Ailevi Akdeniz Ateşli Çocuklarda Ortalama Trombosit Hacmi Ve Trombosit Dağılım Genişliğinin Değerlendirilmesi

Fatma Duksal; Ahmet Sami Güven; Mesut Arslan; Melih Timuçin Doğan; Utku Aygüneş

doi:10.32941/pediatri.775265

Research Article

Ailevi Akdeniz Ateşli Çocuklarda Ortalama Trombosit Hacmi Ve Trombosit Dağılım Genişliğinin Değerlendirilmesi

Year 2020, Volume: 18 Issue: 2, 208 - 219, 01.08.2020

Fatma Duksal Ahmet Sami Güven Mesut Arslan Melih Timuçin Doğan Utku Aygüneş

Abstract

GİRİŞ ve AMAÇ: Trombosit aktivasyonu ateroskleroz sürecinde anahtar rol oynamaktadır. Ateroskleroz riski ailevi Akdeniz ateşi (AAA) hastalığında artmıştır. Ortalama trombosit hacmi, trombosit dağılım genişliği ve trombosit sayısı, trombosit aktivasyonunda önemlidir. Çalışmanın amacı ortalama trombosit hacmi, trombosit dağılım genişliği ve trombosit sayılarıyla ataksız dönemdeki AAA’lı çocukların mutasyon tipinin arasındaki ilişkiyi incelemektir.

YÖNTEM ve GEREÇLER: Ortalama trombosit hacmi, trombosit dağılım genişliği ve trombosit sayıları, yaş, cinsiyet ve mutasyon tipleri, hastaların tıbbi kayıtları geriye dönük incelenerek kaydedilmiştir. Çalışmaya atak döneminde olmayan 368 AAA’lı çocuk hasta ve 379 sağlıklı çocuk dahil edilmiştir.

BULGULAR: Ortalama trombosit hacmi (MPV), hastalarda kontrol grubuna göre daha düşüktür (p<0.001). Fakat trombosit dağılım genişliği kontrol grubuna göre daha yüksektir (p<0.001). Trombosit sayıları açısından hasta ve kontrol grubu arasında fark bulunmamıştır (p>0.05). Homozigot, heterozigot, birleşik mutasyonlar 368 hastanın sırasıyla 51, 267 ve 51’inde saptanmıştır. OTH; homozigot mutasyonlu (p=0.029) ve heterozigot mutasyonlu hastalarda (p=0.041) birleşik mutasyonlu hastalardan daha yüksek bulunmuştur. Homozigot mutasyonlu hastalarla, heterozigot mutasyonlu hastalarda ortalama trombosit hacmi açısından fark bulunmamıştır (p>0.05). Ayrıca, trombosit dağılım genişliği ve trombosit sayılar açısından heterozigot, homozigot ve birleşik mutasyonlar arasında fark saptanmamıştır
(p>0.05). En sık görülen mutasyonlar M694V (131), E148Q (82), M680I, (37), and V726A (32) olarak saptanmıştır. Bu mutasyonlar arasında MPV, trombosit dağılım genişliği ve trombosit sayıları açısından anlamlı fark saptanmamıştır (p > 0.05).

TARTIŞMA ve SONUÇ: Ateroskleroz riski yüksek MPV değerlerinde artmış olsa da, şimdiki çalışmada bu ilişkiyi bulamadık. Bu, belki de tüm hastaların kolşisin tedavisi altında olduğundan kaynaklanmış olabilir. Diğer yandan PDW değerleri kontrol grubuna göre daha yüksek saptanmıştır. PDW ve MPV arasındaki ilişkiyi açıklığa kavuşturmak için daha fazla çalışmaya ihtiyaç vardır.

