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Ülseratif Kolit Tanılı Olgularımızın Retrospektif Olarak Değerlendirilmesi

Year 2012, Volume: 10 Issue: 2, 17 - 23, 01.09.2012

Abstract

Gi rifl: İnflamatuvar barsak hastalıkları İBH , gastrointestinal kanalın remisyon ve alevlenmeler ile seyreden kronik inflamatuvar hastalıklarıdır. Çalışmamızda İBH tanısı ile izlediğimiz hastaların klinik ve laboratuvar özelliklerinin geriye dönük olarak değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Çocuk gastroenteroloji bölümlerimizce 7 yıldır İBH tanısı ile izlemleri yapılan 18 hastanın başvuru yakınmaları, demografik özellikleri ve beraberinde bulunan hastalıklar kayıtlardan incelendi. Fizik bakıda saptanan olağan dışı bulgular endoskopik bulgular, histopatolojik bulgular ve uygulanan tedaviler gözden geçirildi. Bulgular: Çalışmamıza alınan 18 hastanın tanı yaşı ortalamaları 13,6±2,9 yıl 10K, 8E ve semptomların başlangıcından tanıya kadar geçen süre ortalama 6,9±4,5 aydı. Onyedi hasta ülseratif kolit ÜK ve bir hasta da intermediate kolit İK tanısı almıştı. İki hastada %11 hastalık açısından pozitif aile öyküsü vardı. Tanı anında en sık başvuru yakınmaları karın ağrısı %100 , kanlı ishal %94,5 ve tenezm %44,4 olarak bulundu. Laboratuvar bulgularından CRP pozitifliği %89 , sedimantasyon yüksekliği %83,3 ve demir eksikliği anemisi DEA %77,7 en sık rastlanan bulgulardı. Kolonoskopik olarak en sık pankolit %66,6 tutulumuna rastlandı. İBH’na eşlik eden diğer hastalıklar ise ailevi Akdeniz ateşi FMF %11 , çölyak hastalığı ÇH %5,5 ve Helikobakter pylori gastriti Hp %11 olarak bulundu. Pankolit tutulumu olan medikal tedaviye yanıtsız bir hastamıza %5,5 ise kolektomi uygulandı. Sonuç: Ülkemizde çocukluk çağında İBH tanısı alan hasta sayısı her geçen gün artmaktadır. Yine de nonspesifik semptomlar ile seyreden hastaların tanınması güç olabilmekte ve tanı gecikmelerine neden olabilmektedir. İBH’nın otoimmün hastalıklar ile birlikteliği nedeniyle uygun tedaviye rağmen remisyon sağlanamayan hastalarda gastrointestinal inflamasyonla giden FMF gibi hastalıklar da araştırılmalıdır. Gün cel Pe di at ri 2012; 10: 17-23

