Use of Assisted Reproductive Techniques in Special Situations

Year 2023, Volume: 6 Issue: 1, 217 - 225, 17.04.2023

Fatma Aslan Demirtaş , Ergül Aslan

https://doi.org/10.38108/ouhcd.1030647

Abstract

Objective: Assisted reproductive techniques (ART) are advanced technical applications that help infertile individuals to have children. Infertile individuals with special conditions such as sexually transmitted infections (STI), Human Immunodeficiency Virus positive (HIV+), oncological disease and disability may want to become parents. Accordingly, in this article, those with STI, HIV+, oncological treatment patients and disabled individuals are considered as special groups in infertility.
Methods: In this review article, Google Scholar, Pubmed, Science Direct and Ulakbim databases were searched using "STI", "HIV+", "disability", "cancer", "infertility" and "assisted reproductive techniques" as keywords. Studies published in national and international journals between January 2013 and February 2022 were evaluated.
Results: As a result of the literature review, it has been determined that ART is beneficial in order to prevent the transmission of STI to the spouse or fetus, to protect the fertility of cancer patients and to prevent problems that will prevent the pregnancy of individuals with disabilities. In addition, it has been determined that these individuals' wishes to become parents are prejudiced or ignored by the family, environment and health personnel.
Conclusion: As a result of the research, there are ARTs that can be used according to the special situation and health status of the individuals. Accordingly, health professionals should provide comprehensive counseling about ART, encourage asking questions, and provide spiritual support, taking into account special circumstances.

Keywords

STIs, HIV+, disability, cancer, infertility, assisted reproductive techniques

Özel Durumlarda Yardımcı Üreme Tekniklerinin Kullanımı

Abstract

Amaç: Yardımcı üreme teknikleri (YÜT) infertil bireylerin çocuk sahibi olmalarına yardımcı olan ileri düzey teknik uygulamalardır. Cinsel yolla bulaşıcı enfeksiyonlar (CYBE), İnsan İmmün Yetmezlik Virüsü pozitif (HIV+) olanlar, onkolojik hastalık ve engellilik gibi özel durumu olan infertil bireyler ebeveyn olmak isteyebilmektedir. Buna bağlı olarak bu makalede CYBE olanlar, HIV olanlar, onkolojik tedavi hastaları ve engelli bireyler infertilitede özel gruplar olarak ele alınmıştır.
Yöntem: Derleme türündeki bu makalede anahtar kelime olarak “CYBE”, “HIV+”, “engellilik”, “kanser”, “infertilite ve “yardımcı üreme teknikleri” kullanılarak Google Scholar, Pubmed, Science Direct ve Ulakbim veri tabanları taranmıştır. Ocak 2013-Şubat 2022 tarihleri arasında ulusal ve uluslararası dergilerde yayınlanmış çalışmalar değerlendirilmiştir.
Bulgular: Literatür incelemesi sonucunda, CYBE’nin eşe veya fetüse geçişini önlemek, kanser hastalarının doğurganlığını korumak ve engeli olan bireylerin gebeliğini engel olacak sorunları önlemek amacı ile YÜT’ten yararlandığı belirlenmiştir. Ayrıca bu bireylerin ebeveyn olma isteklerine aile, çevre ve sağlık personelleri tarafından ön yargılı yaklaşıldığı veya göz ardı edildiği saptanmıştır.
Sonuç: Araştırmalar sonucunda bireylerin bulunduğu özel duruma ve sağlık durumuna göre uygun kullanılabilecek YTÜ bulunmaktadır. Buna bağlı olarak sağlık profesyonelleri özel durumları göz önünde bulundurarak YÜT hakkında kapsamlı danışmanlık yapmalı, soru sormaya cesaretlendirmeli ve ruhsal destek sağlamalıdır.

