Iron Deficiency in the Pathophysiology of Attention Deficit Hyperactivity Disorder

Year 2015, Volume: 7 Issue: 1, 41 - 55, 01.03.2015

İpek Perçinel Kemal Utku Yazıcı

https://doi.org/10.5455/cap.20140528100225

Abstract

Although attention deficit and hyperactivity disorder is one of the most studied disorders in medical literature, its etiology has not been completely elucidated. Clarification of the factors associated with attention deficit and hyperactivity disorder is of significance for the curative treatment of the disorder. While literature states that iron deficiency may present a risk factor for the pathophysiology of attention deficit and hyperactivity disorder, the studies made on this subject so far have provided contradictory results. This article aims to analyze the studies of children and adolescents in literature made in Turkey and abroad on the levels of iron and iron-related parameters in blood, which are considered to be effective in the pathophysiology of attention deficit and hyperactivity disorder, compile the general characteristics of those studies and present the results.

Keywords

Iron, attention deficit hyperactivity disorder, ferritin, pathophysiology

Dikkat Eksikliği ve Hiperaktivite Bozukluğu Patofizyolojisinde Demir Eksikliği

Abstract

Dikkat eksikliği ve hiperaktivite bozukluğu, tıp literatüründe en iyi araştırılmış bozukluklardan biri olmasına rağmen, etiyolojisi halen net olarak açıklığa kavuşturulamamıştır. Dikkat eksikliği ve hiperaktivite bozukluğu’nun küratif şekilde tedavi edilmesi için bozukluk ile ilişkili etmenlerin net olarak aydınlatılması oldukça önemlidir. Literatür incelendiğinde, demir eksikliğinin dikkat eksikliği ve hiperaktivite bozukluğu patofizyolojisi için bir risk faktörü olabileceği belirtilmekle birlikte, konu ile ilgili şu ana kadar yapılan çalışmalarda çelişkili sonuçlar elde edildiği gözlenmektedir. Bu yazıda, dikkat eksikliği ve hiperaktivite bozukluğu patofizyolojisinde etkili olduğu düşünülen demir ve demirle ilişkili parametrelerin kan düzeyleri ile ilgili literatürdeki, çocuk ve ergen yaş grubunda, ülkemizde ve yurt dışında yapılmış konu ile ilgili çalışmaların incelenmesi, genel özelliklerinin derlenmesi ve sonuçlarının sunulması amaçlanmıştır.

Keywords

Demir, dikkat eksikliği hiperaktivite bozukluğu, ferritin, patofizyoloji

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