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Intermittent Explosive Disorder

Year 2011, , - 1, 01.09.2011
https://doi.org/10.5455/cap.20110318

Abstract

Intermittent explosive disorder is an impulse control disorder characterized by the occurrence of discrete episodes of failure to resist aggressive impulses that result in violent assault or destruction of property. Though the prevalence intermittent explosive disorder has been reported to be relatively rare in frontier studies on the field, it is now common opinion that intermittent explosive disorder is far more common than previously thought especially in clinical psychiatry settings. Etiological studies displayed the role of both psychosocial factors like childhood traumas and biological factors like dysfunctional neurotransmitter systems and genetics. In differential diagnosis of the disorder, disorders involving agression as a symptom such as alcohol and drug intoxication, antisocial and borderline personality disorders, personality changes due to general medical conditions and behavioral disorder should be considered. A combination of pharmacological and psychotherapeutic approaches are suggested in the treatment of the disorder. This article briefly reviews the historical background, diagnostic criteria, epidemiology, etiology and treatment of intermittent explosive disorder.

References

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  • Olvera RL. Intermittent explosive disorder: epidemiology, diagnosis and management. CNS Drugs 2002; 16:517-526.
  • Tamam L. Başka türlü sınıflandırılmamış dürtü kontrol bozuklukları. In Psikiyatri Temel Kitabı (Eds E Köroğlu, C Güleç, S Şenol). Ankara, MedicoGraphics Matbaa- sı, 2007.
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  • Coccaro EF, Kavoussi RJ, Hauger RL Cooper TB, Ferris CF.Cerebrospinal fluid vasopressin levels: correlates with aggression and serotonin function in personality- disordered subjects. Arch Gen Psychiatry 1998; 55:708-714.
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  • Coccaro EF, Lee R, McCloskey M. Norepinephrine function in personality disorder: plasma free MHPG correlates inversely with life history of aggression. CNS Spectr 2003; 8:731-736.
  • Bradford J, Geller J, Lesieur HR, Rosenthal R, Wise M. Impulse control disorders. In DSM-IV Sourcebook Vol.2 (Eds TA Widiger, AJ Widiger, AJ Frances, HA Pincus, MB First, R Ross, W Davis):1007-1032. Washington D.C., American Psychiatric Press, 1994.
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  • Kessler RC, Coccaro EF, Fava M, Jaeger S, Jin R, Walters E. The prevalence and correlates of DSM-IV Intermittent Explosive Disorder in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2006; 63:669-678.
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  • Tangur R. Sivas il merkezinde başka bir yerde sınıflandırılmamış dürtü kontrol bo- zuklukları: epidemiyoloji, komorbidite, belirti tarama listesi ve aile işlevlerinin değer- lendirilmesi (Uzmanlık Tezi). Sivas, Cumhuriyet Üniversitesi Tıp Fakültesi, 2001.
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  • Coccaro EF. Intermittent explosive disorder. In Aggression: Psychiatric Assessment and Treatment (Ed EF Coccaro):149-166. New York, Marcel Dekker, 2003.
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  • Coccaro EF, Bergeman CS, Kavoussi RJ, Seroczynski AD. Heritability of aggression and irritability:a twin study of the Buss-Durkee Aggression Scales in adult male subjects. Biol Psychiatry 1997; 41:273-284.
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Aralıklı Patlayıcı Bozukluk

Year 2011, , - 1, 01.09.2011
https://doi.org/10.5455/cap.20110318

Abstract

Aralıklı patlayıcı bozukluk ciddi saldırganlık ya da diğer insanların malına za-rar verme ile sonuçlanan ve yineleyen biçimde saldırganlık dürtülerine karşı koyamama atakları ile tanımlanan bir dürtü kontrol bozukluğudur. Önceleri oldukça nadir bir bozukluk olduğu bildirilmişse de, artık özellikle psikiyatrik örneklem gruplarında olmak üzere daha önce düşünüldüğünden çok daha sık görüldüğü kabul edilmektedir. Aralıklı patlayıcı bozukluğun etyolojisinde çocukluk travmaları gibi psikososyal nedenlerin yanı sıra genetik faktörler ve serotonin, noradrenalin ve dopamin gibi çeşitli nörotransmitter sistemlerindeki düzensizlikler gibi biyolojik nedenlerinde rol oynadığı bildirilmektedir. Bu bozukluğun ayırıcı tanısında alkol ve madde intoksikasyonu, antisosyal ve borderline kişilik bozuklukları, genel tıbbi duruma bağlı kişilik değişiklikleri ve davranım bozukluğu gibi agresyonun bir belirti olarak yer aldığı hastalıklar düşünülmelidir. Tedavisinde ise farmakolojik tedavi ile psikoterapötik sürecin bir arada sürdürülmesi önerilmektedir. Bu yazıda aralıklı patlayıcı bozukluk tanısının tarihsel gelişimi, tanı ölçütleri, epidemiyolojisi, nedenleri ve tedavi yaklaşımları gözden geçirilmeye çalışılmıştır.

