Quality of Life and Affecting Factors of Patients Receiving Outpatient Chemotherapy: Descriptive and Cross-Sectional Study

Year 2024, , 634 - 644, 01.12.2024

Zeynep Pehlivan Köksal , Nesrin Nural

https://doi.org/10.38108/ouhcd.1376992

Abstract

Objectives: The research was conducted in a descriptive and cross-sectional manner to determine the quality of life and affecting factors of outpatient chemotherapy patients.
Methods: The sample consisted of 314 patients who received treatment in the outpatient chemotherapy unit of a university hospital between May and July 2023. Data were collected by face-to-face interview method using the "Patient Information Form" and "World Health Organization Quality of Life Scale".
Results: The mean total score of the patients on the World Health Organization Quality of Life Scale is 25.96±5.81. Female gender, unemployed, illiterate, diagnosed with gynecological cancer, not receiving additional treatment to chemotherapy, taste change after chemotherapy, nausea-vomiting, loss of appetite, fatigue, insomnia, weakness, pain, infection, and bleeding, analgesic. It was determined that the quality of life of patients using antidepressant medication was lower and the difference between the groups was significant (p <0.05). No significant relationship was found between the age at diagnosis of cancer, comorbid disease status, and the amount of daily fluid consumed, and the total score averages of the World Health Organization Quality of Life Scale (p>0.05).
Conclusion: The quality of life of patients receiving chemotherapy is above average. There are several factors that affect patients' quality of life. These are gender, employment status, education level, cancer type, duration of chemotherapy, receiving additional treatment to chemotherapy, and symptoms experienced due to chemotherapy.

Keywords

cancer, chemotherapy, quality life

Ayaktan Kemoterapi Alan Hastaların Yaşam Kalitesi ve Etkileyen Faktörler: Tanımlayıcı ve Kesitsel Çalışma

Abstract

Amaç: Araştırma, ayaktan kemoterapi alan hastaların yaşam kalitesini ve etkileyen faktörleri belirlemek amacıyla tanımlayıcı ve kesitsel tipte yapılmıştır.
Yöntem: Araştırmanın örneklemini bir üniversite hastanesinin ayaktan kemoterapi ünitesinde Mayıs-Temmuz 2023 tarihleri arasında tedavi alan 314 hasta oluşturmuştur. Veriler, “Hasta Bilgi Formu” ve “Dünya Sağlık Örgütü Yaşam Kalitesi Ölçeği” kullanılarak yüz yüze görüşme yöntemi ile toplanmıştır.
Bulgular: Hastaların Dünya Sağlık Örgütü Yaşam Kalitesi Ölçeği toplam puan ortalaması 25.96±5.81’dir. Kadın cinsiyet, çalışmayan, okuryazar olmayan, jinekolojik kanser tanısı olan, kemoterapiye ek tedavi almayan, kemoterapiden sonra tat alma değişikliği, bulantı-kusma, iştahsızlık, yorgunluk, uykusuzluk, güçsüzlük, ağrı, enfeksiyon yaşayan ve kanaması olan, analjezik ve antidepresan ilaç kullanan hastaların yaşam kalitelerinin daha düşük olduğu ve gruplar arasındaki farkın anlamlı olduğu belirlenmiştir (p<0.05). Kanser hastalığı tanı yaşı, komorbid hastalık durumu ve günlük tüketilen sıvı miktarı ile Dünya Sağlık Örgütü Yaşam Kalitesi Ölçeği toplam puan ortalamaları arasında anlamlı ilişki saptanmamıştır (p>0.05).
Sonuç: Kemoterapi alan hastaların yaşam kaliteleri orta düzeyin üzerindedir. Hastaların yaşam kalitesini etkileyen faktörler; cinsiyet, çalışma durumu, eğitim düzeyi, kanser türü, kemoterapi alma süresi, kemoterapiye ilave tedavi alma durumu ve kemoterapiye bağlı yaşanan semptomlardır.