Keywords

akdeniz ateşi,, çocuk,, trombosit,

References

1. Woo P, Laxer RM, Sherry DD. Autoinflammatory syndromes. In: Woo, P, Laxer, RM. and Sherry, DD. Eds., Pediatric Rheumatology in Clinical Practice, Springer, London, 2007; 123-36
2. Tunca M, Akar S, Onen F, Ozdogan H, Kasapcopur O, Yalcinkaya F, et al; Turkish FMF Study Group. Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study. Medicine (Baltimore). 2005; 84: 1–11
3. Sarı I, Birlik M, Kasifoglu T. Familial Mediterranean fever: an updated review. Eur J Rheum. 2014; 1: 21-33.
4. Onen F. Familial Mediterranean fever. Rheumatol Int. 2006; 26: 489-96
5. Ben-Chetrit E, Touitou I. Familial Mediterranean fever in the world. Arthritis Rheum. 2009; 61: 1447-53
6. Marzouk H, Lotfy HM, Farag Y, Rashed LA, El-Garf K. Mean platelet volume and splenomegaly as useful markers of subclinical activity in Egyptian children with familial Mediterranean fever: A Cross-Sectional Study. Int J Chronic Dis. 2015;2015:152616. doi: 10.1155/2015/152616.
7. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17:47-58.
8. Wang X, Meng H, Xu L, Chen Z, Shi D, Lv D. Mean platelet volume as an inflammatory marker in patients with severe periodontitis. Platelets. 2015;26:67-71.doi: 10.3109/09537104.2013.875137.
9. Ben-Zvi I, Livneh A. Chronic inflammation in FMF: markers, risk factors, outcomes and therapy. Nature Reviews Rheumatology. 2011; 7: 105-12.
10. Ozkayar N, Piskinpasa S, Akyel F, Dede F, Yildirim T, Turgut D, et al. Evaluation of the mean platelet volume in secondary amyloidosis due to familial Mediterranean fever. Rheumatol Int. 2013; 33: 2555-9.
11. Oral A, Sahin T, Turker F, Kocak E. Evaluation of plateletcrit and platelet distribution width in patients with non-alcoholic fatty liver disease: A Retrospective Chart Review Study. Med Sci Monit. 2019 Dec 23;25:9882-9886. doi: 10.12659/MSM.920172.
12. Coban E, Adanir H. Platelet activation in patients with Familial Mediterranean Fever. Platelets. 2008; 19: 405-8.
13. Uluca Ü, Ece A, Şen V, Karabel D, Yel S, Güneş , et al. Usefulness of mean platelet volume and neutrophil-to-lymphocyte ratio for evaluation of children with Familial Mediterranean fever. Med Sci Monit. 2014. 5; 20: 1578-82.
14. Ekiz F, Gürbüz Y, Basar O, Aytekin G, Ekiz Ö, Sentürk ÇŞ, et al. Mean Platelet Volume in the Diagnosis and Prognosis of Crimean-Congo Hemorrhagic Fever. Clin Appl Thromb Hemost 2013. 19: 441-4.
15. Tozkoparan E, Deniz O, Ucar E, Bilgic H, Ekiz K. Changes in platelet count and indices in pulmonary tuberculosis. Clin Chem Lab Med 2007; 45: 1009-13.
16. Küçükbayrak A, Oz G, Fındık G, Karaoğlanoğlu N, Kaya S, Taştepe I. Evaluation of platelet parameters in patients with pulmonary hydatid cyst. Mediterr J Hematol Infect Dis. 2010; 14; 2:e2010006.
17. Kodiatte TA, Manikyam UK, Rao SB, Jagadish TM, Reddy M, Lingaiah HK. Mean platelet volume in patients with type 2 diabetes mellitus. J Lab Physicians. 2012; 4: 5-9
18. Sahin Balcik O, Bilen S, Ulusoy EK, Akdeniz D, Uysal S, Ikizek M. Thrombopoietin and Mean Platelet Volume in Patients With Ischemic Stroke. Clin Appl Thromb Hemost. 2013;19: 92-5
19. Yesil Y, Kuyumcu ME, Cankurtaran M, Kara A, Kilic MK, Halil M. Increased mean platelet volume (MPV) indicating the vascular risk in Alzheimer's disease (AD). Arch Gerontol Geriatr. 2012; 55: 257-60
20. Mayda-Domaç F, Misirli H, Yilmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke Cerebrovasc Dis. 2010; 19: 66-72
21. Ulasli SS, Ozyurek BA, Yilmaz EB, Ulubay G. Mean platelet volume: an inflammatory marker in acute exacerbation of chronic obstructive pulmonary disease. Pol Arch Med Wewn. 2012; 122:284-90
22. Sahin S, Senel S, Ataseven H, Yalcin I. Does mean platelet volume influence the attack or attack-free period in the patients with Familial Mediterranean fever? Platelets. 2013; 24: 320–3
23. Arıca S, Ozer C, Arıca V, Karakuş A, Celik T, Güneşaçar R. Evaluation of the mean platelet volume in children with familial Mediterranean fever. Rheumatol Int. 2012; 32: 3559–63
24. Makay B, Türkyilmaz Z, Unsal E. Mean platelet volume in children with familial Mediterranean fever. Clin Rheumatol. 2009; 28: 975–8
