Is the Systemic Immune-Inflammation Index Associated with the Prognosis and Severity of Bell’s Palsy?

Year 2024, Volume: 9 Issue: 4, 373 - 378

Ahmet Kara , Halil Elden

https://doi.org/10.26453/otjhs.1576219

Abstract

Objective: To investigate the effect of newly defined systemic immune-inflammation index levels on the diagnosis, prognosis, and severity of Bell's palsy.
Materials and Methods: The study group was formed from patients diagnosed with Bell's palsy. Calculated ratios with the data obtained from the complete blood count examinations taken before the treatment were statistically investigated for the diagnosis, prognosis, and severity of the disease.
Results: We did not determine any statistically significant correlation between the determined facial paralysis stages and the investigated ratios. Similarly, there was no correlation between the first and sixth-month recovery rates of the study group and the investigated parameters (p>0.05). In addition, differences in parameters between the control and study groups were not statistically significant.
Conclusions: The results of the presented study contain differences from the current literature. In addition, it provides new information about the effect of the systemic immune-inflammation index on the prognosis of Bell's palsy. Considering the outcomes of research on hematological parameters is important, as various factors can impact them.

Keywords

Bell, ınflammation, lymphocytes, neutrophils, platelets

Ethical Statement

Our study was approved by the Sakarya University Ethics Committee (Date: 12.02.2021, decision no: 84). The study was carried out following the international declaration, guidelines, etc.

Sistemik İmmün-İnflamasyon İndeksi, Bell Palsinin Prognozu ve Şiddeti ile İlişkili mi?

Abstract

Amaç: Yeni tanımlanan sistemik immün-inflamasyon indeksi seviyelerinin Bell paralizisinin tanı, prognoz ve şiddeti üzerindeki etkisini araştırmak.
Materyal ve Metot: Çalışma grubu, Bell paralizisi tanısı konan hastalardan oluşturuldu. Tedavi öncesi alınan tam kan sayımı verileri ile hesaplanan oranlar, hastalığın tanı, prognoz ve şiddeti açısından istatistiksel olarak incelendi.
Bulgular: Belirlenen fasial paralizi evreleri ile araştırılan oranlar arasında istatistiksel olarak anlamlı bir korelasyon tespit edilmedi. Benzer şekilde, çalışma grubunun birinci ve altıncı ay iyileşme oranları ile incelenen parametreler arasında bir ilişki bulunmadı (p>0,05). Ayrıca, kontrol ve çalışma grubu arasındaki parametre farklılıkları da istatistiksel olarak anlamlı değildi.
Sonuç: Sunulan çalışmanın sonuçları mevcut literatürden farklılıklar içermektedir. Ayrıca, sistemik immün-inflamasyon indeksinin Bell paralizisinin prognozu üzerindeki etkisi hakkında yeni bilgiler sağlamaktadır. Bu hematolojik parametreler üzerinde yapılan araştırma sonuçlarının çeşitli faktörlerden etkilenebileceği göz önünde bulundurulmalıdır.

Keywords

Bell palsi, inflamasyon, lenfositler, nötrofiller, trombositler

Ethical Statement

Our study was approved by the Sakarya University Ethics Committee (Date: 12.02.2021, decision no: 84). The study was carried out following the international declaration, guidelines, etc.

