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Preeklamptik Anne Bebeklerinde Ortalama Trombosit Hacimleri

Year 2009, Volume: 7 Issue: 3, 53 - 56, 01.12.2009

Abstract

Amaç: Bu çalışmada, preeklamptik anne bebekleri ile normal gebelikten olanbebeklerin ortalama trombosit hacimlerini MPV karşılaştırmak ve preeklamptikanne bebeklerinde ortaya çıkan trombositopeninin MPV ile ilişkisini araştırmakamaçlandı. Gereç ve Yöntem: Bu retrospektif çalışmaya gebelik yaşları benzer olan 63yenidoğan alınmıştır. Bunlar trombositopeni gelişen 21 preeklamptik anne bebeği Grup A , trombositopeni gelişmeyen 21 preeklamptik anne bebeği Grup B vetrombositopeni gelişmeyen 21 normal anne bebeği Grup C olmak üzere üç grubaayrılmıştır. Hastaların yaşamın ilk 72 saati içerisinde bakılan hematolojik verileritıbbi kayıtlarından elde edilmiştir. Olgular, doğum ağırlıkları, trombosit sayıları,MPV’leri açısından, karşılaştırıldılar. Bulgular: Her üç grubun da gestasyon yaşları benzerdi ve doğum ağırlıklarıarasındaki fark anlamlı değildi. Grup A’nın trombosit sayısı anlamlı olarak düşüktü p

References

  • 1. Cunningham FG, Lindheimer MD. Hypertansion in pregnancy. N Engl J Med 1992;326:927-32.
  • 2. Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK. Preeclampsia: An endothelial cell disorder. Am J Obstet Gynecol 1989;161:1200-4.
  • 3. Bessman JD, Williams LJ, Gilmer PR Jr. Mean platelet volume. The inverse relation of platelet size and count in normal subjects, and an artifact of other particles. Am J Clin Pathol 1981;76:289-93.
  • 4. Giles C. The platelet count and mean platelet volume. Br J Haematol 1981;48:31-7.
  • 5. Stubbs TM, Lazarchick J, Van Dorsten JP, Cox J, Loadholt CB. Evidence of accelerated platelet production and consumption in nonthrombocytopenic preeclampsia. Am J Obstet Gynecol 1986;155:263-5.
  • 6. Tygart SG, McRoyan DK, Spinnato JA, Mc Royan CJ, Kitay DZ. Longitudinal study of platelet indices during normal pregnancy. Am J Obstet Gynecol 1986;154:883-7.
  • 7. Romero R, Lockwood C, Oyarzun E, Hobbins JC. Toxemia: new concepts in an old disease. Semin Perinatol 1988;12:302-23.
  • 8. Fay RA, Hughes AO, Farron NT. Platelets in pregnancy: hyperdestruction in pregnancy. Obstet Gynecol 1983; 61: 238-40.
  • 9. Hutt R, Ogunniyi SO, Sullivan MH, Elder MG. Increased platelet volume and aggregation precede the onset of preeclampsia. Obstet Gynecol 1994;83:146-9.
  • 10. Burrows RF, Andrew M. Neonatal thrombocytopenia in the hypertensive disorders of pregnancy. Obstet Gynecol 1990;76:234-38.
  • 11. Beiner M, Simchen M, Sivan E, Chetrit AM, Kuint J, Schiff E. Risk factors for neonatal thrombocytopenia. Am Journ of Perinat 2003;20:49-54.
  • 12. Fraser SH, Tudehope DI. Neonatal neutropenia and thrombocytopenia following maternal hypertansion. Journ of Ped and Child Health 1996;32:31-4.
  • 13. Roberts I, Murray NA. Neonatal Thrombocytopenia: causes and management. Arch Dis Child Fetal Neonatal Ed 2003;88:359-64.
  • 14. ACOG Committee on Obstetric Practice. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet 2002;77:67-75.
  • 15. Dinesh M. Shah. Hypertensive disorders of pregnancy. In:Richard J. Martin, Avroy A. Fanaroff, Michele C. Walsh. Fanaroff and Martin’s Neonatal-Perinatal Medicine. Diseases of the Fetus and Infant. 8th edition. Philadelphia: Mosby, Inc.; 2006. p.307-20.
  • 16. Lyall F, Greer IA, Boswell F, Fleming R. Suppression of serum vascular endothelial growth factor immunoreactivity in normal pregnancy and in pre-eclampsia. Br J Obstet Gynaecol 1997;104:223-8.
  • 17. Casella I, Feccia T, Chelucci C, et al. Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt 1 receptor. Blood 2003;101:1316-23.
  • 18. Ahmet Y, Van Iddekinge B, Paul C, Sullivan HF, Elder MG. Retrospective analysis of platelet numbers and volumes in normal pregnancy and in pre-eclempsia. Br J Obstet Gynaecol 1993;100:216-20.
  • 19. Howarth S, Marshall LR, Barr AL, Evans S, Pontre M, Ryan N. Platelet indices during normal pregnancy and pre-eclempsia. Br J Med Sci 1999;56:20-2.
  • 20. Ceyhan T, Beyan C, Baser I, Kaptan K, Güngör S, Ifran A. The effect of preeclampsia on complete blood count, platelet count and mean platelet volume. Ann Hematol 2006; 85:320-22.
  • 21. Jaremo P, Lindahl TL, Lennmarken C, Forsgren H. The use of platelet density and volume measurements to estimate the severity of pre-eclampsia. Eur J Clin Invest 2000;30:1113-8.
  • 22. Dundar O, Yoruk P, Tutuncu L, Erikci Akyol A, Muhcu M, Ergur Rustu A, et al. Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre-eclampsia. Prenat Diagn 2008;28:1052-6.
  • 23. Meberg A, Orstavik I, Sovde A. Erythroblastemia and thrombocytopenia in small for gestational age infants. Acta Pediatr Belg 1978;31:213.
  • 24. Samuels P, Main EK, Tomaski A, Mennuti MT, Gabbe SG,Cines DB. Abnormalities in platelet antiglobulin tests in preeclamptic mothers and their neonates. Am J Obstet Gynecol 1987;157:109-13.
  • 25. Tsao PN, Wei SC, Su YN, Chou HC, Chen CY, Hsieh WS. Excess soluble fms-like tyrosine kinase 1 and low platelet counts in premature neonates of preeclamptic mothers. Pediatrics 2005;116:468-72.

