Predictive value of serum vitamin B12 elevation in acute leukemia

Abstract

Purpose: In this study; we sought to assess whether elevated vitamin B12 levels during the course of diagnosis might be a predictor of acute leukemias.
Materials and method: The study was prepared by retrospectively evaluating the anamnesis and laboratory information of 95 patients diagnosed with acute leukemia (AML or ALL). Those who had any of the conditions clearly known to increase vitamin B12 levels by scanning their anamnesis and laboratory information were not included in the study.
Results: In total, it was observed that serum vitamin B12 level at the time of diagnosis was above the normal reference range (>771ng/L) in 36% of the patients. In the survival analysis performed to evaluate the effect of high serum vitamin B12 levels on prognosis, no statistically significant difference was found.
Conclusion: The data we obtained from this study; shows that high serum vitamin B12 levels may have predictive value for acute leukemia.

Keywords

• Acute leukemia
• cancer
• cobalamin
• vitamin B12

Akut lösemilerde serum vitamin B12 yüksekliğinin prediktif değeri

Abstract

Amaç: Bu çalışmada; tanı anında bakılan yüksek vitamin B12 düzeylerinin akut lösemilerde prediktif bir faktör olup olmadığını belirlemeyi amaçladık.
Gereç ve yöntem: Çalışmamız akut lösemi (AML ve ya ALL) tanısı alan 95 hastanın anamnez ve laboratuvar bilgileri retrospektif olarak değerlendirilerek hazırlanmıştır. Anamnez ve laboratuvar bilgileri taranarak B12 vitamini düzeyini yükselttiği açıkça bilinen durumlardan herhangi birine sahip olanlar çalışmaya dahil edilmemiştir.
Bulgular: Toplamda hastaların %36'sında tanı anındaki serum vitamin B12 düzeyinin normal referans aralığının (>771ng/L) üzerinde olduğu görüldü. Yüksek serum vitamin B12 düzeyinin prognoza etkisini değerlendirmek için yapılan sağ kalım analizinde istatistiksel olarak anlamlı bir fark gözlenmedi.
Sonuç: Bu çalışmadan elde ettiğimiz veriler; yüksek serum vitamin B12 düzeylerinin akut lösemi için öngörü değeri olabileceğini göstermektedir.

Keywords

• vitamin B12
• Akut lösemi
• kanser
• kobalamin

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