CONUT skoru multipl myelomda prognostik bir gösterge midir?

Öz

Amaç: Multiple Myelom (MM) hastalarında CONUT skorunun prognoza etkisini değerlendirmeyi amaçladık. Gereç ve yöntem: Çalışmamız retrospektif bir çalışma olarak tasarlandı. CONUT skorunu serum albumin, total kolesterol ve lenfosit değerlerine göre hesapladık. Bu çalışmaya 99'u (%46,5) kadın, 114'ü (%53,5) erkek olmak üzere 213 hasta dahil edildi. Median takip süresi 38 ay idi (1-161). Bulgular: Median yaş 64 idi. Hastaları CONUT skoruna göre dört gruba ayırdık: normal (0-1), düşük (2-4), orta (5-8) ve yüksek (9-12). CONUT skoruna göre genel sağkalım (OS) ve progresyonsuz sağkalım (PFS) arasında sırasıyla yüksek (OS:12, PFS:1 ay), orta (OS:27, PFS:13 ay) ve düşük (OS:54, PFS:28 ay) anlamlı farklar bulduk (p<0,001 ve p=0,001). OS için yapılan çok değişkenli analizde CONUT skorunun orta düzeyde olması 2,21 kat (HR:2,21, p=0,005), CONUT skorunun yüksek olması 2,38 kat (HR:2,38, p=0,033) mortalite riskini arttırıyordu. PFS için yapılan çok değişkenli analizde normal CONUT düzeyiyle karşılaştırıldığında orta derecede CONUT skorunun (HR:1,85, p=0,007), yüksek CONUT skorunun (HR:2,01, p=0,043) ilerleme riskini arttırdığı belirlendi. Sonuç: Yüksek CONUT skorunun OS ve PFS'de azalma ile ilişkili olduğunu belirledik. Çalışmamızda CONUT skorunun MM’da bağımsız, güçlü bir prognostik indeks olduğunu gösterdik.

Anahtar Kelimeler

• CONUT skor
• multipl myelom
• sağkalım
• prognoz

Is the CONUT score a prognostic index in multiple myeloma?

Abstract

patients with multiple myeloma (MM). Materials and methods: Our study was designed retrospectively. We calculated the CONUT score based on serum albumin, total cholesterol and lymphocytes. The study included 213 patients; 99 (46.5%) were female and 114 (53.5%) were male. The median follow-up period was 38 months (1-161). Results: The median age was 64 years. We participated the patients into four groups. It was defined as CONUT scores: normal (0-1), low (2-4), moderate (5-8), and high (9-12). We found significant differences between overall survival (OS) and progression-free survival (PFS) with regard to CONUT score, respectively, as high (OS:12, PFS:1 months), moderate (OS:27, PFS:13 months) and low (OS:54, PFS:28 months) (p<0.001 and p=0.001). In the multivariate analysis for OS, having moderate CONUT score (HR: 2.21, p=0.005) and high CONUT score (HR: 2.38, p=0.033) were increased the risk of mortality. In the multivariate analysis for PFS, compared to a normal CONUT score, a moderate CONUT score (HR: 1.85, p=0.007), and a high CONUT score (HR: 2.01, p=0.043) were found to increase the risk of progression. Conclusion: We found that a high CONUT score is related to decreased OS and PFS. In our study, we showed that the CONUT score is an independent, useful and strong prognostic index in MM.

Keywords

• CONUT score
• multiple myeloma
• survival
• prognosis

Kaynakça

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