Music Therapy in Various Physical and Mental Conditions and Its Effects on Cancer Patients Receiving Radiotherapy

Abstract

Music therapy is widely used as a non-pharmacological intervention in a variety of different clinical and therapeutic settings. Several studies have been conducted on the possible effect of music on immediate symptoms, especially anxiety, stress and pain, resulting from disease states and/or invasive medical procedures. The aim of this review is to discuss the use of music therapy in various physical and mental disorders and to examine its effects on adult cancer patients undergoing radiation therapy. The results obtained show that music therapy applications have the potential to be used alone or in combination with standard pharmacological treatment to reduce perceived pain, anxiety and fatigue levels in cancer patients receiving radiotherapy during their treatment and may have positive effects on improving the experience of cancer patients receiving radiotherapy during the treatment process. It is stated that more well-designed research is needed to investigate the effects of music therapy, especially in the field of radiation oncology.

Keywords

• Cancer
• radiotherapy
• music therapy
• anxiety
• fatigue
• pain

Müzik Terapisinin Çeşitli Fiziksel ve Ruhsal Durumlarda Kullanımı ve Radyoterapi Alan Kanser Hastalarında Etkileri

Öz

Müzik ve müzik terapisi, çeşitli nitelikteki farklı klinik ve terapötik ortamlarda, farmakolojik olmayan müdahale yöntemleri olarak yaygın şekilde kullanılmaktadır. Müziğin, hastalık durumlarından ve/veya özellikle invaziv tıbbi prosedürlerden kaynaklanan, özellikle anksiyete, stres ve ağrı gibi anlık semptomlar üzerindeki olası etkisi ile ilgili çeşitli çalışmalar yapılmıştır. Bu derlemenin amacı, müzik terapi uygulamasının çeşitli fiziksel ve tuhsal bozukluklarda kullanımından söz ederek, radyasyon tedavisi gören yetişkin kanserli hastalar üzerindeki etkilerini incelemektir. Elde edilen sonuçlar, müzik terapi uygulamalarının radyoterapi alan kanser hastalarında tedavileri sırasında algılanan ağrı, anksiyete ve yorgunluk seviyelerini azaltmak için standart farmakolojik tedavi ile birlikte ya da tek başına kullanılma potansiyeline sahip olduğunu ve radyoterapi alan kanser hastalarının tedavi sürecindeki deneyimini iyileştirmede olumlu etkileri olabileceğini göstermektedir. Müzik terapisinin özellikle radyasyon onkolojisi alanındaki etkilerini araştırmak için iyi tasarlanmış daha fazla araştırmaya ihtiyaç olduğu belirtilmektedir.

Anahtar Kelimeler

• Kanser
• radyoterapi
• müzik terapi
• kaygı
• yorgunluk
• ağrı

References

1. Alcântara-Silva TR, de Freitas-Junior R, Freitas NMA, de Paula Junior W, da Silva DJ, Machado GDP et al. (2018) Music therapy reduces radiotherapy-induced fatigue in patients with breast or gynecological cancer: a randomized trial. Integr Cancer Ther, 17:628–635.
2. Atiwannapat P, Thaipisuttikul P, Poopityastaporn P, Katekaew W (2016) Active versus receptive group music therapy for major depressive disorder: A pilot study. Complement Ther Med, 26:141–145.
3. Bashiri M, Akcali D, Coskun D, Cindoruk M, Dikmen A, Ucaner Cifdaloz B (2018) Evaluation of pain and patient satisfaction by music therapy in patients with endoscopy/colonoscopy. Turk J Gastroenterol, 29:574–579.
4. Bates D, Bolwell B, Majhail NS, Rybicki L, Yurch M, Abounader D et al. (2017) Music therapy for symptom management after autologous stem cell transplantation: results from a randomized study. Biol Blood Marrow Transplant, 23:1567–1572.
5. Beck BD, Meyer SL, Simonsen E, Søgaard U, Petersen I, Arnfred SMH et al. (2021) Music therapy was noninferior to verbal standard treatment of traumatized refugees in mental health care: Results from a randomized clinical trial. Eur J Psychotraumatol, 12:1930960.
6. Bradt J, Dileo C, Magill L, Teague A (2016) Music interventions for improving psychological and physical outcomes in cancer patients Cochrane Database Syst Rev, 8:CD006911..
7. Bradt J, Potvin N, Kesslick A, Shim M, Radl D, Schriver E et al. (2015) The impact of music therapy versus music medicine on psychological outcomes and pain in cancer patients: a mixed methods study. Support Care Cancer, 23:1261–1271.
8. Chau I, Fuchs CS, Ohtsu A, Barzi A, Liepa AM, Cui ZL et al. (2019) Association of quality of life with disease characteristics and treatment outcomes in patients with advanced gastric cancer: Exploratory analysis of RAINBOW and REGARD phase III trials. Eur J Cancer, 107:115–123.

