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Üreme Çağındaki Kadınlarda Metabolik Sendrom Riski ile Menstrual Düzensizlik Arasındaki İlişkinin ve Etkileyen Faktörlerin Belirlenmesi

Year 2025, Volume: 8 Issue: 1, 14 - 24

Abstract

Amaç: Araştırmanın amacı, üreme çağındaki kadınlarda Metabolik Sendrom (MetS) riski ile menstual düzensizlik arasındaki ilişkinin ve etkileyen faktörlerin belirlenmesidir.
Yöntem: Tanımlayıcı tipte tasarlanan araştırmanın verileri Ocak 2022-Temmuz 2022 tarihleri arasında, çevrimiçi platformlar aracılığı ile toplanmıştır. Araştırmanın evrenini 15-49 yaş aralığında üreme çağındaki kadınlar örneklemini ise 320 kadın oluşturmuştur. Veriler, Kişisel Bilgi Formu ve Metabolik Sendrom Araştırma Formu aracılığıyla toplanmıştır. Araştırma verileri IBM SPSS 27 programı ile değerlendirilmiş olup verilerin analizinde sayı, yüzde, ortalama ve standart sapma, minimum, maksimum değerler gibi tanımlayıcı istatistikler, Chi-square Bağımsızlık Testi ve Lojistik Regresyon Analizi kullanılmıştır.
Bulgular: Bu araştırmaya katılan kadınların %50,6’sının MetS açısından orta risk grubunda olduğu belirlenmiştir. Menstruasyona yönelik sorun yaşayan kadınların %53,0’ının MetS gelişme riskinin anlamlı düzeyde daha yüksek olduğu saptanmıştır. Bu araştırmaya katılan kadınlar arasında hiç kanaması olmayan, düzensiz kanaması olan ve kanama miktarı normalden fazla olan kadınların MetS gelişme riskinin olarak anlamlı düzeyde daha yüksek olduğu saptanmıştır. MetS riskindeki varyansın %10’unun menstrual düzensizlik tarafından açıklandığı bulunmuştur.
Sonuç: Bu araştırma menstrual düzensizliği olan kadınlarda MetS riskinin arttığını düşündürmektedir. Menstrual düzensizlik ile MetS arasındaki ilişkinin belirlenmesi için daha geniş çaplı ve MetS’in tanı kriterlerine göre tanılandığı araştırmaların yapılması önerilebilir. Ayrıca birinci basamak sağlık hizmeti sunan birimlerde doğurganlık çağındaki kadınlar için MetS risk faktörlerinin değerlendirilmesi önerilmektedir.

