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Bipolar Disorder and Childhood Trauma

Year 2015, Volume: 7 Issue: 2, 157 - 165, 31.05.2015
https://doi.org/10.5455/cap.20140719110459

Abstract

Bipolar disorder is a chronic disorder in which irregular course of depressive, mania or mixed episodes or a complete recovery between episodes can be observed. The studies about the effects of traumatic events on bipolar disorder showed that they had significant and long-term effects on the symptoms of the disorder. Psychosocial stress might change the neurobiology of bipolar disorder over time. The studies revealed that the traumatic events could influence not only the onset of the disorder but also the course of the disorder and in these patients the rate of suicide attempt and comorbid substance abuse might increase. Bipolar patients who had childhood trauma had an earlier onset, higher number of episodes and comorbid disorders. In this review, the relationship between childhood trauma and bipolar disorder is reviewed.

 

References

  • Acehan S, Bilen A, Ay MO, Gülen M, Avcı A, İçme F (2013) Çocuk istismarı ve ihmalinin değerlendirilmesi. Arşiv Kaynak Tarama Dergisi, 22:591-614.
  • APA (1994) Diagnostic and Statistical Manual for Mental Disorders, 4th edition (DSM-IV). Washington, DC: American Psychiatric Association.
  • APA (2013) Diagnostic and Statistical Manual for Mental Disorders, 5th edition (DSM-5). Washington, DC: American Psychiatric Association.
  • Anisman, H, Zaharia MD, Meaney MJ & Merali Z (1998) Do early-life events permanently alter behavioral and hormonal responses to stressors? Int J Dev Neurosci, 16:149-164.
  • Brown GR, McBride L, Bauer MS, Williford WO, Cooperative Studies Program 430 Study Team (2005) Impact of childhood abuse on the course of bipolar disorder: a replication study in U.S. veterans. J Affect Disord, 89:57-67.
  • Bryer JB, Nelson BA, Miller JB, Krol PA (1987) Childhood sexual and physical abuse as factors in adult psychiatric illness. Am J Psychiatry, 144:1426-1430.
  • Conus P, Cotton S, Schimmelmann BG, Berk M, Daglas R, McGorry PD et al. (2010) Pretreatment and outcome correlates of past sexual and physical trauma in 118 bipolar I disorder patients with a first episode of psychotic mania. Bipolar Disord, 12:244- 252.
  • Darves-Bornoz JM, Lemperiere T, Degiovanni A, Gaillard P (1995) Sexual victimization in women with schizophrenia and bipolar disorder. Soc Psychiatry Psychiatric Epidemiol, 30:78-84.
  • De Bellis MD, Keshavan MS, Clark DB , Casey BJ, Giedd JN, Boring AM et al. (1999) Developmental traumatology. Part II:brain development. Biol Psychiatry, 45:1271- 1284.
  • Erten E, Uney Kalkay AF, Saatçioğlu O, Ozdemir A, Fıstıkçı N, Çakmak D (2014) Effects of childhood trauma and clinical features on determining quality of life in patients with bipolar I disorder. J Affect Disord, 162:107-113.
  • Etain B, AAs M, Andreassen OA, Lorentzen S, Dieset I, Gard S et al.(2013) Childhood trauma is associated with severe clinical characteristics of bipolar disorders. J Clin Psychiatry, 74:991-998.
  • Etain B, Henry C, Bellivier F, Mathieu F, Leboyer M (2008) Beyond genetics: childhood affective trauma in bipolar disorder. Bipolar Disord, 10:867-876.
  • Fisher HL, Hosang GM (2010) Childhood maltreatment and bipolar disorder: a critical review of the evidence. Mind&Brain, The Journal of Psychiatry, 1:1-10.
  • Francis DD, Caldji C, Champagne F, Plotsky PM, Meaney MJ (1999) The role of corticotropin-releasing factor-norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress . Biol Psychiatry , 46:1153-1166.
  • Gao K, Tolliver BK, Kemp DE, Ganocy SJ, Bilali S, Brady KL et al. (2009) Correlates of historical suicide attempt in rapid-cycling bipolar disorder: a cross-sectional assessment. J Clin Psychiatry, 70:1032-1040.
