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Treatment Resistant Bipolar Disorder

Year 2015, Volume: 7 Issue: 4, 401 - 418, 15.08.2015

Elvan Özalp Ersin Hatice Karslıoğlu

https://doi.org/10.5455/cap.20150209101507

Abstract

Many patients diagnosed with bipolar disorder respond incompletely or unsatisfactorily to available treatments. Defining refractoriness in bipolar disorder is a complex issue and should concern and include either every phase and pole or the disorder as a whole. There are only limited and sometimes confusing data on the treatment of refractory bipolar patients. The objective of this paper was to review the evidence for treatment options in treatment resistant patients on depressive, manic attack and maintanence phase as found in randomized controlled trials and with special attention to the definition and assessment of treatment resistance.

 

Keywords

Bipolar disorder treatment resistance

References

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Tedaviye Dirençli Bipolar Bozukluk

Year 2015, Volume: 7 Issue: 4, 401 - 418, 15.08.2015

Elvan Özalp Ersin Hatice Karslıoğlu

https://doi.org/10.5455/cap.20150209101507

Abstract

Bipolar bozukluk tanısı alan pek çok hasta uygun tedavilere yetersiz yanıt verirler. Bipolar bozuklukta dirençliliği tanımlamak oldukça zordur ve hastalığın hem bütününü ve hem de her atağını ayrı ayrı kapsamalıdır. Tedaviye dirençli bipolar bozukluk hastaları ile ilgili çalışmalar az sayıdadır ve çelişkili bilgiler içermektedirler. Bu yazının amacı, mani, depresyon atağında olan ya da idame dönemdeki tedaviye dirençli bipolar hastaların randomize kontrollü çalışmalar düzeyinde verilerini değerlendirmek ve tedaviye direncin değerlendirilmesi ve tanımlanmasına dikkat çekmektir.

 

Keywords

Bipolar bozukluk tedavi direnci

References

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  • Akhondzadeh S, Milajerdi MR, Amini H, Tehrani-Doost M (2006) Allopurinol as an adjunct to lithium and haloperidol for treatment of patients with acute mania: a double-blind, randomized, placebo-controlled trial. Bipolar Disord, 8:485–489.
  • Altshuler LL, Post RM, Hellemann G, Leverich GS, Nolen WA, Frye MA et al.(2009) Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study. J Clin Psychiatry, 70:450–
  • Amrollahi Z, Rezaei F, Salehi B, Modabbernia AH, Maroufi A, Esfandiari GR et al. (2011) Double-blind, randomized, placebo- controlled 6-week study on the efficacy and safety of the tamoxifen adjunctive to lithium in acute bipolar mania. J Affect Disord, 129:327–331.
  • Bailine S, Fink M, Knapp R, Petrides G, Husain MM, Rasmussen K et al. (2010) Electroconvulsive therapy ıs equally effective in unipolar and bipolar depression. Acta Psychiatr Scand, 121:431–436.
  • BALANCE investigators and collaborators, Geddes JR, Goodwin GM, Rendell J, Azorin JM, Cipriani A et al. (2010) Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (balance): a randomised open- label trial. Lancet, 375:385–395.
  • Ballenger JC, Davidson JR, Lecrubier Y, Nutt DJ, Baldwin DS, den Boer JA et al. (1998) Consensus statement on panic disorder from the ınternational consensus group on depression and anxiety. J Clin Psychiatry, 59 (Suppl 8):47–54.
  • Baumgartner A (2000) Thyroxine and the treatment of affective disorders: an overview of the results of basic and clinical research. Int J Neuropsychopharmacol, 3:149–165.
  • Behzadi AH, Omrani Z, Chalian M, Asadi S, Ghadiri M (2009) Folic acid efficacy as an alternative drug added to sodium valproate in the treatment of acute phase of mania in bipolar disorder: a double-blind randomized controlled trial. Acta Psychiatr Scand, 120:441–445.
  • Benedetti A, Di Paolo A, Lastella M, Casamassima F, Candiracci C, Litta A et al. (2010) Augmentation of clozapine with aripiprazole in severe psychotic bipolar and schizoaffective disorders: a pilot study. Clin Pract Epidemiol Ment Health, 6:30-35.
  • Benedetti F, Barbini B, Fulgosi MC, Colombo C, Dallaspezia S, Pontiggia A et al. (2005) combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression: acute response and long-term remission rates. J Clin Psychiatry, 66:1535–1540.
  • Berwaerts J, Lane R, Nuamah IF, Lim P, Remmerie B, Hough DW (2011) Paliperidone extended-release as adjunctive therapy to lithium or valproate in the treatment of acute mania: a randomized, placebo-controlled study. J Affect Disord, 129:252–260.
  • Bowden CL (2004) Making optimal use of combination pharmacotherapy in bipolar disorder. J Clin Psychiatry, 65 (Suppl 15):21– 24.
  • Bowden CL (2005) Atypical antipsychotic augmentation of mood stabilizer therapy in bipolar disorder. Journal Clin Psychiatry, 66 (Suppl 3):12–19.
  • Brown E, Dunner DL, McElroy SL, Keck PE, Adams DH, Degenhardt E et al. (2009) Olanzapine/fluoxetine Combination vs. lamotrigine in the 6-month treatment of bipolar I depression. Int J Neuropsychopharmacol, 12:773–782.
  • Burt T, Sachs GS, Demopulos C (1999) Donepezil in treatment-resistant bipolar disorder. Biol Psychiatry, 45:959–964.
  • Calabrese JR, Kimmel SE, Woyshville MJ, Rapport DJ, Faust CJ, Thompson PA, Meltzer HY (1996) Clozapine for treatment- refractory mania. Am J Psychiatry, 153:759–764.
  • Chang JS, Ha KS, Young Lee K, Sik Kim Y, Min Ahn Y (2006) The effects of long-term clozapine add-on therapy on the rehospitalization rate and the mood polarity patterns in bipolar disorders. J Clin Psychiatry, 67:461–467.
  • Chen J, Muzina DJ, Kemp DE, Conroy C, Chan P, Serrano MB et al. (2011) Safety and efficacy of olanzapine monotherapy in treatment-resistant bipolar mania: a 12-week open-label study. Hum Psychopharmacol, 26:588–595.
  • Ciapparelli A, Dell'Osso L, Bandettini di Poggio A, Carmassi C, Cecconi D et al. (2003) Clozapine in treatment-resistant patients with schizophrenia, schizoaffective disorder, or psychotic bipolar disorder: a naturalistic 48-month follow-up study. J Clin Psychiatry, 64:451–458.
  • Cipriani A, Barbui C, Salanti G, Rendell J, Brown R, Stockton S et al. (2011) Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis. Lancet, 378:1306–1315.
  • Dell'Osso B, Mundo E, D'Urso N, Pozzoli S, Buoli M, Ciabatti M et al. (2009) Augmentative repetitive navigated transcranial magnetic stimulation (rTMS) in drug-resistant bipolar depression. Bipolar Disord, 11:76–81.
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Details

Primary Language Turkish
Journal Section Review
Authors

Elvan Özalp This is me

Ersin Hatice Karslıoğlu This is me

Publication Date August 15, 2015
Published in Issue Year 2015 Volume: 7 Issue: 4

Cite

AMA Özalp E, Karslıoğlu EH. Tedaviye Dirençli Bipolar Bozukluk. Psikiyatride Güncel Yaklaşımlar - Current Approaches in Psychiatry. August 2015;7(4):401-418. doi:10.5455/cap.20150209101507

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