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Kronik Tekrarlayan Multifokal Osteomiyelit

Year 2017, Volume: 15 Issue: 1, 25 - 37, 01.04.2017
https://doi.org/10.4274/jcp.52724

Abstract

Kronik tekrarlayan multifokal osteomiyelit KTMO kemik ağrısı ve ateş, alevlenme ve iyileşme dönemleri ile karakterize otoenflamatuvar bir hastalık nonbakteriyel osteomiyelit olup, sıklıkla diğer enflamatuvar hastalıklar ile ilişkilidir. Bu makalede KTMO’lu olgularımızın bulguları ile birlikte son literatür verileri eşliğinde KTMO’nun epidemiyolojisi, etiyolojisi, klinik, histopatolojik ve radyolojik bulguları ve tedavisi tartışılmıştır

References

  • 1. Khanna G, Sato TS, Ferguson P. Imaging of chronic recurrent multifocal osteomyelitis. Radiographics 2009;29:1159-77.
  • 2. El-Shanti HI, Ferguson PJ. Chronic recurrent multifocal osteomyelitis: a concise review and genetic update. Clin Orthop Relat Res 2007;462:11-9.
  • 3. Jurik AG. Chronic recurrent multifocal osteomyelitis. Semin Musculoskelet Radiol 2004;8:243-53.
  • 4. Giedion A, Holthusen W, Masel LF, Vischer D. Subacute and chronic “symmetrical” osteomyelitis. Ann Radiol (Paris) 1972;15:329-42.
  • 5. Probst FP, Bjorksten B, Gustavson KH. Radiological aspect of chronic recurrent multifocal osteomyelitis. Ann Radiol (Paris) 1978;21:115-25.
  • 6. Girschick HJ, Raab P, Surbaum S, Trusen A, Kirschner S, Schneider P, et al. Chronic non-bacterial osteomyelitis in children. Ann Rheum Dis 2005;64:279-85.
  • 7. Ferguson PJ, Sandu M. Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis. Curr Rheumatol Rep 2012;14:130-41.
  • 8. Havıtçıoğlu H, Kıter E. Kronik rekürrent multifokal osteomiyelit. Acta Orthop Traumatol Turc 1998;32:248-52.
  • 9. Yüksel HY, Yılmaz S, Gürbüzel M. Kronik tekrarlayan multifokal osteomiyelitle görülen normofosfatemik tip tümoral kalsinozis. Acta Orthop Traumatol Turc 2011;45:124-9.
  • 10. von Kalle T, Heim N, Hospach T, Langendörfer M, Winkler P, Stuber T. Typical patterns of bone involvement in whole-body MRI of patients with chronic recurrent multifocal osteomyelitis (CRMO). Rofo 2013;185:655-61.
  • 11. Catalano-Pons C, Comte A, Wipff J, Quartier P, Faye A, Gendrel D, et al. Clinical outcome in children with chronic recurrent multifocal osteomyelitis. Rheumatology (Oxford) 2008;47:1397-9.
  • 12. Falip C, Alison M, Boutry N, Job-Deslandre C, Cotten A, Azoulay R, et al. Chronic recurrent multifocal osteomyelitis (CRMO): a longitudinal case series review. Pediatr Radiol 2013;43:355-75.
  • 13. Marino C, McDonald E, Megna D, Brennessel D, Reddy KS, Jain PC. Chronic recurrent multifocal osteomyelitis in adult women. N Y State J Med 1992;92:360-2.
  • 14. Golla A, Jansson A, Ramser J, Hellebrand H, Zahn R, Meitinger T, et al. Chronic recurrent multifocal osteomyelitis (CRMO): evidence for a susceptibility gene located on chromosome 18q21.3-18q22. Eur J Hum Genet 2002;10:217-21.
  • 15. Mandell GA, Contreras SJ, Conard K, Harcke HT, Maas KW. Bone scintigraphy in the detection of chronic recurrent multifocal osteomyelitis. J Nucl Med 1998;39:1778-83.
  • 16. Yu L, Kasser JR, O’Rourke E, Kozakewich H. Chronic recurrent multifocal osteomyelitis. Association with vertebra plana. J Bone Joint Surg Am 1989;71:105-12.
  • 17. Jurik AG, Egund N. MRI in chronic recurrent multifocal osteomyelitis. Skeletal Radiol 1997;26:230-8.
  • 18. Fritz J, Tzaribatchev N, Claussen CD, Carrino JA, Horger MS. Chronic recurrent multifocal osteomyelitis: comparison of whole-body MR imaging with radiography and correlation with clinical and laboratory data. Radiology 2009;252:842-51.
  • 19. Huber AM, Lam PY, Duffy CM, Yeung RS, Ditchfield M, Laxer D, et al. Chronic recurrent multifocal osteomyelitis: clinical outcomes after more than five years of follow-up. J Pediatr 2002;141:198-203.
