Effects of quercetin on adipokine profile in fructose-induced metabolic syndrome
Abstract
Purpose: Metabolic syndrome (MetS) is a health condition characterized by obesity, insulin resistance, dyslipidemia and type 2 diabetes (T2DM). This study aimed to assess the effects of quercetin, a natural flavonoid on MetS induced by fructose in Sprague Dawley rats.
Materials and methods: The rats, aged 8-10 weeks, were divided into 4 groups: control (C) group, metabolic syndrome (MetS) group, control+quercetin (C+Q) group, and metabolic syndrome+quercetin (MetS+Q) group. The MetS groups received a 20% fructose solution in drinking water for a duration of 10 weeks. For the last 4 weeks of the study, rats in the Q groups were administered 50 mg/kg/body weight quercetin. After 10 weeks, serum samples were tested using ELISA for Triglycerides (TG), High-Density Lipoprotein (HDL), fasting insulin, resistin, (Interleukin 6) IL6, Tumor Necrosis Factor-alpha (TNF-α), leptin, C-Reactive Protein (CRP) and, adiponectin (ADP). The body weights, Lee index and HOMA-IR scores were also measured.
Results: Fructose-fed rats showed significant increases in body weight, Lee index, HOMA-IR scores and, fasting insulin with significant decrease in HDL compared to controls. In MetS group, ADP levels were significantly lower compared to control group. In MetS+Q group, there was a tendency for reduced levels of resistin, IL-6, and leptin compared to the untreated MetS group.
Conclusion: These findings suggest that quercetin may be beneficial in managing MetS, though further research is needed to explore its mechanisms and effectiveness.
Keywords
Adipokine, fructose, metabolic syndrome, quercetin
Supporting Institution
The authors did not receive funding for this study.
Ethical Statement
This study was approved by the Pamukkale University Animal Experiments Local Ethics Committee (PAUHDEK-2023/32-19.10.2023, 2023/06).
Thanks
The authors thank Assist. Prof. Hande Senol for her help in statistical analyses.
References
- Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009;2(5-6):231-237. doi:10.1242/dmm.001180
- Kim JE, Kim JS, Jo MJ, et al. The Roles and Associated Mechanisms of Adipokines in Development of Metabolic Syndrome. Molecules. 2022;27(2):334. Published 2022 Jan 6. doi:10.3390/molecules27020334
- Horwitz A, Birk R. Adipose Tissue Hyperplasia and Hypertrophy in Common and Syndromic Obesity-The Case of BBS Obesity. Nutrients. 2023;15(15):3445. Published 2023 Aug 4. doi:10.3390/nu15153445
- Zorena K, Jachimowicz Duda O, Wąż P. The cut-off value for interleukin 34 as an additional potential inflammatory biomarker for the prediction of the risk of diabetic complications. Biomarkers. 2016;21(3):276-282. doi:10.3109/1354750X.2016.1138321
- Bastard JP, Maachi M, Lagathu C, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006;17(1):4-12.
- Pandey G, Shihabudeen MS, David HP, Thirumurugan E, Thirumurugan K. Association between hyperleptinemia and oxidative stress in obese diabetic subjects. J Diabetes Metab Disord. 2015;14:24. Published 2015 Apr 14. doi:10.1186/s40200-015-0159-9
- Monda V, Polito R, Lovino A, et al. Short-Term Physiological Effects of a Very Low-Calorie Ketogenic Diet: Effects on Adiponectin Levels and Inflammatory States. Int J Mol Sci. 2020;21(9):3228. Published 2020 May 2. doi:10.3390/ijms21093228
- Ruban A, Stoenchev K, Ashrafian H, Teare J. Current treatments for obesity. Clin Med (Lond). 2019;19(3):205-212. doi:10.7861/clinmedicine.19-3-205
- Leiherer A, Stoemmer K, Muendlein A, et al. Quercetin Impacts Expression of Metabolism- and Obesity-Associated Genes in SGBS Adipocytes. Nutrients. 2016;8(5):282. Published 2016 May 12. doi:10.3390/nu8050282
- Yamamoto Y, Oue E. Antihypertensive effect of quercetin in rats fed with a high-fat high-sucrose diet. Biosci Biotechnol Biochem. 2006;70(4):933-939. doi:10.1271/bbb.70.933
