Habitüel Abortusta Vitamin B12 ve Folatın Rolü

Year 2021, Volume: 6 Issue: 3, 347 - 352, 05.09.2021

Zehra Yılmaz Huri Güvey , Samettin Çelik , Canan Soyer Çalışkan , Burak Yaşar , Bahadır Yazıcıoğlu , Eda Türe , Hasan Ulubaşoğlu

https://doi.org/10.26453/otjhs.822978

Abstract

Amaç: Habitüel abortus etiyolojisinde birçok patofizyolojik mekanizma tanımlanmış olsa da vakaların yarısının nedeni hala aydınlatılamamıştır. Folat ve B12 vitamininin erken gebelik komplikasyonları üzerinde etkili olduğu bildirilmektedir. Biz de çalışmamızda habitüel abortus ile folat ve vitamin B12 düzeyleri arasındaki ilişkiyi ortaya koymayı amaçladık.

Materyal ve Metot: Habitüel abortus hikayesi olan 124 gebe ve böyle bir hikayesi olmayan 242 gebe olmak üzere, toplam 366 hasta çalışmaya dahil edilmiştir. Hastaların yaş, gestasyonel hafta, boy, kilo, vücut kitle indeksi (VKİ), gebelik, parite, düşük ve yaşayan çocuk sayısı ve vitamin B12 ve folat seviyeleri değerlendirildi.

Bulgular: Çalışma sonuçlarımıza göre çalışma grubunun yaş, gravida ve düşük sayıları kontrol grubundan anlamlı olarak yüksek bulunmuştur (p<0,05). Grupların boy, kilo ölçümleri, vitamin B12 ve folat ölçümleri arasında istatistiksel olarak anlamlı bir fark bulunmazken (p>0,05), çalışma grubunun VKİ ölçümleri ve yaşayan çocuk sayısı kontrol grubundan anlamlı olarak düşük bulunmuştur (p<0,05).

Sonuç: Çalışmamızın sonuçlarına göre vitamin B12 ve folat ile habitüel abrtus arasında herhangi bir anlamlı ilişki saptamadık. Konuyla ilgili literature katkıda bulunacak daha büyük örneklemli prospektif çalışmalara ihtiyaç vardır.

Anahtar Kelimeler: Folat

Keywords

Folat, Habitüel abort, Vitamin B12

The Role of Vitamin B12 and Folate in Habitual Abortion

Abstract

Objective: Although several pathophysiological mechanisms are defined in the etiology of habitual abortion, still causes half of the cases haven’t been clarified yet. It has been reported that folate and vitamin B12 are effective in early pregnancy complications. In our study, we aimed to reveal the relationship between habitual abortion with folate and vitamin B12 levels.

Materials and Methods: We included our study 124 pregnant having habitual abortion history and 242 pregnants without this, a total of 366 patients. Maternal and gestational age, height, weight, body mass index (BMI), gravidity, parity, abortion, and living children count and vitamin B12 and folate levels of these pregnants were evaluated retrospectively.

Results: The ages, gravidity, and abortion counts of the study group were significantly higher than the control group (p<0.05). While the weight, height measurements, vitamin B12, and folate measurements showed no significant difference (p>0.05) between groups, the BMI measurements, living children count, and of the study group were significantly lower than the control group (p<0.05). 

Conclusion: According to our results, we didn’t find any relationship between habitual abortion with folate and vitamin B12 levels. Further larger sample-sized and prospective studies are required to contribute to the literature about this issue. 

Keywords

Folate, habitual abortion, vitamin B12

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