  • Garcia-Amador M, Colom F, Valenti M, Horga G, Vieta E (2009) Suicide risk in rapid cycling bipolar patients. J Affect Disord, 117:74-78.
  • Garno JL, Goldberg JF, Ramirez PM, Ritzler BA (2005) Impact of childhood abuse on the clinical course of bipolar disorder. Br J Psychiatry, 186:121-125.
  • Goldberg JF, Garno JL (2005) Development of posttraumatic stress disorder in adult bipolar patients with histories of severe childhood abuse. J Psychiatr Res, 9:595-601.
  • González-Pinto A, Barbeito S, Alonso M, Alberich S, Karım-Haidar M, Vieta E et al. (2011) Poor long-term prognosis in mixed bipolar patients: 10-year outcomes in the Vitoria prospective naturalistic study in Spain. J Clin Psychiatry, 72:671-676.
  • Goodwin FK, Jamison KR (2007) Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression. New York, Oxford University Press.
  • Heim C, Nemeroff CB (2001) The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry, 49:1023-1039.
  • Hyun M, Friedman SD, Dunner DL(2000) Relationship of childhood physical and sexual abuse to adult bipolar disorder. Bipolar Disord, 2:131-135.
  • Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S et al.(1994) Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry, 51:8 19.
  • Kleinman L, Lowin A, Flood E, Gandhi G, Edgell E, Revicki DA (2003) Costs of bipolar disorder. Pharmacoeconomics, 21:601-622.
  • Kupka RW, Luckenbaugh DA, Post RM , Suppes T, Altshuler L, Keck P et al. (2005) A comparative study of rapid and non-rapid cycling bipolar disorder using daily prospective mood ratings in 539 outpatients. Am J Psychiatry, 162:1273-1280.
  • Leboyer M, Etain B, Mathieu F, Henry C, Jamain S, Bellivier F (2007) Childhood affective trauma in bipolar affective disorder. Bipolar Disord, 9(Suppl 1):9.
  • Leverich GS, McElroy SL, Suppes T, Keck PE, Jr, Denicoff KD, Nolen WA et al. (2002) Early physical and sexual abuse associated with an adverse course of bipolar illness. Biol Psychiatry, 51:288-297.
  • Levine S, Huchton DM, Wiener SG & Rosenfeld P(1991) Time course of the effect of maternal deprivation on the hypothalamic- pituitary-adrenal axis in the infant rat. Dev Psychobiol, 24:547-558.
  • Levitan RD, Parikh SV, Lesage AD, Hegadoren KM, Adams M, Kennedy SH et al. (1998) Major depression in individuals with a history of childhood physical or sexual abuse: relationship to neurovegetative features, mania, and gender. Am J Psychiatry, 155:1746-1752.
  • Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, Freedman A et al. (1997) Maternal care, hippocampal glucocorticoid receptors and hypothalamic-pituitary-adrenal responses to stress. Science 1277:1659-1662.
  • Maguire C, McCusker CG, Meenagh C, Mulholland C, Shannon C (2008) Effects of trauma on bipolar disorder: the mediational role of interpersonal difficulties and alcohol dependence. Bipolar Disord, 10:293-302.
  • Maniglio R (2013) The impact of child sexual abuse on the course of bipolar disorder: a systematic review Bipolar Disord, 15:341- 358.
  • March JS, Amaya-Jackson L, Pynoos RS (1997) Pediatric posttraumatic stres disorder. In AACAP Textbook of Child & Adolescent Psychiatry 2nd ed (Ed: JM Wiener):507-526. Washington DC: American Psychiatric Press.
  • Meade CS, McDonald LJ, Graff FS, Fitzmaurice GM, Griffin ML, Weiss RD (2009) A prospective study examining the effects of gender and sexual/physical abuse on mood outcomes in patients with co-occurring bipolar I and substance use disorders. Bipolar Disord, 11:425-433.
  • Nader K, Pynoos R,Fairbanks L, Frederick C (1990) Children's reactions one year after a sniper attack at their school. Am J Psychiatry, 147:1526-1530.
