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Obez Çocuklarda Serum Magnezyum Düzeyinin İnsülin Direnci ile Olan İlişkisi

Yıl 2010, Cilt: 8 Sayı: 2, 24 - 29, 01.09.2010

Öz

Giriş: Obez çocuklarda serum magnezyum düzeyinin metabolik lipid profili, glukoz, insülin, insülin direnç indeksi ve antropometrik parametreler VKİ, VKİ SDS ile olan ilişkisini ortaya koymak. Gereç ve Yöntem: Çalışmaya, kilo artışı şikayeti ile başvuran vücut kitle indeks VKİ persentili 95 p üzerinde olan obez çocuklar ve VKİ persentili 0,05 . Sonuç: Bu çalışma literatürdeki veriler ile benzer şekilde obez çocuklarda serum magnezyum düzeyinin sağlıklı çocuklara göre düşük olduğunu desteklemektedir. Ancak bu çalışmada serum magnezyum düzeyi ile insülin direnci ve lipid profilleri arasında anlamlı korelasyon gösterilememiştir. Sonuç olarak, düşük magnezyum düzeyi ile ilişkili komplikasyonların önlenmesi için obez çocuklar yeterli miktarlarda magnezyum tüketmelidirler. Güncel Pediatri 2010; 8: 24-9

Kaynakça

  • 1. Çoban E, Y›lmaz A, Sar› R. The effect of weight loss on the mean platelet volume in obese patients. Platelets 2007;18:212-6.
  • 2. Ebbeling CB, Pawlak DB, Ludwig DS. Childhood obesity: public-health crisis, common sense cure. Lancet 2002;360:473-82.
  • 3. Spiotta RT, Luma GB. Evaluating obesity and cardiovascular risk factors in children and adolescents. Am Fam Physician 2008;78:1052-8.
  • 4. Haslam DW, James WP. Obesity. Lancet 2005;366:1197-209.
  • 5. Paolisso G, Barbagallo M. Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium. Am J Hypertens 1997;10:346-55.
  • 6. Takaya J, Higashino H, Kobayashi Y. Intracellular magnesium and insulin resistance. Magnes Res 2004;17:126-36.
  • 7. Elin RJ. Magnesium metabolism in health and disease. Dis Mon 1988;34:161-218.
  • 8. Guerrero-Romero F, Rodriguez-Moran M. Low serum magnesium levels and metabolic syndrome. Acta Diabetol 2002;39:209-13.
  • 9. Tosiello L. Hypomagnesemia and diabetes mellitus. A review of clinical implications. Arch Intern Med 1996; 156:1143-8.
  • 10. Sales CH, Pedrosa LF. Magnesium and diabetes mellitus: their relation. Clin Nutr 2006;25:554-62.
  • 11. Huerta MG, Roemmich JN, Kington ML, Bovbjerg VE, Weltman AL, Holmes VF et al. Magnesium deficiency is associated with insulin resistance in obese children. Diabetes Care 2005;28:1175-81.
  • 12. Lima ML, Cruz T, Rodrigues LE, Bomfim O, Melo J, Correia R et al. Serum and intracellular magnesium deficiency in patients with metabolic syndrome-evidences for its relation to insulin resistance. Diabetes Res Clin Pract 2009;83:257-62.
  • 13. Nadler JL, Buchanan T, Natarajan R, Antonipillai I, Bergman R, Rude R. Magnesium deficiency produces insulin resistance and increased thromboxane synthesis. Hypertension 1993;21:1024-9.
  • 14. National Center for Health Statistics-CDC Growth Charts: UnitedStates, 2002 [article online]. Available from http://www.cdc.gov/nchs/about/major/nhanes/growth￾charts/datafiles.htm.
  • 15. Bundak R, Furman A, Gunoz H, Darendeliler F, Bas F, Neyzi O. Body mass index references for Turkish children. Acta Paediatr 2006;95:194-8.
  • 16. American Academy of Pediatrics. National Cholesterol Education Program: Report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents Pediatrics 1992;89: 525-84.
  • 17. Genuth S, Alberti KG, Bennett P, Buse J, Defronzo R, Kahn R, et al. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 2003;26:3160-7.
  • 18. Valerio G, Licenziati MR, Iannuzzi A, Franzese A, Siani P, Riccardi G et al. Insulin resistance and impaired glucose tolerance in obese children and adolescents from Southern Italy. Nutr Metab Cardiovasc Dis 2006;16:279-84.
  • 19. Rodriguez-Hernandez H, Gonzalez JL, Rodriguez-Moran M, Guerrero-Romero F. Hypomagnesemia, insulin resistance, and non-alcoholic steatohepatitis in obese subjects. Arch Med Res 2005;36:362-6.
  • 20. Takaya J, Higashino H, Kotera F, Kobayashi Y. Intracellular magnesium of platelets in children with diabetes and obesity. Metabolism 2003;52:468-71.
  • 21. Yakinci C, Pac A, Kucukbay FZ, Tayfun M, Gul A. Serum zinc, copper, and magnesium levels in obese children. Acta Paediatr Jpn 1997;39:339-41.
  • 22. Guerrero-Romero F, Rodriguez-Moran M. Relationship between serum magnesium levels and C-reactive protein concentration, in non-diabetic, non-hypertensive obese subjects. Int J Obes Relat Metab Disord 2002;26:469-74.
  • 23. Chaudhary DP, Sharma R, Bansal DD. Implications of Magnesium Deficiency in Type 2 Diabetes: A Review. Biol Trace Elem Res 2009.
  • 24. Paolisso G, Scheen A, D'Onofrio F, Lefebvre P. Magnesium and glucose homeostasis. Diabetologia 1990;33:511-4.
  • 25. Rosolova H, Mayer O, Jr., Reaven GM. Insulin-mediated glucose disposal is decreased in normal subjects with relatively low plasma magnesium concentrations. Metabolism 2000;49:418-20.
  • 26. Rosolova H, Mayer O, Jr Reaven G. Effect of variations in plasma magnesium concentration on resistance to insulin￾mediated glucose disposal in nondiabetic subjects. J Clin Endocrinol Metab 1997;82:3783-5.
  • 27. Alzaid AA, Dinneen SF, Moyer TP, Rizza RA. Effects of insulin on plasma magnesium in noninsulin-dependent diabetes mellitus: evidence for insulin resistance. J Clin Endocrinol Metab 1995;80:1376-81.
  • 28. Humphries S, Kushner H, Falkner B. Low dietary magnesium is associated with insulin resistance in a sample of young, nondiabetic Black Americans. Am J Hypertens 1999;12:747-56.
  • 29. King JL, Miller RJ, Blue JP Jr, O'Brien WD Jr, Erdman JW Jr. Inadequate dietary magnesium intake increases atherosclerotic plaque development in rabbits. Nutr Res 2009;29:343-9.
  • 30. Ouchi Y, Tabata RE, Stergiopoulos K, Sato F, Hattori A, Orimo H. Effect of dietary magnesium on development of atherosclerosis in cholesterol-fed rabbits. Arteriosclerosis 1990;10:732-7.
  • 31. Singh RB, Rastogi SS, Sharma VK, Saharia RB, Kulshretha SK. Can dietary magnesium modulate lipoprotein metabolism? Magnes Trace Elem 1990;9:255-64