References

  • Apridonidze T, Essah PA, Iuorno MJ, Nestler JE. (2005). Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism, 90(4), 1929-1935.
  • Arslan M, Aydın EB. (2022). Üniversite Öğrencilerinde Metabolik Sendrom Riski, Fiziksel Aktivite, Uyku Kalitesi ve Yorgunluk Arasındaki İlişki. Turkish Journal of Cardiovascular Nursing, 13(30), 9-13.
  • Belete R, Ataro Z, Abdu A, Sheleme M. (2021). Global prevalence of metabolic syndrome among patients with type I diabetes mellitus: A systematic review and meta-analysis. Diabetology & Metabolic Syndrome, 13(1), 1-13.
  • Brumpton BM, Camargo CA, Romundstad PR, Langhammer A, Chen Y, Mai XM. (2013). Metabolic syndrome and incidence of asthma in adults: the HUNT study. European Respiratory Journal, 42(6), 1495-1502.
  • Bouzas IC, Cader SA, Leão L, Kuschnir MC, Braga C. (2014). Menstrual cycle alterations during adolescence: early expression of metabolic syndrome and polycystic ovary syndrome. Journal of Pediatric and Adolescent Gynecology, 27(6), 335-341.
  • Dars S, Sayed K, Yousufzai Z. (2014). Relationship of menstrual irregularities to BMI and nutritional status in adolescent girls. Pakistan Journal of Medical Sciences, 30(1), 140-144.
  • Boer GM, Tramper-Stranders GA, Houweling L, van Zelst CM, Pouw N, Verhoeven GT, Braunstahl GJ. (2021). Adult but not childhood onset asthma is associated with the metabolic syndrome, independent from body mass index. Respiratory Medicine, 188, 106603.
  • Deng L, Wang L, Zheng X, Shuai P, Liu Y. (2021). Women with subclinical hypothyroidism are at higher prevalence of metabolic syndrome and its components compared to men in an older Chinese population. Endocrine Research, 46(4), 186-195.
  • Ding X, Zhao Y, Zhu CY, Wu LP, Wang Y, Peng ZY, Shi BY. (2021). The association between subclinical hypothyroidism and metabolic syndrome: an update meta-analysis of observational studies. Endocrine Journal, EJ20-0796.
  • Dünya Sağlık Örgütü (DSÖ). Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO Consultation. World Health Organization, 1999. Erişim tarihi: 12.12.2021, https://apps.who.int/iris/bitstream/handle/10665/66040/WHO_NCD_NCS_99.2.pdf;jsessionid=72195BF 7147CFF0371E1C580B9CD4EFB?sequence=1
  • Ecklund LC, Usadi RS. (2015). Endocrine and reproductive effects of polycystic ovarian syndrome. Obstetrics and Gynecology Clinics, 42(1), 55-65.
  • Erdoğmuş O. (2005). “Metabolik sendrom; harekete geçmenin zamanı!”. Memory, 2(16), 6-7.
  • Fu L, Xie N, Qu F, Zhou J, Wang F. (2022). The Association Between Polycystic Ovary Syndrome and Metabolic Syndrome in Adolescents: a Systematic Review and Meta-analysis. Reproductive Sciences, 1-13.
  • Glueck CJ, Papanna R, Wang P, Goldenberg N, Sieve-Smith L. (2003). Incidence and treatment of metabolic syndrome in newly referred women with confirmed polycystic ovarian syndrome. Metabolism, 52(7), 908-915.
  • Hahn KA, Wise LA, Riis AH, Mikkelsen EM, Rothman KJ, Banholzer K, Hatch EE. (2013). Correlates of menstrual cycle characteristics among nulliparous Danish women. Clinical Epidemiology, 19(5), 311–19.
  • Kang W, Jang KH, Lim HM, Ahn JS, Park WJ. (2019). The menstrual cycle associated with insomnia in newly employed nurses performing shift work: a 12-month follow-up study. International Archives of Occupational and Environmental Health, 92(2), 227-235.
  • Karadeniz G, Yanıkkerem E, Sarıcan ES, Bülez A, Arıkan Ç, Esen A. (2007). Manisa ili sağlık çalışanlarında metabolik sendrom riski. Fırat Sağlık Hizmetleri Dergisi, 2(6), 13-24.
  • Karamzad N, Izadi N, Sanaie S, Ahmadian E, Eftekhari A, Sullman MJ, Safiri S. (2020). Asthma and metabolic syndrome: a comprehensive systematic review and meta-analysis of observational studies. Journal of Cardiovascular and Thoracic Research, 12(2), 120.
  • Kim SW, Kim HJ, Min K, Lee H, Lee SH, Kim S, Oh B. (2021). The relationship between smoking cigarettes and metabolic syndrome: A cross-sectional study with non-single residents of Seoul under 40 years old. PloS One, 16(8), e0256257.
  • Kim T, Nam GE, Han B, Cho SJ, Kim J, Eum DH, Lee SW, Min SH, Lee W, Han K, Park YG. (2018). 'Associations of mental health & sleep duration with menstrual cycle irregularity: a population-based study'. Archives Womens Mental Health, 21(6), 619-26.
  • Kollipaka R, Arounassalame B, Lakshminarayanan S. (2013). Does psychosocial stress influence menstrual abnormalities in medical students? Journal of Obstetrics and Gynaecology, 33, 489–93.
  • Lee SS, Kim DH, Nam GE, Nam HY, Kim YE, Lee SH, Han KD, Park YG. (2016). Association between Metabolic Syndrome and Menstrual Irregularity in Middle-Aged Korean Women. Korean Journal of Family Medicine, 37(1), 31–36. https://doi.org/10.4082/kjfm.2016.37.1.31
  • Mollaoğlu M, Fertelli TK, Tuncay FÖ. (2010). Bir sağlık ocağına başvuran erişkinlerde metabolik sendrom risk düzeyleri ve ilişkili faktörler. Florence Nightingale Journal of Nursing, 18(2), 72-79.
  • National Cholesterol Education Program (NCEP). Expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III). National Heart, Lung and Blood Institute: NIH Publication 2001. Erişim tarihi: 12.09.2021. https://www.nhlbi.nih.gov/files/docs/resources/heart/atp-3- cholesterol-full-report.pdf
  • Palm-fischbacher S, Ehlert U. (2014). Dispositional resilience as a moderator of the relationship between chronic stress and irregular menstrual cycle. Journal of Psychosomatic Obstetrics & Gynaecology. 35(2), 42–50.
  • Park HR, Choi Y, Lee HJ, Oh JY, Hong YS, Sung YA. (2007). The metabolic syndrome in young Korean women with polycystic ovary syndrome. Diabetes Research and Clinical Practice, 77(3), 243-246.
  • Park S, Han K, Lee S, Kim Y, Lee Y, Kang MW, Kim DK. (2021). Smoking, development of or recovery from metabolic syndrome, and major adverse cardiovascular events: A nationwide population-based cohort study including 6 million people. Plos One, 16(1), e0241623.
  • Radivojevic UD, Lazovic GB, Kravic-Stevovic TK, Puzigaca ZD, Canovic FM, Nikolic RR, Milicevic SM. (2014). Differences in anthropometric and ultrasonographic parameters between adolescent girls with regular and irregular menstrual cycles: a case-study of 835 cases. Journal of Pediatric and Adolescent Gynecology. 27(4), 227-31.
  • Reaven GM. (1993). Role of insulin resistance in human disease (syndrome X): an expanded definition. Annual Review of Medicine 44, 121–131.
  • Robinson S, Kiddy D, Gelding SV, Willis D, Niththyananthan R, Bush A, Franks S. (1993). The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries. Clinical Endocrinology, 39(3), 351-355.
  • Uçar T, Derya YA, Taşhan ST. (2015). Üniversite öğrencilerinde menstrual düzensizlik durumu ve etkileyen faktörlerin belirlenmesi. TAF Preventive Medicine Bulletin, 14(3), 215-221.
  • Weerakiet S, Bunnag P, Phakdeekitcharoen B, Wansumrith S, Chanprasertyothin S, Jultanmas R, Thakkinstian A. (2007). Prevalence of the metabolic syndrome in Asian women with polycystic ovary syndrome: using the International Diabetes Federation criteria. Gynecological Endocrinology, 23(3), 153-160.
  • Weiss DJ, Charles MA, Dunaif A, Prior DE, Lillioja S, Knowler WC, Herman WH. (1994). Hyperinsulinemia is associated with menstrual irregularity and altered serum androgens in Pima Indian women. Metabolism, 43(7), 803-807.
  • Yu M, Han K, Nam, GE. (2017). 'The association between mental health problems & menstrual cycle irregularity among adolescent Korean girls'. Journal of Affective Disorders, 210(1), 43-48.