  • Neria Y, Bromet EJ, Carlson GA, Naz B (2005) Assaultive trauma and illness course in psychotic bipolar disorder: findings from the Suffolk county mental health project. Acta Psychiatr Scand,111:380-383.
  • Neria Y, Bromet EJ, Sievers S, Lavelle J, Fochtmann LJ (2002) Trauma exposure and posttraumatic stress disorder in psychosis: findings from a first-admission cohort. J Consult Clin Psychol, 70: 246-251.
  • Otto MW, Perlman CA, Wernicke R, Reese HE, Bauer MS, Pollack MH (2004) Postraumatic stres disorder in patients with bipolar disorder: a review of prevalence, correlates and treatment strategies. Bipolar Disord, 6:470-479.
  • Pfefferbaum B (2002) Posttraumatic stres disorder. In Child and Adolescent Psychiatry: A Comprehensive Textbook (Ed M Lewis):912-925. Philadelphia, Lippincott Williams&Wilkins.
  • Pfefferbaum B, Allen JR (1998) Stress in children exposed to violence: reenactment and rage. Child Adolesc Psychiatr Clin N Am, 7:121-135.
  • Plotsky PM, Thrivikraman KV, Nemeroff CB, Caldji C, Sharma S, Meaney MJ (2005) Long- term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring. Neuropsychopharmacology, 30:2192-2204.
  • Post RM (1992) Transduction of psychological social stress into the neurobiology of recurrent affective disorder. Am J Psychiatry, 149:999-1010.
  • Post RM, Leverich GS (2006) The role of psychosocial the role of psychosocial stress in the onset and progression of bipolar disorder and its comorbidities: the need for earlier and alternative modes of therapeutic intervention. Dev Psychopathol, 18:1181-1211.
  • Post RM, Weiss SRB, Pert A, Uhde TW (1987) Chronic cocaine administration: Sensitization and kindling effects. In Cocaine: Clinical and biobehavioral aspects (Eds A Raskin, S Fisher):109-173. New York, Oxford University Press.
  • Pynoos RS, Goenjian A, Tashjian M ,Karakashian M,Manjikian R, Manoukian G et al. (1993) Posttraumatic stres reactions in children after the 1988 Armenian earthquake. Br J Psychiatry, 163:239-247.
  • Romero S, Birmaher B, Axelson D, Goldstein T, Goldstein BI, Gill MK et al.(2009) Prevalence and correlates of physical and sexual abuse in children and adolescents with bipolar disorder. J Affect Disord; 112:144-150.
  • Rush AJ(2003) Toward an understanding of bipolar disorder and its origin. J Clin Psychiatry, 64 (Suppl 6):4S-8S.
  • Shaw JA, Applegate B, Tanner S (1995) Psychological effects of hurricane Andrew on elementary school population. J Am Acad Child Adolesc Psychiatry, 34:1185-1192.
  • Southwick SM, Krystal JH, Morgan CA , Johnson D, Nagy LM, Nicolau A et al. (1993) Abnormal noradrenergic function in posttraumatic stres disorder. Arch Gen Psychiatry, 50:266-274.
  • Şar V(1997) Kötüye kullanım ve ihmalle ilişkili sorunlar. In Temel Psikiyatri (Eds C Güleç, E Köroğlu):823-834. Ankara, Hekimler Yayın Birliği.
  • Tyano S, Iancu I, Solomon Z, Sever J, Goldstein I, Touvtana Y et al. (1996) Seven-year follow-up of child survivors of a bus-train collision. J Am Acad Child Adolesc Psychiatry, 35:365-367.
  • Van Der Kolk BA, Greenberg MS (1987) The psychobiology of the trauma response: hyperarousal, constriction and addiction to traumatic reexposure. In Psychological Trauma (Ed BA Van Der Kolk):63-87. Washington DC, American Psychiatric Press.
  • Weili L, Mueser KT, Rosenberg SD, Jankowski MK (2008) Correlates of adverse childhood experiences among adults with severe mood disorders. Psychiatr Serv, 59:1018-1026.
  • WHO (1993) The ICD-10 Classification of Mental and Behavioural Disorders. Diagnostic Criteria for Research. Geneva, World Health Organization.
  • Yule W, Williams RM (1990) Post traumatic stres reactions in children. J Trauma Stress, 3: 279-295.

