Prognostic Value and Significance of Oxidative Stress in Breast Cancer

Year 2022, Volume: 7 Issue: 3, 453 - 459, 01.09.2022

İsmail Zengin , Havva Belma Koçer , Tayfur Demiray , Kerem Yılmaz

https://doi.org/10.26453/otjhs.1080001

Abstract

Objective: The aims of this study were to investigate Total Antioxidative Status (TAS), Total Oxidative Status (TOS), and Oxidative Stress Index (OSI) levels in breast cancer patients and compare them to levels in healthy women.

Materials and Methods: In the study, 45 breast cancer patients and 46 healthy women participated. The OSI value was calculated as the % ratio of the TAS and TOS values. The data were analyzed on IBM SPSS 21.0 package software.

Results: When the mean TOS values in patients and healthy women were compared, the control group had a TOS of 3.44 µ mIU/L and the patient group had a TOS of 11.93 µ mIU/L. TAS was found to have a mean value of 1.74 µ mIU/L in the control group and 1.63 m/mol/L in the patient group. OSI was determined to have a mean value of 7.23 in patients with breast cancer and 1.99 in healthy women. In female patients with breast cancer, TOS value was higher, TAS value was lower, and OSI value was significantly higher than healthy women (p<0.01).

Conclusion: TOS, TAS and OSI values ​​can be a marker that can be used to differentiate patients with breast cancer and healthy women. 

Keywords

Breast cancer, TAS, TOS, OSI, prognostic factor.

Supporting Institution

Sakarya University Scientific Research Projects Support Fund

Project Number

Project Number: 2017-08-06-004

Thanks

The authors would like to special thanks to general surgery and clinical microbiology laboratory sections of Sakarya University, Training and Research Hospital for their help in this research.

Meme Kanserinde Oksidatif Stresin Prognostik Değeri ve Önemi

Abstract

Amaç: Meme kanseri hastalarında Total Antioksidan Status (TAS), Total Oksidan Status (TOS), Oksidatif Stres İndeks (OSI) düzeylerini araştırmak ve bunları sağlıklı kadınlarla karşılaştırmaktır.

Materyal ve Metot: Çalışmaya 45 meme kanseri hastası ve sağlıklı 46 kadın dahil edildi. Bu hastaların serumlarında TAS ve TOS değerleri ölçülerek OSİ değerleri hesaplandı. Veriler IBM SPSS 21.0 paket programında değerlendirildi.

Bulgular: Hasta ve sağlıklı kadınların ortalama TOS değerleri karşılaştırıldığında, kontrol grubunun TOS değeri 3,44 µmIU/L, hasta grubunun TOS değeri 11,93 µmIU/L bulundu. TAS’ın ortalama değeri kontrol grubunda 1,74 µmIU/L, hasta grubunda ise 1,63 m/mol/L olarak bulundu. OSİ, meme kanserli hastalarda ortalama 7,23 iken sağlıklı kadınlarda 1,99 olarak belirlendi. Meme kanserli kadın hastalarda, sağlıklı kadınlara göre TOS değeri yüksek, TAS değeri düşük, OSİ değeri anlamlı düzeyde yüksek bulundu (p<0,01).

Sonuç: TOS, TAS ve OSİ değerleri meme kanserli hastalar ile sağlıklı kadınların ayrımında kullanılabilecek bir belirteç olabilir.

Keywords

Meme kanseri, oksidatif stres indeks, prognostik faktör, total antioksidan status, total oksidan status

