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Kuru kayısılardaki kükürt miktarının serum oksidatif stres parametleri üzerine etkisi

Year 2019, Volume: 25 Issue: 7, 889 - 892, 26.12.2019

Abstract

Kayısı, dünyanın farklı bölgelerinde yetiştirilebilen ve ticari öneme sahip bir meyvedir. Kayısılar güneşte veya depolanma süresini uzatmak amacıyla kükürtle muamele edilerek kurutulmaktadır. Özellikle Avrupa Birliği ülkeleri ve ülkemizde kuru kayısıda bulunması gereken kükürt miktarı 2000 mg/L olarak belirlenmiştir ve bu miktar azaltılmak istenmektedir. Çalışmanın amacı, yüksek ve düşük kükürt içerikli kayısılarla beslenmenin serum oksidatif stres parametreleri üzerine etkilerini karşılaştırmaktır. Toplamda 84 adet Wistar albino rat, gün kurusu kayısı ve farklı miktarda kükürt içeren kuru kayısıların kullanıldığı yemlerle 12 hafta boyunca beslendi. Ratların serum Total antioksidan seviye, Total oksidan seviye, Malondialdehit ve Glutatyon seviyeleri ölçüldü. En yüksek total antioksidan seviye gün kurusu kayısı ile beslenen grupta, en düşük total antioksidan seviye ise 3000 mg/L grubunda gözlemlenmiştir. Malondialdehit seviyelerinde sadece 1000 mg/L grubunda, Glutatyon seviyelerinde ise 1000 mg/L, 2000 mg/L ve 3000 mg/L gruplarında anlamlı artışlar görülmüştür.