References

  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. Washington, DC, American Psychiatric Association, 2000.
  • Olvera RL. Intermittent explosive disorder: epidemiology, diagnosis and management. CNS Drugs 2002; 16:517-526.
  • Tamam L. Başka türlü sınıflandırılmamış dürtü kontrol bozuklukları. In Psikiyatri Temel Kitabı (Eds E Köroğlu, C Güleç, S Şenol). Ankara, MedicoGraphics Matbaa- sı, 2007.
  • Gulli LF, Nasser B. Intermittent explosive disorder. In Gale Encylopedia of Mental Disorders Vol.2 (Eds E Thackery, M Harris):534-536. Farmington Hills, Thomson Gale, 2003.
  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 2nd ed. Washington, DC, American Psychiatric Association, 1968.
  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Third Edition. Washington, DC, American Psychiatric Association, 1980.
  • Greenberg HR. Impulse-control disorders not elsewhere classified. In Kaplan & Sadock’s Comprehensive Textbook of Psychiatry 8th ed. Vol.1. (Eds BJ Sadock, VA Sadock ):2035-2054 . Philadelphia, Lippincott Williams & Wilkins, 2005.
  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 3rd Edition, Revised. Washington, DC, American Psychiatric Association, 1987.
  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC, American Psychiatric Association,
  • Coccaro EF, Kavoussi RJ, Berman ME. Intermittent explosive disorder-revised: development, reliability and validity of research criteria. Compr Psychiatry 1998; 39:368-376.
  • Coccaro EF, Kavoussi RJ, Hauger RL Cooper TB, Ferris CF.Cerebrospinal fluid vasopressin levels: correlates with aggression and serotonin function in personality- disordered subjects. Arch Gen Psychiatry 1998; 55:708-714.
  • DiGiuseppe R, Tafrate RC. Understanding Anger Disorders. New York, Oxford University Press, 2007.
  • Coccaro EF, Lee R, McCloskey M. Norepinephrine function in personality disorder: plasma free MHPG correlates inversely with life history of aggression. CNS Spectr 2003; 8:731-736.
  • Bradford J, Geller J, Lesieur HR, Rosenthal R, Wise M. Impulse control disorders. In DSM-IV Sourcebook Vol.2 (Eds TA Widiger, AJ Widiger, AJ Frances, HA Pincus, MB First, R Ross, W Davis):1007-1032. Washington D.C., American Psychiatric Press, 1994.
  • Koelsch S, Sammler D, Jenstchke S, Siebel WA. EEG correlates of moderate intermittent explosive disorder. Clin Neurophysiol 2008; 119:151-162.
  • Grant JE, Levine L, Kim D, Potenza MN. Impulse control disorders in adult psychiatric inpatients. Am J Psychiatry 2005; 162:2184-2188.
  • Kessler RC, Coccaro EF, Fava M, Jaeger S, Jin R, Walters E. The prevalence and correlates of DSM-IV Intermittent Explosive Disorder in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2006; 63:669-678.
  • Monopolis S, Lion JR. Problems in the diagnosis of intermittent explosive disorder. Am J Psychiatry 1983; 140:1200-1202.
  • Felthous AR, Bryant SG, Wingerter CB, Barratt E. The diagnosis of intermittent explosive disorder in violent men. Bull Am Acad Psychiatry Law 1991;19:71-79.
  • Coccaro EF, Schmidt CA, Samuels JF Nestadt G. Lifetime and 1-month prevalence rates of intermittent explosive disorder in a community sample. J Clin Psychiatry 2004; 65:820-824.
  • Coccaro EF, Posternak MA, Zimmerman M. Prevalence and features of intermittent explosive disorder in a clinical setting. J Clin Psychiatry 2005; 66:1221-1227.
  • Tangur R. Sivas il merkezinde başka bir yerde sınıflandırılmamış dürtü kontrol bo- zuklukları: epidemiyoloji, komorbidite, belirti tarama listesi ve aile işlevlerinin değer- lendirilmesi (Uzmanlık Tezi). Sivas, Cumhuriyet Üniversitesi Tıp Fakültesi, 2001.
  • Tamam L, Zengin M, Karakuş G, Ozturk Z. The prevalence of impulse control disorders in an university psychiatry inpatient clinics. Klinik Psikofarmakoloji Bülte- ni 2008; 18:153-161.
  • Annagür BB, Tamam L. Depresyon hastalarında dürtü kontrol bozuklukları eş tanıla- rı. Nöropsikiyatri Arşivi 2011; 48:22-30.
  • McElroy SL, Soutullo CA, Beckman DA, Taylor P Jr, Keck PE Jr, DSM-IV intermittent explosive disorder: a report of 27 cases. J Clin Psychiatry 1998; 59:203
  • Galovski T, Blanchard EB. Psychological characteristics of aggressive drivers with and without intermittent explosive disorder. Behav Res Ther 2002; 40:1157-1168.
