Review
BibTex RIS Cite

Prenatal Enflamasyon ve Dikkat Eksikliği Hiperaktivite Bozukluğu İlişkisi

Year 2021, Volume: 13 Issue: 3, 478 - 489, 30.09.2021
https://doi.org/10.18863/pgy.811846

Abstract

Dikkat Eksikliği Hiperaktivite Bozukluğu (DEHB) dikkat eksikliği, hiperaktivite ve dürtüsellik ile karakterize kronik, nörogelişimsel bir bozukluktur. Akademik, sosyal, duygusal ve bilişsel alanlarda bozulma ile seyreder. DEHB etiyolojisinde genetik ve çevresel birçok faktör rol oynamaktadır. DEHB tanısı alanlarda yapılan çok sayıda çalışmada enflamasyon ile ilişkili parametrelerde yükseklik saptanmıştır. Alerjik ve immünolojik durumlar ile DEHB birlikteliği, DEHB etiyolojisinde immün sistem etkisini düşündürmektedir. Prenatal dönemde maruz kalınan enflamasyon ile nörogelişimsel bozukluklar arasındaki güçlü bir ilişki olduğu gösterilmiştir. DEHB oluşumuna neden olabilecek prenatal risk faktörlerinden kabul edilen maternal diyabet, vücut kitle indeksi, preeklampsi, enfeksiyon, annenin kronik veya otoimmün hastalıkları gibi parametreler annenin enflamatuvar profili ile ilişkili bulunmaktadır. Bu nedenle intrauterin enflamasyona maruziyet ile DEHB arasındaki ilişki ilgi çekmektedir. Bu derlemede, maternal immün sistem hiperaktivasyonuna neden olabilecek durumlar ile olası prenatal nöroenflamasyon ve DEHB ilişkisi gözden geçirilmiştir.

References

  • Adriani W, Romano E, Pucci M, Pascale E, Cerniglia L, Cimino S, Tambelli R, Curatolo P, Granstrem O, Maccarrone M, Laviola G, D’Addario C (2018) Potential for diagnosis versus therapy monitoring of attention deficit hyperactivity disorder: a new epigenetic biomarker interacting with both genotype and auto-immunity. Eur Child Adolesc Psychiatry, 27(2):241-252
  • Alvarez-Arellano L, González-García N, Salazar-García M, Corona JC (2020) Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder. Antioxidants, 9(2), 176.
  • Amiri S, Malek A, Sadegfard M, Abdi S (2012) Pregnancy-related maternal risk factors of attention-deficit hyperactivity disorder: a case-control study. ISRN Pediatr, 458064.
  • Anand D, Colpo GD, Zeni G, Zeni CP, Teixeira AL (2017) Attention-Deficit/Hyperactivity Disorder And Inflammation: What Does Current Knowledge Tell Us? A Systematic Review. Front Psychiatry. 8, 228. [PubMed: 29170646]
  • Anderson JO, Thundiyil JG, Stolbach A (2012) Clearing the air: a review of the effects of particulate matter air pollution on human health. J. Med. Toxicol, 8, 166-175.
  • American Psychiatry Association (2013) Diagnostic and statistical manual of mental disorders (5th ed.). American Psychiatric Publishing, Arlington, VA.
  • Avcil S (2018) Evaluation of the neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume as inflammatory markers in children with attention-deficit hyperactivity disorder . Psychiatry Clin Neurosci, 72(7):522–530
  • Bierderman J, Faraone SV (2005) Attention-deficit hyperactivity disorder. Lancet, 366:237–248.
  • Böhm S, Curran EA, Kenny LC, O'Keeffe GW, Murray D, Khashan AS (2019) The Effect of Hypertensive Disorders of Pregnancy on the Risk of ADHD in the Offspring. J Atten Disord. May;23(7):692-701. doi: 10.1177/1087054717690230. Epub 2017 Feb 4. PMID: 28162026.
  • Bytoft B, Knorr S, Vlachova Z, Jensen RB, Mathiesen ER, Beck-Nielsen H, et al (2017) Assessment of attention deficits in adolescent offspring exposed to maternal type 1 diabetes. PLoS One.;12(1):e0169308
  • Calderón-Garcidueñas L, Solt AC, Henríquez-Roldán C, Torres-Jardón R, Nuse B, Herritt L, et al (2008) Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. Toxicol Pathol. Feb;36(2):289-310. doi: 10.1177/0192623307313011. Epub 2008 Mar 18. PMID: 18349428.
  • Calderón-Garcidueñas L, Engle R, Mora-Tiscareño A, Styner M, Gómez-Garza G, Zhu H, et al (2011) Exposure to severe urban air pollution influences cognitive outcomes, brain volume and systemic inflammation in clinically healthy children. Brain Cogn. Dec;77(3):345-55. doi: 10.1016/j.bandc.2011.09.006. Oct 26. PMID: 22032805.
  • Calderón-Garcidueñas L, Mora-Tiscareño A, Styner M, Gómez-Garza G, Zhu H, Torres-Jardón R, et al (2012) White matter hyperintensities, systemic inflammation, brain growth, and cognitive functions in children exposed to air pollution. J Alzheimers Dis.;31(1):183-91. doi: 10.3233/JAD-2012-120610. PMID: 22531421.
  • Chahal N, McLain AC, Ghassabian A, Michels KA, Bell EM, Lawrence DA, et al (2017) Maternal Smoking and Newborn Cytokine and Immunoglobulin Levels. Nicotine Tob Res. Jul 1;19(7):789-796. doi: 10.1093/ntr/ntw324. PMID: 28011791; PMCID: PMC5939663.
  • Chandna AR, Kuhlmann N, Bryce CA, Greba Q, Campanucci VA, Howland JG (2015) Chronic maternal hyperglycemia induced during mid-pregnancy in rats increases RAGE expression, augments hippocampal excitability, and alters behavior of the offspring. Neuroscience.; 303:241-60.
  • Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV et al (2016) The maternal interleukin17a pathway in mice promotes autism-like phenotypes in offspring. Science (New York, NY) ;351:933–939
  • Chudal R, Brown AS, Gyllenberg D, Hinkka-Yli-Salomäki S, Sucksdorff M, Surcel HM et al (2020) Maternal serum C-reactive protein (CRP) and offspring attention deficit hyperactivity disorder (ADHD). Eur Child Adolesc Psychiatry. https://doi.org/10.1007/s00787-019-01372-y
  • Chung KF (2005) Inflammatory mediators in chronic obstructive pulmonary disease. Curr Drug Targets Inflamm Allergy, 4:619-625.
  • Class QA, Abel KM, Khashan AS, Rickert ME, Dalman C, Larsson H, et al (2014) Offspring psychopathology following preconception, prenatal and postnatal maternal bereavement stress. Psychol Med; 44: 71–84. [PubMed: 23591021]
  • Cowell WJ, Bellinger DC, Wright RO, Wright RJ (2019) Antenatal active maternal asthma and other atopic disorders is associated with ADHD behaviors among school-aged children. Brain Behav Immun. Aug;80:871-878. doi: 10.1016/j.bbi.2019.05.040. Epub 2019 May 31. PMID: 31158498; PMCID: PMC6660383
  • Dachew BA, Scott JG, Mamun A, Alati R (2019) Pre-eclampsia and the risk of attention-deficit/hyperactivity disorder in offspring: Findings from the ALSPAC birth cohort study. Psychiatry Res. Feb;272:392-397. doi: 10.1016/j.psychres.2018.12.123. Epub 2018 Dec 25. PMID: 30605798.
  • Darwish AH, Elgohary TM, Nosair NA (2018) Serum Interleukin-6 Level in Children With Attention-Deficit Hyperactivity Disorder (ADHD). J Child Neurol;883073818809831.
  • Dietz PM, Homa D, England LJ, Burley K, Tong VT, Dube SR, et al (2011) Estimates of nondisclosure of cigarette smoking among pregnant and nonpregnant women of reproductive age in the United States. Am J Epidemiol;173(3):355–359
  • Donfrancesco R, Nativio P, Borrelli E, Giua E, Andriola E, Villa MP, et al (2016) Serum cytokines in paediatric neuropsychiatric syndromes: focus on Attention Deficit Hyperactivity Disorder. Minerva Pediatr., Dec 22. Epub ahead of print. PMID: 28006890.
  • Dong T, Hu W, Zhou X, Lin H, Lan L, Hang B, et al (2018) Prenatal exposure to maternal smoking during pregnancy and attention-deficit/hyperactivity disorder in offspring: A meta-analysis. Reproductive Toxicology, 76, 63-70.
  • Dreier JW, Andersen AN, Hvolby A, Garne E, Andersen PK, Berg-Beckhoff G (2016) Fever and infections in pregnancy and risk of attention deficit/hyperactivity disorder in the offspring. Journal of Child Psychology and Psychiatry; 57, 540–548.
  • Dunn GA, Nigg JT, Sullivan EL (2019) Neuroinflammation as a Risk Factor for Attention Deficit Hyperactivity Disorder. Pharmacol. Biochem. Behav, 182, 22–34.
  • Dürr DW, Høyer BB, Christensen LH, Pedersen HS, Zinchuk A, Jönsson BA, et al (2015) Tobacco smoking during pregnancy and risk of adverse behaviour in offspring: a follow-up study. Reprod Toxicol.; 58:65–72
  • Dwyer JB, McQuown SC, Leslie FM (2009) The dynamic effects of nicotine on the developing brain. Pharmacol Ther;122(2):125–39.
  • Eidelman AI, Samueloff A (2002) The pathophysiology of the fetus of the diabetic mother. Semin Perinatol;26(3):232-6. 32.
  • Ek CJ, Dziegielewska KM, Habgood MD, Saunders NR (2012) Barriers in the developing brain and Neurotoxicology. Neurotoxicology. Jun;33(3):586-604. doi: 10.1016/j.neuro.2011.12.009. Epub 2011 Dec 19. PMID: 22198708.
  • Eskenazi B, Trupin LS (1995) Passive and active maternal smoking during pregnancy, as measured by serum cotinine, and postnatal smoke exposure. II. Effects on neurodevelopment at age 5 years. Am J Epidemiol.;142(suppl 9): S19–S29
  • Faraone SV, Asherson P, Banaschewski T, Biederman J, Buitelaar JK, Ramos-Quiroga JA, et al (2015) Attention-Deficit/Hyperactivity Disorder. Nat. Rev. Dis. Primers, 1, 15020.
  • Forns J, Sunyer J, Garcia-Esteban R, Porta D, Ghassabian A, Giorgis-Allemand L, et al (2018a) Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe. Epidemiology. Sep;29(5):618-626. doi: 10.1097/EDE.0000000000000874. PMID: 29923866.
  • Forns J, Stigum H, Høyer BB, Sioen I, Sovcikova E, Nowack N, et al (2018b) Prenatal and postnatal exposure to persistent organic pollutants and attention-deficit and hyperactivity disorder: a pooled analysis of seven European birth cohort studies. Int J Epidemiol. Aug 1;47(4):1082-1097. doi: 10.1093/ije/dyy052. PMID: 29912347; PMCID: PMC6124627
  • Giana G, Romano E, Porfirio MC, D’Ambrosio R, Giovinazzo S, Troianiello M, et al (2015) Detection of auto-antibodies to DAT in the serum: interactions with DAT genotype and psycho-stimulant therapy for ADHD. J Neuroimmunol,; 278, 212–222. [PubMed: 25468771]
  • Ginsberg Y, D'Onofrio BM, Rickert ME, Class QA, Rosenqvist MA, Almqvist C, et al (2019) Maternal infection requiring hospitalization during pregnancy and attention-deficit hyperactivity disorder in offspring: a quasi-experimental family-based study. J Child Psychol Psychiatry. Feb;60(2):160-168. doi: 10.1111/jcpp.12959. Epub 2018 Aug 23. PMID: 30136726.
  • Golmirzaei J, Namazi S, Amiri S, Zare S, Rastikerdar N, Hesam AA, et al (2013) Evaluation of attention-deficit hyperactivity disorder risk factors. Int J Pediatr.; 2013:953103.
  • Gustafsson P, Källén K (2011) Perinatal, maternal, and fetal characteristics of children diagnosed with attention-deficit–hyperactivity disorder: results from a population-based study utilizing the Swedish Medical Birth Register. Dev Med Child Neurol. ;53(3):263-268.