25. Karakurt Arıtürk Ö, Üreten K, Sarı M, Yazıhan N, Ermiş E, Ergüder İ. Relationship of paraoxonase-1, malondialdehyde and mean platelet volume with markers of atherosclerosis in familial Mediterranean fever: an observational study. Anadolu Kardiyol Derg. 2013; 13: 357–62
26. Sakallı H, Kal O. Mean platelet volume as a potential predictor of proteinuria and amyloidosis in familial Mediterranean fever. Clin Rheumatol. 2013; 32: 1185–90
27. Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum. 1997; 40: 1879-85
28. Uslu AU, Deveci K, Korkmaz S, Aydin B, Senel S, Sancakdar E. Is Neutrophil/Lymphocyte Ratio Associated with Subclinical Inflammation and Amyloidosis in Patients with Familial Mediterranean Fever? Biomed Res Int. 2013, 2013:185317. doi: 10.1155/2013/185317
29. Dursun I, Gok F, Babacan O, Sarı E, Sakallıoglu O. Are mean platelet volume and splenomegaly subclinical inflammatory marker in children with familial mediterranean fever? Health. 2010; 2: 692-695 doi: 10.4236/health.2010.27105
30. Ozturk ZA, Sayıner H, Kuyumcu ME, Yesil Y, Savas E, Sayıner ZA. Mean Platelet Volume in Assessment of Brucellosis Disease. Biomed Res- India. 2012; 23: 541-6
31. Albayrak Y, Albayrak A, Albayrak F, Yildirim R, Aylu B, Uyanik A. Mean platelet volume: a new predictor in confirming acute appendicitis diagnosis. Clin Appl Thromb Hemost. 2011; 17: 362-6
32. Yüksel O, Helvaci K, Basar O, Köklü S, Caner S, Helvaci N. An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets. 2009; 20: 277-81
33. Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine. 2008; 75: 291-4
34. Beyazit Y, Sayilir A, Torun S, Suvak B, Yesil Y, Purnak T. Mean platelet volume as an indicator of disease severity in patients with acute pancreatitis. Clin Res Hepatol Gastroenterol. 2012; 36: 162-8
35. A.Bakan A, Oral A, Alışır Ecder S, Şaşak Kuzgun G, Elçioğlu ÖC, Demirci R, et al. Assessment of mean platelet volume in patients with AA Amyloidosis and AA amyloidosis secondary to familial Mediterranean fever: A Retrospective Chart - Review Study. Med Sci Monit. 2019;25:3854-9. doi: 10.12659/MSM.914343.
36. Senaran H, Ileri M, Altinbas A, Koşar A, Yetkin E, Oztürk M. Thrombopoietin and mean platelet volume in coronary artery disease. Clin Cardiol. 2001; 24: 405-8.
37. Yorulmaz A, Akbulut H, Taş SA, Tıraş M, Yahya İ, Peru H. Evaluation of hematological parameters in children with FMF. Clin Rheumatol. 2019 ;38:701-7. doi: 10.1007/s10067-018-4338-1.
38. Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res. 1983; 32: 443-60.
39. Brown AS, Hong Y, de Belder A, Beacon H, Beeso J, Sherwood R. Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis. Arterioscler Thromb Vasc Biol. 1997; 17: 802-7
40. Yildirim Cetin G, Gul O, Metin Kesici F, Gokalp I, Sayarlıoglu M. Evaluation of the Mean Platelet Volume and Red Cell Distribution Width in FMF: Are They Related to Subclinical Inflammation or Not? Hindawi Publishing Corporation, International Journal of Chronic Diseases. 2014; 2014:127426. doi: 10.1155/2014/127426
41. Duzova A, Bakkaloglu A, Besbas N, Topaloglu R, Ozen S, Ozaltin F. Role of A-SAA in monitoring subclinical inflammation and in colchicine dosage in familial Mediterranean fever. Clin Exp Rheumatol. 2003; 21: 509–14
42. Lachmann HJ, Sengül B, Yavuzşen TU, Booth DR, Booth SE, Bybee A. Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. Rheumatology (Oxford). 2006; 45: 746–50
43. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011; 17: 47–58.
44. Li B, Liu X, Cao ZG, Li Y, Liu TM, Wang RT. Elevated mean platelet volume is associated with silent cerebral infarction. Intern Med J. 2014; 44: 653-7.
45. Leader A, Pereg D, Lishner M. Are platelet volume indices of clinical use? A multidisciplinary review. Ann Med. 2012; 44: 805–16.
46. Turhan O, Coban E, Inan D, Yalcin AN. Increased mean platelet volume in chronic hepatitis B patients with inactive disease. Med Sci Monit. 2010; 16: CR202–5.
47. Bostan F, Coban E. The relationship between levels of von Willebrand factor and mean platelet volume in subjects with isolated impaired fasting glucose. Med Sci Monit, 2011; 17: PR1-4.