Keywords

CYBE, HIV+, engellilik, kanser, infertilite, yardımcı üreme teknikleri

References

• Akdemir N. (2018). Fertilitenin korunması. Bezmialem Science, 6(2), 143-146.
• Altıntaş A, Uygunoğlu U, Zeydan B, Coşkun T. (2013). Özel durumlarda multipl sklerozlu hastaya yaklaşım. Türk Noroloji Dergisi, 19(3), 77-84.
• Alshdefat A, Abu Baker R, Francis F. (2020). Hysterectomy as forced sterilization in ıntellectual disabilities adolescences: legal and ethical argumentations. International Journal of Psychosocial Rehabilitation, 24(6), 1860- 1867.
• Alvarez RM., Ramanathan P. (2018). Fertility preservation in female oncology patients: the influence of the type of cancer on ovarian stimulation response. Human Reproduction, 33(11), 2051-2059.
• Bell M, Edelstein M, Hurwitz S, Irwin, R. (2020). Accessibility and availability of assisted reproductive technology for people living with HIV in Europe: a thematic literature review. AIDS care, 32(8), 949-953.
• Bourdon M, Garnier A, Maignien C, Marcellin L, Dulioust E, Sogni P, et. al. (2021). Assisted reproductive technology outcomes in women with a chronic viral disease. AIDS, 35(7), 1073-1081.
• Bozkurt O, Bayırlı Turan D. (2020). HIV/AIDS ile ilgili bilgi ve damgalanma düzeyinin ve ilişkili faktörlerin değerlendirilmesi. Psikiyatri Hemşireliği Dergisi, 11(1), 41-48.
• Cangöl E, Karaca P, Aslan E. (2013). Engelli bireylerde cinsel sağlık. Androloji Bülteni, 53(1), 141-146.
• Cito G, Coccia ME, Fucci R, Picone R, Cocci A, Sessa M, et. al. (2021). Hepatitis B surface antigen seropositive men in serodiscordant couples: Effects on the assisted reproductive outcomes. The World Journal of Men's Health, 39(1), 99.
• Çayan S. (2015). Erkek infertilitesi değerlendirme, medikal ve cerrahi tedaviler. Türk Üroloji Derneği, Erişim tarihi:16.10.2021, https://www.uroturk.org.tr/ urolojiData/Uploads/files/Selahittin_cayan-Erkek_ infertilitesi_degerlendirme_Medikal_ve_Cerrahi_Tedaviler_sertifikasyon.pdf.
• Çaynak S, Keser İ. (2021). Türkiye’de engelliliğe ilişkin sağlık alanında yapılmış lisansüstü tezlerin farklı değişkenler açısından değerlendirilmesi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 12(1), 118-123.
• Del Romero J, Baza MB, Río I, Jerónimo A, Vera M, Hernando V, et. al. (2016). Natural conception in HIV-serodiscordant couples with the infected partner in suppressive antiretroviral therapy: A prospective cohort study. Medicine, 95(30), e4398.
• Devkota HR, Kett M, Groce N. (2019). Societal attitude and behaviours towards women with disabilities in rural Nepal: pregnancy, childbirth and motherhood. BMC Pregnancy and Childbirth, 19(1), 1-13.
• Erbin A, Özdemir H, Akbulut MF. (2016). Spinal kord hasarı sonrası gelişen üreme ve cinsel fonksiyon bozukluğuna yaklaşım. Androloji Bülteni, 18(67), 263–266.
• Ethics Committee of the American Society for Reproductive Medicine. (2018). Fertility preservation and reproduction in patients facing gonadotoxic therapies: an Ethics Committee opinion. Fertility and Sterility, 110(3), 380-386.
• Ethics Committee of the American Society for Reproductive Medicine. (2015). Human immunodeficiency virus (HIV) and infertility treatment: a committee opinion. Fertility and Sterility, 104(1), e1-e8.
• Ganle JK, Apolot RR, Rugoho T, Sumankuuro J. (2020). ‘They are my future’: childbearing desires and motivations among women with disabilities in Ghana-implications for reproductive healthcare. Reproductive Health, 17(1), 1-12.
• Garolla A, Pizzol D, Bertoldo A, Menegazzo M, Barzon L, Foresta, C. (2013). Sperm viral infection and male infertility: focus on HBV, HCV, HIV, HPV, HSV, HCMV, and AAV. Journal of Reproductive Immunology, 100(1), 20-29.
• Gerstl B, Sullivan E, Ives A, Saunders C, Wand H, Anazodo A. (2018). Pregnancy outcomes after a breast cancer diagnosis: a systematic review and meta-analysis. Clinical Breast Cancer, 18(1), e79-e88.
