CONUT skoru multipl myelomda prognostik bir gösterge midir?

Year 2025, Volume: 18 Issue: 3, 628 - 636, 02.07.2025

Eda Nilufer Coskun , Gulsum Akgun Cagliyan

https://doi.org/10.31362/patd.1650758

Abstract

Amaç: Multiple Myelom (MM) hastalarında CONUT skorunun prognoza etkisini değerlendirmeyi amaçladık.
Gereç ve yöntem: Çalışmamız retrospektif bir çalışma olarak tasarlandı. CONUT skorunu serum albumin, total kolesterol ve lenfosit değerlerine göre hesapladık. Bu çalışmaya 99'u (%46,5) kadın, 114'ü (%53,5) erkek olmak üzere 213 hasta dahil edildi. Median takip süresi 38 ay idi (1-161).
Bulgular: Median yaş 64 idi. Hastaları CONUT skoruna göre dört gruba ayırdık: normal (0-1), düşük (2-4), orta (5-8) ve yüksek (9-12). CONUT skoruna göre genel sağkalım (OS) ve progresyonsuz sağkalım (PFS) arasında sırasıyla yüksek (OS:12, PFS:1 ay), orta (OS:27, PFS:13 ay) ve düşük (OS:54, PFS:28 ay) anlamlı farklar bulduk (p<0,001 ve p=0,001). OS için yapılan çok değişkenli analizde CONUT skorunun orta düzeyde olması 2,21 kat (HR:2,21, p=0,005), CONUT skorunun yüksek olması 2,38 kat (HR:2,38, p=0,033) mortalite riskini arttırıyordu. PFS için yapılan çok değişkenli analizde normal CONUT düzeyiyle karşılaştırıldığında orta derecede CONUT skorunun (HR:1,85, p=0,007), yüksek CONUT skorunun (HR:2,01, p=0,043) ilerleme riskini arttırdığı belirlendi.
Sonuç: Yüksek CONUT skorunun OS ve PFS'de azalma ile ilişkili olduğunu belirledik. Çalışmamızda CONUT skorunun MM’da bağımsız, güçlü bir prognostik indeks olduğunu gösterdik.

Keywords

CONUT skor , multipl myelom , sağkalım , prognoz

Is the CONUT score a prognostic index in multiple myeloma?

Abstract

patients with multiple myeloma (MM).
Materials and methods: Our study was designed retrospectively. We calculated the CONUT score based on serum albumin, total cholesterol and lymphocytes. The study included 213 patients; 99 (46.5%) were female and 114 (53.5%) were male. The median follow-up period was 38 months (1-161).
Results: The median age was 64 years. We participated the patients into four groups. It was defined as CONUT scores: normal (0-1), low (2-4), moderate (5-8), and high (9-12). We found significant differences between overall survival (OS) and progression-free survival (PFS) with regard to CONUT score, respectively, as high (OS:12, PFS:1 months), moderate (OS:27, PFS:13 months) and low (OS:54, PFS:28 months) (p<0.001 and p=0.001). In the multivariate analysis for OS, having moderate CONUT score (HR: 2.21, p=0.005) and high CONUT score (HR: 2.38, p=0.033) were increased the risk of mortality. In the multivariate analysis for PFS, compared to a normal CONUT score, a moderate CONUT score (HR: 1.85, p=0.007), and a high CONUT score (HR: 2.01, p=0.043) were found to increase the risk of progression.
Conclusion: We found that a high CONUT score is related to decreased OS and PFS. In our study, we showed that the CONUT score is an independent, useful and strong prognostic index in MM.

Keywords

CONUT score , multiple myeloma , survival , prognosis

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