Mean Platelet Volumes in Babies of Preeclamptic Mothers

Year 2009, Volume: 7 Issue: 3, 53 - 56, 01.12.2009

Abstract

Aim: The aim of this study was to compare the mean platelet volumes MPV inbabies of preeclamptic and normal pregnant women and to investigate the correlation between thrombocytopenia and MPV in the babies of preeclamptic mothers. Materials and Method: A total of 63 newborns with similar gestational age wereincluded in this retrospective study. They were divided into three groups as 21babies of preeclamptic mothers with thrombocytopenia Group A , 21 without thrombocytopenia Group B and 21 babies of normal pregnant women without thrombocytopenia Group C . Hematologic data of the patients, obtained in the first 72 hoursof their life, were achieved from their medical records. Groups were comparedaccording to their birth weights, platelet counts and mean platelet volumes MPV . Results: Gestastional age and birth weights of all groups were similar. Theplatelet count of group A was significantly lower p

References

  • 1. Cunningham FG, Lindheimer MD. Hypertansion in pregnancy. N Engl J Med 1992;326:927-32.
  • 2. Roberts JM, Taylor RN, Musci TJ, Rodgers GM, Hubel CA, McLaughlin MK. Preeclampsia: An endothelial cell disorder. Am J Obstet Gynecol 1989;161:1200-4.
  • 3. Bessman JD, Williams LJ, Gilmer PR Jr. Mean platelet volume. The inverse relation of platelet size and count in normal subjects, and an artifact of other particles. Am J Clin Pathol 1981;76:289-93.
  • 4. Giles C. The platelet count and mean platelet volume. Br J Haematol 1981;48:31-7.
  • 5. Stubbs TM, Lazarchick J, Van Dorsten JP, Cox J, Loadholt CB. Evidence of accelerated platelet production and consumption in nonthrombocytopenic preeclampsia. Am J Obstet Gynecol 1986;155:263-5.
  • 6. Tygart SG, McRoyan DK, Spinnato JA, Mc Royan CJ, Kitay DZ. Longitudinal study of platelet indices during normal pregnancy. Am J Obstet Gynecol 1986;154:883-7.
  • 7. Romero R, Lockwood C, Oyarzun E, Hobbins JC. Toxemia: new concepts in an old disease. Semin Perinatol 1988;12:302-23.
  • 8. Fay RA, Hughes AO, Farron NT. Platelets in pregnancy: hyperdestruction in pregnancy. Obstet Gynecol 1983; 61: 238-40.
  • 9. Hutt R, Ogunniyi SO, Sullivan MH, Elder MG. Increased platelet volume and aggregation precede the onset of preeclampsia. Obstet Gynecol 1994;83:146-9.
  • 10. Burrows RF, Andrew M. Neonatal thrombocytopenia in the hypertensive disorders of pregnancy. Obstet Gynecol 1990;76:234-38.
  • 11. Beiner M, Simchen M, Sivan E, Chetrit AM, Kuint J, Schiff E. Risk factors for neonatal thrombocytopenia. Am Journ of Perinat 2003;20:49-54.
  • 12. Fraser SH, Tudehope DI. Neonatal neutropenia and thrombocytopenia following maternal hypertansion. Journ of Ped and Child Health 1996;32:31-4.
  • 13. Roberts I, Murray NA. Neonatal Thrombocytopenia: causes and management. Arch Dis Child Fetal Neonatal Ed 2003;88:359-64.
  • 14. ACOG Committee on Obstetric Practice. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet 2002;77:67-75.
  • 15. Dinesh M. Shah. Hypertensive disorders of pregnancy. In:Richard J. Martin, Avroy A. Fanaroff, Michele C. Walsh. Fanaroff and Martin’s Neonatal-Perinatal Medicine. Diseases of the Fetus and Infant. 8th edition. Philadelphia: Mosby, Inc.; 2006. p.307-20.
