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Persistan Pulmoner Hipertansiyon

Yıl 2006, Cilt: 4 Sayı: 3, 105 - 108, 01.09.2006

Hilal Özkan Nilgün Köksal Merih Çetinkaya

Öz

Persistan pulmoner hipertansiyon PPH yenidoğanda bir grup hastalığın klinik bulgusu olarak karşımıza çıkan, mortalite ve morbiditesi yüksek önemli bir patolojidir. ilk kez 1967 yı- lında, pulmoner vasküler direncin azalmamasına bağlı, postnatal fetal dolaşımın aynen devam etmesi ve duktus arteriosus ve foramen ovaleden sağ-sol şantın kardiyak yapısal anomali olmadan devam etmesi şeklinde tanımlanmıştır 1 . Gerçek insidansı bilinmemekle birlikte ortalama 500-1000 do- ğumda bir görülmektedir . Çok merkezli bir çalışmada 1.9/1000 olarak bildirilmiştir 2 . Özellikle term ve terme yakın bebeklerde daha sık görülmektedir 1 .

Kaynakça

  • 1. Yiğit Ş. Persistan Pulmoner Hipertansiyon. Yurdakök M, Erdem G (eds). Neonatoloji. 2.Baskı. Alp Ofset I. 2004.p.447-51.
  • 2. Walsh-Sukys ML, Tyson JE, Wright LL, et al. Persistent pulmonary hypertension in the newborn in the era before nitric oxide: Practice variation and outcomes. Pediatr 2000; 105:12-20.
  • 3. Martin RJ, Sosenko I, Bancalari E. Respiratory problems. In: Klaus MH, Fanaroff AA (eds). Care of the High Risk Neonate, Philadelphia: WB Saunders, 2001.p.243-76.
  • 4. Whitsett JA, Pryhuber GS, Rica WR, Warner BB, Wert SE. Acute respiratory disorders. In: Avery GB, Fletcher MA, MacDonald MG (eds). Neonatology. Philadelphia: Lippincott, 1999.p. 485-531.
  • 5. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 27:373-6.
  • 6. Endo A, Shimada M, Ayusawa M, et al. Nitric oxide and endothelin 1 during postnatal life. Biol Neonate 1996; 70:15-20.
  • 7. Haegerstrand A, Hemsen A, Gillis C, Larsson O, Lundberg JM. Endothelin: presence in human umbilical vessels, high levels in fetal blood and potent constrictor effect. Acta Physiol Scand 1989; 137:541-2.
  • 8. Ivy DD, Kinsella JP, Abman SH. Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation. J Clin Invest 1994; 93:2141-8.
  • 9. Soukka H, Jalonen J, Kero P, Kaapa P. Endothelin-1, atrial natriuretic peptide and pathophysiology of pulmonary hypertension in porcine meconium aspiration. Acta Paediatr 1998; 87:424-8.
  • 10. Hashiguchi K, Takagi K, Nakabayashi M, Takeda Y, Sakamoto S, Naruse M, Naruse K, Demura H. Relationship between fetal hypoxia and endothelin-1 in fetal circulation. J Cardiovasc Pharmacol 1991; 7:509-10.
  • 11. Kumar P, Kazzi NJ, Shankaran S. Plasma immunoreactive endothelin-1 concentrations in infants with persistent pulmonary hypertension of the newborn. Am J Perinatol 1996; 13:335-41.
  • 12. Leffler CW, Hessler JR, Green RS. The onset of breathing at birth stimulates pulmonary vascular prostacyclin synthesis. Pediatr Res 1984; 18:938-42.
  • 13. Fox WW, Duara S. Persistent pulmonary hypertension in the neonate: Diagnosis and management. J Pediatr 1983; 103:505-14.
  • 14. Drummond WH. Persistent pulmonary hypertension of the neonate (Persistent fetal circulation syndrome). 1984, Year Book Medical Publishers, 61-85.
  • 15. Nair PM, Bataclan MF. Persistent pulmonary hypertension of the newborn. Saudi Med J 2004; 25:693-9.
  • 16. Suguihara C. Treatment of persistent pulmonary hypertension of the newborn. J Pediatr 2001; 1:17-24.
  • 17. Fugelseth D. Persistent pulmonary hypertension in newborn infants. Tidsskr Nor Laegeforen 2001; 121:3074-8.