• Grover NS, Deal AM, Wood WA, Mersereau JE. (2016). Young men with cancer experience low referral rates for fertility counseling and sperm banking. Journal of Oncology Practice, 12(5), 465-471.
• Hameed S, Maddams A, Lowe H. Davies, L. Khosla R, Shakespeare T. (2020). From words to actions: systematic review of interventions to promote sexual and reproductive health of persons with disabilities in low-and middle-income countries. BMJ Global Health, 5(10), e002903.
• Hatipoğlu H, Altındiş M. (2016). Cinsel yolla bulaşan hastalıkların erkek infertilitesi ile ilişkisi. Androloji Bülteni, 18(67), 269- 274.
• HIV/AIDS Treatment Guidelines (2020). Preconception counseling and care for women of childbearing age living with HIV. Erişim tarihi:30.11.2021, https://clinicalinfo.hiv.gov/en/guidelines/perinatal/overview-1.
• Houtchens MK, Edwards NC, Hayward B, Mahony MC, Phillips AL. (2020). Live birth rates, infertility diagnosis, and infertility treatment in women with and without multiple sclerosis: Data from an administrative claims database. Multiple Sclerosis and Related Disorders, 46, 102541.
• Ibrahim E, Brackett NL, Lynne CM. (2016). Advances in the management of infertility in men with spinal cord injury. Asian Journal of Andrology, 18(3), 382–390.
• Jacobson MH, Mertens AC, Spencer JB, Manatunga AK, Howards PP. (2016). Menses resumption after cancer treatment–induced amenorrhea occurs early or not at all. Fertility and sterility, 105(3), 765-772.
• Jindal SK, Rawlins RG, Muller CH, Drobnis EZ. (2016). Guidelines for risk reduction when handling gametes from infectious patients seeking assisted reproductive technologies. Reproductive Biomedicine Online, 33(2), 121-130.
• Kapan BK, Boyacıoğlu NE. (2019). Engelli gebelerin karşılaştıkları zorluklar ve ebelik yaklaşımı. Ankara Sağlık Bilimleri Dergisi, 8(2), 64-71.
• Keleş MG, Taşpınar A, Altınkaya Ö. (2020). Özel durumlara sahip ebeveynlerin doğum sonrası yeni hayata uyumları ve ebelerin sorumlulukları. Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi, 15(2), 94-100.
• Khawcharoenporn T, Beverly ES. (2016). HIV infection and infertility. Darwish AM, editor. Genital infections and infertility. InTech, e-Kitap: Erişim tarihi: 30.11.2021 https://www.intechopen.com/chapters/49932.
• Kırca N, Pasinlioğlu T. (2013). İnfertilite tedavisinde karşılaşılan psikososyal sorunlar. Psikiyatride Güncel Yaklaşımlar, 5, 162-78.
• Klock SC, Zhang JX, Kazer RR. (2010). Fertility preservation for female cancer patients: early clinical experience. Fertility and Sterility, 94(1), 149-155.
• Koçak DY, Duman Büyükkayacı N. (2017). Jinekolojik kanserlerde fertilite koruyucu yaklaşımlar. Turkiye Klinikleri Journal of Obstetric-Women’s Health Diseases Nursing-Special Topics, 3(1), 27-34.
• Kokanalı D, Karaca M, Özel Ş, Üstün YE. (2018). Engelli kadınlarda üreme sağlığı. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, 15(1), 28-30.
• Lambertini M, Peccatori FA, Demeestere I, Amant F, Wyns C, Stukenborg JB, et al. (2020). Fertility preservation and post-treatment pregnancies in post-pubertal cancer patients: ESMO Clinical Practice Guidelines. Annals of Oncology, 31(12), 1664-1678.
• Mykitiuk R, Ena C. (2011). Sites of exclusion: Disabled women’s sexual and reproductive rights. Rioux MH, Basser LA, Jones M, editor. Critical Perspectives on Human Rights and Disability Law. Leiden, NL: Martinus Nijhoff Publishers, p.157-199.
• Osborn L, Ronen K, Larsen AM, Richardson B, Khasimwa B, Chohan B, et al. (2022). Antenatal depressive symptoms in Kenyan women living with HIV: contributions of recent HIV diagnosis, stigma, and partner violence. AIDS care, 34(1), 69-77.
• Patel V, Jones P, Judd A, Senko V, Altieri G, Pettee D. (2020). Recollection of fertility discussion in adolescent and young adult oncology patients: a single-institution study. Journal of Adolescent and Young Adult Oncology, 9(1), 72-77.