  • Gustafsson HC, Sullivan EL, Battison EAJ, Holton KF, Graham AM, Karalunas SL, et al (2020) Evaluation of maternal inflammation as a marker of future offspring ADHD symptoms: A prospective investigation. Brain Behav Immun. Jul 21:S0889-1591(20)30731-5. doi: 10.1016/j.bbi.2020.07.019. Epub ahead of print. PMID: 32707260.
  • Gustavson K, Ask H, Ystrom E, Stoltenberg C, Lipkin WI, Surén P, et al (2019) Maternal fever during pregnancy and offspring attention deficit hyperactivity disorder. Sci Rep. Jul 2;9(1):9519. doi: 10.1038/s41598-019-45920-7. PMID: 31266998; PMCID: PMC6606630.
  • Hantsoo L, Kornfield S, Anguera MC, Epperson CN (2019) Inflammation: A Proposed Intermediary Between Maternal Stress and Offspring Neuropsychiatric Risk. Biol Psychiatry. Jan 15;85(2):97-106. doi: 10.1016/j.biopsych.2018.08.018. Epub 2018 Sep 5. PMID: 30314641; PMCID:
  • Hegvik TA, Instanes JT, Haavik J, Klungsøyr K, Engeland A (2019) Associations between attention-deficit/hyperactivity disorder and autoimmune diseases are modified by sex: a population-based cross-sectional study. Eur Child Adolesc Psychiatry; 27(5):663–675. https ://doi.org/10.1007/s0078 7-017-1056-1
  • Huang L, Wang Y, Zhang L, Zheng Z, Zhu T, Qu Y, et al (2018) Maternal smoking and attention-deficit/hyperactivity disorder in offspring: a meta-analysis. Pediatrics.;141(1): e20172465
  • Instanes JT, Halmøy A, Engeland A, Haavik J, Furu K, Klungsøyr K (2017) Attention-deficit/Hyperactivity disorder in offspring of mothers with inflammatory and immune system diseases. Biol Psychiatry;81(5):452-9.
  • Jallow J, Halt AH, Öhman H, Hurtig T (2020) Prenatal inflammation does not increase the risk for symptoms of attention deficit hyperactivity disorder (ADHD) in offspring. European Child & Adolescent Psychiatry,; 1-4.
  • Jenabi E, Bashirian S, Khazaei S, Basiri Z (2019) The maternal prepregnancy body mass index and the risk of attention deficit hyperactivity disorder among children and adolescents: a systematic review and meta-analysis. Korean journal of pediatrics; 62(10), 374.
  • Ji J, Chen T, Sundquist J, Sundquist K (2018) Type 1 diabetes in parents and risk of attention deficit/hyperactivity disorder in offspring: a populationbased study in Sweden. Diabetes Care; 41:770–774
  • Kelly Y, Sacker A, Gray R, Kelly J, Wolke D, Ma Quigley (2009) Light drinking in pregnancy, a risk for behavioural problems and cognitive defcits at 3 years of age? Int J Epidemiol; 38(1):129– 140. https://doi.org/10.1093/Ije/Dyn230
  • Kelly Yi, Sacker A, Gray R, Kelly J, Wolke D, Head J, et al (2012) Light drinking during pregnancy: still no increased risk for socioemotional difculties or cognitive defcits at 5 years of age? J Epidemiol Community Health; 66(1):41–48. https://doi. org/10.1136/Jech.2009.103002
  • Knopik VS, Maccani MA, Francazio S, McGeary JE (2012) The epigenetics of maternal cigarette smoking during pregnancy and effects on child development. Dev Psychopathol.; 24(4):1377–1390
  • Kong L, Norstedt G, Schalling M, Gissler M, Lavebratt C (2018) The risk of offspring psychiatric disorders in the setting of maternal obesity and diabetes. Pediatrics;142(3):e20180776.
  • Lee J, Taneja V, Vassallo R (2012) Cigarette smoking and inflammation: cellular and molecular mechanisms. J Dent Res. Feb;91(2):142-9. doi: 10.1177/0022034511421200. Epub 2011 Aug 29. PMID: 21876032; PMCID: PMC3261116.
  • Li J, Olsen J, Vestergaard M, Obel C (2010) Attention-deficit/hyperactivity disorder in the offspring following prenatal maternal bereavement: a nationwide follow-up study in Denmark. Eur Child Adolesc Psychiatry. 19: 747–753. [PubMed: 20495989]
  • Li J, Zhong H, Liang ZC, Xy L (2014) Study on correlation between gestational diabetes merged pregnancy-induced hypertension and hyperactivity syndrome in children. J Clin Exp Med.;13(19):1583–1585
  • Liu X, Dalsgaard S, Munk-Olsen T, Li J, Wright RJ, Momen NC (2019) Parental asthma occurrence, exacerbations and risk of attention-deficit/hyperactivity disorder. Brain Behav Immun. Nov;82:302-308. doi: 10.1016/j.bbi.2019.08.198. Epub 2019 Aug 30. PMID: 31476415; PMCID: PMC7408292.
  • MacKinnon N, Kingsbury M, Mahedy L, Evans J, Colman I (2018) The Association Between Prenatal Stress and Externalizing Symptoms in Childhood: Evidence From the Avon Longitudinal Study of Parents and Children. Biological Psychiatry, Early Life Environments and Later Vulnerabilities; 83: 100–108.
  • Maher GM, McCarthy FP, McCarthy CM, Kenny LC, Kearney PM, Khashan AS, et al (2019) A perspective on pre-eclampsia and neurodevelopmental outcomes in the offspring: does maternal inflammation play a role? Int J Dev Neurosci; 77:69–76.
  • Maher GM, Dalman C, O'Keeffe GW, Kearney PM, McCarthy FP, Kenny LC, et al (2020) Association between preeclampsia and attention-deficit hyperactivity disorder: a population-based and sibling-matched cohort study. Acta Psychiatr Scand. Feb 13. doi: 10.1111/acps.13162. Epub ahead of print. PMID: 32056200.