Determination of the Relationship Between Metabolic Syndrome Risk and Menstrual Irregularity and Affecting Factors in Reproductive Age Women

Year 2025, Volume: 8 Issue: 1, 14 - 24

Abstract

Objective: The aim of the study was to determine the relationship between the risk of Metabolic Syndrome (MetS) and menstrual irregularity in women of reproductive age and the factors affecting it.
Methods: The research was designed in a descriptive type. The population of the study consisted of women in reproductive age between the ages of 15-49 and the sample of 320 women. Data in the study were collected using Personal Information Form and Metabolic Syndrome Research Form. The research data were evaluated with the IBM SPSS 27 program.
Results: It was determined that 50.6% of the women participating in this study were in the intermediate risk group for MetS. It was determined that 53.0% of women who had problems with menstruation had a statistically significantly higher risk of developing MetS. Among the women who participated in this study, it was found that women with no bleeding, irregular bleeding and abnormal bleeding had a significantly higher risk of developing MetS. It was found that 10% of the variance in MetS risk was explained by menstrual irregularity.
Conclusion: Our study suggests that the risk of MetS is increased in women with menstrual irregularity. In order to determine the relationship between menstrual irregularity and MetS, it may be recommended to conduct larger studies in which MetS is diagnosed according to the diagnostic criteria. In addition, evaluating the risk factors of MetS for women of childbearing age in primary health care units is recommended.