Year 2020, Volume: 18 Issue: 2, 208 - 219, 01.08.2020

Fatma Duksal Ahmet Sami Güven Mesut Arslan Melih Timuçin Doğan Utku Aygüneş

Abstract

References

1. Woo P, Laxer RM, Sherry DD. Autoinflammatory syndromes. In: Woo, P, Laxer, RM. and Sherry, DD. Eds., Pediatric Rheumatology in Clinical Practice, Springer, London, 2007; 123-36
2. Tunca M, Akar S, Onen F, Ozdogan H, Kasapcopur O, Yalcinkaya F, et al; Turkish FMF Study Group. Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study. Medicine (Baltimore). 2005; 84: 1–11
3. Sarı I, Birlik M, Kasifoglu T. Familial Mediterranean fever: an updated review. Eur J Rheum. 2014; 1: 21-33.
4. Onen F. Familial Mediterranean fever. Rheumatol Int. 2006; 26: 489-96
5. Ben-Chetrit E, Touitou I. Familial Mediterranean fever in the world. Arthritis Rheum. 2009; 61: 1447-53
6. Marzouk H, Lotfy HM, Farag Y, Rashed LA, El-Garf K. Mean platelet volume and splenomegaly as useful markers of subclinical activity in Egyptian children with familial Mediterranean fever: A Cross-Sectional Study. Int J Chronic Dis. 2015;2015:152616. doi: 10.1155/2015/152616.
7. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17:47-58.
8. Wang X, Meng H, Xu L, Chen Z, Shi D, Lv D. Mean platelet volume as an inflammatory marker in patients with severe periodontitis. Platelets. 2015;26:67-71.doi: 10.3109/09537104.2013.875137.
9. Ben-Zvi I, Livneh A. Chronic inflammation in FMF: markers, risk factors, outcomes and therapy. Nature Reviews Rheumatology. 2011; 7: 105-12.
10. Ozkayar N, Piskinpasa S, Akyel F, Dede F, Yildirim T, Turgut D, et al. Evaluation of the mean platelet volume in secondary amyloidosis due to familial Mediterranean fever. Rheumatol Int. 2013; 33: 2555-9.
11. Oral A, Sahin T, Turker F, Kocak E. Evaluation of plateletcrit and platelet distribution width in patients with non-alcoholic fatty liver disease: A Retrospective Chart Review Study. Med Sci Monit. 2019 Dec 23;25:9882-9886. doi: 10.12659/MSM.920172.
12. Coban E, Adanir H. Platelet activation in patients with Familial Mediterranean Fever. Platelets. 2008; 19: 405-8.
13. Uluca Ü, Ece A, Şen V, Karabel D, Yel S, Güneş , et al. Usefulness of mean platelet volume and neutrophil-to-lymphocyte ratio for evaluation of children with Familial Mediterranean fever. Med Sci Monit. 2014. 5; 20: 1578-82.
14. Ekiz F, Gürbüz Y, Basar O, Aytekin G, Ekiz Ö, Sentürk ÇŞ, et al. Mean Platelet Volume in the Diagnosis and Prognosis of Crimean-Congo Hemorrhagic Fever. Clin Appl Thromb Hemost 2013. 19: 441-4.
15. Tozkoparan E, Deniz O, Ucar E, Bilgic H, Ekiz K. Changes in platelet count and indices in pulmonary tuberculosis. Clin Chem Lab Med 2007; 45: 1009-13.
16. Küçükbayrak A, Oz G, Fındık G, Karaoğlanoğlu N, Kaya S, Taştepe I. Evaluation of platelet parameters in patients with pulmonary hydatid cyst. Mediterr J Hematol Infect Dis. 2010; 14; 2:e2010006.