9. Chen LC, Wang TF, Shih YN, Wu LJ (2013) Fifteen-minute music intervention reduces pre-radiotherapy anxiety in oncology patients. Eur J Oncol Nurs, 17:436–441.
10. Chu H, Yang CY, Lin Y, Ou KL, Lee TY, O’Brien AP et al. (2014) The impact of group music therapy on depression and cognition in elderly persons with dementia: a randomized controlled study. Biol Res Nurs, 16:209–217.
11. Chu-Hui-Lin Chi G, Young A, McFarlane J, Watson M, Coleman RL, Eifel PJ et al. (2015) Effects of music relaxation video on pain and anxiety for women with gynaecological cancer receiving intracavitary brachytherapy: a randomised controlled trial. J Res Nurs, 20:129–144.
12. Clark M, Gloria Isaacks-Downton M, Nancy Wells M, Redlin-Frazier S, Carol Eck O, Joseph R et al. (2006) Use of preferred music to reduce emotional distress and symptom activity during radiation therapy. J Music Ther, 43:247–265.
13. Clemens P, Szeverinski P, Tschann P, Dietl M, Gurk J, Kowatsch M, et al. (2023) Physical and nonphysical effects of weekly music therapy intervention on the condition of radiooncology patients. Strahlenther Onkol, 199:268–277.
14. Çağlar A, Ünal H, Aydın K, Yavuz MG, Kılıç Ş (2021) Türk musikisinin ve müzik terapinin kesişimi: TÜMATA. Ankara, İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü.
15. Çelebi D, Yılmaz E, Şahin ST, Baydur H (2020) The effect of music therapy during colonoscopy on pain, anxiety and patient comfort: A randomized controlled trial. Complement Ther Clin Pract, 38:101084.
16. de Witte M, Pinho A da S, Stams GJ, Moonen X, Bos AER, van Hooren S (2022) Music therapy for stress reduction: a systematic review and meta-analysis. Health Psychol Rev, 16:134–159.
17. Deng C, Xie Y, Liu Y, Li Y, Xiao Y (2022) Aromatherapy plus music therapy ımprove pain ıntensity and anxiety scores in patients with breast cancer during perioperative periods: a randomized controlled trial: aromatherapy plus music therapy on pain and anxiety. Clin Breast Cancer, 22:115–120.
18. Frye S, Weaver C, Dwiggins A, McMunn A, Hardy A, Batha C et al. (2020) Live music therapy impact on anxiety of patients receiving PET/CT scans. J Nucl Med, 61(Suppl 1):30-34.
19. Gallagher LM, Gardner V, Bates D, Mason S, Nemecek J, DiFiore JB et al. (2018) Impact of music therapy on hospitalized patients post-elective orthopaedic surgery. Orthop Nurs, 37:124–133.
20. Gök Ugur H, Yaman Aktaş Y, Orak OS, Sağlambilen O, Aydin Avci İ (2017) The effect of music therapy on depression and physiological parameters in elderly people living in a Turkish nursing home: a randomized-controlled trial. Aging Ment Health, 21:1280–1286.
21. Grocke D, Bloch S, Castle D, Thompson G, Newton R, Stewart S et al. (2014) Group music therapy for severe mental illness: a randomized embedded‐experimental mixed methods study. Acta Psychiatr Scand, 130:144–153.
22. Hanedan Uslu G (2017) Influence of music therapy on the state of anxiety during radiotherapy. Turk Onkoloji Dergisi, 32:141–147.
23. Hsu MH, Flowerdew R, Parker M, Fachner J, Odell-Miller H (2015) Individual music therapy for managing neuropsychiatric symptoms for people with dementia and their carers: a cluster randomised controlled feasibility study. BMC Geriatr, 15:84.
24. Huda N, Banda KJ, Liu AI, Huang TW (2023) Effects of music therapy on spiritual well-being among patients with advanced cancer in palliative care: a meta-analysis of randomized controlled trials. Semin Oncol Nurs, 39:151481.
