Association of Hemogram Parameters with Body Mass Index in Knee Osteoarthritis

Year 2024, Volume: 9 Issue: 3, 202 - 208, 16.09.2024

Koksal Gundogdu , Gülşah Gündoğdu , Alper Kurtoğlu

https://doi.org/10.26453/otjhs.1410851

Abstract

Objective: This study aims to investigate the relationship between hemogram parameters, which are low-cost, easy, routinely applied low-grade inflammation indicators, and severity of knee osteoarthritis (KOA) and obesity.
Materials and Methods: This study involved 140 KOA patients aged 45 to 85 who underwent knee radiographs, weight and height measurements, and routine laboratory tests. Recorded data included demographic information (gender, age), body mass index (BMI), routine hemogram, and laboratory parameters. Patients were categorized into two groups based on their Kellgren-Lawrence (KL) scores (mild: KL 1-3, severe: KL 4) and four groups according to their BMI (BMI <25, BMI = 25-30, BMI = 30-35, BMI >35).
Results: The findings revealed significantly elevated levels of serum Neutrophil-to-Lymphocyte Ratio (NLR) and C-reactive protein (CRP) in severe KOA compared to mild KOA (P<0.05). Evaluation by BMI demonstrated a statistically significant increase in serum NLR and Neutrophil-to-monocyte Ratio (NMR) in patients with BMI>30 in mild KOA groups, while mean blood NLR was notably higher in patients with BMI=30-35 in severe KOA groups.
Conclusions: These results suggest that NLR and NMR could provide a new perspective on the relationship between obesity and mild KOA in clinical practice, presenting a cost-effective and easily applicable alternative for determining disease prognosis and progression.

Keywords

Knee osteoarthritis, neutrophil/lymphocyte ratio, neutrophil monocyte ratio

Ethical Statement

This study was approved by the Ethics Committee of the Medical Faculty of Atatürk University (date of approval of the Ethics Committee: 30.11.2017, decision number: B.30.2.ATA.0.01.00/91).

Supporting Institution

none

Project Number

none

Thanks

The authors are grateful to all participants for their help with sample collection

Diz Osteoartritinde Hemogram Parametrelerinin Vücut Kitle İndeksi ile İlişkisi

Abstract

Amaç: Bu çalışmada, düşük maliyetli, kolay, rutin olarak uygulanan düşük dereceli inflamasyon göstergeleri olan hemogram parametreleri ile obezite ve diz osteoartriti (DOA) şiddeti arasındaki ilişkinin araştırılması amaçlanmıştır.
Materyal ve Metot: Bu çalışmaya, diz grafileri, kilo ve boy ölçümleri ve rutin laboratuvar testleri yapılmış 45-85 yaş arası 140 KOA hastası dahil edilmiştir. Kaydedilen veriler demografik bilgileri (cinsiyet, yaş), vücut kitle indeksini (BMI), rutin hemogramı ve laboratuvar parametrelerini içeriyordu. Hastalar Kellgren-Lawrence (KL) skorlarına göre iki gruba (hafif: KL 1-3, şiddetli: KL 4) ve BMI'larına göre dört gruba (BMI<25, BMI=25-30, BMI=30-35, BMI>35) ayrılmıştır.
Bulgular: Bu çalışmada, serum CRP ve NLR değerleri şiddetli DOA hastalarında hafif DOA hastalarına kıyasla anlamlı derecede yüksek bulunmuştur (P<0,05). VKİ'ye göre değerlendirildiğinde, kan nötrofil lenfosit (NLR) ve nötrofil monosit (NMR) oranları hafif DOA gruplarında VKİ>30 olan hastalarda istatistiksel olarak anlamlı şekilde artmıştır. Ayrıca, şiddetli DOA gruplarında ortalama kan NLR değeri VKİ=30-35 olan hastalarda diğer gruplara kıyasla anlamlı derecede yüksek bulunmuştur.
Sonuç: Bu sonuçlar, NLR ve NMR'nin klinik ortamda obezite ve hafif DOA arasındaki ilişkiye yeni bir bakış açısı sağlayabileceğini göstermektedir. Bu parametrelerin düşük maliyetli ve kolay uygulanabilmesi, hastalığın prognozunu ve seyrini belirlemede alternatif olabilir.

Keywords

Diz osteoartriti, nötrofil/lenfosit oranı, nötrofil/monosit oranı

Project Number

none

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