Effects of quercetin on adipokine profile in fructose-induced metabolic syndrome

Öz

Purpose: Metabolic syndrome (MetS) is a health condition characterized by obesity, insulin resistance, dyslipidemia and type 2 diabetes (T2DM). This study aimed to assess the effects of quercetin, a natural flavonoid on MetS induced by fructose in Sprague Dawley rats. Materials and methods: The rats, aged 8-10 weeks, were divided into 4 groups: control (C) group, metabolic syndrome (MetS) group, control+quercetin (C+Q) group, and metabolic syndrome+quercetin (MetS+Q) group. The MetS groups received a 20% fructose solution in drinking water for a duration of 10 weeks. For the last 4 weeks of the study, rats in the Q groups were administered 50 mg/kg/body weight quercetin. After 10 weeks, serum samples were tested using ELISA for Triglycerides (TG), High-Density Lipoprotein (HDL), fasting insulin, resistin, (Interleukin 6) IL6, Tumor Necrosis Factor-alpha (TNF-α), leptin, C-Reactive Protein (CRP) and, adiponectin (ADP). The body weights, Lee index and HOMA-IR scores were also measured. Results: Fructose-fed rats showed significant increases in body weight, Lee index, HOMA-IR scores and, fasting insulin with significant decrease in HDL compared to controls. In MetS group, ADP levels were significantly lower compared to control group. In MetS+Q group, there was a tendency for reduced levels of resistin, IL-6, and leptin compared to the untreated MetS group. Conclusion: These findings suggest that quercetin may be beneficial in managing MetS, though further research is needed to explore its mechanisms and effectiveness.

Anahtar Kelimeler

• Adipokine
• fructose
• metabolic syndrome
• quercetin

Fruktoz ile indüklenen metabolik sendromda quercetinin adipokin profili üzerine etkileri

Öz

Amaç: Metabolik sendrom (MetS) obezite, insülin direnci, dislipidemi ve tip 2 diyabet (T2DM) ile karakterize bir sağlık durumudur. Bu çalışmada, Sprague Dawley sıçanlarında fruktoz ile indüklenen MetS üzerinde doğal bir flavonoid olan quercetinin etkilerinin değerlendirilmesi amaçlandı. Gereç ve yöntem: 8-10 haftalık sıçanlar 4 gruba ayrıldı: kontrol (C) grubu, metabolik sendrom (MetS) grubu, kontrol+quercetin (C+Q) grubu ve metabolik sendrom+quercetin (MetS+Q) grubu. MetS gruplarına 10 hafta boyunca içme suyunda %20 fruktoz çözeltisi verildi. Çalışmanın son 4 haftasında Q verilen gruplardaki sıçanlara 50 mg/kg/vücut ağırlığı quercetin uygulandı. 10 hafta sonra, serum örnekleri Trigliserid (TG), Yüksek Yoğunluklu Lipoprotein (HDL), açlık insülini, resistin, (Interleukin 6) IL6, Tümör Nekroz Faktörü-alfa (TNF-α), leptin, C-Reaktif Protein (CRP) ve adiponektin (ADP) için ELISA kullanılarak test edildi. Vücut ağırlıkları, Lee indeksi ve HOMA-IR skorları da ölçüldü. Bulgular: Fruktozla beslenen sıçanların vücut ağırlığında, Lee indeksinde, HOMA-IR skorlarında ve açlık insülininde kontrol grubuna kıyasla anlamlı artışlar, HDL'de ise anlamlı düşüşler görüldü. MetS grubunda ADP seviyeleri kontrol grubuna kıyasla anlamlı derecede düşüktü. MetS+Q grubunda, tedavi edilmeyen MetS grubuna kıyasla resistin, IL-6 ve leptin seviyelerinde azalma eğilimi vardı. Sonuç: Bu bulgular, quercetinin MetS yönetiminde faydalı olabileceğini, ancak mekanizmalarını ve etkinliğini keşfetmek için daha fazla araştırmaya ihtiyaç olduğunu göstermektedir.

Anahtar Kelimeler

• Adipokin
• fruktoz
• metabolik sendrom
• quercetin

Kaynakça

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