25. Iliya YA (2015) Music therapy as grief therapy for adults with mental ıllness and complicated grief: a pilot study. Death Stud, 39:173–184.
26. Impellizzeri F, Leonardi S, Latella D, Maggio MG, Foti Cuzzola M, Russo M, et al. (2020) An integrative cognitive rehabilitation using neurologic music therapy in multiple sclerosis: a pilot study. Medicine, 99:e18866.
27. Jelen B, Uçaner B (2015) Müzik terapi uygulamaları ve bazi ülkelerdeki eğitimi. Folklor Edebiyat, 21:35–46.
28. Jeon BK, Yeo JD (2011) Effects of music therapy on the anxiety of patients who take the magnetic resonance imaging(MRI) test. The Journal of the Korea Contents Association, 11:289–301.
29. Khan FM, Gibbons JP, Sperduto PW (2016) Khan’s Treatment Planning in Radiation Oncology, 4nd ed. Philadelphia, Wolters Kluwer Health.
30. Kizir A, Güveli ME (2019) Radyoterapi. In Onkoloji Hemşireliği. 2nd ed. (Ed G Can):103–116. İstanbul, Nobel Tıp Kitabevleri.
31. Knoerl R, Mazzola E, Woods H, Buchbinder E, Frazier L, LaCasce A et al. (2022) Exploring the feasibility of a mindfulness-music therapy ıntervention to ımprove anxiety and stress in adolescents and young adults with cancer. J Pain Symptom Manage, 63:357-363.
32. Köhler F, Martin ZS, Hertrampf RS, Gäbel C, Kessler J, Ditzen B et al. (2020) Music therapy in the psychosocial treatment of adult cancer patients: a systematic review and meta-analysis. Front Psychol, 11:651.
33. Leonard H (2019) Live Music therapy during rehabilitation after total knee arthroplasty: a randomized controlled trial. J Music Ther, 56:61–89.
34. Li Y, Xing X, Shi X, Yan P, Chen Y, Li M et al. (2020) The effectiveness of music therapy for patients with cancer: a systematic review and meta-analysis. J Adv Nurs, 76:1111–1123.
35. Lin ZW, Huang ST, Xu N, Cao H, Chen LW, Chen Q (2020) Effect of music therapy on the chronic pain and midterm quality of life of patients after mechanical valve replacement. Ann Thorac Cardiovasc Surg, 26:196–201.
36. Liu H, Gao X, Hou Y (2019) Effects of mindfulness-based stress reduction combined with music therapy on pain, anxiety, and sleep quality in patients with osteosarcoma. Braz J Psychiatry, 41:540–545.
37. Liu Q, Li W, Yin Y, Zhao Z, Yang Y, Zhao Y et al. (2022) The effect of music therapy on language recovery in patients with aphasia after stroke: a systematic review and meta-analysis. Neurol Sci, 43:863–872.
38. Liu Y, Petrini MA (2015) Effects of music therapy on pain, anxiety, and vital signs in patients after thoracic surgery. Complement Ther Med, 23:714–718.
39. Lorber M, Divjak S (2022) Music Therapy as an intervention to reduce blood pressure and anxiety levels in older adults with hypertension: a randomized controlled trial. Res Gerontol Nurs, 15:85–92.
40. Lu G, Jia R, Liang D, Yu J, Wu Z, Chen C (2021) Effects of music therapy on anxiety: a meta-analysis of randomized controlled trials. Psychiatry Res, 304:114137.
41. Lyu J, Zhang J, Mu H, Li W, Champ M, Xiong Q et al. (2018) The effects of music therapy on cognition, psychiatric symptoms, and activities of daily living in patients with alzheimer’s disease. J Alzheimers Dis, 64:1347–1358.
42. M Smith, L Casey, D Johnson, C Gwede, O Z Riggin (2001) Music as a therapeutic intervention for anxiety in patients receiving radiation therapy. Oncol Nurs Forum, 28:855–862.
43. Machado Sotomayor MJ, Arufe-Giráldez V, Ruíz-Rico G, Navarro-Patón R (2021) Music therapy and parkinson’s disease: a systematic review from 2015–2020. Int J Environ Res Public Health, 18:11618.