References

  • 1. Kelsen J, Baldassano RN. Inflammatory bowel disease: the difference between children and adults. Inflamm Bowel Dis 2008;14:9-11.
  • 2. IBD working group of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). Inflammatory bowel disease in children and adolescents: recommendations for diagnosis-the Porto criteria. J Pediatr Gastroenterol Nutr 2005;41:1-7.
  • 3. Shikhare G, Kugathasan S. Inflammatory bowel disease in children: current trends. J Gastroenterol 2010;45:673-82.
  • 4. Diefenbach KA, Breuer CK. Pediatric inflammatory bowel disease. World J Gastroenterol 2006;12:3204-12.
  • 5. Baumgart DC. What’s new inflammatory bowel disease 2008? World J Gastroenterol 2008;14:329-30.
  • 6. Sawczenko A, Sandhu BK. Presenting features of inflammatory bowel disease in Great Britain and Ireland. Arch Dis Child 2003;88:995-1000.
  • 7. Grifiths AM. Specificities of inflammatory bowel disease in childhood. Best Pract Res Clin Gastroenterology 2004;18:509- 523.
  • 8. Sauer CG, Kugathasan S. Pediatric Inflammatory bowel disease: highlighting pediatric differences in IBD. Med Clin North Am 2010;94:35-52.
  • 9. Cho JH. The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol 2008;8:458-66.
  • 10. Halme L, Paavola-Sakki P, Turunen U, Lappalainen M, Farkkila M, Kontula K. Family and twin studies in inflammatory bowel disease. World J Gastroenterol 2006;12:3668-72.
  • 11. Noble CL, Arnott ID. What ıs the risk that a child will develop ınflammatory bowel disease if 1 or both parents have IBD? Inflamm Bowel Dis 2008;4:22-5.
  • 12. Ardizzone S, Bianchi Porro G. Inflammatory bowel disease: new insights into pathogenesis and treatment. J Intern Med 2002;252:475-96.
  • 13. Castro M, Papadatou B, Baldassare M, Barabino A, Barbera C, Barca S et al. Inflammatory bowel disease in children and adolescents in Italy: data from the pediatric national IBD register (1996-2003). Inflamm Bowel Dis 2008;14;1246-52.
  • 14. Beattie RM, Croft NM, Fell JM, Afzal NA, Heuschkel RB. Inflammatory bowel disease. Arch Dis Child 2006;91:426-32.
  • 15. Campos FG, Waitzberg DL, Teixeira MG, Mucerino DR, Habr￾Gama A, Kiss DR. Inflammatory bowel diseases: principles of nutritional therapy. Rev Hosp Clin Fac Med Sao Paulo 2002;57:187-98.
  • 16. Kugathasan S, Nebel J, Skelton JA, Markowitz J, Keljo D, Rosh J et al. Body mass index in children with newly diagnosed inflammatory bowel disease: observations from two multicenter North American inception cohorts. J Pediatr 2007;151:523-30.
  • 17. Somers EC, Thomas SL, Smeeth L, Hall AJ. Autoimmune diseases co-occurring within individuals and within families: a systematic review. Epidemiology 2006;17:202-17.
  • 18. Yang A, Chen Y, Scherl E, Neugut A, Bhagat G, Green P. Inflammatory Bowel Disease in Patients with Celiac Disease. Inflam Bowel Dis 2005;11:528-32.
  • 19. Leeds JS, Höroldt BS, Sidhu R, Hopper AD, Robinson K, Toulson B et al. Is there an association between coeliac disease and inflammatory bowel diseases? A study of relative prevalence in comparison with population controls. Scand J Gastroenterol 2007;42:1214-20.
  • 20. Di Tola M, Sabbatella L, Ananio MC, Viscido A, Caprilli R, Pica R et al. Anti-tissue transglutaminase antibadies in inflammatory bowel disease: new evidence. Clin Chem Lab Med 2004;42:1092-7.
  • 21. Yalcınkaya F, Ozen S, Ozcakar ZB, Aktay N, Cakar N, Duzova A et al. A new set of criteria for the diagnosis of familial Mediterranean fever in childhood. Rheumatology 2009;48:395-403.
  • 22. Yilmaz E, Ozen S, Balci B, Duzova A, Topaloglu, Besbas N et al. Mutation frequency of familial Mediterranean fever and evidence for a high carrier rate in the Turkish population. Eur J Hum Genet 2001;9:553-8.
  • 23. Tunca M, Akar S, Onen F, Ozdogan H, Kasapcapur O, Yalcınkaya F et al. Familial Mediterranean fever (FMF) disease in Turkey: results of nationwide multicenter study. Medicine 2005;84:1-11.
  • 24. Giaglis S, Mimidis K, Papadopoulos V, Thomopoulos K, Sidiropoulos P, Rafail S et al. Increased Frequency of Mutations in the Gene Responsible for Familial Mediterranean Fever (MEFV) in a Cohort of Patients with Ulcerative Colitis: Evidence for a Potential Disease-Modifying Effect? Dig Dis Sci 2006;51:687-92.
  • 25. Uslu N, Yüce A, Demir H, Saltık-Temizel IN, Usta Y, Yilmaz E et al. The Association of Inflammatory Bowel Disease and Mediterranean Fever Gene (MEFV) Mutations in Turkish Children. Dig Dis Sci 2010;55:3488-94.
  • 26. Holmquist L, Ahren C, Fallstrom SP. Relationship between results of laboratory tests and inflammatory activity assessed by colonoscopy in children and adolescents with ulcerative colitis and Crohn’s colitis. J Pediatr Gastroenterol Nutr 1989;9:187-93.
  • 27. Cabrera-Abreu JC, Davies P, Matek Z, Murphy MS. Performance of blood tests in diagnosis of inflammatory bowel disease in a specialist clinic. Arch Dis Child 2004;89:69-71.
  • 28. Kappelman MD, Bousvaros A. Nutritional concerns in pediatric inflammatory bowel disease patients. Mol Nutr Food Res 2008;52:867-74.
  • 29. Headstrom PD, Rulyak SJ, Lee SD. Prevalence of and risk factors for vitamin B(12) deficiency in patients with Crohn’s disease. Inflamm Bowel Dis 2008;14:217-23.
  • 30. Oldenburg B, Van Tuyl BA, van der Griend R, Fijnheer R, van Berge Henegouwen GP. Risk factors for thromboembolic complications in inflammatory bowel disease: the role of hyperhomocysteinaemia. Dig Dis Sci 2005;50:235-40.
  • 31. Zezos P, Papaioannou G, Nikolaidis N, Vasiliadis T, Giouleme O, Evgenidis O. Hyperhomocysteinemia in ulcerative colitis is related to folate levels. World J Gastroenterol 2005;11:6038-42.
  • 32. Dubinsky MC, Ofman JJ, Urman M, Targan SS, Seidman EG. Clinical utility of serodiagnostic testing in suspected pediatric inflammatory bowel disease. Am J Gastroenterol 2001;96:758-65.
  • 33. Dubinsky MC. What is the role of serological markers in IBD? Inflamm Bowel Dis 2008:14:185-91.
  • 34. Romano C, Famiani A, Gallizzi R, Comito D, Ferrau' V, Rossi P. Indeterminate colitis: a distinctive clinical pattern of inflammatory bowel disease in children. Pediatrics 2008;122:1278-81.
  • 35. Sandhu BK, Fell JHE, Beattie RM, Mitton SG, Jenkins H, on behlaf of the IBD working group of the British Society of Pediatric Gastroenterolgy, Hepatology an Nutrition. Guidelines for the management of inflammatory bowel disease (IBD) in children in the United Kingdom. J Peiatr Gastroenterol and Nutr 2010;50:1-13.
  • 36. Tobin JM, Sinha B, Ramani P, Saleh AR, Murphy MS. Upper gastrointestinal mucosal disease in pediatric Crohn disease and ulcerative colitis: a blinded, controlled study. J Pediatr Gastroenterol Nutr 2001;32:443-51.
  • 37. Jevon GP, Madhur R. Endoscopic and histologic findings in pediatric ınflammatory bowel disease. Gastroenterol Hepatol 2010;6:174-80.
  • 38. Turner D, Otley AR, Mack D, Hyams J, de Bruijne J, Uusoue K et al. Development and evaluation of a paediatric ulcerative colitis activity ındex (PUCAI): A prospective multicentre study. Gastroenterology 2007;133:423-32.
  • 39. Friedman S. General principles of medical therapy of inflammatory bowel disease. Gastroenterol Clin North Am 2004;33:191-208.
  • 40. Turner D, Travis SPL, Griffiths AM, Ruemmele FM, Levine A, Benchimol EI et al. Consensus for managing acute severe ulcerative colitis in children: a systematic review and joint statement from ECCO, ESPGHAN, and the Porto IBD Working Group of ESPGHAN Consensus. Am J Gastroenterol 2011;106:574-88.
  • 41. Gisbert JP, Gomollón F. Thiopurine-induced myelotoxcity in patients with inflamatory bowel disease: a rewiew. Am J Gastroenterol 2008;103:1783-800