  • 20. Jansson A, Renner ED, Ramser J, Mayer A, Haban M, Meindl A, et al. Classification of non-bacterial osteitis: retrospective study of clinical, immunological and genetic aspects in 89 patients. Rheumatology (Oxford) 2007;46:154-60.
  • 21. Mortensson W, Edeburn G, Fries M, Nilsson R. Chronic recurrent multifocal osteomyelitis in children. A roentgenologic and scintigraphic investigation. Acta Radiol 1988;29:565-70.
  • 22. Manson D, Wilmot DM, King S, Laxer RM. Physeal involvement in chronic recurrent multifocal osteomyelitis. Pediatr Radiol 1989;20:76-9.
  • 23. Sato TS, Ferguson PJ, Khanna G. Primary multifocal osseous lymphoma in a child. Pediatr Radiol 2008;38:1338-41.
  • 24. Girschick HJ, Krauspe R, Tschammler A, Huppertz HI. Chronic recurrent osteomyelitis with clavicular involvement in children: diagnostic value of different imaging techniques and therapy with non-steroidal anti-inflammatory drugs. Eur J Pediatr 1998;157:28-33.
  • 25. Suresh S, Saifuddin A. Unveiling the ‘unique bone’: a study of the distribution of focal clavicular lesions. Skeletal Radiol 2008;37:749-56.
  • 26. Appell RG, Oppermann HC, Becker W, Kratzat R, Brandeis WE, et al. Condensing osteitis of the clavicle in childhood: a rare sclerotic bone lesion. Review of literature and report of seven patients. Pediatr Radiol 1983;13:301-6.
  • 27. Azouz EM, Jurik AG, Bernard C. Sternocostoclavicular hyperostosis in children: a report of eight cases. AJR Am J Roentgenol 1998;171:461-6.
  • 28. Jurriaans E, Singh NP, Finlay K, Friedman L. Imaging of chronic recurrent multifocal osteomyelitis. Radiol Clin North Am 2001;39:305-27.
  • 29. Baulot E, Bouillien D, Giroux EA, Grammont PM. Chronic recurrent multifocal osteomyelitis causing spinal cord compression. Eur Spine J 1998;7:340-3.
  • 30. Martin JC, Desoysa R, O’Sullivan MM, Silverstone E, Williams H. Chronic recurrent multifocal osteomyelitis: spinal involvement and radiological appearances. Br J Rheumatol 1996;35:1019-21.
  • 31. Jurik AG, Helmig O, Ternowitz T, Moller BN. Chronic recurrent multifocal osteomyelitis: a followup study. J Pediatr Orthop 1988;8:49-58.
  • 32. Vittecoq O, Said LA, Michot C, Mejjad O, Thomine JM, Mitrofanoff P, et al. Evolution of chronic recurrent multifocal osteitis toward spondylarthropathy over the long term. Arthritis Rheum 2000;43:109-19.
  • 33. Kahn MF, Hayem F, Hayem G, Grossin M. Is diffuse sclerosing osteomyelitis of the mandible part of the synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome? Analysis of seven cases. Oral Surg Oral Med Oral Pathol 1994;78:594-8.
  • 34. Suei Y, Taguchi A, Tanimoto K. Diffuse sclerosing osteomyelitis of the mandible: its characteristics and possible relationship to synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome. J Oral Maxillofac Surg 1996;54:1194-9.
  • 35. van Merkesteyn JP, Groot RH, Bras J, McCarroll RS, Bakker DJ. Diffuse sclerosing osteomyelitis of the mandible: a new concept of its etiology. Oral Surg Oral Med Oral Pathol 1990;70:414-9.
  • 36. King SM, Laxer RM, Manson D, Gold R. Chronic recurrent multifocal osteomyelitis: a noninfectious inflammatory process. Pediatr Infect Dis J 1987;6:907-11.
  • 37. Deogaonkar K, Ghandour A, Jones A, Ahuja S, Lyons K.Chronic recurrent multifocal osteomyelitis presenting as acute scoliosis: a case report and review of literature. Eur Spine J 2008;17 (Suppl 2):S248-52.
  • 38. Schilling F, Wagner AD. Azithromycin: an anti-inflammatory effect in chronic reccurent multifocal osteomyelitis? A preliminary report]. Z Rheumatol 2000;59:352-3.
  • 39. Miettunen PM, Wei X, Kaura D, Reslan WA, Aguirre AN, Kellner JD. Dramatic pain relief and resolution of bone inflammation following pamidronate in 9 pediatric patients with persistent chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol Online J 2009;7:2.