Project Number

Project Number: 2017-08-06-004

References

• Özcan O, Erdal H, Çakırca G, Yönden Z. Oxidative stress and its impacts on intracellular lipids, proteins and DNA. J Clin Exp Invest. 2015;6(3):331-336. doi:10.5799/ahinjs.01.2015.03.0545
• Altan N, Dinçel AS, Koca C. Diabetes mellitus ve oksidatif stres. Turk J Biochem. 2006;31:51-56.
• Kim SY, Kim JW, Ko YS, Koo JE, Chung HY, Lee-Kim YC. Changes in lipid peroxidation and antioxidant trace elements in serum of women with cervical intraepithelial neoplasia and invasive cancer. Nutr Cancer. 2003;47(2):126-130. doi:10.1207/s15327914nc4702_3
• Nayak SB, Yashwanth S, Pinto SM, Bhat VR, Mayya SS. Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substance status in liver cancer associated with elevated levels of alpha-fetoprotein. Indian J Physiol Pharmacol. 2005;49(3):341-344.
• Leung EY, Crozier JE, Talwar D, et al. Vitamin antioxidants, lipid peroxidation, tumour stage, the systemic inflammatory response and survival in patients with colorectal cancer. Int J Cancer. 2008;123(10):2460–2464. doi:10.1002/ijc.23811
• Kundaktepe BP, Sozer V, Durmus S, et al. The evaluation of oxidative stress parameters in breast and colon cancer. Medicine (Baltimore). 2021;100(11):e25104. doi:10.1097/MD.0000000000025104
• Rainis T, Maor I, Lanir A, Shnizer S, Lavy A. Enhanced oxidative stress and leucocyte activation in neoplastic tissues of the colon. Dig Dis Sci. 2007;52(2):526–530. doi:10.1007/s10620-006-9177-2
• Srivastava DS, Mittal RD. Free radical injury and antioxidant status in patients with benign prostate hyperplasia and prostate cancer. Indian J Clin Biochem. 2005;20(2):162–165. doi:10.1007/BF02867419
• Yang YW, Dai CM, Chen XH, Feng JF. The Relationship between serum trace elements and oxidative stress of patients with different types of cancer. Oxid Med Cell Longev. 2021;2021:4846951. doi:10.1155/2021/4846951
• Huang Y, Sheu J, Lin T. Association between oxidative stress and changes of trace elements in patients with breast cancer. Clin Biochem. 1999;32:131-136. doi:10.1016/s0009-9120(98)00096-4
• Rajizadeh A, Mozaffari-Khosravi H, Zavar-Reza J, Shiryazdi SM. Comparison of hematological parameters, iron levels, and oxidative stress in women with and without breast cancer: A case- control study. Med J Islam Repub Iran. 2017;31:114. doi:10.14196/mjiri.31.114
• Feng JF, Lu L, Dai CM, et al. Analysis of the diagnostic efficiency of serum oxidative stress parameters in patients with breast cancer at various clinical stages. Clin. Biochem. 2016;49(9):692-698. doi:10.1016/j.clinbiochem.2016.02.005
• Wang M, Dhingra K, Hittelman WN, Liehr JG, de Andrade M, Li D. Lipid peroxidation-induced putative malondialdehyde-DNA adducts in human breast tissues. Cancer Epidemiol Biomarkers Prev. 1996;5(9):705–710.
• Erel O. A new automated colorimetric method for measuring total oxidant status. Clin. Biochem. 2005;38(12):1103-11. doi:10.1016/j.clinbiochem.2005.08.008
• Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin. Biochem. 2004;37(2):112-9. doi:10.1016/j.clinbiochem.2003.10.014
• Kamala HM , EL Sayeda WM, Ibrahemb AH, EL Sokaryc MA, Behiry EG. Study of metallothionein-2A mRNA relative expression and oxidant status in females with breast cancer. Meta Gene. 2020;24:100678. doi:10.1016/j.mgene.2020.100678
• Rezk NA, Zidan HE, Riad M, Mansy W, Mohamad SA. Metallothionein 2A expression and its relation to different clinical stages and grades of breast cancer in Egyptian patients. Gene. 2015;571(1):17-22. doi:10.1016/j.gene.2015.06.035
• Panis C, Herrera AC, Victorino VJ, et al. Oxidative stress and hematological profiles of advanced breast cancer patients subjected to paclitaxel or doxorubicin chemotherapy. Breast Cancer Res. Treat. 2012;133(1):89-97. doi:10.1007/s10549-011-1693-x
• Ramírez-Expósito MJ, Sánchez-López E, Cueto-Ureña C. et al. Circulating oxidative stress parameters in pre- and post-menopausal healthy women and in women suffering from breast cancer treated or not with neoadjuvant chemotherapy. Exp Gerontol. 2014;58:34-42. doi:10.1016/j.exger.2014.07.006
• Didžiapetrienė J, Kazbarienė B, Tikuišis R, et al. Oxidant/Antioxidant status of breast cancer patients in pre- and post-operative periods. Medicina (Kaunas). 2020;56(2):70. doi:10.3390/medicina56020070
• Zhou Y, Li H, Xia N. The Interplay between adipose tissue and vasculature: Role of oxidative stress in obesity. Front Cardiovasc Med. 2021;8:650214. doi:10.3389/fcvm.2021.650214
• Khalil Arjmandi M, Moslemi D, Sadati Zarrini A, et al. Pre and post radiotherapy serum oxidant/antioxidant status in breast cancer patients: Impact of age, BMI and clinical stage of the disease. Rep Pract Oncol Radiother. 2016;21(3):141-148. doi:10.1016/j.rpor.2015.12.009
• Sateesh R, Rao BAR, Budugu SR, et al. Oxidative stress in relation to obesity in breast cancer. Indian J Cancer. 2019;56(1):41-44. doi:10.4103/ijc.IJC_247_18
• Pedroza DA, Subramani R, Tiula K, et al. Crosstalk between progesterone receptor membrane component 1 and estrogen receptor α promotes breast cancer cell proliferation. Lab Invest. 2021;101(6):733-744. doi:10.1038/s41374-021-00594-6
• Li Y, Yang D, Yin X, et al. Clinicopathological characteristics and breast cancer–specific survival of patients with single hormone receptor–positive breast cancer. JAMA Netw Open. 2020;3(1):e1918160. doi:10.1001/jamanetworkopen.2019.18160