Novel Codes of Psychiatry: microRNAs

Abstract

Current knowledge on neurobiology and genetics of psychiatric disorders are limited. MicroRNA are approximately 22 nucleotides long. Their biogenesis starts in the nucleus and maturation continues in the cytoplasm of cells. MicroRNA influence the genes in posttranscriptional level that commonly appear as inhibition. MicroRNAs are crucial for neurogenesis, synaptic plasticity and several neurobiological processes. For psychiatric disorders they are found to be dysregulated in both central nervous system and peripheral tissues. Knowledge and research on microRNAs keep evolving day by day. Although they have been investigated widely, we still need extensive research on this field.

 

Keywords

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Psikiyatrinin Yeni Kodları: MikroRNA’lar

Abstract

Psikiyatrik bozuklukların nörobiyolojisi ve genetiği halen tam olarak anlaşılabilmiş değildir. MikroRNA’lar çekirdekte sentezlenip olgunlaşmasını sitoplazmada devam ettiren, yaklaşık 22 nükleotid uzunluğuna erişen, genlerin açılımını post-transkripsiyonel aşamalarda etkileyen yapılardır. Sıklıkla inhibisyon yönünde etki eden bu yapıların sinaptik plastisite, nörogenez ve diğer nörobiyolojik süreçlerde oldukça önemli bir role sahip oldukları, psikiyatrik hastalıklarda gerek santral gerekse periferik dokularda disregüle oldukları gösterilmiştir. MikroRNA’ların zaman geçtikçe gelişen ve gençleşen bir alan olduğu, bugüne kadar yapılmış olan çalışmaların ilerde yapılacak olan çalışmalara ışık tutacağı ve halen yeni çalışmalara ihtiyaç duyulduğu akılda tutulmalıdır.

Keywords

• Psikiyatri, mikroRNA, nörobiyoloji

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