  • Mittleman BB, Castellanos FX, Jacobsen LK, Rapoport JL, Swedo SE, Shearer GM (1997) Cerebrospinal fluid cytokines in pediatric neuropsychiatric disease. J Immunol; 159(6), 2994–2999. [PubMed: 9300724]
  • Money KM, Barke TL, Serezani A, Gannon M, Garbett KA, Aronoff DM, et al (2018) Gestational diabetes exacerbates maternal immune activation effects in the developing brain. Mol Psychiatry;23(9):1–9.
  • Myhre O, Låg M, Villanger GD, Oftedal B, Øvrevik J, Holme JA, et al (2018) Early life exposure to air pollution particulate matter (PM) as risk factor for attention deficit/hyperactivity disorder (ADHD): Need for novel strategies for mechanisms and causalities. Toxicol Appl Pharmacol. Sep 1;354:196-214. doi: 10.1016/j.taap.2018.03.015. Epub 2018 Mar 14. PMID: 29550511.
  • Newby DE, Mannucci PM, Tell GS, Baccarelli AA, Brook RD, Donaldson K, et al (2015) Expert position paper on air pollution and cardiovascular disease. Eur. Heart J; 36, 83–93b.
  • Niclasen J, Am Nybo Andersen, Tw Teasdale, Strandberg-Larsen K (2014) Prenatal exposure to alcohol, and gender diferences on child mental health at age 7 years. J Epidemiol Commun Health; 68(3):224–232. https://doi.org/10.1136/Jech-2013-202956
  • Nielsen PR, Benros ME, Dalsgaard S (2017) Associations between autoimmune diseases and attention-deficit/hyperactivity disorder: a nationwide study. J Am Acad Child Adolesc Psychiatry; 56(3):234–240.e1. https://doi.org/10.1016/j.jaac.2016.12.010
  • Nomura Y, Marks DJ, Grossman B, Yoon M, Loudon H, Stone J, et al (2012) Exposure to gestational diabetes mellitus and low socioeconomic status: effects on neurocognitive development and risk of attention-deficit/hyperactivity disorder in offspring. Arch Pediatr Adolesc Med;166(4):337–343.
  • Oades RD, Myint AM, Dauvermann MR, Schimmelmann BG, Schwarz MJ (2010) Attention-deficit hyperactivity disorder (ADHD) and glial integrity: an exploration of associations of cytokines and kynurenine metabolites with symptoms and attention. Behav Brain Funct; 6, 32. [PubMed: 20534153]
  • Okano L, Ji Y, Riley AW, Wang X (2019) Maternal psychosocial stress and children's ADHD diagnosis: a prospective birth cohort study. J Psychosom Obstet Gynaecol. Sep;40(3):217-225. doi: 10.1080/0167482X.2018.1468434. Epub 2018 May 23. PMID: 29790815; PMCID: PMC6251762.
  • Oldenburg KS, O’Shea TM, Fry RC (2020) Genetic and epigenetic factors and early life inflammation as predictors of neurodevelopmental outcomes. In Seminars in Fetal and Neonatal Medicine; (p. 101115).
  • Ornoy A, Reece EA, Pavlinkova G, Kappen C, Miller RK (2015) Effect of maternal diabetes on the embryo, fetus, and children: congenital anomalies, genetic and epigenetic changes and developmental outcomes. Birth Defects Res C Embryo Today;105(1):53–72.
  • Oudin A, Frondelius K, Haglund N, Källén K, Forsberg B, Gustafsson P, et al (2019) Prenatal exposure to air pollution as a potential risk factor for autism and ADHD. Environ Int. Dec;133(Pt A):105149. doi: 10.1016/j.envint.2019.105149. Epub 2019 Oct 16. PMID: 31629172.
  • Önder A, Gizli Çoban Ö, Sürer Adanır A (2020) Elevated neutrophil-to-lymphocyte ratio in children and adolescents with attention-deficit/hyperactivity disorder. International Journal of Psychiatry in Clinical Practice; 1-6.
  • Pagliaccio D, Herbstman JB, Perera F, Tang D, Goldsmith J, Peterson BS, et al (2020) Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood. J Child Psychol Psychiatry. Jan 7:10.1111/jcpp.13189. doi: 10.1111/jcpp.13189. Epub ahead of print. PMID: 31907931; PMCID: PMC7338249.
  • Pagnin D, Zamboni Grecco ML, Furtado EF (2019) Prenatal alcohol use as a risk for attention-deficit/hyperactivity disorder. Eur Arch Psychiatry Clin Neurosci. Sep;269(6):681-687. doi: 10.1007/s00406-018-0946-7. Epub 2018 Oct 23. PMID: 30353263.
  • Perera FP, Chang HW, Tang D, Roen EL, Herbstman J, Margolis A, et al (2014) Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. PLoS One. Nov 5;9(11):e111670. doi: 10.1371/journal.pone.0111670. PMID: 25372862; PMCID: PMC4221082.
  • Perera FP, Wheelock K, Wang Y, Tang D, Margolis AE, Badia G, et al (2018) Combined effects of prenatal exposure to polycyclic aromatic hydrocarbons and material hardship on child ADHD behavior problems. Environ Res. Jan; 160:506-513. doi: 10.1016/j.envres.2017.09.002. Epub 2017 Oct 4. PMID: 28987706; PMCID: PMC5724364.
  • Peterson BS, Rauh VA, Bansal R, Hao X, Toth Z, Nati G, et al (2015) Effects of prenatal exposure to air pollutants (polycyclic aromatic hydrocarbons) on the development of brain white matter, cognition, and behavior in later childhood. JAMA Psychiatry. Jun;72(6):531-40. doi: 10.1001/jamapsychiatry.2015.57. Erratum in: JAMA Psychiatry. 2015 Jun;72(6):625. PMID: 25807066; PMCID: PMC4456286.
