Year 2016, Volume 8 , Issue 1, Pages 19 - 31 2016-01-23

P-glycoprotein and its Role in Treatment Resistance
P-glikoprotein ve Tedaviye Dirençteki Rolü

Işıl Göğcegöz Gül [1] , Gül Eryılmaz [2] , K. Oğuz Karamustafalıoğlu [3]


Polypharmacy which has often used to increase efficacy of treatment and to prevent resistance in psychiatry may lead to pharmacokinetic and pharmacodynamic drug interactions. One of the intensively studied topic in recent years to clarify the mechanism of drug interactions, in the pharmacokinetic area is p-glycoprotein related drug-drug and drug-food interactions. The interactions of some drugs with p-glycoprotein which is a carrier protein, can lead to a decrease in the bioavailability of these drugs and reduction in passage through the blood-brain barrier. In this review, the role of p-glycoprotein on drug pharmacokinetics and bioavailability of psychiatric drugs are discussed.
Psikiyatride tedavi etkinliğini artırmak ve direnci önlemek amacıyla sıklıkla uygulanan polifarmasi, farmakokinetik ve farmakodinamik ilaç etkileşimlerine neden olabilmektedir. İlaç etkileşim mekanizmalarının aydınlatılması amacıyla, farmakokinetik alanında son yıllarda üzerinde yoğun olarak çalışılan bir konu p-glikoproteine bağlı ilaç-ilaç ve ilaç-besin etkileşmeleridir. Bazı ilaçların bir taşıyıcı protein olan p-glikoprotein ile olan etkileşmeleri, bu ilaçların biyoyararlanımlarında düşüşe ve kan-beyin bariyerinden geçişlerinde azalmaya yol açabilmektedir. Bu derlemede, p-glikoproteinin ilaç farmakokinetiğinde ve psikiyatrik ilaçların biyoyararlanımındaki rolü tartışılmıştır.
P-glikoprotein, çoklu ilaç direnci, kan-beyin bariyeri
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  • Işıl Göğcegöz Gül, Yrd.Doç.Dr., Üsküdar Üniversitesi, İstanbul; Gül Eryılmaz, Yrd.Doç.Dr., Üsküdar Üniversi
  • tesi, İstanbul; K. Oğuz Karamustafalıoğlu, Prof.Dr., Üsküdar Üniversitesi, İstanbul
Primary Language en
Journal Section Review
Authors

Author: Işıl Göğcegöz Gül

Author: Gül Eryılmaz

Author: K. Oğuz Karamustafalıoğlu

Dates

Acceptance Date : November 17, 2019
Publication Date : January 23, 2016

Bibtex @ { pgy133527, journal = {Psikiyatride Güncel Yaklaşımlar}, issn = {1309-0658}, eissn = {1309-0674}, address = {}, publisher = {Lut TAMAM}, year = {2016}, volume = {8}, pages = {19 - 31}, doi = {}, title = {P-glycoprotein and its Role in Treatment Resistance}, key = {cite}, author = {Göğcegöz Gül, Işıl and Eryılmaz, Gül and Karamustafalıoğlu, K. Oğuz} }
APA Göğcegöz Gül, I , Eryılmaz, G , Karamustafalıoğlu, K . (2016). P-glycoprotein and its Role in Treatment Resistance. Psikiyatride Güncel Yaklaşımlar , 8 (1) , 19-31 . Retrieved from https://dergipark.org.tr/en/pub/pgy/issue/11171/133527
MLA Göğcegöz Gül, I , Eryılmaz, G , Karamustafalıoğlu, K . "P-glycoprotein and its Role in Treatment Resistance". Psikiyatride Güncel Yaklaşımlar 8 (2016 ): 19-31 <https://dergipark.org.tr/en/pub/pgy/issue/11171/133527>
Chicago Göğcegöz Gül, I , Eryılmaz, G , Karamustafalıoğlu, K . "P-glycoprotein and its Role in Treatment Resistance". Psikiyatride Güncel Yaklaşımlar 8 (2016 ): 19-31
RIS TY - JOUR T1 - P-glycoprotein and its Role in Treatment Resistance AU - Işıl Göğcegöz Gül , Gül Eryılmaz , K. Oğuz Karamustafalıoğlu Y1 - 2016 PY - 2016 N1 - DO - T2 - Psikiyatride Güncel Yaklaşımlar JF - Journal JO - JOR SP - 19 EP - 31 VL - 8 IS - 1 SN - 1309-0658-1309-0674 M3 - UR - Y2 - 2019 ER -
EndNote %0 Psikiyatride Güncel Yaklaşımlar P-glycoprotein and its Role in Treatment Resistance %A Işıl Göğcegöz Gül , Gül Eryılmaz , K. Oğuz Karamustafalıoğlu %T P-glycoprotein and its Role in Treatment Resistance %D 2016 %J Psikiyatride Güncel Yaklaşımlar %P 1309-0658-1309-0674 %V 8 %N 1 %R %U
ISNAD Göğcegöz Gül, Işıl , Eryılmaz, Gül , Karamustafalıoğlu, K. Oğuz . "P-glycoprotein and its Role in Treatment Resistance". Psikiyatride Güncel Yaklaşımlar 8 / 1 (January 2016): 19-31 .
AMA Göğcegöz Gül I , Eryılmaz G , Karamustafalıoğlu K . P-glycoprotein and its Role in Treatment Resistance. pgy. 2016; 8(1): 19-31.
Vancouver Göğcegöz Gül I , Eryılmaz G , Karamustafalıoğlu K . P-glycoprotein and its Role in Treatment Resistance. Psikiyatride Güncel Yaklaşımlar. 2016; 8(1): 31-19.