References

  • Asma BM, Gültek A, Kan T, Birhanlı O. Kayısıda Kükürt Sorunu. 1. Baskı. Malatya, Türkiye, Öz Gayret Ofset, 2005.
  • Altan N, Dinçel AS, Koca C. “Diabetes mellitus ve oksidatif stres”. Turk Journal of Biochemistry, 31(2), 51-56, 2006.
  • Gorrini C, Harris IS, Mak TW. Modulation of oxidative stress as an anticancer strategy. Nature Reviews Drug Discovery, 12, 931-47, 2013.
  • Hardy J, Selkoe DJ. “The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics”. Science, 297(5580), 353-56, 2002.
  • Phaniendra A, Jestadi DB, Periyasamy L. “Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases”. Indian Journal of Clinical Biochemistry, 30(1), 11-26, 2015.
  • Rania V, Deep G, Singh RK, Palle K, Yadav UCS. “Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies”. Life Sciences, 148, 183-193, 2016.
  • Mercan U. “Toksikolojide Serbest Radikallerin Önemi”. Yüzüncü yıl Üniversitesi Veterinerlik Fakültesi Dergisi, 15 (1-2), 91-96, 2004.
  • Pisoschi AM, Pop A. “The role of antioxidants in the chemistry of oxidative stress: A review”. European Journal of Medicinal Chemistry, 97, 55-74, 2015.
  • Koç S. Glutatyon S-Transferaz Genindeki Delesyonların (Gstt1, Gsttm1) Koroner Arter Hastalığı ve Akut Miyokart İnfarktüsü ile İlişkisi. Yüksek Lisans Tezi, Çukurova Üniversitesi, Adana, Türkiye, 2008.
  • Placer, ZA, Cushman LL, Johnson BC. “Estimation of product of lipid peroxidation [Malondy Dialdehyde] in biochemical systems”. Analytical Biochemistry, 16(2), 259-264, 1990.
  • Halliwell B, Chirico S. “Lipid peroxidation: its mechanism, measurement, and significance”. The American Journal of Clinical Nutrition, 57(5), 715-725, 1993.
  • Meng, Z. “Oxidative damage of sulfur dioxide on various organs of mice: sulfur dioxide İs a systemic oxidative damage agent”. Inhalation Toxicology, 15(2), 181-195, 2003.
  • Meng Z, Qin G, Zhang B, Bai J. “DNA damaging effects of sulfur dioxide derivatives in cells from various organs of mice”. Mutagenesis, 19(6), 465-468, 2004.
  • Parlakpinar, H, Olmez E,Acet A, Ozturk F,Tasdemir S,Ates B, Gul M,Otlu A. “Beneficial effects of apricot-feeding on myocardial ischemia-reperfusion injury in rats”. Food Chemical Toxicology, 47(4), 802-8, 2009.
  • Ozturk F, Gul M, Ates B, Ozturk IC. “Protective effect of apricot [Prunus armeniaca L.] on hepatic steatosis and damage induced by carbon tetrachloride in wistar rats”. British Journal of Nutrition, 102(12), 1767-1775, 2009.
  • Rel Assay Diagonostics. “Total Antioxidant Status Assay Kit”. https://www.relassay.com/uploads/TASinsert.pdf. (08.02.2019).
  • Rel Assay Diagnostics. “Total Oxidant Status Assay Kit”. https://www.relassay.com/uploads/TOSinsert.pdf. (08.02.2019).
  • Mihara M, Uchiyama M. “Determination of malonaldehyde precursor in tissues by thiobarbituric acid test”. Analitical Biochemistry, 86(1), 271-8, 1978.
  • Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Analytical Biochemistry, 27, 502–522, 1969.
  • Koksal N, Hasanoglu HC, Gokirmak M, Yildirim Z, Gultek A. “Apricot sulfurization: An occupation that induces an asthma-like syndrome in agricultural environments”. American Journal of Industrial Medicine, 43(4), 447-453, 2003.
  • Koksal N, Yıldırım Z, Gokirmak M, Hasanoglu HC, Mehmet N, Avcı H. “The role of nitric oxide and cytokines in asthma-like syndrome induced by sulfur dioxide exposure in agricultural environment”. Clinica Chimica Acta, 336(1-2), 115-122, 2003.
  • Gokirmak M, Yildirim Z, Hasanoglu HC, Koksal N, Mehmet N. “The role of oxidative stress in bronchoconstriction due to occupational sulfur dioxide exposure”. Clinica Chimica Acta, 331(1-2), 119-126, 2003.
  • Uren N, Yuksel S, Onal Y. “Genotoxic effects of sulfur dioxide in human lymphocytes”. Toxicology and Industrial Health, 30(4), 311-315, 2014.
  • Türkyılmaz M, Özkan M, Güzel N. “Loss of sulfur dioxide and changes in some chemical properties of Malatya apricots [Prunus armeniaca L.] during sulfuring and drying”. Journal of Science of Food and Agriculture, 94(12), 2488-2496, 2014.
  • Kan T, Bostan SZ. “Effect of sulfurization and process conditions on polyphenol content of anatolian apricots [prunus armeniaca]”. Journal of Food Processing Preservation, 37(2), 163-170, 2013.

Effect of sulfur amount in dry apricot on serum oxidative stress parameters

Year 2019, Volume: 25 Issue: 7, 889 - 892, 26.12.2019

Abstract

Apricot is one of the important fruit that can be grown in many parts of the world. The apricots are dried in the sun or by treatment with sulfur to prolong the storage time. In many European countries and in our country, the amount of sulfur required in dried apricots is 2000mg/L and this amount is likely to drop down. The aim of this study is to compare the effects of feeding with high and low sulfur bearing apricot on serum oxidative stress parameters. In total, 84 Wistar albino rats were fed for 12 weeks with dried apricots containing different amounts of sulfur or sun-dried apricots. Serum total antioxidant level, total oxidant level, malondialdehyde and glutathione levels of the rats were measured. The highest total antioxidant level was observed in the group fed with sun dried apricot, while the lowest total antioxidant level was observed in the 3000 mg/L group. Malondialdehyde levels increased only in 1000 mg/L group, while glutathione levels were significantly increased in 1000 mg/L, 2000 mg/L and 3000 mg/L groups.