  • Pineles BL, Park E, Samet JM (2014) Systematic review and meta-analysis of miscarriage and maternal exposure to tobacco smoke during pregnancy. Am J Epidemiol;179(7):807–823
  • Popova S, Lange S, Shield K, Mihic A, Ae Chudley, Ra Mukherjee, et al (2016) Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis. Lancet; 387(10022):9
  • Rzehak P, Saffery R, Reischl E, Covic M, Wahl S, Grote V, et al (2016) European Childhood Obesity Trial Study group. Maternal smoking during pregnancy and DNA-methylation in children at age 5.5 years: epigenomewide- analysis in the European Childhood Obesity Project (CHOP)-study. PLoS One;11(5): e0155554
  • San Martin Porter M, Maravilla JC, Betts KS, Alati R (2019) Low-moderate prenatal alcohol exposure and offspring attention-deficit hyperactivity disorder (ADHD): systematic review and meta-analysis. Arch Gynecol Obstet. Aug;300(2):269-277. doi: 10.1007/s00404-019-05204-x. Epub 2019
  • Sanchez CE, Barry C, Sabhlok A, Russell K, Majors A, Kollins SH, et al (2018) Maternal pre-pregnancy obesity and child neurodevelopmental outcomes: a meta-analysis. Obes Rev;19:464-84.
  • Say GN, Karabekiroğlu K, Babadağı Z, Yüce M (2016) Maternal stress and perinatal features in autism and attention deficit/hyperactivity disorder. Pediatr Int. Apr;58(4):265-9. doi: 10.1111/ped.12822. Epub 2016 Feb 2. PMID: 26338105.
  • Sayal K, Es Draper, Fraser R, Barrow M, Smith Gd, Gray R (2013) Light drinking in pregnancy and mid-childhood mental health and learning outcomes. Arch Dis Child Fetal Neonatal Ed; 98(2):107–111. https://doi.org/10.1111/Acer.12214
  • Schans JV, Çiçek R, de Vries TW, Hak E, Hoekstra PJ (2017) Association of atopic diseases and attention-deficit/hyperactivity disorder: a systematic review and meta-analyses. Neurosci Biobehav Rev; 74(Pt A):139–148. https://doi.org/10.1016/j.neubiorev.2017.01.011
  • Segman RH, Meltzer A, Gross-Tsur V, Kosov A, Frisch A, Inbar E, et al (2002) Preferential transmission of interleukin-1 receptor antagonist alleles in attention deficit hyperactivity disorder. Molecular psychiatry;7(1), 72-74.
  • Shao S, Wang J, Huang K, Wang S, Liu H, Wan S, et al (2020) Prenatal pregnancy-related anxiety predicts boys' ADHD symptoms via placental C-reactive protein. Psychoneuroendocrinology. Oct;120:104797. doi: 10.1016/j.psyneuen.2020.104797. Epub 2020 Jul 11. PMID: 32682173.
  • Skogheim TS, Villanger GD, Weyde KVF, Engel SM, Surén P, Øie MG, et al (2020) Prenatal exposure to perfluoroalkyl substances and associations with symptoms of attention-deficit/hyperactivity disorder and cognitive functions in preschool children. Int J Hyg Environ Health. Jan;223(1):80-92. doi: 10.1016/j.ijheh.2019.10.003. Epub 2019 Oct 22. PMID: 31653559; PMCID: PMC6922090.
  • Sourander A, Sucksdorff M, Chudal R, Surcel HM, Hinkka-Yli-Salomäki S, Gyllenberg D, et al (2019) Prenatal Cotinine Levels and ADHD Among Offspring. Pediatrics. Mar;143(3):e20183144. doi: 10.1542/peds.2018-3144. PMID: 30804074; PMCID: PMC6398365.
  • Terasaki LS, Schwarz JM (2016) Effects of Moderate Prenatal Alcohol Exposure during Early Gestation in Rats on Inflammation across the Maternal-Fetal-Immune Interface and Later-Life Immune Function in the Offspring. J Neuroimmune Pharmacol, 11(4), 680–692. [PubMed: 27318824]
  • Tong VT, Althabe F, Alemán A, Johnson CC, Dietz PM, Berrueta M, et al (2015) Prenatal Tobacco Cessation Intervention Collaborative. Accuracy of self-reported smoking cessation during pregnancy. Acta Obstet Gynecol Scand;94(1):106–111
  • Toto M, Margari F, Simone M, Craig F, Petruzzelli MG, Tafuri S, et al (2015) Antibasal Ganglia Antibodies and Antistreptolysin O in Noncomorbid ADHD. Journal of attention disorders; 19(11), 965–970. [PubMed: 22956712]
  • Verlaet AA, Noriega DB, Hermans N, Savelkoul HF (2014) Nutrition, immunological mechanisms and dietary immunomodulation in ADHD. European child & adolescent psychiatry, 23(7), 519-529.
  • Werenberg Dreier J, Nybo Andersen AE, Hvolby A, Garne E, Andersen PK, Berg-Beckhoff G (2016) Fever and infections in pregnancy and risk of attention deficit/hyperactivity disorder in the offspring. J Child Psychol Psychiatry; 57(4):540–548.https://doi.org/10.1111/jcpp.12480
  • Xiang AH, Orcid Id, Wang X, Martinez MP, Getahun D, Page KA, et al (2018) Maternal gestational diabetes mellitus, type 1 diabetes, and type 2 diabetes during pregnancy and risk of ADHD in offspring. Diabetes Care;41(12):2502-8.
  • Yolton K, Cornelius M, Ornoy A, Mcgough J, Makris S, Schantz S (2014) Exposure to neurotoxicants and the development of attention defcit hyperactivity disorder and its related behaviors in childhood. Neurotoxicol Teratol; 44:30–45. https://doi. org/10.1016/J.Ntt.2014.05.003 10.
  • Zhang X, Li X, Jing Y, Fang X, Zhang X, Lei B, et al (2017) Transplacental transfer of polycyclic aromatic hydrocarbons in paired samples of maternal serum, umbilical cord serum, and placenta in Shanghai, China. Environ Pollut. Mar;222:267-275. doi: 10.1016/j.envpol.2016.12.046. Epub 2016 Dec 24. PMID: 28024810.

