GE. Gallstones. Niger J Surg. 2013;19(2):49–55.
- Batajoo H, Hazra NK. Analysis of serum lipid profile in cholelithiasis patients. J Nepal Health Res Counc. 2013;11(23):53-5
- Moghaddam AA, Khorram A, Bonjar MM, Mohammadi M, Ansari H. The prevalence and risk Factors of gallstone among adults in south-east of iran. A Population-Based Study. Glob J Health Sci. 2016;8(4):60–67.
- Apstein MD, Carey MC. Pathogenesis of cholesterol gallstones: A parsimonious hypothesis. Eur J Clin Invest. 1996; 26:343-52.
- Malik AA, Wani ML, Tak SI, Irshad I, Hassan NU. Association of dyslipidemia with cholilithiasis and effect of cholecystectomy on the same. International Journal of Surgery. 2011;9(8):641-42.
- Channa NA, Khand F, Ghanghro AB, Soomro AM. Quantitative analysis of serum lipid profile in gallstone patients and controls. Pak J Anal Environ Chem. 2010;11(1):59-65.
- Weerakoon HTW, Ranasinghe S, Navaratne A, Sivakanesan R, Galketiya KB, Rosairo S. Serum lipid concentrations in patients with cholesterol and pigment gallstones. BMC Res Notes. 2014; 7:548.
- Thijs C, Knipschild P, Brombacher P. Serum lipids and gallstones. A case-control study. Gastroenterology. 1990; 99:943-949.
- Ibrahim M, Sarvepalli S, Stiff GM, Rizk M, Bhatt A, Walsh RM, Hayat U, Garber A, Vargo J, Burke CA. Gallstones: Watch and wait, or intervene? Cleveland Clinic Journal of Medicine. 2018;85(4):323-331.
- Jorgensen T. Gall stones in a Danish population. Relation to weight, physical activity, smoking, coffee consumption, and diabetes mellitus. Gut. 1989; 30:528-534.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research article |
| Authors | |
| Publication Date | June 30, 2019 |
| Submission Date | October 5, 2018 |
| Acceptance Date | October 11, 2018 |
| Published in Issue | Year 2019 Volume: 4 Issue: 2 |