  • 18. Alano MA, Ngougmna E, Ostrea EM Jr, et al. Analysis of nonsteroidal antiinflammatory drugs in meconium and its relation to persistent pulmonary hypertension of the newborn. Pediatrics 2001; 107:519-23.
  • 19. Morin FC, Stenmark KR. Persistent pulmonary hypertension of the newborn. Am J Respir Crit Care Med 1995; 151:2010-32.
  • 20. Steinhorn HR. Pulmonary Hypertension, Persistent-Newborn. e - Medicine 2006; 1-10.
  • 21. Zahka KG, Patel CR. Cardiovascular problems of the neonate. In: Fanaroff AA, Martin RJ (eds). Neonatal Perinatal Medicine St. Louis, Mosby, 2002.p.1140-50.
  • 22. Tolsa JF, Cotting J, Sekarski N, Payot M, Micheli JL, Calame A. Magnesium sulphate as an alternative and safe treatment for severe persistent pulmonary hypertension of the newborn. Arch Dis Child Fetal Neonatal Ed 1995; 72:184-7.
  • 23. Drummond WH, Gregory GA, et al. The independent effects of hyperventilation, tolazoline, and dopamine on infants with persistent pulmonary hypertension. J Pediatr 1981; 9:603-11.
  • 24. Hintz SR, Suttner DM, Sheehan AM, Rhine WD, Van Meurs KP. Decreased use of neonatal extracorporeal membrane oxygenation (ECMO): how new treatment modalities have affected ECMO utilization. Pediatrics 2000; 106:1339-43.
  • 25. Kinsella JP, Abman SH. Clinical approach to the use of high frequency oscillatory ventilation in neonatal respiratory failure. J Perinatal 1996; 16:52-5.
  • 26. Clark RH, Yoder BA, Sell MS. Prospective, randomized comparison of high-frequency oscillation and conventional ventilation in candidates for extracorporeal membrane oxygenation. J Pediatr 1994; 124:427-30.
  • 27. Rowley S, Kuschel C. Persistent Pulmonary Hypertension of the Newborn. Clinical Guideline 2001.
  • 28. Bland RD, Albertine KH, Carlton DP, MacRitchie AJ. Inhaled Nitric Oxide Effects on Lung Structure and Function in Chronically Ventilated Preterm Lambs. Am J Respir Crit Care Med 172: 899-906.
  • 29. The Neonatal Inhaled Nitric Oxide Study Group. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. N Engl J Med 1997; 337:434.
  • 30. Kinsella JP, Abman SH. Inhaled nitric oxide in the premature infant: animal models and clinical experience. Semin Perinatol 1997; 21:418-25.
  • 31. Clark RH, Kueser TJ, Walker MW, et al. Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. N Eng J Med 2000; 342:469-75.
  • 32. Rais-Bahrami K, Short BL. The current status of neonatal extracorporeal membrane oxygenation. Sem Perinatal 2000; 24:406-17.
  • 33. Khammash H, Perlman M, Wojtulewicz J, Dunn M. Surfactant therapy in full-term neonates with severe respiratory failure. Pediatrics 1993 Jul; 92:135-9.
  • 34. al-Mateen KB, Dailey K, Grimes MM, Gutcher GR. Improved oxygenation with exogenous surfactant administration in experimental meconium aspiration syndrome. Pediatr Pulmonol 1994; 17:75-80.
  • 35. Herting E, Gefeller O, Land M, van Sonderen L, Harms K, Robertson B. Surfactant treatment of neonates with respiratory failure and group B streptococcal infection. Members of the Collaborative European Multicenter Study Group. Pediatrics. 2000; 106:957-64.
  • 36. Lotze A, Mitchell BR, Bulas DI, et al. Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure. Survanta in Term Infants Study Group. J Pediatr 1998; 132:40-7.
  • 37. Lasky RE, Wiorek L, Becker TR: Hearing loss in survivors of neonatal extracorporeal membrane oxygenation and high-frequency oscillatory therapy. J Am Acad Audiol 1998; 9:47-58.