Bipolar Bozukluk ve Çocukluk Çağı Travması

Year 2015, Volume: 7 Issue: 2, 157 - 165, 31.05.2015
https://doi.org/10.5455/cap.20140719110459

Abstract

Bipolar bozukluk, belli bir düzen olmaksızın tekrarlayan depresyon, mani ya da her ikisini de kapsayan karma ataklar ile giden ve bu ataklar arasında kişinin tamamen iyileşebildiği kronik bir bozukluktur. Travmatik yaşantıların bipolar bozuklukla ilişkisi üzerine yapılan çalışmalar, belirtiler üzerinde anlamlı, uzun süreli etkileri olduğunu göstermektedir. Psikososyal streslerin varolan bipolar bozukluğun nörobiyolojisini zaman içinde değiştirebileceği bildirilmiştir. Travmatik olayların bipolar bozukluğun yalnızca ortaya çıkışını değil, seyrini, atakların ortaya çıkışını etkilediği, bu hastalarda intihar girişimi oranını arttırdığını, madde kötüye kullanımının sıklıkla eşlik edebildiğini gösteren çalışmalar bulunmaktadır. Çocukluk çağında travmatik yaşantısı olanlarda bipolar bozukluk daha erken yaşta başlamakta, bu hastalar daha fazla sayıda duygudurum atağı geçirmekte, daha fazla ek tanı görülmektedir. Bu yazıda, çocukluk çağı travması ve bipolar bozukluk ilişkisi gözden geçirilmiştir.

 