Serum Magnesium Level and Its Relation with Insulin Resistance in Obese Children

Yıl 2010, Cilt: 8 Sayı: 2, 24 - 29, 01.09.2010

Öz

Introduction: To determine the relation of serum magnesium level with metabolic and clinical parameters in obese children. Materials and Methods: Children presenting with weight gain whose BMI was over 95th percentile obese children and children with BMI lower than 85th percentile non-obese were included to the study. Taking drugs or having a history or evidence of chronic diseases, syndromal or endocrine causes of obesity were excluded. Weight and height were measured for comparing the anthropometric values. For laboratory evaluation, fasting serum glucose, insulin, lipid profile and serum magnesium levels were measured. We compared the differences in between obese and lean groups with Student’s t-test and Pearson’s correlation analysis was used to compare the variables. The value of p< 0.05 was considered statistically significant. Results: A total of 80 obese children 10.2±2.7 years of age, 40 male patients and 60 age and gender matched lean children 10.9±2.6, years of age, 30 male patients were included in this study. The obese subjects had significantly higher serum magnesium, insulin, HOMA-IR, total cholesterol, triglyceride, and HDL-cholesterol levels than the lean subjects p< 0.05 , while there were no significant differences between glucose and LDL-cholesterol levels p> 0.05 . In obese group serum magnesium level significantly correlated with only SDS-BMI p< 0.05 , while there were no correlation between BMI, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, fasting glucose, and insulin levels p> 0.05 . Conclusions: In accordance with previous studies, the present study supports the finding that serum magnesium levels are lower in children with obesity compared to healthy controls. On the other hand, we did not find a correlation between serum magnesium levels and insulin resistance and lipid levels. In conclusion, obese children should ingest adequate a mounts of magnesium in order to prevent complications associated with low magnesium levels.