  • Galovski T, Blanchard EB, Veazey C. Intermittent explosive disorder and other psychiatric comorbidity among court-referred and self-referred aggressive drivers. Behav Res Ther 2002; 40:641-651.
  • Kay J, Tasman A. Essentials of Psychiatry. New York, John Wiley & Sons, 2006.
  • Winer JA, Pollock GH. Disorders of impulse control. In Comprehensive Textbook of Psychiatry, 3rd ed. Vol.2 (Eds HI Kaplan, AM Freedman, BJ Sadock):1817-1829. Baltimore, Williams& Wilkins, 1980.
  • Bach-Y-Rita G, Lion JR, Climent CF, Ervin FR. Episodic dyscontrol: A study of 130 violent patients. Am J Psychiatry 1971; 127:1473-1478.
  • Mattes JA, Fink M. A family study of patients with temper outbursts. J Psychiatr Res 1987; 21:249–255.
  • Coccaro EF. A family history study of intermittent explosive disorder. J Psychiatr Res 2010; 44:1101-1105.
  • Coccaro EF. Intermittent explosive disorder. In Aggression: Psychiatric Assessment and Treatment (Ed EF Coccaro):149-166. New York, Marcel Dekker, 2003.
  • Seroczynski AD, Bergeman CS, Coccaro EF. Etiology of the impulsivity/aggression relationship: genes or environment? Psychiatry Res 1999; 86:41-57.
  • Coccaro EF, Kavoussi RJ. Fluoxetine and impulsive aggressive behavior in personality disordered subjects. Arch Gen Psychiatry 1997; 54:1081-1088.
  • Coccaro EF, Bergeman CS, Kavoussi RJ, Seroczynski AD. Heritability of aggression and irritability:a twin study of the Buss-Durkee Aggression Scales in adult male subjects. Biol Psychiatry 1997; 41:273-284.
  • Coccaro EF, Kavoussi RJ, Cooper TB, Hauger RL. Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects. Am J Psychiatry 1997; 154:1430- 1435.
  • Manuck SB, Flory JD, Ferrell RE, Dent KM, Mann JJ, Muldoon MF. Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene. Biol Psychiatry 1999; 45:603-614.
  • Manuck SB, Flory JD, Ferrell RE, Mann JJ, Muldoon MF. A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity. Psychiatry Res 2000; 95:9-23.
  • Bioulac B, Benezech M, Renaud B, Noel B, Roche D. Serotoninergic dysfunction in the 47, XYY syndrome. Biol Psychiatry 1980; 15:917-923.
  • Coccaro EF. Intermittent explosive disorder: Taming temper tantrums in the volatile, impulsive adult. Curr Psychiatry 2003; 2:42-60.
  • Coccaro EF, Danehy M. Intermittent explosive disorder. In Clinical Manual of Impulse Control Disorders (Eds E Hollander, DJ Stein):19-38. Arlington, American Psychiatric Publishing, 2006.
  • Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M. Suicidality and 5- hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Arch Gen Psychiatry 1994; 51:34-38.
  • Virkkunen M, Rawlings R, Tokola R, Poland RE, Guidotti A, Nemeroff C et al. CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiatry 1994; 51:20-27.
  • Brown GL, Goodwin FK, Ballenger JC, Gover PF, Major LF. Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res 1979; 1:131- 139.
  • Linnoila M, Virkkunen M, Scheinin M, Nuutila A, Rimon R, Goodwin FK. Low cerebrospinal fluid 5-hydroxyindolacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci 1983; 33:2609-2614.
  • Abay E, Tuğlu C. Şiddet ve Agresyonun Nörobiyolojisi. Klinik Psikiyatri Dergisi 2000; 3:21-26.
  • Coccaro EF, Berman ME, Kavoussi RJ, Hauger RL. Relationship of prolactin response to d-fenfluramine to behavioral and questionnaire assessments of aggression in personality-disordered men. Biol Psychiatry 1996; 40:157-164.
  • Lyons WE, Mamounas LA, Ricaurte GA, Coppola V, Reid SW, Bora SH et al. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc Natl Acad Sci U S A 1999; 21:15239-15244.
  • Delville Y, Mansour KM, Ferris CF. Serotonin blocks vasopressin-facilitated offensive aggression: interactions within the ventrolateral hypothalamus of golden hamsters. Physiol Behav 1996; 59:813-816
  • Nelson RJ, Trainor BC. Neural mechanisms of aggression. Nature Rev Neurosci 2007; 8:536-546.
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There are 88 citations in total.

Details

Primary Language Turkish
Journal Section Review
Authors

Lut Tamam This is me

Meliha Zengin Eroğlu This is me

Özlem Paltacı This is me

Publication Date September 1, 2011
Published in Issue Year 2011

Cite

AMA Tamam L, Eroğlu MZ, Paltacı Ö. Aralıklı Patlayıcı Bozukluk. Psikiyatride Güncel Yaklaşımlar. September 2011;3(3):1. doi:10.5455/cap.20110318

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