References

  • Asma BM, Gültek A, Kan T, Birhanlı O. Kayısıda Kükürt Sorunu. 1. Baskı. Malatya, Türkiye, Öz Gayret Ofset, 2005.
  • Altan N, Dinçel AS, Koca C. “Diabetes mellitus ve oksidatif stres”. Turk Journal of Biochemistry, 31(2), 51-56, 2006.
  • Gorrini C, Harris IS, Mak TW. Modulation of oxidative stress as an anticancer strategy. Nature Reviews Drug Discovery, 12, 931-47, 2013.
  • Hardy J, Selkoe DJ. “The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics”. Science, 297(5580), 353-56, 2002.
  • Phaniendra A, Jestadi DB, Periyasamy L. “Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases”. Indian Journal of Clinical Biochemistry, 30(1), 11-26, 2015.
  • Rania V, Deep G, Singh RK, Palle K, Yadav UCS. “Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies”. Life Sciences, 148, 183-193, 2016.
  • Mercan U. “Toksikolojide Serbest Radikallerin Önemi”. Yüzüncü yıl Üniversitesi Veterinerlik Fakültesi Dergisi, 15 (1-2), 91-96, 2004.
  • Pisoschi AM, Pop A. “The role of antioxidants in the chemistry of oxidative stress: A review”. European Journal of Medicinal Chemistry, 97, 55-74, 2015.
  • Koç S. Glutatyon S-Transferaz Genindeki Delesyonların (Gstt1, Gsttm1) Koroner Arter Hastalığı ve Akut Miyokart İnfarktüsü ile İlişkisi. Yüksek Lisans Tezi, Çukurova Üniversitesi, Adana, Türkiye, 2008.
  • Placer, ZA, Cushman LL, Johnson BC. “Estimation of product of lipid peroxidation [Malondy Dialdehyde] in biochemical systems”. Analytical Biochemistry, 16(2), 259-264, 1990.
  • Halliwell B, Chirico S. “Lipid peroxidation: its mechanism, measurement, and significance”. The American Journal of Clinical Nutrition, 57(5), 715-725, 1993.
  • Meng, Z. “Oxidative damage of sulfur dioxide on various organs of mice: sulfur dioxide İs a systemic oxidative damage agent”. Inhalation Toxicology, 15(2), 181-195, 2003.
  • Meng Z, Qin G, Zhang B, Bai J. “DNA damaging effects of sulfur dioxide derivatives in cells from various organs of mice”. Mutagenesis, 19(6), 465-468, 2004.
  • Parlakpinar, H, Olmez E,Acet A, Ozturk F,Tasdemir S,Ates B, Gul M,Otlu A. “Beneficial effects of apricot-feeding on myocardial ischemia-reperfusion injury in rats”. Food Chemical Toxicology, 47(4), 802-8, 2009.
  • Ozturk F, Gul M, Ates B, Ozturk IC. “Protective effect of apricot [Prunus armeniaca L.] on hepatic steatosis and damage induced by carbon tetrachloride in wistar rats”. British Journal of Nutrition, 102(12), 1767-1775, 2009.
  • Rel Assay Diagonostics. “Total Antioxidant Status Assay Kit”. https://www.relassay.com/uploads/TASinsert.pdf. (08.02.2019).
  • Rel Assay Diagnostics. “Total Oxidant Status Assay Kit”. https://www.relassay.com/uploads/TOSinsert.pdf. (08.02.2019).
  • Mihara M, Uchiyama M. “Determination of malonaldehyde precursor in tissues by thiobarbituric acid test”. Analitical Biochemistry, 86(1), 271-8, 1978.
  • Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Analytical Biochemistry, 27, 502–522, 1969.
  • Koksal N, Hasanoglu HC, Gokirmak M, Yildirim Z, Gultek A. “Apricot sulfurization: An occupation that induces an asthma-like syndrome in agricultural environments”. American Journal of Industrial Medicine, 43(4), 447-453, 2003.
  • Koksal N, Yıldırım Z, Gokirmak M, Hasanoglu HC, Mehmet N, Avcı H. “The role of nitric oxide and cytokines in asthma-like syndrome induced by sulfur dioxide exposure in agricultural environment”. Clinica Chimica Acta, 336(1-2), 115-122, 2003.
  • Gokirmak M, Yildirim Z, Hasanoglu HC, Koksal N, Mehmet N. “The role of oxidative stress in bronchoconstriction due to occupational sulfur dioxide exposure”. Clinica Chimica Acta, 331(1-2), 119-126, 2003.
  • Uren N, Yuksel S, Onal Y. “Genotoxic effects of sulfur dioxide in human lymphocytes”. Toxicology and Industrial Health, 30(4), 311-315, 2014.
  • Türkyılmaz M, Özkan M, Güzel N. “Loss of sulfur dioxide and changes in some chemical properties of Malatya apricots [Prunus armeniaca L.] during sulfuring and drying”. Journal of Science of Food and Agriculture, 94(12), 2488-2496, 2014.
  • Kan T, Bostan SZ. “Effect of sulfurization and process conditions on polyphenol content of anatolian apricots [prunus armeniaca]”. Journal of Food Processing Preservation, 37(2), 163-170, 2013.
There are 25 citations in total.