Retrospective Evaluation of Cases Diagnosed with Ulcerative Colitis

Year 2012, Volume: 10 Issue: 2, 17 - 23, 01.09.2012

Abstract

In tro duc ti on: Inflammatory bowel disease IBD is a chronic inflammatory disease of thegastrointestinal canal characterised by remissions and exacerbations. This study aimedto make a retrospective evaluation of clinical and laboratory findings of patients beingmonitored with a diagnosis of IBD.Materials and Methods: Medical records of 18 patients with a diagnosis of IBD and 7years of follow-up at our pediatric gastroenterology departments were investigatedwith respect to demographic data, complaints on presentation and accompanyingdiseases. Unusual findings from physical examination, endoscopic findings,histopathological findings and the applied treatments were examined.Results: The 18 patients 10 female, 8 male included in this study had a mean age of13.6±2.9 years and the mean time from onset of symptoms to diagnosis was 6.9±4.5months. Seventeen patients were diagnosed with ulcerative colitis and 1 patient withintermediate colitis. There was a positive family history of the disease in 2 patients 11% . At the time of diagnosis, the most common complaints on presentation werefound to be abdominal pain 100% , bloody diarrhea 94.5% and tenesmus 44.4% . Themost frequent laboratory findings were CRP positivity 89% , increased sedimentationrate 83.3% and iron-deficient anaemia 77.7% . On colonoscopy, pancolitisinvolvement 66.6% was most frequently encountered. Accompanying diseases to IBD were found to be familialMediterranean fever FMF 11% , celiac disease 5.5% and Heliobacter pylori gastritis 5.5% . One patient 5.5% who didnot respond to medical treatment for pancolitis involvement underwent a colectomy. Discussion: The number of diagnoses of IBD in childhood is gradually increasing. Nonetheless, it can be difficult to define diseaseswith non-specific symptoms and this may cause a delay in diagnosis. Because of the association of autoimmune diseases withIBD, despite appropriate therapy, diseases with no remission which lead to gastrointestinal inflammation, such as FMF, should be further investigated. Jo ur nal of Cur rent Pe di at rics 2012; 10: 17-23

