Treatment Resistant Bipolar Disorder

Abstract

Many patients diagnosed with bipolar disorder respond incompletely or unsatisfactorily to available treatments. Defining refractoriness in bipolar disorder is a complex issue and should concern and include either every phase and pole or the disorder as a whole. There are only limited and sometimes confusing data on the treatment of refractory bipolar patients. The objective of this paper was to review the evidence for treatment options in treatment resistant patients on depressive, manic attack and maintanence phase as found in randomized controlled trials and with special attention to the definition and assessment of treatment resistance.

 

Keywords

• Bipolar disorder, treatment resistance

Tedaviye Dirençli Bipolar Bozukluk

Öz

Bipolar bozukluk tanısı alan pek çok hasta uygun tedavilere yetersiz yanıt verirler. Bipolar bozuklukta dirençliliği tanımlamak oldukça zordur ve hastalığın hem bütününü ve hem de her atağını ayrı ayrı kapsamalıdır. Tedaviye dirençli bipolar bozukluk hastaları ile ilgili çalışmalar az sayıdadır ve çelişkili bilgiler içermektedirler. Bu yazının amacı, mani, depresyon atağında olan ya da idame dönemdeki tedaviye dirençli bipolar hastaların randomize kontrollü çalışmalar düzeyinde verilerini değerlendirmek ve tedaviye direncin değerlendirilmesi ve tanımlanmasına dikkat çekmektir.

 

Anahtar Kelimeler

• Bipolar bozukluk, tedavi direnci

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