Yıl 2006, Cilt: 4 Sayı: 3, 105 - 108, 01.09.2006

Hilal Özkan Nilgün Köksal Merih Çetinkaya

Öz

Kaynakça

  • 1. Yiğit Ş. Persistan Pulmoner Hipertansiyon. Yurdakök M, Erdem G (eds). Neonatoloji. 2.Baskı. Alp Ofset I. 2004.p.447-51.
  • 2. Walsh-Sukys ML, Tyson JE, Wright LL, et al. Persistent pulmonary hypertension in the newborn in the era before nitric oxide: Practice variation and outcomes. Pediatr 2000; 105:12-20.
  • 3. Martin RJ, Sosenko I, Bancalari E. Respiratory problems. In: Klaus MH, Fanaroff AA (eds). Care of the High Risk Neonate, Philadelphia: WB Saunders, 2001.p.243-76.
  • 4. Whitsett JA, Pryhuber GS, Rica WR, Warner BB, Wert SE. Acute respiratory disorders. In: Avery GB, Fletcher MA, MacDonald MG (eds). Neonatology. Philadelphia: Lippincott, 1999.p. 485-531.
  • 5. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 27:373-6.
  • 6. Endo A, Shimada M, Ayusawa M, et al. Nitric oxide and endothelin 1 during postnatal life. Biol Neonate 1996; 70:15-20.
  • 7. Haegerstrand A, Hemsen A, Gillis C, Larsson O, Lundberg JM. Endothelin: presence in human umbilical vessels, high levels in fetal blood and potent constrictor effect. Acta Physiol Scand 1989; 137:541-2.
  • 8. Ivy DD, Kinsella JP, Abman SH. Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation. J Clin Invest 1994; 93:2141-8.
  • 9. Soukka H, Jalonen J, Kero P, Kaapa P. Endothelin-1, atrial natriuretic peptide and pathophysiology of pulmonary hypertension in porcine meconium aspiration. Acta Paediatr 1998; 87:424-8.
  • 10. Hashiguchi K, Takagi K, Nakabayashi M, Takeda Y, Sakamoto S, Naruse M, Naruse K, Demura H. Relationship between fetal hypoxia and endothelin-1 in fetal circulation. J Cardiovasc Pharmacol 1991; 7:509-10.
  • 11. Kumar P, Kazzi NJ, Shankaran S. Plasma immunoreactive endothelin-1 concentrations in infants with persistent pulmonary hypertension of the newborn. Am J Perinatol 1996; 13:335-41.
  • 12. Leffler CW, Hessler JR, Green RS. The onset of breathing at birth stimulates pulmonary vascular prostacyclin synthesis. Pediatr Res 1984; 18:938-42.
  • 13. Fox WW, Duara S. Persistent pulmonary hypertension in the neonate: Diagnosis and management. J Pediatr 1983; 103:505-14.
  • 14. Drummond WH. Persistent pulmonary hypertension of the neonate (Persistent fetal circulation syndrome). 1984, Year Book Medical Publishers, 61-85.
  • 15. Nair PM, Bataclan MF. Persistent pulmonary hypertension of the newborn. Saudi Med J 2004; 25:693-9.
  • 16. Suguihara C. Treatment of persistent pulmonary hypertension of the newborn. J Pediatr 2001; 1:17-24.
  • 17. Fugelseth D. Persistent pulmonary hypertension in newborn infants. Tidsskr Nor Laegeforen 2001; 121:3074-8.
  • 18. Alano MA, Ngougmna E, Ostrea EM Jr, et al. Analysis of nonsteroidal antiinflammatory drugs in meconium and its relation to persistent pulmonary hypertension of the newborn. Pediatrics 2001; 107:519-23.
  • 19. Morin FC, Stenmark KR. Persistent pulmonary hypertension of the newborn. Am J Respir Crit Care Med 1995; 151:2010-32.
  • 20. Steinhorn HR. Pulmonary Hypertension, Persistent-Newborn. e - Medicine 2006; 1-10.
  • 21. Zahka KG, Patel CR. Cardiovascular problems of the neonate. In: Fanaroff AA, Martin RJ (eds). Neonatal Perinatal Medicine St. Louis, Mosby, 2002.p.1140-50.
  • 22. Tolsa JF, Cotting J, Sekarski N, Payot M, Micheli JL, Calame A. Magnesium sulphate as an alternative and safe treatment for severe persistent pulmonary hypertension of the newborn. Arch Dis Child Fetal Neonatal Ed 1995; 72:184-7.
  • 23. Drummond WH, Gregory GA, et al. The independent effects of hyperventilation, tolazoline, and dopamine on infants with persistent pulmonary hypertension. J Pediatr 1981; 9:603-11.
  • 24. Hintz SR, Suttner DM, Sheehan AM, Rhine WD, Van Meurs KP. Decreased use of neonatal extracorporeal membrane oxygenation (ECMO): how new treatment modalities have affected ECMO utilization. Pediatrics 2000; 106:1339-43.
  • 25. Kinsella JP, Abman SH. Clinical approach to the use of high frequency oscillatory ventilation in neonatal respiratory failure. J Perinatal 1996; 16:52-5.
  • 26. Clark RH, Yoder BA, Sell MS. Prospective, randomized comparison of high-frequency oscillation and conventional ventilation in candidates for extracorporeal membrane oxygenation. J Pediatr 1994; 124:427-30.
  • 27. Rowley S, Kuschel C. Persistent Pulmonary Hypertension of the Newborn. Clinical Guideline 2001.
  • 28. Bland RD, Albertine KH, Carlton DP, MacRitchie AJ. Inhaled Nitric Oxide Effects on Lung Structure and Function in Chronically Ventilated Preterm Lambs. Am J Respir Crit Care Med 172: 899-906.
  • 29. The Neonatal Inhaled Nitric Oxide Study Group. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. N Engl J Med 1997; 337:434.
  • 30. Kinsella JP, Abman SH. Inhaled nitric oxide in the premature infant: animal models and clinical experience. Semin Perinatol 1997; 21:418-25.
  • 31. Clark RH, Kueser TJ, Walker MW, et al. Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. N Eng J Med 2000; 342:469-75.
  • 32. Rais-Bahrami K, Short BL. The current status of neonatal extracorporeal membrane oxygenation. Sem Perinatal 2000; 24:406-17.
  • 33. Khammash H, Perlman M, Wojtulewicz J, Dunn M. Surfactant therapy in full-term neonates with severe respiratory failure. Pediatrics 1993 Jul; 92:135-9.
  • 34. al-Mateen KB, Dailey K, Grimes MM, Gutcher GR. Improved oxygenation with exogenous surfactant administration in experimental meconium aspiration syndrome. Pediatr Pulmonol 1994; 17:75-80.
  • 35. Herting E, Gefeller O, Land M, van Sonderen L, Harms K, Robertson B. Surfactant treatment of neonates with respiratory failure and group B streptococcal infection. Members of the Collaborative European Multicenter Study Group. Pediatrics. 2000; 106:957-64.
  • 36. Lotze A, Mitchell BR, Bulas DI, et al. Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure. Survanta in Term Infants Study Group. J Pediatr 1998; 132:40-7.
  • 37. Lasky RE, Wiorek L, Becker TR: Hearing loss in survivors of neonatal extracorporeal membrane oxygenation and high-frequency oscillatory therapy. J Am Acad Audiol 1998; 9:47-58.
Toplam 37 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Collection
Yazarlar