Kaynakça

  • 1. Çoban E, Y›lmaz A, Sar› R. The effect of weight loss on the mean platelet volume in obese patients. Platelets 2007;18:212-6.
  • 2. Ebbeling CB, Pawlak DB, Ludwig DS. Childhood obesity: public-health crisis, common sense cure. Lancet 2002;360:473-82.
  • 3. Spiotta RT, Luma GB. Evaluating obesity and cardiovascular risk factors in children and adolescents. Am Fam Physician 2008;78:1052-8.
  • 4. Haslam DW, James WP. Obesity. Lancet 2005;366:1197-209.
  • 5. Paolisso G, Barbagallo M. Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium. Am J Hypertens 1997;10:346-55.
  • 6. Takaya J, Higashino H, Kobayashi Y. Intracellular magnesium and insulin resistance. Magnes Res 2004;17:126-36.
  • 7. Elin RJ. Magnesium metabolism in health and disease. Dis Mon 1988;34:161-218.
  • 8. Guerrero-Romero F, Rodriguez-Moran M. Low serum magnesium levels and metabolic syndrome. Acta Diabetol 2002;39:209-13.
  • 9. Tosiello L. Hypomagnesemia and diabetes mellitus. A review of clinical implications. Arch Intern Med 1996; 156:1143-8.
  • 10. Sales CH, Pedrosa LF. Magnesium and diabetes mellitus: their relation. Clin Nutr 2006;25:554-62.
  • 11. Huerta MG, Roemmich JN, Kington ML, Bovbjerg VE, Weltman AL, Holmes VF et al. Magnesium deficiency is associated with insulin resistance in obese children. Diabetes Care 2005;28:1175-81.
  • 12. Lima ML, Cruz T, Rodrigues LE, Bomfim O, Melo J, Correia R et al. Serum and intracellular magnesium deficiency in patients with metabolic syndrome-evidences for its relation to insulin resistance. Diabetes Res Clin Pract 2009;83:257-62.
  • 13. Nadler JL, Buchanan T, Natarajan R, Antonipillai I, Bergman R, Rude R. Magnesium deficiency produces insulin resistance and increased thromboxane synthesis. Hypertension 1993;21:1024-9.
  • 14. National Center for Health Statistics-CDC Growth Charts: UnitedStates, 2002 [article online]. Available from http://www.cdc.gov/nchs/about/major/nhanes/growth￾charts/datafiles.htm.
  • 15. Bundak R, Furman A, Gunoz H, Darendeliler F, Bas F, Neyzi O. Body mass index references for Turkish children. Acta Paediatr 2006;95:194-8.
  • 16. American Academy of Pediatrics. National Cholesterol Education Program: Report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents Pediatrics 1992;89: 525-84.
  • 17. Genuth S, Alberti KG, Bennett P, Buse J, Defronzo R, Kahn R, et al. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 2003;26:3160-7.
  • 18. Valerio G, Licenziati MR, Iannuzzi A, Franzese A, Siani P, Riccardi G et al. Insulin resistance and impaired glucose tolerance in obese children and adolescents from Southern Italy. Nutr Metab Cardiovasc Dis 2006;16:279-84.
  • 19. Rodriguez-Hernandez H, Gonzalez JL, Rodriguez-Moran M, Guerrero-Romero F. Hypomagnesemia, insulin resistance, and non-alcoholic steatohepatitis in obese subjects. Arch Med Res 2005;36:362-6.
  • 20. Takaya J, Higashino H, Kotera F, Kobayashi Y. Intracellular magnesium of platelets in children with diabetes and obesity. Metabolism 2003;52:468-71.
  • 21. Yakinci C, Pac A, Kucukbay FZ, Tayfun M, Gul A. Serum zinc, copper, and magnesium levels in obese children. Acta Paediatr Jpn 1997;39:339-41.
  • 22. Guerrero-Romero F, Rodriguez-Moran M. Relationship between serum magnesium levels and C-reactive protein concentration, in non-diabetic, non-hypertensive obese subjects. Int J Obes Relat Metab Disord 2002;26:469-74.
  • 23. Chaudhary DP, Sharma R, Bansal DD. Implications of Magnesium Deficiency in Type 2 Diabetes: A Review. Biol Trace Elem Res 2009.
  • 24. Paolisso G, Scheen A, D'Onofrio F, Lefebvre P. Magnesium and glucose homeostasis. Diabetologia 1990;33:511-4.
  • 25. Rosolova H, Mayer O, Jr., Reaven GM. Insulin-mediated glucose disposal is decreased in normal subjects with relatively low plasma magnesium concentrations. Metabolism 2000;49:418-20.
  • 26. Rosolova H, Mayer O, Jr Reaven G. Effect of variations in plasma magnesium concentration on resistance to insulin￾mediated glucose disposal in nondiabetic subjects. J Clin Endocrinol Metab 1997;82:3783-5.
  • 27. Alzaid AA, Dinneen SF, Moyer TP, Rizza RA. Effects of insulin on plasma magnesium in noninsulin-dependent diabetes mellitus: evidence for insulin resistance. J Clin Endocrinol Metab 1995;80:1376-81.
  • 28. Humphries S, Kushner H, Falkner B. Low dietary magnesium is associated with insulin resistance in a sample of young, nondiabetic Black Americans. Am J Hypertens 1999;12:747-56.
  • 29. King JL, Miller RJ, Blue JP Jr, O'Brien WD Jr, Erdman JW Jr. Inadequate dietary magnesium intake increases atherosclerotic plaque development in rabbits. Nutr Res 2009;29:343-9.
  • 30. Ouchi Y, Tabata RE, Stergiopoulos K, Sato F, Hattori A, Orimo H. Effect of dietary magnesium on development of atherosclerosis in cholesterol-fed rabbits. Arteriosclerosis 1990;10:732-7.
  • 31. Singh RB, Rastogi SS, Sharma VK, Saharia RB, Kulshretha SK. Can dietary magnesium modulate lipoprotein metabolism? Magnes Trace Elem 1990;9:255-64
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Research Article
Yazarlar