44. Martínez-Molina N, Siponkoski ST, Kuusela L, Laitinen S, Holma M, Ahlfors M et al. (2021) Resting-state network plasticity ınduced by music therapy after traumatic brain ınjury. Neural Plast, 2021:6682471.
45. Mejía-Rubalcava C, Alanís-Tavira J, Mendieta-Zerón H, Sánchez-Pérez L (2015) Changes induced by music therapy to physiologic parameters in patients with dental anxiety. Complement Ther Clin Pract, 21:282–286.
46. Mercier LJ, Langelier DM, Lee CH, Brown-Hall B, Grant C, Plamondon S (2023) Effects of music therapy on mood, pain, and satisfaction in the neurologic inpatient setting. Disabil Rehabil, 45:2964–2975.
47. Miladinia M, Voss JG, Molavynejad S, Malehi AS, Zarea K, Nouri EM et al. (2021) Slow-stroke back massage compared with music therapy for leukemia-related pain and fatigue: a randomized controlled trial. JCO Oncol Pract, 17:1614-1621.
48. Moreno-Morales C, Calero R, Moreno-Morales P, Pintado C (2020) Music therapy in the treatment of dementia: a systematic review and meta-analysis. Front Med, 7:160.
49. Mou Q, Wang X, Xu H, Liu X, Li J (2020) Effects of passive music therapy on anxiety and vital signs in lung cancer patients undergoing peripherally inserted central catheter placement procedure. J Vasc Access, 21:875–882.
50. Nardone V, Vinciguerra C, Correale P, Guida C, Tini P, Reginelli A et al. (2020) Music therapy and radiation oncology: state of art and future directions. Complement Ther Clin Pract, 39:101124.
51. O’Callaghan C, Sproston M, Wilkinson K, Willis D, Milner A, Grocke D et al. (2012) Effect of self-selected music on adults’ anxiety and subjective experiences during initial radiotherapy treatment: a randomised controlled trial and qualitative research. J Med Imaging Radiat Oncol, 56:473-477.
52. O’steen L, Lockney NA, Morris CG, Johnson-Mallard V, Pereira D, Amdur RJ (2021) A prospective randomized trial of the ınfluence of music on anxiety in patients starting radiation therapy for cancer. Int J Radiat Oncol Biol Phys, 109:670–674.
53. Ortega A, Gauna F, Munoz D, Oberreuter G, Breinbauer HA, Carrasco L (2019) Music therapy for pain and anxiety management in nasal bone fracture reduction: randomized controlled clinical trial. Otolaryngol Head Neck Surg, 161:613–619.
54. Öztürk L (2020) Müzik terapide reseptif yaklaşımlar ve somnolojik/somnojenik müzik terapi. In Müzik Terapi, Müzik Tıbbı ve Müzik Temelli Diğer Uygulamalar (Ed Ş Torun): 31–40. Ankara, Türkiye Klinikleri.
55. Pandey S, Singaravelan RR (2019) Effects of music therapy on cognitive function and mood in patients with middle cerebral artery stroke. Int J Health Sci, 9:151.
56. Paul S, Ramsey D (2000) Music therapy in physical medicine and rehabilitation. Aust Occup Ther J, 47:111-118.
57. Peterson N (2021) The music man: TUMATA and Turkish music therapy. liberated arts: Liberated Arts, 8:7.
58. Raglio A, Bellandi D, Baiardi P, Gianotti M, Ubezio MC, Zanacchi E et al. (2015) Effect of active music therapy and ındividualized listening to music on dementia: a multicenter randomized controlled trial. J Am Geriatr Soc, 63:1534-1539.
59. Raglio A, Giovanazzi E, Pain D, Baiardi P, Imbriani C, Imbriani M et al. (2016) Active music therapy approach in amyotrophic lateral sclerosis: a randomized-controlled trial. Int J Rehabil Res, 39:365-367.
60. Raglio A, Oddone E, Meaglia I, Monti MC, Gnesi M, Gontero G et al. (2021) Conventional and algorithmic music listening before radiotherapy treatment: a randomized controlled pilot study. Brain Sci, 11:1618.