References

  • Apridonidze T, Essah PA, Iuorno MJ, Nestler JE. (2005). Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism, 90(4), 1929-1935.
  • Arslan M, Aydın EB. (2022). Üniversite Öğrencilerinde Metabolik Sendrom Riski, Fiziksel Aktivite, Uyku Kalitesi ve Yorgunluk Arasındaki İlişki. Turkish Journal of Cardiovascular Nursing, 13(30), 9-13.
  • Belete R, Ataro Z, Abdu A, Sheleme M. (2021). Global prevalence of metabolic syndrome among patients with type I diabetes mellitus: A systematic review and meta-analysis. Diabetology & Metabolic Syndrome, 13(1), 1-13.
  • Brumpton BM, Camargo CA, Romundstad PR, Langhammer A, Chen Y, Mai XM. (2013). Metabolic syndrome and incidence of asthma in adults: the HUNT study. European Respiratory Journal, 42(6), 1495-1502.
  • Bouzas IC, Cader SA, Leão L, Kuschnir MC, Braga C. (2014). Menstrual cycle alterations during adolescence: early expression of metabolic syndrome and polycystic ovary syndrome. Journal of Pediatric and Adolescent Gynecology, 27(6), 335-341.
  • Dars S, Sayed K, Yousufzai Z. (2014). Relationship of menstrual irregularities to BMI and nutritional status in adolescent girls. Pakistan Journal of Medical Sciences, 30(1), 140-144.
  • Boer GM, Tramper-Stranders GA, Houweling L, van Zelst CM, Pouw N, Verhoeven GT, Braunstahl GJ. (2021). Adult but not childhood onset asthma is associated with the metabolic syndrome, independent from body mass index. Respiratory Medicine, 188, 106603.
  • Deng L, Wang L, Zheng X, Shuai P, Liu Y. (2021). Women with subclinical hypothyroidism are at higher prevalence of metabolic syndrome and its components compared to men in an older Chinese population. Endocrine Research, 46(4), 186-195.
  • Ding X, Zhao Y, Zhu CY, Wu LP, Wang Y, Peng ZY, Shi BY. (2021). The association between subclinical hypothyroidism and metabolic syndrome: an update meta-analysis of observational studies. Endocrine Journal, EJ20-0796.
  • Dünya Sağlık Örgütü (DSÖ). Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO Consultation. World Health Organization, 1999. Erişim tarihi: 12.12.2021, https://apps.who.int/iris/bitstream/handle/10665/66040/WHO_NCD_NCS_99.2.pdf;jsessionid=72195BF 7147CFF0371E1C580B9CD4EFB?sequence=1
  • Ecklund LC, Usadi RS. (2015). Endocrine and reproductive effects of polycystic ovarian syndrome. Obstetrics and Gynecology Clinics, 42(1), 55-65.
  • Erdoğmuş O. (2005). “Metabolik sendrom; harekete geçmenin zamanı!”. Memory, 2(16), 6-7.
  • Fu L, Xie N, Qu F, Zhou J, Wang F. (2022). The Association Between Polycystic Ovary Syndrome and Metabolic Syndrome in Adolescents: a Systematic Review and Meta-analysis. Reproductive Sciences, 1-13.
  • Glueck CJ, Papanna R, Wang P, Goldenberg N, Sieve-Smith L. (2003). Incidence and treatment of metabolic syndrome in newly referred women with confirmed polycystic ovarian syndrome. Metabolism, 52(7), 908-915.
  • Hahn KA, Wise LA, Riis AH, Mikkelsen EM, Rothman KJ, Banholzer K, Hatch EE. (2013). Correlates of menstrual cycle characteristics among nulliparous Danish women. Clinical Epidemiology, 19(5), 311–19.
  • Kang W, Jang KH, Lim HM, Ahn JS, Park WJ. (2019). The menstrual cycle associated with insomnia in newly employed nurses performing shift work: a 12-month follow-up study. International Archives of Occupational and Environmental Health, 92(2), 227-235.
  • Karadeniz G, Yanıkkerem E, Sarıcan ES, Bülez A, Arıkan Ç, Esen A. (2007). Manisa ili sağlık çalışanlarında metabolik sendrom riski. Fırat Sağlık Hizmetleri Dergisi, 2(6), 13-24.
  • Karamzad N, Izadi N, Sanaie S, Ahmadian E, Eftekhari A, Sullman MJ, Safiri S. (2020). Asthma and metabolic syndrome: a comprehensive systematic review and meta-analysis of observational studies. Journal of Cardiovascular and Thoracic Research, 12(2), 120.
  • Kim SW, Kim HJ, Min K, Lee H, Lee SH, Kim S, Oh B. (2021). The relationship between smoking cigarettes and metabolic syndrome: A cross-sectional study with non-single residents of Seoul under 40 years old. PloS One, 16(8), e0256257.