Details

Primary Language Turkish
Subjects Engineering
Journal Section Research Article
Authors

Önder Otlu

Tuğba Raika Kıran

Ercan Karabulut

Aysun Bay Karabulut This is me

Publication Date December 26, 2019
Published in Issue Year 2019 Volume: 25 Issue: 7

Cite

APA Otlu, Ö., Kıran, T. R., Karabulut, E., Bay Karabulut, A. (2019). Kuru kayısılardaki kükürt miktarının serum oksidatif stres parametleri üzerine etkisi. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi, 25(7), 889-892.
AMA Otlu Ö, Kıran TR, Karabulut E, Bay Karabulut A. Kuru kayısılardaki kükürt miktarının serum oksidatif stres parametleri üzerine etkisi. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi. December 2019;25(7):889-892.
Chicago Otlu, Önder, Tuğba Raika Kıran, Ercan Karabulut, and Aysun Bay Karabulut. “Kuru kayısılardaki kükürt miktarının Serum Oksidatif Stres Parametleri üzerine Etkisi”. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi 25, no. 7 (December 2019): 889-92.
EndNote Otlu Ö, Kıran TR, Karabulut E, Bay Karabulut A (December 1, 2019) Kuru kayısılardaki kükürt miktarının serum oksidatif stres parametleri üzerine etkisi. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi 25 7 889–892.
IEEE Ö. Otlu, T. R. Kıran, E. Karabulut, and A. Bay Karabulut, “Kuru kayısılardaki kükürt miktarının serum oksidatif stres parametleri üzerine etkisi”, Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi, vol. 25, no. 7, pp. 889–892, 2019.
ISNAD Otlu, Önder et al. “Kuru kayısılardaki kükürt miktarının Serum Oksidatif Stres Parametleri üzerine Etkisi”. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi 25/7 (December 2019), 889-892.
JAMA Otlu Ö, Kıran TR, Karabulut E, Bay Karabulut A. Kuru kayısılardaki kükürt miktarının serum oksidatif stres parametleri üzerine etkisi. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi. 2019;25:889–892.
MLA Otlu, Önder et al. “Kuru kayısılardaki kükürt miktarının Serum Oksidatif Stres Parametleri üzerine Etkisi”. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi, vol. 25, no. 7, 2019, pp. 889-92.
Vancouver Otlu Ö, Kıran TR, Karabulut E, Bay Karabulut A. Kuru kayısılardaki kükürt miktarının serum oksidatif stres parametleri üzerine etkisi. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi. 2019;25(7):889-92.





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