61. Reimnitz L, Silverman MJ (2020) A randomized pilot study of music therapy in the form of patient-preferred live music on fatigue, energy and pain in hospitalized adult oncology patients on a blood and marrow transplant unit. Arts Health, 12:154–168.
62. Rennie C, Irvine DS, Huang E, Huang J (2022) Music therapy as a form of nonpharmacologic pain modulation in patients with cancer: a systematic review of the current literature. Cancers, 14:4416.
63. Ridder HMO, Stige B, Qvale LG, Gold C (2013) Individual music therapy for agitation in dementia: an exploratory randomized controlled trial. Aging Ment Health, 17:667–678.
64. Rossetti A, Chadha M, Torres BN, Lee JK, Hylton D, Loewy J V et al. (2017) The impact of music therapy on anxiety in cancer patients undergoing simulation for radiation therapy. Int J Radiat Oncol Biol Phys, 99:103–110.
65. Rossetti A, Loewy J, Fischer Z, Deshpande S, Chadha M (2023) The effects of environmental music therapy on anxiety and waiting in radiation oncology. Music Med, 15(1):7.
66. Sezen S, Can ÜK (2023) Türklerde müzikle tedavi merkezlerinin günümüz temsilcisi: türk musikisini araştırma ve tanıtma grubu. Motif Akademi Halkbilimi Dergisi, 16:1807–1826.
67. Sezgin MG, Bektas H (2022) The effect of music therapy interventions on fatigue in patients with hematological cancers: a systematic review and meta-analysis of randomized controlled trials. Support Care Cancer, 30:8733–8744.
68. Shirani Bidabadi S, Mehryar A (2015) Music therapy as an adjunct to standard treatment for obsessive compulsive disorder and co-morbid anxiety and depression: A randomized clinical trial. J Affect Disord, 184:13–17.
69. Siponkoski ST, Martínez-Molina N, Kuusela L, Laitinen S, Holma M, Ahlfors M et al. (2020) Music therapy enhances executive functions and prefrontal structural neuroplasticity after traumatic brain ınjury: evidence from a randomized controlled trial. J Neurotrauma, 37:618–634.
70. Strzemecka J (2013) Music therapy in rehabilitation. Journal of Pre-Clinical and Clinical Research, 7:19–22.
71. Torun Ş (2020) Müzik terapide aktif yaklaşımlar ve nörokreatif müzik terapi. In Müzik Terapi, Müzik Tıbbı ve Müzik Temelli Diğer Uygulamalar. (Ed Ş Torun):20-30. Ankara, Türkiye Klinikleri
72. Torun Ş (2020) Sağlık alanında müzik temelli uygulamalar: müzik terapi, müzik tıbbı ve diğerleri. Türkiye Klinikleri Geleneksel ve Tamamlayıcı Tıp-Özel Konular, 1:9-19.
73. Trigueros-Murillo A, Martinez-Calderon J, Casuso-Holgado MJ, González-García P, Heredia-Rizo AM (2023) Effects of music-based interventions on cancer-related pain, fatigue, and distress: an overview of systematic reviews. Support Care Cancer, 31:488.
74. Tuinmann G, Preissler P, Böhmer H, Suling A, Bokemeyer C (2017) The effects of music therapy in patients with high‐dose chemotherapy and stem cell support: a randomized pilot study. Psychooncology, 26:377–384.
75. Ünal Toprak F, Uysal N, Göksel F, Soylu Y (2024) The effect of music on anxiety, pain levels, and physiological parameters in women undergoing brachytherapy: a randomized controlled trial. Semin Oncol Nurs, 40:151575.
76. van Bruggen-Rufi MCH, Vink AC, Wolterbeek R, Achterberg WP, Roos RAC (2017) The effect of music therapy in patients with huntington’s disease: a randomized controlled trial. J Huntingtons Dis, 6:63–72.
77. Vaudreuil R, Avila L, Bradt J, Pasquina P (2019) Music therapy applied to complex blast injury in interdisciplinary care: A case report. Disabil Rehabil, 41:2333–2342.