• Naredi N, Agrawal A. (2021). From disability to fatherhood: Journey of serving soldiers with spinal cord injury. Medical Journal Armed Forces India, 77(4), 444-451.
• Periyasamy AJ, Anbalagan D, Sudharshin S. (2016). Hepatitis B and C Virus in assisted reproductive technology-a review of literature. Women’s Health & Gynecology, 2(4),1-5.
• Practice Committee of the American Society for Reproductive Medicine. (2013). Recommendations for reducing the risk of viral transmission during fertility treatment with the use of autologous gametes: a committee opinion. Fertility and Sterility, 99(2), 340-346.
• Reignier A, Lammers J, Splingart C, Redhead D, Labat JJ, Mirallié S, et al. (2018). Sperm cryopreservation and assisted reproductive technology outcome in patients with spinal cord injury. Andrologia, 50(1), e12833.
• Rivera Drew JA. (2013). Hysterectomy and disability among US women. Perspectives on Sexual and Reproductive Health, 45(3), 157-163.
• Ruggeri M, Pagan E, Bagnardi V, Bianco N, Gallerani E, Buser K, et al. (2019). Fertility concerns, preservation strategies and quality of life in young women with breast cancer: baseline results from an ongoing prospective cohort study in selected European Centers. The breast, 47, 85-92.
• Sayar S, Yarar S. (2021). Üniversite öğrencilerinin cinsel yolla bulaşan hastalıklardan korunmaya ilişkin bilgi ve tutumlarının incelenmesi. İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi, 9(2), 732-745.
• Shandra CL, Hogan DP, Short SE. (2014). Planning for motherhood: fertility attitudes, desires and intentions among women with disabilities. Perspectives on sexual and reproductive health, 46(4), 203-210.
• Stora C, Epelboin S, Devouche E, Matheron S, Epelboin L, Yazbeck C, et al. (2016). Women infected with human immunodeficiency virus type 1 have poorer assisted reproduction outcomes: a case-control study. Fertility and Sterility, 105(5), 1193-1201.
• Sun L, Wang F, Liu A, Xin R, Zhu Y, Li J, et al. (2015). Natural conception may be an acceptable option in HIV-serodiscordant couples in resource limited settings. PloS One, 10(11), e0142085.
• Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209-249.
• Şahin N, Bilgiç D. (2016). İnfertilite. Kızılkaya Beji N, editör. Kadın Sağlığı ve Hastalıkları. Genişletilmiş İkinci Baskı. İstanbul: Nobel Tıp Kitapevleri, s. 41-145.
• T.C. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü (2021). HIV-AIDS istatistik. Erişim tarihi:30.11.2021, https://hsgm.saglik.gov.tr/tr/bulasici-hastaliklar/hiv-aids/hiv-aids-liste/hiv-aids-istatislik.html.
• Topal S. (2021). Fiziksel engelli annelerin çocuklarının bakımı ile ilgili deneyimleri ve hemşirelerden beklentileri. Doktora Tezi, Sakarya Üniversitesi Sağlık Bilimleri Enstitüsü, Sakarya.
• Tsevat DG, Wiesenfeld HC, Parks C, Peipert JF. (2017). Sexually transmitted diseases and infertility. American Journal of Obstetrics and Gynecology, 216(1), 1-9.
• United Nations Programme on HIV/AIDS (UNAIDS). UNAIDS data 2021, Erişim tarihi: 28.02.2022, https://www.unaids.org/sites/default/files/media_asset/JC3032_AIDS_Data_book_2021_En.pdf
• Üremeye Yardımcı Tedavi (ÜYTE) Uygulamaları ve Üremeye Yardımcı Tedavi Merkezleri Hakkında Yönetmelik (2014). Erişim tarihi: 07.02.2022, https://www.mevzuat.gov.tr/mevzuat?MevzuatNo=20085&MevzuatTur=7&MevzuatTertip=5
• World Health Organization (WHO) (2022). Cancer, Erişim tarihi:28.02.2022, https://www.who.int/news-room/fact-sheets/detail/cancer.
• World Health Organization (WHO). (2016). Global health sector strategy on sexually transmıtted ınfectıons 2016–2021. Erişim tarihi:28.02.2022, https://apps. who.int/iris/bitstream/handle/10665/246296/WHO-RHR-16.09-eng.pdf
• World Health Organization (WHO) (2020). Infertility, Erişim tarihi:16.10.2021, https://www.who.int/news-room/fact-sheets/detail/infertility.