References

  • 1. Kelsen J, Baldassano RN. Inflammatory bowel disease: the difference between children and adults. Inflamm Bowel Dis 2008;14:9-11.
  • 2. IBD working group of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). Inflammatory bowel disease in children and adolescents: recommendations for diagnosis-the Porto criteria. J Pediatr Gastroenterol Nutr 2005;41:1-7.
  • 3. Shikhare G, Kugathasan S. Inflammatory bowel disease in children: current trends. J Gastroenterol 2010;45:673-82.
  • 4. Diefenbach KA, Breuer CK. Pediatric inflammatory bowel disease. World J Gastroenterol 2006;12:3204-12.
  • 5. Baumgart DC. What’s new inflammatory bowel disease 2008? World J Gastroenterol 2008;14:329-30.
  • 6. Sawczenko A, Sandhu BK. Presenting features of inflammatory bowel disease in Great Britain and Ireland. Arch Dis Child 2003;88:995-1000.
  • 7. Grifiths AM. Specificities of inflammatory bowel disease in childhood. Best Pract Res Clin Gastroenterology 2004;18:509- 523.
  • 8. Sauer CG, Kugathasan S. Pediatric Inflammatory bowel disease: highlighting pediatric differences in IBD. Med Clin North Am 2010;94:35-52.
  • 9. Cho JH. The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol 2008;8:458-66.
  • 10. Halme L, Paavola-Sakki P, Turunen U, Lappalainen M, Farkkila M, Kontula K. Family and twin studies in inflammatory bowel disease. World J Gastroenterol 2006;12:3668-72.
  • 11. Noble CL, Arnott ID. What ıs the risk that a child will develop ınflammatory bowel disease if 1 or both parents have IBD? Inflamm Bowel Dis 2008;4:22-5.
  • 12. Ardizzone S, Bianchi Porro G. Inflammatory bowel disease: new insights into pathogenesis and treatment. J Intern Med 2002;252:475-96.
  • 13. Castro M, Papadatou B, Baldassare M, Barabino A, Barbera C, Barca S et al. Inflammatory bowel disease in children and adolescents in Italy: data from the pediatric national IBD register (1996-2003). Inflamm Bowel Dis 2008;14;1246-52.
  • 14. Beattie RM, Croft NM, Fell JM, Afzal NA, Heuschkel RB. Inflammatory bowel disease. Arch Dis Child 2006;91:426-32.
  • 15. Campos FG, Waitzberg DL, Teixeira MG, Mucerino DR, Habr￾Gama A, Kiss DR. Inflammatory bowel diseases: principles of nutritional therapy. Rev Hosp Clin Fac Med Sao Paulo 2002;57:187-98.
  • 16. Kugathasan S, Nebel J, Skelton JA, Markowitz J, Keljo D, Rosh J et al. Body mass index in children with newly diagnosed inflammatory bowel disease: observations from two multicenter North American inception cohorts. J Pediatr 2007;151:523-30.
  • 17. Somers EC, Thomas SL, Smeeth L, Hall AJ. Autoimmune diseases co-occurring within individuals and within families: a systematic review. Epidemiology 2006;17:202-17.
  • 18. Yang A, Chen Y, Scherl E, Neugut A, Bhagat G, Green P. Inflammatory Bowel Disease in Patients with Celiac Disease. Inflam Bowel Dis 2005;11:528-32.
  • 19. Leeds JS, Höroldt BS, Sidhu R, Hopper AD, Robinson K, Toulson B et al. Is there an association between coeliac disease and inflammatory bowel diseases? A study of relative prevalence in comparison with population controls. Scand J Gastroenterol 2007;42:1214-20.
  • 20. Di Tola M, Sabbatella L, Ananio MC, Viscido A, Caprilli R, Pica R et al. Anti-tissue transglutaminase antibadies in inflammatory bowel disease: new evidence. Clin Chem Lab Med 2004;42:1092-7.
  • 21. Yalcınkaya F, Ozen S, Ozcakar ZB, Aktay N, Cakar N, Duzova A et al. A new set of criteria for the diagnosis of familial Mediterranean fever in childhood. Rheumatology 2009;48:395-403.
  • 22. Yilmaz E, Ozen S, Balci B, Duzova A, Topaloglu, Besbas N et al. Mutation frequency of familial Mediterranean fever and evidence for a high carrier rate in the Turkish population. Eur J Hum Genet 2001;9:553-8.
  • 23. Tunca M, Akar S, Onen F, Ozdogan H, Kasapcapur O, Yalcınkaya F et al. Familial Mediterranean fever (FMF) disease in Turkey: results of nationwide multicenter study. Medicine 2005;84:1-11.