Chronic Recurrent Multifocal Osteomyelitis

Year 2017, Volume: 15 Issue: 1, 25 - 37, 01.04.2017
https://doi.org/10.4274/jcp.52724

Abstract

Chronic recurrent multifocal osteomyelitis CRMO is an autoinflamatory disorder a nonbacterial osteomyelitis frequently associated with other inflammatory conditions and characterized by bone pain and fever and waxing and waning periods. In this article, details of our CRMO cases were presented and recent research about its epidemiology, etiology, clinical features, histopathologic and radiological findings, and treatment are discussed

References

  • 1. Khanna G, Sato TS, Ferguson P. Imaging of chronic recurrent multifocal osteomyelitis. Radiographics 2009;29:1159-77.
  • 2. El-Shanti HI, Ferguson PJ. Chronic recurrent multifocal osteomyelitis: a concise review and genetic update. Clin Orthop Relat Res 2007;462:11-9.
  • 3. Jurik AG. Chronic recurrent multifocal osteomyelitis. Semin Musculoskelet Radiol 2004;8:243-53.
  • 4. Giedion A, Holthusen W, Masel LF, Vischer D. Subacute and chronic “symmetrical” osteomyelitis. Ann Radiol (Paris) 1972;15:329-42.
  • 5. Probst FP, Bjorksten B, Gustavson KH. Radiological aspect of chronic recurrent multifocal osteomyelitis. Ann Radiol (Paris) 1978;21:115-25.
  • 6. Girschick HJ, Raab P, Surbaum S, Trusen A, Kirschner S, Schneider P, et al. Chronic non-bacterial osteomyelitis in children. Ann Rheum Dis 2005;64:279-85.
  • 7. Ferguson PJ, Sandu M. Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis. Curr Rheumatol Rep 2012;14:130-41.
  • 8. Havıtçıoğlu H, Kıter E. Kronik rekürrent multifokal osteomiyelit. Acta Orthop Traumatol Turc 1998;32:248-52.
  • 9. Yüksel HY, Yılmaz S, Gürbüzel M. Kronik tekrarlayan multifokal osteomiyelitle görülen normofosfatemik tip tümoral kalsinozis. Acta Orthop Traumatol Turc 2011;45:124-9.
  • 10. von Kalle T, Heim N, Hospach T, Langendörfer M, Winkler P, Stuber T. Typical patterns of bone involvement in whole-body MRI of patients with chronic recurrent multifocal osteomyelitis (CRMO). Rofo 2013;185:655-61.
  • 11. Catalano-Pons C, Comte A, Wipff J, Quartier P, Faye A, Gendrel D, et al. Clinical outcome in children with chronic recurrent multifocal osteomyelitis. Rheumatology (Oxford) 2008;47:1397-9.
  • 12. Falip C, Alison M, Boutry N, Job-Deslandre C, Cotten A, Azoulay R, et al. Chronic recurrent multifocal osteomyelitis (CRMO): a longitudinal case series review. Pediatr Radiol 2013;43:355-75.
  • 13. Marino C, McDonald E, Megna D, Brennessel D, Reddy KS, Jain PC. Chronic recurrent multifocal osteomyelitis in adult women. N Y State J Med 1992;92:360-2.
  • 14. Golla A, Jansson A, Ramser J, Hellebrand H, Zahn R, Meitinger T, et al. Chronic recurrent multifocal osteomyelitis (CRMO): evidence for a susceptibility gene located on chromosome 18q21.3-18q22. Eur J Hum Genet 2002;10:217-21.
  • 15. Mandell GA, Contreras SJ, Conard K, Harcke HT, Maas KW. Bone scintigraphy in the detection of chronic recurrent multifocal osteomyelitis. J Nucl Med 1998;39:1778-83.
  • 16. Yu L, Kasser JR, O’Rourke E, Kozakewich H. Chronic recurrent multifocal osteomyelitis. Association with vertebra plana. J Bone Joint Surg Am 1989;71:105-12.
  • 17. Jurik AG, Egund N. MRI in chronic recurrent multifocal osteomyelitis. Skeletal Radiol 1997;26:230-8.
  • 18. Fritz J, Tzaribatchev N, Claussen CD, Carrino JA, Horger MS. Chronic recurrent multifocal osteomyelitis: comparison of whole-body MR imaging with radiography and correlation with clinical and laboratory data. Radiology 2009;252:842-51.
  • 19. Huber AM, Lam PY, Duffy CM, Yeung RS, Ditchfield M, Laxer D, et al. Chronic recurrent multifocal osteomyelitis: clinical outcomes after more than five years of follow-up. J Pediatr 2002;141:198-203.
