Vitamin D reseptör gen polimorfizmlerinin Türk çocuklarında obezite, metabolik sendrom ve hepatostetoz ile ilişkisi

Abstract

Amaç: Bu çalışmanın amacı, TaqI (rs731236), ApaI (rs7975232), BsmI (rs1544410), FokI (rs10735810) gibi Vitamin D reseptör (VDR) polimorfizmlerinin çocuklarda obezite, metabolik sendrom ve hepatosteatoz riski ile ilişkisini belirlemektir.
Gereç ve yöntem: Çalışmaya yaşları 10-16 arasında değişen 130 obez ve 130 sağlıklı çocuk dahil edildi. Tüm çocukların antropometrik ölçümleri, biyokimyasal değerlendirmeleri ve batın USG'leri yapıldı. Obez ve sağlıklı çocuklar, VDR geninin en yaygın polimorfizmlerine restriksiyon fragment uzunluğu polimorfizm yöntemi kullanılarak analiz edildi. Metabolik sendrom tanısı Uluslararası Diyabet Federasyonu kriterleri kullanılarak konuldu.
Bulgular: BsmI, FokI ve TaqI polimorfizminin genotipik dağılımı, obez hastalar ve kontrol grubu arasında istatistiksel olarak farklı bulundu, ancak çalışılan tüm polimorfizmlerin genotipik dağılımı, metabolik sendromlu veya hepatosteotozu olan obez hastalarda istatistiksel olarak farklı bulunmadı.
Sonuç: VDR geni BsmI polimorfizminin (rs1544410) obezite, metabolik sendrom ve hepatosteatoz gelişimine katkısının olduğu bulundu. Obezite gelişim riski taşıyan çocuklarda, obezite ve komplikasyonlar oluşmadan önce tespit etmek için BsmI polimorfizmi tarama amaçlı kullanılabilir.

Keywords

• obezite
• polimorfizm
• D vitamini
• metabolik sendrom

Project Number

This study was supported by Pamukkale University Scientific Research Projects Commission with the decision numbered 2015TPF019.

The relation of vitamin D receptor gene polymorphisms with risk of obesity, metabolic syndrome, hepatostetosis in Turkish children

Abstract

Purpose: The aim of study was to determine the relation of vitamin D receptor gene (VDR) polymorphisms of TaqI (rs731236), ApaI (rs7975232), BsmI (rs1544410), FokI (rs10735810) with the risk of obesity, metabolic syndrome and hepatosteatosis in children.
Materials and methods: 130 obese and 130 healthy children of age range between 10-16 years included in this study. Anthropometric measurements, biochemical evaluations and abdominal USG of all children were done. Obese and healty children were analyzed for the most common polymorphisms of the VDR gene by restriction fragment length polymorphism’s technique. The diagnosis of metabolic syndrome was made using the International Diabetes Federation criteria.
Results: Genotypic distribution of BsmI, FokI, and TaqI polymorphism were found statistically different between obese patients and control group, but genotypic distribution of all studied polymorphisms were not found statistically different in obese patients with metabolic syndrome or hepatosteotosis.
Conclusion: BsmI polymorphism (rs1544410) was found to have a significant positive effect on the development of obesity, metabolic syndrome and hepatosteatosis. Children who carry risk factors for childhood obesity could be screened before the development of obesity and associated metabolic complications using the BsmI polymorphism of the VDR gene.

Keywords

• obesity
• polymorphism
• Vitamin D
• metabolic syndrome

Supporting Institution

This study was supported by Pamukkale University Scientific Research Projects Commission with the decision numbered 2015TPF019.

Project Number

This study was supported by Pamukkale University Scientific Research Projects Commission with the decision numbered 2015TPF019.