Relationship between Prenatal Inflammation and Attention Deficit Hyperactivity Disorder

Year 2021, Volume: 13 Issue: 3, 478 - 489, 30.09.2021
https://doi.org/10.18863/pgy.811846

Abstract

Attention Deficit Hyperactivity Disorder (ADHD) is a chronic neurodevelopmental disorder characterized by attention deficit, hyperactivity, and impulsivity. ADHD presents impairments in academic, social, emotional and cognitive domains. Genetic and environmental factors play a role in the etiology of ADHD. Numerous studies showed that parameters associated with inflammation were higher in patients with ADHD. Due to the co-occurrence of ADHD and allergic and immunologic disorders, it is thought that the immune system has an effect on ADHD etiology. Previous studies showed that there is a strong association between prenatal inflammation exposure and neurodevelopmental disorders. Maternal diabetes mellitus, body mass index, preeclampsia, infections and chronic or autoimmune disorders of the mother are accepted as prenatal risk factors of ADHD. All these risk factors are associated with the immune profile of the mother. Because of this, the association between ADHD and intrauterine inflammation exposure is attractive. In this paper, the association of ADHD and perinatal inflammation due to maternal immune activation is reviewed.

References

  • Adriani W, Romano E, Pucci M, Pascale E, Cerniglia L, Cimino S, Tambelli R, Curatolo P, Granstrem O, Maccarrone M, Laviola G, D’Addario C (2018) Potential for diagnosis versus therapy monitoring of attention deficit hyperactivity disorder: a new epigenetic biomarker interacting with both genotype and auto-immunity. Eur Child Adolesc Psychiatry, 27(2):241-252
  • Alvarez-Arellano L, González-García N, Salazar-García M, Corona JC (2020) Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder. Antioxidants, 9(2), 176.
  • Amiri S, Malek A, Sadegfard M, Abdi S (2012) Pregnancy-related maternal risk factors of attention-deficit hyperactivity disorder: a case-control study. ISRN Pediatr, 458064.
  • Anand D, Colpo GD, Zeni G, Zeni CP, Teixeira AL (2017) Attention-Deficit/Hyperactivity Disorder And Inflammation: What Does Current Knowledge Tell Us? A Systematic Review. Front Psychiatry. 8, 228. [PubMed: 29170646]
  • Anderson JO, Thundiyil JG, Stolbach A (2012) Clearing the air: a review of the effects of particulate matter air pollution on human health. J. Med. Toxicol, 8, 166-175.
  • American Psychiatry Association (2013) Diagnostic and statistical manual of mental disorders (5th ed.). American Psychiatric Publishing, Arlington, VA.
  • Avcil S (2018) Evaluation of the neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume as inflammatory markers in children with attention-deficit hyperactivity disorder . Psychiatry Clin Neurosci, 72(7):522–530
  • Bierderman J, Faraone SV (2005) Attention-deficit hyperactivity disorder. Lancet, 366:237–248.
  • Böhm S, Curran EA, Kenny LC, O'Keeffe GW, Murray D, Khashan AS (2019) The Effect of Hypertensive Disorders of Pregnancy on the Risk of ADHD in the Offspring. J Atten Disord. May;23(7):692-701. doi: 10.1177/1087054717690230. Epub 2017 Feb 4. PMID: 28162026.
  • Bytoft B, Knorr S, Vlachova Z, Jensen RB, Mathiesen ER, Beck-Nielsen H, et al (2017) Assessment of attention deficits in adolescent offspring exposed to maternal type 1 diabetes. PLoS One.;12(1):e0169308
  • Calderón-Garcidueñas L, Solt AC, Henríquez-Roldán C, Torres-Jardón R, Nuse B, Herritt L, et al (2008) Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. Toxicol Pathol. Feb;36(2):289-310. doi: 10.1177/0192623307313011. Epub 2008 Mar 18. PMID: 18349428.
  • Calderón-Garcidueñas L, Engle R, Mora-Tiscareño A, Styner M, Gómez-Garza G, Zhu H, et al (2011) Exposure to severe urban air pollution influences cognitive outcomes, brain volume and systemic inflammation in clinically healthy children. Brain Cogn. Dec;77(3):345-55. doi: 10.1016/j.bandc.2011.09.006. Oct 26. PMID: 22032805.
  • Calderón-Garcidueñas L, Mora-Tiscareño A, Styner M, Gómez-Garza G, Zhu H, Torres-Jardón R, et al (2012) White matter hyperintensities, systemic inflammation, brain growth, and cognitive functions in children exposed to air pollution. J Alzheimers Dis.;31(1):183-91. doi: 10.3233/JAD-2012-120610. PMID: 22531421.
  • Chahal N, McLain AC, Ghassabian A, Michels KA, Bell EM, Lawrence DA, et al (2017) Maternal Smoking and Newborn Cytokine and Immunoglobulin Levels. Nicotine Tob Res. Jul 1;19(7):789-796. doi: 10.1093/ntr/ntw324. PMID: 28011791; PMCID: PMC5939663.
  • Chandna AR, Kuhlmann N, Bryce CA, Greba Q, Campanucci VA, Howland JG (2015) Chronic maternal hyperglycemia induced during mid-pregnancy in rats increases RAGE expression, augments hippocampal excitability, and alters behavior of the offspring. Neuroscience.; 303:241-60.
  • Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV et al (2016) The maternal interleukin17a pathway in mice promotes autism-like phenotypes in offspring. Science (New York, NY) ;351:933–939
  • Chudal R, Brown AS, Gyllenberg D, Hinkka-Yli-Salomäki S, Sucksdorff M, Surcel HM et al (2020) Maternal serum C-reactive protein (CRP) and offspring attention deficit hyperactivity disorder (ADHD). Eur Child Adolesc Psychiatry. https://doi.org/10.1007/s00787-019-01372-y
  • Chung KF (2005) Inflammatory mediators in chronic obstructive pulmonary disease. Curr Drug Targets Inflamm Allergy, 4:619-625.
  • Class QA, Abel KM, Khashan AS, Rickert ME, Dalman C, Larsson H, et al (2014) Offspring psychopathology following preconception, prenatal and postnatal maternal bereavement stress. Psychol Med; 44: 71–84. [PubMed: 23591021]
  • Cowell WJ, Bellinger DC, Wright RO, Wright RJ (2019) Antenatal active maternal asthma and other atopic disorders is associated with ADHD behaviors among school-aged children. Brain Behav Immun. Aug;80:871-878. doi: 10.1016/j.bbi.2019.05.040. Epub 2019 May 31. PMID: 31158498; PMCID: PMC6660383
  • Dachew BA, Scott JG, Mamun A, Alati R (2019) Pre-eclampsia and the risk of attention-deficit/hyperactivity disorder in offspring: Findings from the ALSPAC birth cohort study. Psychiatry Res. Feb;272:392-397. doi: 10.1016/j.psychres.2018.12.123. Epub 2018 Dec 25. PMID: 30605798.
