Cardiac Causes of Sudden Infant Death

Yıl 2014, Cilt: 12 Sayı: 1, 37 - 42, 01.06.2014

Fatih Aygün , Nilgün Köksal

Öz

The mechanism and causes of sudden infant death syndrome SIDS is still remains its mystery. The pathophysiology of SIDS is not clear. Sleeping in prone position is thought to contribute to pathophysiology. Schwartz was the first physician suggesting that SIDS can be associated with heart and autonomic nervous system. Congenital long QT syndrome may trigger SIDS by causing ventricular tachycardia. Normal cardiac rhythm is regulated by ion channels and specific proteins, but genetical analyses clearly demonstrated that 5 ion channel genes were responsible for rare arrhythmias. The infections, fever and sleeping in prone position can increase the risk of long QT syndrome in babies having mutations in cardiac ion channels. In this review we tried to draw attention to SIDS as an important cause of death in childhood period and association of SIDS with long QT syndrome which is not necessarily noticed by physicians.

Anahtar Kelimeler

Sudden infant death, cardiac causes, ion channel, arrhythmias, long QT

Ani Bebek Ölümünün Kardiyak Nedenleri

Öz

Ani bebek ölümü sendromu ABÖS halen sebepleri ve mekanizmasıyla sırrını korumaktadır. ABÖS’e neden olan patofizyolojik mekanizma tam olarak anlaşılamamıştır. Yüz üstü pozisyonda uyumanın bu patofizyolojik olaylara katkısının olduğu düşünülmektedir. İlk defa Schwartz tarafından ABÖS ile kalp ve otonom sinir sistemi arasında ilişki olabileceği hipotezi öne sürülmüştür. Konjenital uzun QT sendromunun ventriküler taşiaritmi yaparak bazı ABÖS vakalarının sebebi olabileceği düşünülmektedir. Normal kardiyak ritimden birçok iyon kanalı ve diğer proteinlersorumlu iken, nadir bulunan aritmik bozukluklardan, genetik analizler sonucu, 5 iyon kanalı geni kesinlikle sorumlu tutulmaktadır. Özellikle kardiyak iyon kanallarında mutasyonu olan bebeklerde enfeksiyonlar, ateş, yüzüstü pozisyonda yatma gibi birçok faktörün uzun QT’ye eğilimi arttırdığı düşünülmektedir. Bu derlemede çocukluk çağında ölümlerin önemli bir nedenini oluşturan ve klinisyenlerin nispeten daha az önemsediği ABÖS’e dikkat çekilmek istenmiş ve ABÖS ile uzun QT ilişkisi değerlendirilmiştir

Anahtar Kelimeler

Ani bebek ölümü, kardiyak neden, iyon kanalı, aritmi, uzun QT

Kaynakça

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