Siklik Nötropeni ve Konjenital Nötropeni Kostmann Hastalığı

Year 2004, Volume: 2 Issue: 1, 64 - 68, 01.03.2004

Fatih Kılıçbay Sara Şebnem Kılıç

Abstract

Nötrofiller immünolojik savunmanın önemli bir bileşenini oluşturan fagositik hücrelerdir. Kemik iliğinde çok yönlü kök hücrelerinden türeyen fagosit prokürsörleri , granülosit monosit koloni uyarıcı faktör GM-CSF ve granülosit koloni uyarıcı faktör G-CSF gibi uyarıcılarla, kemik iliğinde prolifere olarak olgun segmente nötrofillere dönüşmektedirler

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