Aim: Tarragon, or Artemisia dracunculus, is a member of the Asteraceae family that grows wild in Eastern Anatolia of Turkey. According to previously published studies, Artemisia dracunculus extracts possess antibacterial, antifungal, antioxidant and anti-inflammatory effects. Thus, these extracts can be used to heal wounds. Nanoemulsion (NE) is a suitable dosage form for the application of active substances/compounds via the skin. The aim of this study is to develop and in vitro characterize NE and NE-based gel formulations containing Artemisia dracunculus ethanol extract.
Methods: Extract-containing (E-NE) or blank (B-NE) NE formulations were prepared using ethyl oleate, Lipoid S100, Tween 80, Pluronic F127, DMSO, and ultrapure water. NaCMC was added to NE formulations to obtain NE-based gels (NEGs). The droplet size, PDI and zeta potential values of NEs were determined; pH measurement, FT-IR and rheological analyzes were also performed for NEs and NEGs.
Results: The droplet size and zeta potential values of B-NE and E-NE were found as 139.13±5.15 nm and 135.59±4.81 nm, (-)27.53±2.05 mV and (-)26.28±3.21 mV, respectively. Also, PDI values of NE formulations were <0.3, indicating monodispersity. The pH values of NEs and NEGs were found in the range of 4.26±0.10 - 6.16±0.03, using suitably for topical application. In addition, NEGs formulations showed a pseudoplastic behavior which is important for the topical application. FT-IR results showed that the extract is completely dissolved in the oil phase of formulations.
Conclusion: The NE and NEG may be useful for the topical application of Artemisia dracunculus ethanol extract.
Yasar Furkan KILINBOZ would like to thank to the scholarship along his postgraduate program provided by the Turkish Scientific and Technical Research Council (TUBITAK).
Primary Language | English |
---|---|
Subjects | Pharmacology and Pharmaceutical Sciences |
Journal Section | Research Articles |
Authors | |
Publication Date | April 6, 2022 |
Published in Issue | Year 2022 Volume: 2 Issue: 2 |