  • 16. Lyall F, Greer IA, Boswell F, Fleming R. Suppression of serum vascular endothelial growth factor immunoreactivity in normal pregnancy and in pre-eclampsia. Br J Obstet Gynaecol 1997;104:223-8.
  • 17. Casella I, Feccia T, Chelucci C, et al. Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt 1 receptor. Blood 2003;101:1316-23.
  • 18. Ahmet Y, Van Iddekinge B, Paul C, Sullivan HF, Elder MG. Retrospective analysis of platelet numbers and volumes in normal pregnancy and in pre-eclempsia. Br J Obstet Gynaecol 1993;100:216-20.
  • 19. Howarth S, Marshall LR, Barr AL, Evans S, Pontre M, Ryan N. Platelet indices during normal pregnancy and pre-eclempsia. Br J Med Sci 1999;56:20-2.
  • 20. Ceyhan T, Beyan C, Baser I, Kaptan K, Güngör S, Ifran A. The effect of preeclampsia on complete blood count, platelet count and mean platelet volume. Ann Hematol 2006; 85:320-22.
  • 21. Jaremo P, Lindahl TL, Lennmarken C, Forsgren H. The use of platelet density and volume measurements to estimate the severity of pre-eclampsia. Eur J Clin Invest 2000;30:1113-8.
  • 22. Dundar O, Yoruk P, Tutuncu L, Erikci Akyol A, Muhcu M, Ergur Rustu A, et al. Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre-eclampsia. Prenat Diagn 2008;28:1052-6.
  • 23. Meberg A, Orstavik I, Sovde A. Erythroblastemia and thrombocytopenia in small for gestational age infants. Acta Pediatr Belg 1978;31:213.
  • 24. Samuels P, Main EK, Tomaski A, Mennuti MT, Gabbe SG,Cines DB. Abnormalities in platelet antiglobulin tests in preeclamptic mothers and their neonates. Am J Obstet Gynecol 1987;157:109-13.
  • 25. Tsao PN, Wei SC, Su YN, Chou HC, Chen CY, Hsieh WS. Excess soluble fms-like tyrosine kinase 1 and low platelet counts in premature neonates of preeclamptic mothers. Pediatrics 2005;116:468-72.
There are 25 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

A. Barış Akcan

Seyhan Erişir Oygucu This is me

Deniz Özel This is me

Nihal Oygür This is me

Publication Date December 1, 2009
Published in Issue Year 2009 Volume: 7 Issue: 3

Cite

APA Akcan, A. B., Oygucu, S. E., Özel, D., Oygür, N. (2009). Preeklamptik Anne Bebeklerinde Ortalama Trombosit Hacimleri. Güncel Pediatri, 7(3), 53-56.
AMA Akcan AB, Oygucu SE, Özel D, Oygür N. Preeklamptik Anne Bebeklerinde Ortalama Trombosit Hacimleri. Güncel Pediatri. December 2009;7(3):53-56.
Chicago Akcan, A. Barış, Seyhan Erişir Oygucu, Deniz Özel, and Nihal Oygür. “Preeklamptik Anne Bebeklerinde Ortalama Trombosit Hacimleri”. Güncel Pediatri 7, no. 3 (December 2009): 53-56.
EndNote Akcan AB, Oygucu SE, Özel D, Oygür N (December 1, 2009) Preeklamptik Anne Bebeklerinde Ortalama Trombosit Hacimleri. Güncel Pediatri 7 3 53–56.
IEEE A. B. Akcan, S. E. Oygucu, D. Özel, and N. Oygür, “Preeklamptik Anne Bebeklerinde Ortalama Trombosit Hacimleri”, Güncel Pediatri, vol. 7, no. 3, pp. 53–56, 2009.
ISNAD Akcan, A. Barış et al. “Preeklamptik Anne Bebeklerinde Ortalama Trombosit Hacimleri”. Güncel Pediatri 7/3 (December 2009), 53-56.
JAMA Akcan AB, Oygucu SE, Özel D, Oygür N. Preeklamptik Anne Bebeklerinde Ortalama Trombosit Hacimleri. Güncel Pediatri. 2009;7:53–56.
MLA Akcan, A. Barış et al. “Preeklamptik Anne Bebeklerinde Ortalama Trombosit Hacimleri”. Güncel Pediatri, vol. 7, no. 3, 2009, pp. 53-56.
Vancouver Akcan AB, Oygucu SE, Özel D, Oygür N. Preeklamptik Anne Bebeklerinde Ortalama Trombosit Hacimleri. Güncel Pediatri. 2009;7(3):53-6.