Çocukluklarda Atopik Dermatit Tedavisinde Güncel ve Gelecek Yaklaşımlar

Yıl 2011, Cilt: 9 Sayı: 2, 39 - 43, 01.09.2011

Elif Karakoç Aydıner Safa Barış Cevdet Özdemir

Öz

Atopik dermatit AD immün yanıtın düzenlenmesindeki bozukluğa bağlı gelişen kronikinflamatuvar bir cilt hastalığıdır. AD çocukların yaklaşık %20’sini etkilemekte veerişkinlerin %6’sında sebat etmektedir. Tedavi prensibi akut hastalığın ortadankaldırılması, yaşam kalitesinin artırılması ve uzun dönemde istenmeyen yan etkilerinönlenmesine yöneliktir. Hafif ve orta şiddetteki olgular genellikle tetikleyici uyaranlardan kaçınma ve topikal medikasyonlarla kontrol altına alınabilmektedir. Şiddetli olgularda ise bunlara ek olarak immünosupresif tedaviler gerekmektedir. Bu ilaçlarınbirikmiş toksisitesinin fazla olması AD tedavisinde kullanımlarını sınırlandırmaktadır.Bu yüzden güvenli ve etkin alternatif tedavi seçeneklerine özellikle çocukluk çağı yaşgrubunda ihtiyaç duyulmaktadır

Anahtar Kelimeler

Atopik dermatit, allerjen, çocuk, tedavi

Current and Future Concepts in Treatment of Childhood Atopic Dermatitis

Öz

Atopic dermatitis AD is a chronic inflammatory skin disorder caused by a dysregulationof immune response to allergenic or non-allergenic stimuli. Interplay of several effector cells including migrating lymphocytes, fibrocytes, Langerhans cells, mastcells and epidermal keratinocytes enroll in the development of AD. Atopic dermatitisaffects approximately 20% of children and persists in 6% of adults. Relieving acute exacerbations, improving the quality of life and prevention of side effects in the longterm are the main steps of the management of AD. Mild to moderate cases can becontrolled with avoidance of triggering factors, skin care and topical medications. Insevere cases immune suppression is an option with cumulative toxicity and variableefficacy of drugs as a limiting factor. It is essential to develop safer and efficaciousalternatives for the treatment of AD, especially in pediatric age group

Anahtar Kelimeler

Atopic dermatitis, allergen, child, therapy

Kaynakça

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