  • Darwish AH, Elgohary TM, Nosair NA (2018) Serum Interleukin-6 Level in Children With Attention-Deficit Hyperactivity Disorder (ADHD). J Child Neurol;883073818809831.
  • Dietz PM, Homa D, England LJ, Burley K, Tong VT, Dube SR, et al (2011) Estimates of nondisclosure of cigarette smoking among pregnant and nonpregnant women of reproductive age in the United States. Am J Epidemiol;173(3):355–359
  • Donfrancesco R, Nativio P, Borrelli E, Giua E, Andriola E, Villa MP, et al (2016) Serum cytokines in paediatric neuropsychiatric syndromes: focus on Attention Deficit Hyperactivity Disorder. Minerva Pediatr., Dec 22. Epub ahead of print. PMID: 28006890.
  • Dong T, Hu W, Zhou X, Lin H, Lan L, Hang B, et al (2018) Prenatal exposure to maternal smoking during pregnancy and attention-deficit/hyperactivity disorder in offspring: A meta-analysis. Reproductive Toxicology, 76, 63-70.
  • Dreier JW, Andersen AN, Hvolby A, Garne E, Andersen PK, Berg-Beckhoff G (2016) Fever and infections in pregnancy and risk of attention deficit/hyperactivity disorder in the offspring. Journal of Child Psychology and Psychiatry; 57, 540–548.
  • Dunn GA, Nigg JT, Sullivan EL (2019) Neuroinflammation as a Risk Factor for Attention Deficit Hyperactivity Disorder. Pharmacol. Biochem. Behav, 182, 22–34.
  • Dürr DW, Høyer BB, Christensen LH, Pedersen HS, Zinchuk A, Jönsson BA, et al (2015) Tobacco smoking during pregnancy and risk of adverse behaviour in offspring: a follow-up study. Reprod Toxicol.; 58:65–72
  • Dwyer JB, McQuown SC, Leslie FM (2009) The dynamic effects of nicotine on the developing brain. Pharmacol Ther;122(2):125–39.
  • Eidelman AI, Samueloff A (2002) The pathophysiology of the fetus of the diabetic mother. Semin Perinatol;26(3):232-6. 32.
  • Ek CJ, Dziegielewska KM, Habgood MD, Saunders NR (2012) Barriers in the developing brain and Neurotoxicology. Neurotoxicology. Jun;33(3):586-604. doi: 10.1016/j.neuro.2011.12.009. Epub 2011 Dec 19. PMID: 22198708.
  • Eskenazi B, Trupin LS (1995) Passive and active maternal smoking during pregnancy, as measured by serum cotinine, and postnatal smoke exposure. II. Effects on neurodevelopment at age 5 years. Am J Epidemiol.;142(suppl 9): S19–S29
  • Faraone SV, Asherson P, Banaschewski T, Biederman J, Buitelaar JK, Ramos-Quiroga JA, et al (2015) Attention-Deficit/Hyperactivity Disorder. Nat. Rev. Dis. Primers, 1, 15020.
  • Forns J, Sunyer J, Garcia-Esteban R, Porta D, Ghassabian A, Giorgis-Allemand L, et al (2018a) Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe. Epidemiology. Sep;29(5):618-626. doi: 10.1097/EDE.0000000000000874. PMID: 29923866.
  • Forns J, Stigum H, Høyer BB, Sioen I, Sovcikova E, Nowack N, et al (2018b) Prenatal and postnatal exposure to persistent organic pollutants and attention-deficit and hyperactivity disorder: a pooled analysis of seven European birth cohort studies. Int J Epidemiol. Aug 1;47(4):1082-1097. doi: 10.1093/ije/dyy052. PMID: 29912347; PMCID: PMC6124627
  • Giana G, Romano E, Porfirio MC, D’Ambrosio R, Giovinazzo S, Troianiello M, et al (2015) Detection of auto-antibodies to DAT in the serum: interactions with DAT genotype and psycho-stimulant therapy for ADHD. J Neuroimmunol,; 278, 212–222. [PubMed: 25468771]
  • Ginsberg Y, D'Onofrio BM, Rickert ME, Class QA, Rosenqvist MA, Almqvist C, et al (2019) Maternal infection requiring hospitalization during pregnancy and attention-deficit hyperactivity disorder in offspring: a quasi-experimental family-based study. J Child Psychol Psychiatry. Feb;60(2):160-168. doi: 10.1111/jcpp.12959. Epub 2018 Aug 23. PMID: 30136726.
  • Golmirzaei J, Namazi S, Amiri S, Zare S, Rastikerdar N, Hesam AA, et al (2013) Evaluation of attention-deficit hyperactivity disorder risk factors. Int J Pediatr.; 2013:953103.
  • Gustafsson P, Källén K (2011) Perinatal, maternal, and fetal characteristics of children diagnosed with attention-deficit–hyperactivity disorder: results from a population-based study utilizing the Swedish Medical Birth Register. Dev Med Child Neurol. ;53(3):263-268.
  • Gustafsson HC, Sullivan EL, Battison EAJ, Holton KF, Graham AM, Karalunas SL, et al (2020) Evaluation of maternal inflammation as a marker of future offspring ADHD symptoms: A prospective investigation. Brain Behav Immun. Jul 21:S0889-1591(20)30731-5. doi: 10.1016/j.bbi.2020.07.019. Epub ahead of print. PMID: 32707260.
  • Gustavson K, Ask H, Ystrom E, Stoltenberg C, Lipkin WI, Surén P, et al (2019) Maternal fever during pregnancy and offspring attention deficit hyperactivity disorder. Sci Rep. Jul 2;9(1):9519. doi: 10.1038/s41598-019-45920-7. PMID: 31266998; PMCID: PMC6606630.