17. Kodiatte TA, Manikyam UK, Rao SB, Jagadish TM, Reddy M, Lingaiah HK. Mean platelet volume in patients with type 2 diabetes mellitus. J Lab Physicians. 2012; 4: 5-9
18. Sahin Balcik O, Bilen S, Ulusoy EK, Akdeniz D, Uysal S, Ikizek M. Thrombopoietin and Mean Platelet Volume in Patients With Ischemic Stroke. Clin Appl Thromb Hemost. 2013;19: 92-5
19. Yesil Y, Kuyumcu ME, Cankurtaran M, Kara A, Kilic MK, Halil M. Increased mean platelet volume (MPV) indicating the vascular risk in Alzheimer's disease (AD). Arch Gerontol Geriatr. 2012; 55: 257-60
20. Mayda-Domaç F, Misirli H, Yilmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke Cerebrovasc Dis. 2010; 19: 66-72
21. Ulasli SS, Ozyurek BA, Yilmaz EB, Ulubay G. Mean platelet volume: an inflammatory marker in acute exacerbation of chronic obstructive pulmonary disease. Pol Arch Med Wewn. 2012; 122:284-90
22. Sahin S, Senel S, Ataseven H, Yalcin I. Does mean platelet volume influence the attack or attack-free period in the patients with Familial Mediterranean fever? Platelets. 2013; 24: 320–3
23. Arıca S, Ozer C, Arıca V, Karakuş A, Celik T, Güneşaçar R. Evaluation of the mean platelet volume in children with familial Mediterranean fever. Rheumatol Int. 2012; 32: 3559–63
24. Makay B, Türkyilmaz Z, Unsal E. Mean platelet volume in children with familial Mediterranean fever. Clin Rheumatol. 2009; 28: 975–8
25. Karakurt Arıtürk Ö, Üreten K, Sarı M, Yazıhan N, Ermiş E, Ergüder İ. Relationship of paraoxonase-1, malondialdehyde and mean platelet volume with markers of atherosclerosis in familial Mediterranean fever: an observational study. Anadolu Kardiyol Derg. 2013; 13: 357–62
26. Sakallı H, Kal O. Mean platelet volume as a potential predictor of proteinuria and amyloidosis in familial Mediterranean fever. Clin Rheumatol. 2013; 32: 1185–90
27. Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum. 1997; 40: 1879-85
28. Uslu AU, Deveci K, Korkmaz S, Aydin B, Senel S, Sancakdar E. Is Neutrophil/Lymphocyte Ratio Associated with Subclinical Inflammation and Amyloidosis in Patients with Familial Mediterranean Fever? Biomed Res Int. 2013, 2013:185317. doi: 10.1155/2013/185317
29. Dursun I, Gok F, Babacan O, Sarı E, Sakallıoglu O. Are mean platelet volume and splenomegaly subclinical inflammatory marker in children with familial mediterranean fever? Health. 2010; 2: 692-695 doi: 10.4236/health.2010.27105
30. Ozturk ZA, Sayıner H, Kuyumcu ME, Yesil Y, Savas E, Sayıner ZA. Mean Platelet Volume in Assessment of Brucellosis Disease. Biomed Res- India. 2012; 23: 541-6
31. Albayrak Y, Albayrak A, Albayrak F, Yildirim R, Aylu B, Uyanik A. Mean platelet volume: a new predictor in confirming acute appendicitis diagnosis. Clin Appl Thromb Hemost. 2011; 17: 362-6
32. Yüksel O, Helvaci K, Basar O, Köklü S, Caner S, Helvaci N. An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets. 2009; 20: 277-81
33. Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine. 2008; 75: 291-4
34. Beyazit Y, Sayilir A, Torun S, Suvak B, Yesil Y, Purnak T. Mean platelet volume as an indicator of disease severity in patients with acute pancreatitis. Clin Res Hepatol Gastroenterol. 2012; 36: 162-8
35. A.Bakan A, Oral A, Alışır Ecder S, Şaşak Kuzgun G, Elçioğlu ÖC, Demirci R, et al. Assessment of mean platelet volume in patients with AA Amyloidosis and AA amyloidosis secondary to familial Mediterranean fever: A Retrospective Chart - Review Study. Med Sci Monit. 2019;25:3854-9. doi: 10.12659/MSM.914343.
36. Senaran H, Ileri M, Altinbas A, Koşar A, Yetkin E, Oztürk M. Thrombopoietin and mean platelet volume in coronary artery disease. Clin Cardiol. 2001; 24: 405-8.
37. Yorulmaz A, Akbulut H, Taş SA, Tıraş M, Yahya İ, Peru H. Evaluation of hematological parameters in children with FMF. Clin Rheumatol. 2019 ;38:701-7. doi: 10.1007/s10067-018-4338-1.
38. Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res. 1983; 32: 443-60.
39. Brown AS, Hong Y, de Belder A, Beacon H, Beeso J, Sherwood R. Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis. Arterioscler Thromb Vasc Biol. 1997; 17: 802-7
40. Yildirim Cetin G, Gul O, Metin Kesici F, Gokalp I, Sayarlıoglu M. Evaluation of the Mean Platelet Volume and Red Cell Distribution Width in FMF: Are They Related to Subclinical Inflammation or Not? Hindawi Publishing Corporation, International Journal of Chronic Diseases. 2014; 2014:127426. doi: 10.1155/2014/127426
41. Duzova A, Bakkaloglu A, Besbas N, Topaloglu R, Ozen S, Ozaltin F. Role of A-SAA in monitoring subclinical inflammation and in colchicine dosage in familial Mediterranean fever. Clin Exp Rheumatol. 2003; 21: 509–14
42. Lachmann HJ, Sengül B, Yavuzşen TU, Booth DR, Booth SE, Bybee A. Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. Rheumatology (Oxford). 2006; 45: 746–50
43. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011; 17: 47–58.
44. Li B, Liu X, Cao ZG, Li Y, Liu TM, Wang RT. Elevated mean platelet volume is associated with silent cerebral infarction. Intern Med J. 2014; 44: 653-7.
45. Leader A, Pereg D, Lishner M. Are platelet volume indices of clinical use? A multidisciplinary review. Ann Med. 2012; 44: 805–16.
46. Turhan O, Coban E, Inan D, Yalcin AN. Increased mean platelet volume in chronic hepatitis B patients with inactive disease. Med Sci Monit. 2010; 16: CR202–5.
47. Bostan F, Coban E. The relationship between levels of von Willebrand factor and mean platelet volume in subjects with isolated impaired fasting glucose. Med Sci Monit, 2011; 17: PR1-4.

There are 47 citations in total.

Details

Primary Language	Turkish
Subjects	Internal Diseases
Journal Section	Research Article
Authors	Fatma Duksal This is me Ahmet Sami Güven This is me Mesut Arslan This is me Melih Timuçin Doğan This is me Utku Aygüneş This is me
Publication Date	August 1, 2020
Published in Issue	Year 2020 Volume: 18 Issue: 2

Cite

APA	Duksal, F., Güven, A. S., Arslan, M., Doğan, M. T., et al. (2020). Ailevi Akdeniz Ateşli Çocuklarda Ortalama Trombosit Hacmi Ve Trombosit Dağılım Genişliğinin Değerlendirilmesi. Güncel Pediatri, 18(2), 208-219. https://doi.org/10.32941/pediatri.775265
AMA	Duksal F, Güven AS, Arslan M, Doğan MT, Aygüneş U. Ailevi Akdeniz Ateşli Çocuklarda Ortalama Trombosit Hacmi Ve Trombosit Dağılım Genişliğinin Değerlendirilmesi. Güncel Pediatri. August 2020;18(2):208-219. doi:10.32941/pediatri.775265
Chicago	Duksal, Fatma, Ahmet Sami Güven, Mesut Arslan, Melih Timuçin Doğan, and Utku Aygüneş. “Ailevi Akdeniz Ateşli Çocuklarda Ortalama Trombosit Hacmi Ve Trombosit Dağılım Genişliğinin Değerlendirilmesi”. Güncel Pediatri 18, no. 2 (August 2020): 208-19. https://doi.org/10.32941/pediatri.775265.
EndNote	Duksal F, Güven AS, Arslan M, Doğan MT, Aygüneş U (August 1, 2020) Ailevi Akdeniz Ateşli Çocuklarda Ortalama Trombosit Hacmi Ve Trombosit Dağılım Genişliğinin Değerlendirilmesi. Güncel Pediatri 18 2 208–219.
IEEE	F. Duksal, A. S. Güven, M. Arslan, M. T. Doğan, and U. Aygüneş, “Ailevi Akdeniz Ateşli Çocuklarda Ortalama Trombosit Hacmi Ve Trombosit Dağılım Genişliğinin Değerlendirilmesi”, Güncel Pediatri, vol. 18, no. 2, pp. 208–219, 2020, doi: 10.32941/pediatri.775265.
ISNAD	Duksal, Fatma et al. “Ailevi Akdeniz Ateşli Çocuklarda Ortalama Trombosit Hacmi Ve Trombosit Dağılım Genişliğinin Değerlendirilmesi”. Güncel Pediatri 18/2 (August 2020), 208-219. https://doi.org/10.32941/pediatri.775265.
JAMA	Duksal F, Güven AS, Arslan M, Doğan MT, Aygüneş U. Ailevi Akdeniz Ateşli Çocuklarda Ortalama Trombosit Hacmi Ve Trombosit Dağılım Genişliğinin Değerlendirilmesi. Güncel Pediatri. 2020;18:208–219.
MLA	Duksal, Fatma et al. “Ailevi Akdeniz Ateşli Çocuklarda Ortalama Trombosit Hacmi Ve Trombosit Dağılım Genişliğinin Değerlendirilmesi”. Güncel Pediatri, vol. 18, no. 2, 2020, pp. 208-19, doi:10.32941/pediatri.775265.
Vancouver	Duksal F, Güven AS, Arslan M, Doğan MT, Aygüneş U. Ailevi Akdeniz Ateşli Çocuklarda Ortalama Trombosit Hacmi Ve Trombosit Dağılım Genişliğinin Değerlendirilmesi. Güncel Pediatri. 2020;18(2):208-19.

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