  • 24. Giaglis S, Mimidis K, Papadopoulos V, Thomopoulos K, Sidiropoulos P, Rafail S et al. Increased Frequency of Mutations in the Gene Responsible for Familial Mediterranean Fever (MEFV) in a Cohort of Patients with Ulcerative Colitis: Evidence for a Potential Disease-Modifying Effect? Dig Dis Sci 2006;51:687-92.
  • 25. Uslu N, Yüce A, Demir H, Saltık-Temizel IN, Usta Y, Yilmaz E et al. The Association of Inflammatory Bowel Disease and Mediterranean Fever Gene (MEFV) Mutations in Turkish Children. Dig Dis Sci 2010;55:3488-94.
  • 26. Holmquist L, Ahren C, Fallstrom SP. Relationship between results of laboratory tests and inflammatory activity assessed by colonoscopy in children and adolescents with ulcerative colitis and Crohn’s colitis. J Pediatr Gastroenterol Nutr 1989;9:187-93.
  • 27. Cabrera-Abreu JC, Davies P, Matek Z, Murphy MS. Performance of blood tests in diagnosis of inflammatory bowel disease in a specialist clinic. Arch Dis Child 2004;89:69-71.
  • 28. Kappelman MD, Bousvaros A. Nutritional concerns in pediatric inflammatory bowel disease patients. Mol Nutr Food Res 2008;52:867-74.
  • 29. Headstrom PD, Rulyak SJ, Lee SD. Prevalence of and risk factors for vitamin B(12) deficiency in patients with Crohn’s disease. Inflamm Bowel Dis 2008;14:217-23.
  • 30. Oldenburg B, Van Tuyl BA, van der Griend R, Fijnheer R, van Berge Henegouwen GP. Risk factors for thromboembolic complications in inflammatory bowel disease: the role of hyperhomocysteinaemia. Dig Dis Sci 2005;50:235-40.
  • 31. Zezos P, Papaioannou G, Nikolaidis N, Vasiliadis T, Giouleme O, Evgenidis O. Hyperhomocysteinemia in ulcerative colitis is related to folate levels. World J Gastroenterol 2005;11:6038-42.
  • 32. Dubinsky MC, Ofman JJ, Urman M, Targan SS, Seidman EG. Clinical utility of serodiagnostic testing in suspected pediatric inflammatory bowel disease. Am J Gastroenterol 2001;96:758-65.
  • 33. Dubinsky MC. What is the role of serological markers in IBD? Inflamm Bowel Dis 2008:14:185-91.
  • 34. Romano C, Famiani A, Gallizzi R, Comito D, Ferrau' V, Rossi P. Indeterminate colitis: a distinctive clinical pattern of inflammatory bowel disease in children. Pediatrics 2008;122:1278-81.
  • 35. Sandhu BK, Fell JHE, Beattie RM, Mitton SG, Jenkins H, on behlaf of the IBD working group of the British Society of Pediatric Gastroenterolgy, Hepatology an Nutrition. Guidelines for the management of inflammatory bowel disease (IBD) in children in the United Kingdom. J Peiatr Gastroenterol and Nutr 2010;50:1-13.
  • 36. Tobin JM, Sinha B, Ramani P, Saleh AR, Murphy MS. Upper gastrointestinal mucosal disease in pediatric Crohn disease and ulcerative colitis: a blinded, controlled study. J Pediatr Gastroenterol Nutr 2001;32:443-51.
  • 37. Jevon GP, Madhur R. Endoscopic and histologic findings in pediatric ınflammatory bowel disease. Gastroenterol Hepatol 2010;6:174-80.
  • 38. Turner D, Otley AR, Mack D, Hyams J, de Bruijne J, Uusoue K et al. Development and evaluation of a paediatric ulcerative colitis activity ındex (PUCAI): A prospective multicentre study. Gastroenterology 2007;133:423-32.
  • 39. Friedman S. General principles of medical therapy of inflammatory bowel disease. Gastroenterol Clin North Am 2004;33:191-208.
  • 40. Turner D, Travis SPL, Griffiths AM, Ruemmele FM, Levine A, Benchimol EI et al. Consensus for managing acute severe ulcerative colitis in children: a systematic review and joint statement from ECCO, ESPGHAN, and the Porto IBD Working Group of ESPGHAN Consensus. Am J Gastroenterol 2011;106:574-88.
  • 41. Gisbert JP, Gomollón F. Thiopurine-induced myelotoxcity in patients with inflamatory bowel disease: a rewiew. Am J Gastroenterol 2008;103:1783-800
There are 41 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Fatih Ünal