Keywords

kanser, kemoterapi, yaşam kalitesi

References

• Akeren Z, Hintistan S. (2021). Kanser hastalarının semptom yönetiminde aromaterapi kullanımı. Sakarya Üniversitesi Holistik Sağlık Dergisi, 4(3), 136-154. https://doi.org/10.54803/sauhsd.837654
• Albayrak A, Yıldırım İ, Kurt E. (2019). Kanser hastalarında yaşam kalitesini etkileyen din ve maneviyat üzerine teorik yaklaşımlar. Sakarya Üniversitesi İlahiyat Fakültesi Dergisi, 21(40), 349-376. https://doi.org/10.17335/sakaifd.605552
• Bahar A, Ovayolu Ö, Ovayolu N. (2019). Onkoloji hastalarında sık karşılaşılan semptomlar ve hemşirelik yönetimi. ERÜ Sağlık Bilimleri Fakültesi Dergisi. 2019, 6(1),42-58.
• Bilsin E, Yılmaz HB (2018). Approach to taste alteration in patients with cancer. Journal of Health Sciences and Professions, 5(2), 259-266. https://doi.org/ 10.17681/hsp.359196
• Boylu AA, Paçacıoglu B. (2016). Yaşam kalitesi ve göstergeleri. Akademik Araştırmalar ve Çalışmalar Dergisi, 8(15), 137-150. https://doi.org/10.20990/ kilisiibfakademik.266011
• Cheng KKF, Wong WH, Koh C. (2016). Unmet needs mediate the relationship between symptoms and quality of life in breast cancer survivors. Supportive Care in Cancer, 24, 2025-2033. https://doi.org/ 10.1007/s00520-015-2994-0
• Dean AG, Sullivan KM, Soe MM. (2013). OpenEpi: Open Source Epidemiologic Statistics for Public Health, Version. [online]. Available from: https://www.openepi.com/Menu/OE_Menu.htm. [Accessed 29.03.2023].
• Debela DT, Muzazu SG, Heraro KD, Ndalama MT, Mesele BW, Haile DC, et al. (2021). New approaches and procedures for cancer treatment: Current perspectives. SAGE Open Medicine, 9, 1-10. https://doi.org/10.1177/20503121211034366
• Düzen Ö, Göktaş S. (2021). Akciğer kanser cerrahisi geçiren ve adjuvan kemoterapi alan hastaların yaşam kaliteleri ve sosyal destek düzeylerinin belirlenmesi. Sağlık ve Toplum, 31(3), 153-162.
• El-Hussein A, Manoto SL, Ombinda-Lemboumba S, Alrowaili ZA, Mthunzi-Kufa P. (2021). A review of chemotherapy and photodynamic therapy for lung cancer treatment. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 21(2), 149-161. https://doi.org/ 10.2174/1871520620666200403144945
• Escalante J, McQuade RM, Stojanovska V, Nurgali K. (2017). Impact of chemotherapy on gastrointestinal functions and the enteric nervous system. Maturitas, 105, 23-29. https://doi.org/10.1016/j.maturitas.2017 .04.021
• Eser E, Lağarlı T, Baydur H. (2010). Eurohıs (Whoqol8.Tr) Türkçe sürümünün Türk toplumundaki psikometrik özellikleri. Türkiye Halk Sağlığı Dergisi, 8(3), 136-152.
• Fu L, Feng X, Jin Y, Lu Z, Li R, Xu W, et al. (2022). Symptom clusters and quality of life in gastric cancer patients receiving chemotherapy. Journal of Pain and Symptom Management, 63(2), 230-243. https://doi.org/10.1016/j.jpainsymman.2021.09.003
• Galindo DEB, Vidal-Casariego A, Calleja-Fernández A, Hernández-Moreno A, de la Maza BP, Pedraza-Lorenzo M, et al. (2017). Appetite disorders in cancer patients: Impact on nutritional status and quality of life. Appetite, 114, 23-27. https://doi.org/10.1016 /j.appet.2017.03.020
• Gelin D, Ulus B. (2015). Hastanede kemoterapi alan hastaların yaşam kalitesi ve bunu etkileyen faktörler. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 1, 31-35.
• Göl ND, Aşılar RH. (2017). Kemoterapi alan kanserli hastalarda depresyon ve yaşam kalitesinin belirlenmesi. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 6(1), 29-39.
• Hamood R, Hamood H, Merhasin I, Keinan-Boker L. (2018). Chronic pain and other symptoms among breast cancer survivors: prevalence, predictors, and effects on quality of life. Breast Cancer Research and Treatment, 167, 157-169. https://doi.org/10.1007/ s10549-017-4485-0
• Hwang KH, Cho OH, Yoo YS. (2016). Symptom clusters of ovarian cancer patients undergoing chemotherapy, and their emotional status and quality of life. European Journal of Oncology Nursing, 21, 215-222. https://doi.org/10.1016/j.ejon.2015.10.007
