Prognostic factors in vulvar cancer patients: a single center experience

Abstract

Purpose: Many prognostic factors have been investigated in vulvar cancer patients. In our study, we aimed to
compare clinical and pathological prognostic factors and investigate the factors that affect the recurrence and
survival in patients with recurrent and non-recurrent squamous cell vulvar cancer.
Materials and methods: This retrospective study was conducted in Tepecik Research Hospital, Izmir, Turkey
between 1999-2020. The descriptive features, prognostic factors and survival in recurrent patients were
evaluated.
Results: Tumor invasion depth, surgical margin positivity, lymphovascular space invasion (LVSI), are
statistically significant for recurrence (p=0.03, p=0.00, p=0.04). Variables such as age, tumor size, surgical
margin distance (mm), tumor localization, presence of metastatic lymph node, operation type (surgery with
lymph node dissection) and adjuvant therapy were not found to be statistically significant in terms of recurrent
patients with vulvar cancer. There was correlation between recurrence, LVSI, surgical margin positivity, stage
and survival in Kaplan Meier survival analysis.
Conclusion: As in other studies, many prognostic factors like tumor invasion depth, surgical margin positivity,
LVSI are risk factors for recurrence in our study. Stage, LVSI, recurrence, surgical margin positivity were
significant factors for survival as well.

Keywords

• Vulvar cancer
• adjuvant therapy
• recurrence

Vulvar Kanserli Hastalarda Prognostik Faktörler: Tek Merkez Deneyimi

Abstract

Amaç: Vulvar kanserli hastalarda birçok prognostik faktör araştırılmıştır. Çalışmamızda nüks ve nüks olmayan skuamöz hücreli vulvar kanserli hastalarda klinik ve patolojik prognostik faktörleri karşılaştırmayı, nüks ve sağkalımı etkileyen faktörleri araştırmayı amaçladık. Gereç-Yöntem: Bu prospektif çalışma 1999-2020 yılları arasında İzmir, Tepecik Araştırma Hastanesi’nde yapıldı. Tekrarlayan hastalarda tanımlayıcı özellikler, prognostik faktörler ve sağkalım değerlendirildi. Bulgular: Tümör invazyon derinliği, cerrahi sınır pozitifliği, lenfovasküler boşluk invazyonu (LVSI) nüks açısından istatiksel olarak anlamlıdır(p=0,03, p=0,00, p=0,04). Yaş, tümör boyutu, cerrahi sınır mesafesi (mm), tümör lokalizasyonu, metastatik lenf nodu varlığı, operasyon tipi (lenf nodu diseksiyonlu cerrahi) ve adjuvan tedavi gibi değişkenler nüks vulvar kanseri hastaları açısından istatiksel olarak anlamlı bulunmadı. Kaplan Meier sağkalım analizinde nüks, lenfovasküler boşluk invazyonu, cerrahi sınır pozitifliği, evre ve sağkalım arasında korelasyon vardı. Sonuç: Diğer çalışmalarda olduğu gibi bizim çalışmamızda da tümör invazyon derinliği,cerrahi sınır pozitifliği, lenfovasküler boşluk invazyonu gibi birçok prognostik faktör nüks için risk faktörüdür. Evre, lenfovasküler boşluk invazyonu, nüks, cerrahi sınır pozitifliği de sağkalım için önemli faktörlerdendir.

Keywords

• Vulva Kanseri
• adjuvan tedavi
• nüks

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