Gülseren Şahin This is me

Ayşegül Cebe This is me

Semin Ayhan This is me

Filiz Eren This is me

Erhun Kasırga This is me

Publication Date September 1, 2012
Published in Issue Year 2012 Volume: 10 Issue: 2

Cite

APA Ünal, F., Şahin, G., Cebe, A., Ayhan, S., et al. (2012). Ülseratif Kolit Tanılı Olgularımızın Retrospektif Olarak Değerlendirilmesi. Güncel Pediatri, 10(2), 17-23.
AMA Ünal F, Şahin G, Cebe A, Ayhan S, Eren F, Kasırga E. Ülseratif Kolit Tanılı Olgularımızın Retrospektif Olarak Değerlendirilmesi. Güncel Pediatri. September 2012;10(2):17-23.
Chicago Ünal, Fatih, Gülseren Şahin, Ayşegül Cebe, Semin Ayhan, Filiz Eren, and Erhun Kasırga. “Ülseratif Kolit Tanılı Olgularımızın Retrospektif Olarak Değerlendirilmesi”. Güncel Pediatri 10, no. 2 (September 2012): 17-23.
EndNote Ünal F, Şahin G, Cebe A, Ayhan S, Eren F, Kasırga E (September 1, 2012) Ülseratif Kolit Tanılı Olgularımızın Retrospektif Olarak Değerlendirilmesi. Güncel Pediatri 10 2 17–23.
IEEE F. Ünal, G. Şahin, A. Cebe, S. Ayhan, F. Eren, and E. Kasırga, “Ülseratif Kolit Tanılı Olgularımızın Retrospektif Olarak Değerlendirilmesi”, Güncel Pediatri, vol. 10, no. 2, pp. 17–23, 2012.
ISNAD Ünal, Fatih et al. “Ülseratif Kolit Tanılı Olgularımızın Retrospektif Olarak Değerlendirilmesi”. Güncel Pediatri 10/2 (September 2012), 17-23.
JAMA Ünal F, Şahin G, Cebe A, Ayhan S, Eren F, Kasırga E. Ülseratif Kolit Tanılı Olgularımızın Retrospektif Olarak Değerlendirilmesi. Güncel Pediatri. 2012;10:17–23.
MLA Ünal, Fatih et al. “Ülseratif Kolit Tanılı Olgularımızın Retrospektif Olarak Değerlendirilmesi”. Güncel Pediatri, vol. 10, no. 2, 2012, pp. 17-23.
Vancouver Ünal F, Şahin G, Cebe A, Ayhan S, Eren F, Kasırga E. Ülseratif Kolit Tanılı Olgularımızın Retrospektif Olarak Değerlendirilmesi. Güncel Pediatri. 2012;10(2):17-23.