Ayhan Abacı

Şamil Hızlı Bu kişi benim

Osman Özdemir Bu kişi benim

Cem Hasan Razi Bu kişi benim

Mesut Koçak Bu kişi benim

Okhan Akın Bu kişi benim

Nimet Kabakuş Bu kişi benim

Yayımlanma Tarihi 1 Eylül 2010
Yayımlandığı Sayı Yıl 2010 Cilt: 8 Sayı: 2

Kaynak Göster

APA Abacı, A., Hızlı, Ş., Özdemir, O., Razi, C. H., vd. (2010). Obez Çocuklarda Serum Magnezyum Düzeyinin İnsülin Direnci ile Olan İlişkisi. Güncel Pediatri, 8(2), 24-29.
AMA Abacı A, Hızlı Ş, Özdemir O, Razi CH, Koçak M, Akın O, Kabakuş N. Obez Çocuklarda Serum Magnezyum Düzeyinin İnsülin Direnci ile Olan İlişkisi. Güncel Pediatri. Eylül 2010;8(2):24-29.
Chicago Abacı, Ayhan, Şamil Hızlı, Osman Özdemir, Cem Hasan Razi, Mesut Koçak, Okhan Akın, ve Nimet Kabakuş. “Obez Çocuklarda Serum Magnezyum Düzeyinin İnsülin Direnci Ile Olan İlişkisi”. Güncel Pediatri 8, sy. 2 (Eylül 2010): 24-29.
EndNote Abacı A, Hızlı Ş, Özdemir O, Razi CH, Koçak M, Akın O, Kabakuş N (01 Eylül 2010) Obez Çocuklarda Serum Magnezyum Düzeyinin İnsülin Direnci ile Olan İlişkisi. Güncel Pediatri 8 2 24–29.
IEEE A. Abacı, Ş. Hızlı, O. Özdemir, C. H. Razi, M. Koçak, O. Akın, ve N. Kabakuş, “Obez Çocuklarda Serum Magnezyum Düzeyinin İnsülin Direnci ile Olan İlişkisi”, Güncel Pediatri, c. 8, sy. 2, ss. 24–29, 2010.
ISNAD Abacı, Ayhan vd. “Obez Çocuklarda Serum Magnezyum Düzeyinin İnsülin Direnci Ile Olan İlişkisi”. Güncel Pediatri 8/2 (Eylül 2010), 24-29.
JAMA Abacı A, Hızlı Ş, Özdemir O, Razi CH, Koçak M, Akın O, Kabakuş N. Obez Çocuklarda Serum Magnezyum Düzeyinin İnsülin Direnci ile Olan İlişkisi. Güncel Pediatri. 2010;8:24–29.
MLA Abacı, Ayhan vd. “Obez Çocuklarda Serum Magnezyum Düzeyinin İnsülin Direnci Ile Olan İlişkisi”. Güncel Pediatri, c. 8, sy. 2, 2010, ss. 24-29.
Vancouver Abacı A, Hızlı Ş, Özdemir O, Razi CH, Koçak M, Akın O, Kabakuş N. Obez Çocuklarda Serum Magnezyum Düzeyinin İnsülin Direnci ile Olan İlişkisi. Güncel Pediatri. 2010;8(2):24-9.