Pediatrik Onkolojide İlaç Ekstravazasyonu: Tek Merkez Deneyimi

Year 2008, Volume: 6 Issue: 5, 1 - 4, 01.12.2008

Betül Sevinir

Abstract

Amaç: Sitotoksik kemoterapi uygulamalarında ekstravazasyon sıklığı değişkendir. Bu çalışmanın amacı merkezimizde ekstravazasyon sıklığını ve risk faktörlerini tanımlamaktır.Gereç ve Yöntem: Uludağ Üniversitesi Tıp Fakültesi Pediatrik Onkoloji Bilim Dalı’nda 2004-2007 yılları arasındaki hasta kayıtları retrospektif olarak değerlendirildi. Tanı alan hasta sayısı, ekstravazasyon sayısı, demografik ve klinik özellikleribelirlendi.Bulgular: Merkezimizde pediatrik onkoloji hastalarında kemoterapi ekstravazasyonu insidansı %0.4 bulundu. Ekstravazasyon görülen hastaların %41’i üç yaşından küçüktü. Kemoterapi başlangıcından median 9 hafta sonra ekstravazasyon gözlendi.Ekstravazasyonların %77’si poliklinik koşullarında ve %59’u haftada bir tedavi alangrupta idi. En sık vinka alkaloidleri, aktinomisin ve adriamisin kaçışı saptandı.Sonuç: Sitotoksik kemoterapi ekstravazasyon sıklığı literatürle benzerdir. Dahaküçük çocuklarda ve daha sık kemoterapi alanlarda risk daha yüksektir

Keywords

Kemoterapi, ekstravazasyon, insidans, çocukluk çağı

Drug Extravasation in Pediatric Oncology: Single Center Experience

Abstract

Aim: The frequency of cytotoxic chemotherapy extravasation is uncertain. Theaim of this study was to determine extravasation frequency and to verify the riskfactors in our center.Materials and Methods: Hospital records of pediatric oncology patients at Uludağ University Faculty of Medicine, Department of Pediatric Oncology between2004-2007 were reviewed retrospectively. Number of the cases with chemotherapy extravasation, diagnosis, demographic and clinical features were recorded. Results: The incidence of cytotoxic drug extravasation in pediatric oncology cases was 0.4%. Forty-one percent of extravasations were observed in patientsunder 3 years The median extravasation time was 9th week of the chemotherapy. Most of the extravasation injuries were seen in outpatient clinic 77% andmainly in cases who were having therapy weekly 59% . The most frequent siteof extravasation was dorsal hand 82% . Causative drugs were vinca alkaloids,doxorubicin and dactinomycin.Conclusion: The incidence of chemotherapy induced extravasations were similarwith literature. Young age and weekly chemotherapy were major risk factors in pediatric oncology cases

Keywords

Chemotherapy, extravasation, incidence, childhood

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