References

• Stjernquist-Desatnik A, Skoog E, Aurelius E. Detection of herpes simplex and varicella-zoster viruses in patients with Bell's palsy by the polymerase chain reaction technique. Ann Otol Rhinol Laryngol. 2006;115(4):306-311. doi:10.1177/000348940611500410
• Lagalla G, Logullo F, Di Bella P, Provinciali L, Ceravolo MG. Influence of early high-dose steroid treatment on Bell's palsy evolution. Neurol Sci. 2002;23(3):107-112. doi:10.1007/s100720200035
• Oya R, Takenaka Y, Imai T, et al. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Prognostic Hematologic Markers of Bell's Palsy: A Meta-analysis. Otol Neurotol. 2019;40(5):681-687. doi:10.1097/MAO.0000000000002166
• Ulu S, Ulu MS, Bucak A, Ahsen A, Yucedag F, Aycicek A. Neutrophil-to-lymphocyte ratio as a new, quick, and reliable indicator for predicting diagnosis and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol. 2013;34(8):1400-1404. doi:10.1097/MAO.0b013e31829b57df
• Kumbul YÇ, Yasan H, Tüz M, Okur E, Sivrice ME, Büyükçelik B. Prognostic Evaluation of Systemic Immune Inflammation Index in Sudden Idiopathic Sensorineural Hearing Loss. SDÜ Tıp Fakültesi Dergisi. 2020;27(4):455-461. doi.org/10.17343/sdutfd.742573
• Kınar A, Ulu Ş, Bucak A, Kazan E. Can the Systemic Immune-Inflammation Index (SII) be a prognostic factor of Bell's palsy patients? Neurol Sci. 2021;42(8):3197-3201. doi:10.1007/s10072-020-04921-5
• Zhang W, Xu L, Luo T, Wu F, Zhao B, Li X. The etiology of Bell's palsy: a review. J Neurol. 2020;267(7):1896-1905. doi:10.1007/s00415-019-09282-4
• Yilmaz M, Tarakcioglu M, Bayazit N, Bayazit YA, Namiduru M, Kanlikama M. Serum cytokine levels in Bell's palsy. J Neurol Sci. 2002;197(1-2):69-72. doi:10.1016/s0022-510x(02)00049-7
• Cayir S, Hizli O, Kayabasi S. Is C-reactive protein to albumin ratio an indicator of poor prognosis in Bell's palsy? Eur Arch Otorhinolaryngol. 2020;277(1):115-119. doi:10.1007/s00405-019-05691-3
• Bucak A, Ulu S, Oruc S, et al. Neutrophil-to-lymphocyte ratio as a novel-potential marker for predicting prognosis of Bell palsy. Laryngoscope. 2014;124(7):1678-1681. doi:10.1002/lary.24551
• Kiliçkaya MM, Tuz M, Yariktaş M, Yasan H, Aynalı G, Bagci Ö. The Importance of the Neutrophil-Lymphocyte Ratio in Patients with Idiopathic Peripheral Facial Palsy. Int J Otolaryngol. 2015;2015:981950. doi:10.1155/2015/981950
• Wasano K, Kawasaki T, Yamamoto S, et al. Pretreatment Hematologic Findings as Novel Predictive Markers for Facial Palsy Prognosis. Otolaryngol Head Neck Surg. 2016;155(4):581-587. doi:10.1177/0194599816646552
• Sahin C, Varım C. Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, Mean Platelet Volume and Red Cell Distribution Width Measures in Bells Palsy. Open Access Maced J Med Sci. 2017;5(1):14-18. doi:10.3889/oamjms.2017.007
• Atan D, İkincioğulları A, Köseoğlu S, et al. New Predictive Parameters of Bell's Palsy: Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio. Balkan Med J. 2015;32(2):167-170. doi:10.5152/balkanmedj.2015.15456
• Kim DH, Oh JH, Kim J, Cho CH, Lee JH. Predictive Values of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Other Prognostic Factors in Pediatric Patients With Bell's Palsy. Ear Nose Throat J. 2021;100(10):720-725. doi:10.1177/0145561320922097
• Hu B, Yang XR, Xu Y, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014;20(23):6212-6222. doi:10.1158/1078-0432.CCR-14-0442
• Geng Y, Shao Y, Zhu D, et al. Systemic Immune-Inflammation Index Predicts Prognosis of Patients with Esophageal Squamous Cell Carcinoma: A Propensity Score-matched Analysis. Sci Rep. 2016;6:39482. Published 2016 Dec 21. doi:10.1038/srep39482
• Jiang W, Chen Y, Huang J, et al. Systemic immune-inflammation index predicts the clinical outcome in patients with nasopharyngeal carcinoma: a propensity score-matched analysis. Oncotarget. 2017;8(39):66075-66086. Published 2017 Aug 2. doi:10.18632/oncotarget.19796
• Eltohami YI, Kao HK, Lao WW, et al. The Prediction Value of the Systemic Inflammation Score for Oral Cavity Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. 2018;158(6):1042-1050. doi:10.1177/0194599817751678
• Atasever Akkas E, Yucel B. Prognostic value of systemic ımmune ınflammation ındex in patients with laryngeal cancer. Eur Arch Otorhinolaryngol. 2021;278(6):1945-1955. doi:10.1007/s00405-021-06798-2