Hilal Özkan Bu kişi benim

Nilgün Köksal Bu kişi benim

Merih Çetinkaya Bu kişi benim

Yayımlanma Tarihi 1 Eylül 2006
Yayımlandığı Sayı Yıl 2006 Cilt: 4 Sayı: 3

Kaynak Göster

APA Özkan, H., Köksal, N., & Çetinkaya, M. (2006). Persistan Pulmoner Hipertansiyon. Güncel Pediatri, 4(3), 105-108.
AMA Özkan H, Köksal N, Çetinkaya M. Persistan Pulmoner Hipertansiyon. Güncel Pediatri. Eylül 2006;4(3):105-108.
Chicago Özkan, Hilal, Nilgün Köksal, ve Merih Çetinkaya. “Persistan Pulmoner Hipertansiyon”. Güncel Pediatri 4, sy. 3 (Eylül 2006): 105-8.
EndNote Özkan H, Köksal N, Çetinkaya M (01 Eylül 2006) Persistan Pulmoner Hipertansiyon. Güncel Pediatri 4 3 105–108.
IEEE H. Özkan, N. Köksal, ve M. Çetinkaya, “Persistan Pulmoner Hipertansiyon”, Güncel Pediatri, c. 4, sy. 3, ss. 105–108, 2006.
ISNAD Özkan, Hilal vd. “Persistan Pulmoner Hipertansiyon”. Güncel Pediatri 4/3 (Eylül 2006), 105-108.
JAMA Özkan H, Köksal N, Çetinkaya M. Persistan Pulmoner Hipertansiyon. Güncel Pediatri. 2006;4:105–108.
MLA Özkan, Hilal vd. “Persistan Pulmoner Hipertansiyon”. Güncel Pediatri, c. 4, sy. 3, 2006, ss. 105-8.
Vancouver Özkan H, Köksal N, Çetinkaya M. Persistan Pulmoner Hipertansiyon. Güncel Pediatri. 2006;4(3):105-8.