  • 20. Jansson A, Renner ED, Ramser J, Mayer A, Haban M, Meindl A, et al. Classification of non-bacterial osteitis: retrospective study of clinical, immunological and genetic aspects in 89 patients. Rheumatology (Oxford) 2007;46:154-60.
  • 21. Mortensson W, Edeburn G, Fries M, Nilsson R. Chronic recurrent multifocal osteomyelitis in children. A roentgenologic and scintigraphic investigation. Acta Radiol 1988;29:565-70.
  • 22. Manson D, Wilmot DM, King S, Laxer RM. Physeal involvement in chronic recurrent multifocal osteomyelitis. Pediatr Radiol 1989;20:76-9.
  • 23. Sato TS, Ferguson PJ, Khanna G. Primary multifocal osseous lymphoma in a child. Pediatr Radiol 2008;38:1338-41.
  • 24. Girschick HJ, Krauspe R, Tschammler A, Huppertz HI. Chronic recurrent osteomyelitis with clavicular involvement in children: diagnostic value of different imaging techniques and therapy with non-steroidal anti-inflammatory drugs. Eur J Pediatr 1998;157:28-33.
  • 25. Suresh S, Saifuddin A. Unveiling the ‘unique bone’: a study of the distribution of focal clavicular lesions. Skeletal Radiol 2008;37:749-56.
  • 26. Appell RG, Oppermann HC, Becker W, Kratzat R, Brandeis WE, et al. Condensing osteitis of the clavicle in childhood: a rare sclerotic bone lesion. Review of literature and report of seven patients. Pediatr Radiol 1983;13:301-6.
  • 27. Azouz EM, Jurik AG, Bernard C. Sternocostoclavicular hyperostosis in children: a report of eight cases. AJR Am J Roentgenol 1998;171:461-6.
  • 28. Jurriaans E, Singh NP, Finlay K, Friedman L. Imaging of chronic recurrent multifocal osteomyelitis. Radiol Clin North Am 2001;39:305-27.
  • 29. Baulot E, Bouillien D, Giroux EA, Grammont PM. Chronic recurrent multifocal osteomyelitis causing spinal cord compression. Eur Spine J 1998;7:340-3.
  • 30. Martin JC, Desoysa R, O’Sullivan MM, Silverstone E, Williams H. Chronic recurrent multifocal osteomyelitis: spinal involvement and radiological appearances. Br J Rheumatol 1996;35:1019-21.
  • 31. Jurik AG, Helmig O, Ternowitz T, Moller BN. Chronic recurrent multifocal osteomyelitis: a followup study. J Pediatr Orthop 1988;8:49-58.
  • 32. Vittecoq O, Said LA, Michot C, Mejjad O, Thomine JM, Mitrofanoff P, et al. Evolution of chronic recurrent multifocal osteitis toward spondylarthropathy over the long term. Arthritis Rheum 2000;43:109-19.
  • 33. Kahn MF, Hayem F, Hayem G, Grossin M. Is diffuse sclerosing osteomyelitis of the mandible part of the synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome? Analysis of seven cases. Oral Surg Oral Med Oral Pathol 1994;78:594-8.
  • 34. Suei Y, Taguchi A, Tanimoto K. Diffuse sclerosing osteomyelitis of the mandible: its characteristics and possible relationship to synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome. J Oral Maxillofac Surg 1996;54:1194-9.
  • 35. van Merkesteyn JP, Groot RH, Bras J, McCarroll RS, Bakker DJ. Diffuse sclerosing osteomyelitis of the mandible: a new concept of its etiology. Oral Surg Oral Med Oral Pathol 1990;70:414-9.
  • 36. King SM, Laxer RM, Manson D, Gold R. Chronic recurrent multifocal osteomyelitis: a noninfectious inflammatory process. Pediatr Infect Dis J 1987;6:907-11.
  • 37. Deogaonkar K, Ghandour A, Jones A, Ahuja S, Lyons K.Chronic recurrent multifocal osteomyelitis presenting as acute scoliosis: a case report and review of literature. Eur Spine J 2008;17 (Suppl 2):S248-52.
  • 38. Schilling F, Wagner AD. Azithromycin: an anti-inflammatory effect in chronic reccurent multifocal osteomyelitis? A preliminary report]. Z Rheumatol 2000;59:352-3.
  • 39. Miettunen PM, Wei X, Kaura D, Reslan WA, Aguirre AN, Kellner JD. Dramatic pain relief and resolution of bone inflammation following pamidronate in 9 pediatric patients with persistent chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol Online J 2009;7:2.
There are 39 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