  • Hantsoo L, Kornfield S, Anguera MC, Epperson CN (2019) Inflammation: A Proposed Intermediary Between Maternal Stress and Offspring Neuropsychiatric Risk. Biol Psychiatry. Jan 15;85(2):97-106. doi: 10.1016/j.biopsych.2018.08.018. Epub 2018 Sep 5. PMID: 30314641; PMCID:
  • Hegvik TA, Instanes JT, Haavik J, Klungsøyr K, Engeland A (2019) Associations between attention-deficit/hyperactivity disorder and autoimmune diseases are modified by sex: a population-based cross-sectional study. Eur Child Adolesc Psychiatry; 27(5):663–675. https ://doi.org/10.1007/s0078 7-017-1056-1
  • Huang L, Wang Y, Zhang L, Zheng Z, Zhu T, Qu Y, et al (2018) Maternal smoking and attention-deficit/hyperactivity disorder in offspring: a meta-analysis. Pediatrics.;141(1): e20172465
  • Instanes JT, Halmøy A, Engeland A, Haavik J, Furu K, Klungsøyr K (2017) Attention-deficit/Hyperactivity disorder in offspring of mothers with inflammatory and immune system diseases. Biol Psychiatry;81(5):452-9.
  • Jallow J, Halt AH, Öhman H, Hurtig T (2020) Prenatal inflammation does not increase the risk for symptoms of attention deficit hyperactivity disorder (ADHD) in offspring. European Child & Adolescent Psychiatry,; 1-4.
  • Jenabi E, Bashirian S, Khazaei S, Basiri Z (2019) The maternal prepregnancy body mass index and the risk of attention deficit hyperactivity disorder among children and adolescents: a systematic review and meta-analysis. Korean journal of pediatrics; 62(10), 374.
  • Ji J, Chen T, Sundquist J, Sundquist K (2018) Type 1 diabetes in parents and risk of attention deficit/hyperactivity disorder in offspring: a populationbased study in Sweden. Diabetes Care; 41:770–774
  • Kelly Y, Sacker A, Gray R, Kelly J, Wolke D, Ma Quigley (2009) Light drinking in pregnancy, a risk for behavioural problems and cognitive defcits at 3 years of age? Int J Epidemiol; 38(1):129– 140. https://doi.org/10.1093/Ije/Dyn230
  • Kelly Yi, Sacker A, Gray R, Kelly J, Wolke D, Head J, et al (2012) Light drinking during pregnancy: still no increased risk for socioemotional difculties or cognitive defcits at 5 years of age? J Epidemiol Community Health; 66(1):41–48. https://doi. org/10.1136/Jech.2009.103002
  • Knopik VS, Maccani MA, Francazio S, McGeary JE (2012) The epigenetics of maternal cigarette smoking during pregnancy and effects on child development. Dev Psychopathol.; 24(4):1377–1390
  • Kong L, Norstedt G, Schalling M, Gissler M, Lavebratt C (2018) The risk of offspring psychiatric disorders in the setting of maternal obesity and diabetes. Pediatrics;142(3):e20180776.
  • Lee J, Taneja V, Vassallo R (2012) Cigarette smoking and inflammation: cellular and molecular mechanisms. J Dent Res. Feb;91(2):142-9. doi: 10.1177/0022034511421200. Epub 2011 Aug 29. PMID: 21876032; PMCID: PMC3261116.
  • Li J, Olsen J, Vestergaard M, Obel C (2010) Attention-deficit/hyperactivity disorder in the offspring following prenatal maternal bereavement: a nationwide follow-up study in Denmark. Eur Child Adolesc Psychiatry. 19: 747–753. [PubMed: 20495989]
  • Li J, Zhong H, Liang ZC, Xy L (2014) Study on correlation between gestational diabetes merged pregnancy-induced hypertension and hyperactivity syndrome in children. J Clin Exp Med.;13(19):1583–1585
  • Liu X, Dalsgaard S, Munk-Olsen T, Li J, Wright RJ, Momen NC (2019) Parental asthma occurrence, exacerbations and risk of attention-deficit/hyperactivity disorder. Brain Behav Immun. Nov;82:302-308. doi: 10.1016/j.bbi.2019.08.198. Epub 2019 Aug 30. PMID: 31476415; PMCID: PMC7408292.
  • MacKinnon N, Kingsbury M, Mahedy L, Evans J, Colman I (2018) The Association Between Prenatal Stress and Externalizing Symptoms in Childhood: Evidence From the Avon Longitudinal Study of Parents and Children. Biological Psychiatry, Early Life Environments and Later Vulnerabilities; 83: 100–108.
  • Maher GM, McCarthy FP, McCarthy CM, Kenny LC, Kearney PM, Khashan AS, et al (2019) A perspective on pre-eclampsia and neurodevelopmental outcomes in the offspring: does maternal inflammation play a role? Int J Dev Neurosci; 77:69–76.
  • Maher GM, Dalman C, O'Keeffe GW, Kearney PM, McCarthy FP, Kenny LC, et al (2020) Association between preeclampsia and attention-deficit hyperactivity disorder: a population-based and sibling-matched cohort study. Acta Psychiatr Scand. Feb 13. doi: 10.1111/acps.13162. Epub ahead of print. PMID: 32056200.
  • Mittleman BB, Castellanos FX, Jacobsen LK, Rapoport JL, Swedo SE, Shearer GM (1997) Cerebrospinal fluid cytokines in pediatric neuropsychiatric disease. J Immunol; 159(6), 2994–2999. [PubMed: 9300724]
  • Money KM, Barke TL, Serezani A, Gannon M, Garbett KA, Aronoff DM, et al (2018) Gestational diabetes exacerbates maternal immune activation effects in the developing brain. Mol Psychiatry;23(9):1–9.
  • Myhre O, Låg M, Villanger GD, Oftedal B, Øvrevik J, Holme JA, et al (2018) Early life exposure to air pollution particulate matter (PM) as risk factor for attention deficit/hyperactivity disorder (ADHD): Need for novel strategies for mechanisms and causalities. Toxicol Appl Pharmacol. Sep 1;354:196-214. doi: 10.1016/j.taap.2018.03.015. Epub 2018 Mar 14. PMID: 29550511.
  • Newby DE, Mannucci PM, Tell GS, Baccarelli AA, Brook RD, Donaldson K, et al (2015) Expert position paper on air pollution and cardiovascular disease. Eur. Heart J; 36, 83–93b.
  • Niclasen J, Am Nybo Andersen, