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Prenatal Enflamasyon ve Dikkat Eksikliği Hiperaktivite Bozukluğu İlişkisi

Year 2021, , 478 - 489, 30.09.2021
https://doi.org/10.18863/pgy.811846

Abstract

Dikkat Eksikliği Hiperaktivite Bozukluğu (DEHB) dikkat eksikliği, hiperaktivite ve dürtüsellik ile karakterize kronik, nörogelişimsel bir bozukluktur. Akademik, sosyal, duygusal ve bilişsel alanlarda bozulma ile seyreder. DEHB etiyolojisinde genetik ve çevresel birçok faktör rol oynamaktadır. DEHB tanısı alanlarda yapılan çok sayıda çalışmada enflamasyon ile ilişkili parametrelerde yükseklik saptanmıştır. Alerjik ve immünolojik durumlar ile DEHB birlikteliği, DEHB etiyolojisinde immün sistem etkisini düşündürmektedir. Prenatal dönemde maruz kalınan enflamasyon ile nörogelişimsel bozukluklar arasındaki güçlü bir ilişki olduğu gösterilmiştir. DEHB oluşumuna neden olabilecek prenatal risk faktörlerinden kabul edilen maternal diyabet, vücut kitle indeksi, preeklampsi, enfeksiyon, annenin kronik veya otoimmün hastalıkları gibi parametreler annenin enflamatuvar profili ile ilişkili bulunmaktadır. Bu nedenle intrauterin enflamasyona maruziyet ile DEHB arasındaki ilişki ilgi çekmektedir. Bu derlemede, maternal immün sistem hiperaktivasyonuna neden olabilecek durumlar ile olası prenatal nöroenflamasyon ve DEHB ilişkisi gözden geçirilmiştir.

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Relationship between Prenatal Inflammation and Attention Deficit Hyperactivity Disorder

Year 2021, , 478 - 489, 30.09.2021
https://doi.org/10.18863/pgy.811846

Abstract

Attention Deficit Hyperactivity Disorder (ADHD) is a chronic neurodevelopmental disorder characterized by attention deficit, hyperactivity, and impulsivity. ADHD presents impairments in academic, social, emotional and cognitive domains. Genetic and environmental factors play a role in the etiology of ADHD. Numerous studies showed that parameters associated with inflammation were higher in patients with ADHD. Due to the co-occurrence of ADHD and allergic and immunologic disorders, it is thought that the immune system has an effect on ADHD etiology. Previous studies showed that there is a strong association between prenatal inflammation exposure and neurodevelopmental disorders. Maternal diabetes mellitus, body mass index, preeclampsia, infections and chronic or autoimmune disorders of the mother are accepted as prenatal risk factors of ADHD. All these risk factors are associated with the immune profile of the mother. Because of this, the association between ADHD and intrauterine inflammation exposure is attractive. In this paper, the association of ADHD and perinatal inflammation due to maternal immune activation is reviewed.

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There are 97 citations in total.

Details

Primary Language Turkish
Subjects Psychiatry
Journal Section Review
Authors

Canan Kuygun Karcı 0000-0002-9355-9449

Publication Date September 30, 2021
Acceptance Date December 24, 2020
Published in Issue Year 2021

Cite

AMA Kuygun Karcı C. Prenatal Enflamasyon ve Dikkat Eksikliği Hiperaktivite Bozukluğu İlişkisi. Psikiyatride Güncel Yaklaşımlar. September 2021;13(3):478-489. doi:10.18863/pgy.811846

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