References

  • Acehan S, Bilen A, Ay MO, Gülen M, Avcı A, İçme F (2013) Çocuk istismarı ve ihmalinin değerlendirilmesi. Arşiv Kaynak Tarama Dergisi, 22:591-614.
  • APA (1994) Diagnostic and Statistical Manual for Mental Disorders, 4th edition (DSM-IV). Washington, DC: American Psychiatric Association.
  • APA (2013) Diagnostic and Statistical Manual for Mental Disorders, 5th edition (DSM-5). Washington, DC: American Psychiatric Association.
  • Anisman, H, Zaharia MD, Meaney MJ & Merali Z (1998) Do early-life events permanently alter behavioral and hormonal responses to stressors? Int J Dev Neurosci, 16:149-164.
  • Brown GR, McBride L, Bauer MS, Williford WO, Cooperative Studies Program 430 Study Team (2005) Impact of childhood abuse on the course of bipolar disorder: a replication study in U.S. veterans. J Affect Disord, 89:57-67.
  • Bryer JB, Nelson BA, Miller JB, Krol PA (1987) Childhood sexual and physical abuse as factors in adult psychiatric illness. Am J Psychiatry, 144:1426-1430.
  • Conus P, Cotton S, Schimmelmann BG, Berk M, Daglas R, McGorry PD et al. (2010) Pretreatment and outcome correlates of past sexual and physical trauma in 118 bipolar I disorder patients with a first episode of psychotic mania. Bipolar Disord, 12:244- 252.
  • Darves-Bornoz JM, Lemperiere T, Degiovanni A, Gaillard P (1995) Sexual victimization in women with schizophrenia and bipolar disorder. Soc Psychiatry Psychiatric Epidemiol, 30:78-84.
  • De Bellis MD, Keshavan MS, Clark DB , Casey BJ, Giedd JN, Boring AM et al. (1999) Developmental traumatology. Part II:brain development. Biol Psychiatry, 45:1271- 1284.
  • Erten E, Uney Kalkay AF, Saatçioğlu O, Ozdemir A, Fıstıkçı N, Çakmak D (2014) Effects of childhood trauma and clinical features on determining quality of life in patients with bipolar I disorder. J Affect Disord, 162:107-113.
  • Etain B, AAs M, Andreassen OA, Lorentzen S, Dieset I, Gard S et al.(2013) Childhood trauma is associated with severe clinical characteristics of bipolar disorders. J Clin Psychiatry, 74:991-998.
  • Etain B, Henry C, Bellivier F, Mathieu F, Leboyer M (2008) Beyond genetics: childhood affective trauma in bipolar disorder. Bipolar Disord, 10:867-876.
  • Fisher HL, Hosang GM (2010) Childhood maltreatment and bipolar disorder: a critical review of the evidence. Mind&Brain, The Journal of Psychiatry, 1:1-10.
  • Francis DD, Caldji C, Champagne F, Plotsky PM, Meaney MJ (1999) The role of corticotropin-releasing factor-norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress . Biol Psychiatry , 46:1153-1166.
  • Gao K, Tolliver BK, Kemp DE, Ganocy SJ, Bilali S, Brady KL et al. (2009) Correlates of historical suicide attempt in rapid-cycling bipolar disorder: a cross-sectional assessment. J Clin Psychiatry, 70:1032-1040.
  • Garcia-Amador M, Colom F, Valenti M, Horga G, Vieta E (2009) Suicide risk in rapid cycling bipolar patients. J Affect Disord, 117:74-78.
  • Garno JL, Goldberg JF, Ramirez PM, Ritzler BA (2005) Impact of childhood abuse on the clinical course of bipolar disorder. Br J Psychiatry, 186:121-125.
  • Goldberg JF, Garno JL (2005) Development of posttraumatic stress disorder in adult bipolar patients with histories of severe childhood abuse. J Psychiatr Res, 9:595-601.
  • González-Pinto A, Barbeito S, Alonso M, Alberich S, Karım-Haidar M, Vieta E et al. (2011) Poor long-term prognosis in mixed bipolar patients: 10-year outcomes in the Vitoria prospective naturalistic study in Spain. J Clin Psychiatry, 72:671-676.
  • Goodwin FK, Jamison KR (2007) Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression. New York, Oxford University Press.
  • Heim C, Nemeroff CB (2001) The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry, 49:1023-1039.
  • Hyun M, Friedman SD, Dunner DL(2000) Relationship of childhood physical and sexual abuse to adult bipolar disorder. Bipolar Disord, 2:131-135.
  • Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S et al.(1994) Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry, 51:8 19.
  • Kleinman L, Lowin A, Flood E, Gandhi G, Edgell E, Revicki DA (2003) Costs of bipolar disorder. Pharmacoeconomics, 21:601-622.
  • Kupka RW, Luckenbaugh DA, Post RM , Suppes T, Altshuler L, Keck P et al. (2005) A comparative study of rapid and non-rapid cycling bipolar disorder using daily prospective mood ratings in 539 outpatients. Am J Psychiatry, 162:1273-1280.
  • Leboyer M, Etain B, Mathieu F, Henry C, Jamain S, Bellivier F (2007) Childhood affective trauma in bipolar affective disorder. Bipolar Disord, 9(Suppl 1):9.
  • Leverich GS, McElroy SL, Suppes T, Keck PE, Jr, Denicoff KD, Nolen WA et al. (2002) Early physical and sexual abuse associated with an adverse course of bipolar illness. Biol Psychiatry, 51:288-297.
  • Levine S, Huchton DM, Wiener SG & Rosenfeld P(1991) Time course of the effect of maternal deprivation on the hypothalamic- pituitary-adrenal axis in the infant rat. Dev Psychobiol, 24:547-558.
  • Levitan RD, Parikh SV, Lesage AD, Hegadoren KM, Adams M, Kennedy SH et al. (1998) Major depression in individuals with a history of childhood physical or sexual abuse: relationship to neurovegetative features, mania, and gender. Am J Psychiatry, 155:1746-1752.
  • Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, Freedman A et al. (1997) Maternal care, hippocampal glucocorticoid receptors and hypothalamic-pituitary-adrenal responses to stress. Science 1277:1659-1662.
  • Maguire C, McCusker CG, Meenagh C, Mulholland C, Shannon C (2008) Effects of trauma on bipolar disorder: the mediational role of interpersonal difficulties and alcohol dependence. Bipolar Disord, 10:293-302.
  • Maniglio R (2013) The impact of child sexual abuse on the course of bipolar disorder: a systematic review Bipolar Disord, 15:341- 358.
  • March JS, Amaya-Jackson L, Pynoos RS (1997) Pediatric posttraumatic stres disorder. In AACAP Textbook of Child & Adolescent Psychiatry 2nd ed (Ed: JM Wiener):507-526. Washington DC: American Psychiatric Press.
  • Meade CS, McDonald LJ, Graff FS, Fitzmaurice GM, Griffin ML, Weiss RD (2009) A prospective study examining the effects of gender and sexual/physical abuse on mood outcomes in patients with co-occurring bipolar I and substance use disorders. Bipolar Disord, 11:425-433.
  • Nader K, Pynoos R,Fairbanks L, Frederick C (1990) Children's reactions one year after a sniper attack at their school. Am J Psychiatry, 147:1526-1530.
  • Neria Y, Bromet EJ, Carlson GA, Naz B (2005) Assaultive trauma and illness course in psychotic bipolar disorder: findings from the Suffolk county mental health project. Acta Psychiatr Scand,111:380-383.
  • Neria Y, Bromet EJ, Sievers S, Lavelle J, Fochtmann LJ (2002) Trauma exposure and posttraumatic stress disorder in psychosis: findings from a first-admission cohort. J Consult Clin Psychol, 70: 246-251.
  • Otto MW, Perlman CA, Wernicke R, Reese HE, Bauer MS, Pollack MH (2004) Postraumatic stres disorder in patients with bipolar disorder: a review of prevalence, correlates and treatment strategies. Bipolar Disord, 6:470-479.
  • Pfefferbaum B (2002) Posttraumatic stres disorder. In Child and Adolescent Psychiatry: A Comprehensive Textbook (Ed M Lewis):912-925. Philadelphia, Lippincott Williams&Wilkins.
  • Pfefferbaum B, Allen JR (1998) Stress in children exposed to violence: reenactment and rage. Child Adolesc Psychiatr Clin N Am, 7:121-135.
  • Plotsky PM, Thrivikraman KV, Nemeroff CB, Caldji C, Sharma S, Meaney MJ (2005) Long- term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring. Neuropsychopharmacology, 30:2192-2204.
  • Post RM (1992) Transduction of psychological social stress into the neurobiology of recurrent affective disorder. Am J Psychiatry, 149:999-1010.
  • Post RM, Leverich GS (2006) The role of psychosocial the role of psychosocial stress in the onset and progression of bipolar disorder and its comorbidities: the need for earlier and alternative modes of therapeutic intervention. Dev Psychopathol, 18:1181-1211.
  • Post RM, Weiss SRB, Pert A, Uhde TW (1987) Chronic cocaine administration: Sensitization and kindling effects. In Cocaine: Clinical and biobehavioral aspects (Eds A Raskin, S Fisher):109-173. New York, Oxford University Press.
  • Pynoos RS, Goenjian A, Tashjian M ,Karakashian M,Manjikian R, Manoukian G et al. (1993) Posttraumatic stres reactions in children after the 1988 Armenian earthquake. Br J Psychiatry, 163:239-247.
  • Romero S, Birmaher B, Axelson D, Goldstein T, Goldstein BI, Gill MK et al.(2009) Prevalence and correlates of physical and sexual abuse in children and adolescents with bipolar disorder. J Affect Disord; 112:144-150.
  • Rush AJ(2003) Toward an understanding of bipolar disorder and its origin. J Clin Psychiatry, 64 (Suppl 6):4S-8S.
  • Shaw JA, Applegate B, Tanner S (1995) Psychological effects of hurricane Andrew on elementary school population. J Am Acad Child Adolesc Psychiatry, 34:1185-1192.
  • Southwick SM, Krystal JH, Morgan CA , Johnson D, Nagy LM, Nicolau A et al. (1993) Abnormal noradrenergic function in posttraumatic stres disorder. Arch Gen Psychiatry, 50:266-274.
  • Şar V(1997) Kötüye kullanım ve ihmalle ilişkili sorunlar. In Temel Psikiyatri (Eds C Güleç, E Köroğlu):823-834. Ankara, Hekimler Yayın Birliği.
  • Tyano S, Iancu I, Solomon Z, Sever J, Goldstein I, Touvtana Y et al. (1996) Seven-year follow-up of child survivors of a bus-train collision. J Am Acad Child Adolesc Psychiatry, 35:365-367.
  • Van Der Kolk BA, Greenberg MS (1987) The psychobiology of the trauma response: hyperarousal, constriction and addiction to traumatic reexposure. In Psychological Trauma (Ed BA Van Der Kolk):63-87. Washington DC, American Psychiatric Press.
  • Weili L, Mueser KT, Rosenberg SD, Jankowski MK (2008) Correlates of adverse childhood experiences among adults with severe mood disorders. Psychiatr Serv, 59:1018-1026.
  • WHO (1993) The ICD-10 Classification of Mental and Behavioural Disorders. Diagnostic Criteria for Research. Geneva, World Health Organization.
  • Yule W, Williams RM (1990) Post traumatic stres reactions in children. J Trauma Stress, 3: 279-295.
There are 55 citations in total.

Details

Primary Language Turkish
Journal Section Review
Authors

Evrim Erten This is me

Aslı Funda Kalkay Uney This is me

Nurhan Fıstıkcı This is me

Publication Date May 31, 2015
Published in Issue Year 2015 Volume: 7 Issue: 2

Cite

AMA Erten E, Uney AFK, Fıstıkcı N. Bipolar Bozukluk ve Çocukluk Çağı Travması. Psikiyatride Güncel Yaklaşımlar. May 2015;7(2):157-165. doi:10.5455/cap.20140719110459

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