İlhan Hekimsoy This is me

Mehmet Argın This is me

Betül Sözeri This is me

Publication Date April 1, 2017
Published in Issue Year 2017 Volume: 15 Issue: 1

Cite

APA Hekimsoy, İ., Argın, M., & Sözeri, B. (2017). Kronik Tekrarlayan Multifokal Osteomiyelit. Güncel Pediatri, 15(1), 25-37. https://doi.org/10.4274/jcp.52724
AMA Hekimsoy İ, Argın M, Sözeri B. Kronik Tekrarlayan Multifokal Osteomiyelit. Güncel Pediatri. April 2017;15(1):25-37. doi:10.4274/jcp.52724
Chicago Hekimsoy, İlhan, Mehmet Argın, and Betül Sözeri. “Kronik Tekrarlayan Multifokal Osteomiyelit”. Güncel Pediatri 15, no. 1 (April 2017): 25-37. https://doi.org/10.4274/jcp.52724.
EndNote Hekimsoy İ, Argın M, Sözeri B (April 1, 2017) Kronik Tekrarlayan Multifokal Osteomiyelit. Güncel Pediatri 15 1 25–37.
IEEE İ. Hekimsoy, M. Argın, and B. Sözeri, “Kronik Tekrarlayan Multifokal Osteomiyelit”, Güncel Pediatri, vol. 15, no. 1, pp. 25–37, 2017, doi: 10.4274/jcp.52724.
ISNAD Hekimsoy, İlhan et al. “Kronik Tekrarlayan Multifokal Osteomiyelit”. Güncel Pediatri 15/1 (April 2017), 25-37. https://doi.org/10.4274/jcp.52724.
JAMA Hekimsoy İ, Argın M, Sözeri B. Kronik Tekrarlayan Multifokal Osteomiyelit. Güncel Pediatri. 2017;15:25–37.
MLA Hekimsoy, İlhan et al. “Kronik Tekrarlayan Multifokal Osteomiyelit”. Güncel Pediatri, vol. 15, no. 1, 2017, pp. 25-37, doi:10.4274/jcp.52724.
Vancouver Hekimsoy İ, Argın M, Sözeri B. Kronik Tekrarlayan Multifokal Osteomiyelit. Güncel Pediatri. 2017;15(1):25-37.