  • Kim T, Nam GE, Han B, Cho SJ, Kim J, Eum DH, Lee SW, Min SH, Lee W, Han K, Park YG. (2018). 'Associations of mental health & sleep duration with menstrual cycle irregularity: a population-based study'. Archives Womens Mental Health, 21(6), 619-26.
  • Kollipaka R, Arounassalame B, Lakshminarayanan S. (2013). Does psychosocial stress influence menstrual abnormalities in medical students? Journal of Obstetrics and Gynaecology, 33, 489–93.
  • Lee SS, Kim DH, Nam GE, Nam HY, Kim YE, Lee SH, Han KD, Park YG. (2016). Association between Metabolic Syndrome and Menstrual Irregularity in Middle-Aged Korean Women. Korean Journal of Family Medicine, 37(1), 31–36. https://doi.org/10.4082/kjfm.2016.37.1.31
  • Mollaoğlu M, Fertelli TK, Tuncay FÖ. (2010). Bir sağlık ocağına başvuran erişkinlerde metabolik sendrom risk düzeyleri ve ilişkili faktörler. Florence Nightingale Journal of Nursing, 18(2), 72-79.
  • National Cholesterol Education Program (NCEP). Expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III). National Heart, Lung and Blood Institute: NIH Publication 2001. Erişim tarihi: 12.09.2021. https://www.nhlbi.nih.gov/files/docs/resources/heart/atp-3- cholesterol-full-report.pdf
  • Palm-fischbacher S, Ehlert U. (2014). Dispositional resilience as a moderator of the relationship between chronic stress and irregular menstrual cycle. Journal of Psychosomatic Obstetrics & Gynaecology. 35(2), 42–50.
  • Park HR, Choi Y, Lee HJ, Oh JY, Hong YS, Sung YA. (2007). The metabolic syndrome in young Korean women with polycystic ovary syndrome. Diabetes Research and Clinical Practice, 77(3), 243-246.
  • Park S, Han K, Lee S, Kim Y, Lee Y, Kang MW, Kim DK. (2021). Smoking, development of or recovery from metabolic syndrome, and major adverse cardiovascular events: A nationwide population-based cohort study including 6 million people. Plos One, 16(1), e0241623.
  • Radivojevic UD, Lazovic GB, Kravic-Stevovic TK, Puzigaca ZD, Canovic FM, Nikolic RR, Milicevic SM. (2014). Differences in anthropometric and ultrasonographic parameters between adolescent girls with regular and irregular menstrual cycles: a case-study of 835 cases. Journal of Pediatric and Adolescent Gynecology. 27(4), 227-31.
  • Reaven GM. (1993). Role of insulin resistance in human disease (syndrome X): an expanded definition. Annual Review of Medicine 44, 121–131.
  • Robinson S, Kiddy D, Gelding SV, Willis D, Niththyananthan R, Bush A, Franks S. (1993). The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries. Clinical Endocrinology, 39(3), 351-355.
  • Uçar T, Derya YA, Taşhan ST. (2015). Üniversite öğrencilerinde menstrual düzensizlik durumu ve etkileyen faktörlerin belirlenmesi. TAF Preventive Medicine Bulletin, 14(3), 215-221.
  • Weerakiet S, Bunnag P, Phakdeekitcharoen B, Wansumrith S, Chanprasertyothin S, Jultanmas R, Thakkinstian A. (2007). Prevalence of the metabolic syndrome in Asian women with polycystic ovary syndrome: using the International Diabetes Federation criteria. Gynecological Endocrinology, 23(3), 153-160.
  • Weiss DJ, Charles MA, Dunaif A, Prior DE, Lillioja S, Knowler WC, Herman WH. (1994). Hyperinsulinemia is associated with menstrual irregularity and altered serum androgens in Pima Indian women. Metabolism, 43(7), 803-807.
  • Yu M, Han K, Nam, GE. (2017). 'The association between mental health problems & menstrual cycle irregularity among adolescent Korean girls'. Journal of Affective Disorders, 210(1), 43-48.
There are 34 citations in total.

Details

Primary Language Turkish
Subjects Obstetrics and Gynocology Nursing
Journal Section Araştırma
Authors

Fatma Nur Duman 0000-0001-9736-2769

Sümeyra Damsarsan 0000-0001-5310-5250

Didem Şimşek Küçükkelepçe 0000-0003-0001-2581

Zehra Gölbaşı 0000-0002-0410-7433

Early Pub Date March 27, 2025
Publication Date
Submission Date January 11, 2024
Acceptance Date April 16, 2024
Published in Issue Year 2025 Volume: 8 Issue: 1

Cite

APA Duman, F. N., Damsarsan, S., Şimşek Küçükkelepçe, D., Gölbaşı, Z. (2025). Üreme Çağındaki Kadınlarda Metabolik Sendrom Riski ile Menstrual Düzensizlik Arasındaki İlişkinin ve Etkileyen Faktörlerin Belirlenmesi. Ordu Üniversitesi Hemşirelik Çalışmaları Dergisi, 8(1), 14-24.