• IJpma I, Renken RJ, Gietema JA, Slart RH, Mensink MG, Lefrandt JD, Reyners AK. (2017). Changes in taste and smell function, dietary intake, food preference, and body composition in testicular cancer patients treated with cisplatin-based chemotherapy. Clin Nutr, 36(6), 1642-1648. https://doi.org/10.1016/j.clnu. 2016.10.013
• Jacob J, Palat G, Verghese N, Chandran P, Rapelli V, Kumari S, et al. (2019). Health-related quality of life and its socio-economic and cultural predictors among advanced cancer patients: evidence from the APPROACH cross-sectional survey in Hyderabad-India. BMC Palliative Care, 18(1), 1-12. https://doi.org/10.1186/s12904-019-0465-y Kızılırmak D, Göktalay T, Gülteki Ö, Havlucu Y, Çelik P. (2021). Akciğer kanserinin ve kemoterapinin uyku ve yaşam kalitesi üzerine etkisi. İzmir Göğüs Hastanesi Dergisi, 35(2), 82-90. https://doi.org/10.5222/IGH.2021.55265
• Konieczny M, Cipora E, Sygit K, Fal A. (2020). Quality of life of women with breast cancer and socio-demographic factors. Asian Pacific Journal of Cancer Prevention: APJCP, 21(1), 185-193. https://doi.org/10.31557%2FAPJCP.2020.21.1.185
• Kutlutürkan S, Öztürk ES, Erdoğan SB, İyimaya Ö, Bay F, Gül F. (2019). Yaşlı kanser hastalarında yaşam kalitesinin ve semptomların değerlendirilmesi. Van Tıp Dergisi, 26(4), 418-426. https://doi.org/10.5505/vtd.2019.38258
• Lewandowska A, Rudzki G, Lewandowski T, Próchnicki M, Rudzki S, Laskowska B, et al. (2020). Quality of life of cancer patients treated with chemotherapy. International Journal of Environmental Research and Public Health, 17(19), 6938-6954. https://doi.org/10.3390/ijerph17196938
• Mata Tiezzi MFB, de Andrade JM, Romão APMS, Tiezzi DG, Lerri MR, Carrara HAH, et al. (2017). Quality of life in women with breast cancer treated with or without chemotherapy. Cancer Nursing, 40(2), 108-116.https://doi.org/10.1097/NCC.0000000000000370
• Naughton MJ, Weaver KE. (2014). Physical and mental health among cancer survivors: Considerations for long-term care and quality of life. North Carolina Medical Journal, 75(4), 283-286. https://doi.org/ 10.18043%2Fncm.75.4.283
• Peppone LJ, Mustian KM, Morrow GR, Dozier AM, Ossip DJ, Janelsins MC, et al. (2011). The effect of cigarette smoking on cancer treatment-related side effects. Oncologist, 16(12), 1784-92. https://doi.org/ 10.1634/theoncologist.2011-0169
• Sawada NO, Nicolussi AC, Paula JMD, Garcia-Caro MP, Marti-Garcia C, Cruz-Quintana, F. (2016). Quality of life of Brazilian and Spanish cancer patients undergoing chemotherapy: an integrative literature review. Revista Latino-Americana de Enfermagem, 24, 1-12. https://doi.org/10.1590/1518-8345.0564. 2688
• Shrestha A, Martin C, Burton M, Walters S, Collins K, Wyld L. (2019). Quality of life versus length of life considerations in cancer patients: a systematic literature review. Psycho‐Oncology, 28(7), 1367-1380. https://doi.org/10.1002/pon.5054
• Smyth EN, Shen W, Bowman L, Peterson P, John W, Melemed A, et al. (2016). Patient-reported pain and other quality of life domains as prognostic factors for survival in a phase III clinical trial of patients with advanced breast cancer. Health Qual Life Outcomes, 14(52), 1-10. https://doi.org/10.1186/s12955-016-044 9-z
• Tarricone R, Ricca G, Nyanzi-Wakholi B, Medina-Lara A. (2016). Impact of cancer anorexia-cachexia syndrome on health-related quality of life and resource utilization: a systematic review. Critical Reviews in Oncology/Hematology, 99, 49-62. https://doi.org/10.1016/j.critrevonc.2015.12.008
• Temiz G, Durna Z. (2020). Evaluation of quality of life and health care needs in cancer patients receiving chemotherapy. Journal of Cancer Education, 35(4), 796-807. https://doi.org/10.1007/s13187-019-01533-2
• Topçu B, Gülcivan G. (2017). Meme kanserli hastaların yaşam kalitesi ile sağlıklı yaşam biçimi davranışlarının değerlendirilmesi. Namık Kemal Tıp Dergisi, 5(2), 63-74.
• World Health Organization (2020). Cancer [online]. Available from: https://gco.iarc.fr/today/online-analysis-multi-bars. [Accessed 11 June 2023].