78. Verrusio W, Andreozzi P, Marigliano B, Renzi A, Gianturco V, Pecci MT et al. (2014) Exercise training and music therapy in elderly with depressive syndrome: A pilot study. Complement Ther Med, 22:614–620.
79. Wang M, Yi G, Gao H, Wu B, Zhou Y (2020) Music-based interventions to improve fibromyalgia syndrome: A meta-analysis. Explore (NY), 16:357–362.
80. Wang Y, Tang H, Guo Q, Liu J, Liu X, Luo J et al. (2015) Effects of intravenous patient-controlled sufentanil analgesia and music therapy on pain and hemodynamics after surgery for lung cancer: a randomized parallel study. J Altern Complement Med, 21:667–672.
81. Warth M, Keßler J, Hillecke TK, Bardenheuer HJ (2015) Music therapy in palliative care. Dtsch Arztebl Int, 112:788–794.
82. Weller CM, Baker FA (2011) The role of music therapy in physical rehabilitation: a systematic literature review. Nord J Music Ther, 20:43–61.
83. Wellington Ferreira Fontes G (2023) Music therapy in physıcal treatment. Revista Gênero e Interdisciplinaridade, 4:226–246.
84. Wen X, Shi J, Tan W, Jiang H, Wang D, Su J et al. (2023) Effects of aromatherapy and music therapy on patients’ anxiety during MRI examinations: a randomized controlled trial. Eur Radiol, 33:2510–2518.
85. Werner J, Wosch T, Gold C (2017) Effectiveness of group music therapy versus recreational group singing for depressive symptoms of elderly nursing home residents: pragmatic trial. Aging Ment Health, 21:147–155.
86. Xue B, Meng X, Liu Q, Luo X (2023) The effect of receptive music therapy on older adults with mild cognitive impairment and depression: a randomized controlled trial. Sci Rep, 13:22159.
87. Yakupov EZ, Nalbat A V., Semenova M V., Tlegenova KA (2017) Music therapy as an effective method of neurorehabilitation. Zh Nevrol Psikhiatr Im S S Korsakova, 117:14–21.
88. Yaman Aktaş Y, Karabulut N (2016) The effects of music therapy in endotracheal suctioning of mechanically ventilated patients. Nurs Crit Care, 21:44–52.
89. Yaman H, Öztürk B (2024) Investigation of the effects of music therapy on participation in daily living activities and quality of life in males diagnosed with schizophrenia. İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi 21:1050–1064.
90. Yarahmadi S, Mohammadi N, Ardalan A, Najafizadeh H, Gholami M (2018) The combined effects of cold therapy and music therapy on pain following chest tube removal among patients with cardiac bypass surgery. Complement Ther Clin Pract, 31:71–75.
91. Yoon YH, Yoon HJ, Lee SK, Kim KH, Kwon G (2016) The effects of the communication accompanied with music therapy on the anxiety of the patients during the MRI examination. Journal of the Korea Academia-Industrial Cooperation Society, 17:93–102.
92. Zeppegno P, Krengli M, Ferrante D, Bagnati M, Burgio V, Farruggio S et al. (2021) Psychotherapy with music intervention improves anxiety, depression and the redox status in breast cancer patients undergoing radiotherapy: a randomized controlled clinical trial. Cancers (Basel), 13:1752.
93. Zhao F, Sun Z, Niu W (2023) Effect of ward noise reduction technology combined with music therapy on negative emotions in ınpatients undergoing gastric cancer radiotherapy: a retrospective study. Noise Health, 25:257–263.
94. Zhong FP, Zhong J, Zhong MY (2023) Effect of music therapy on chemotherapy-induced nausea and vomiting in gastrointestinal cancer: a systematic review and meta-analysis. World J Gastrointest Surg, 15:471.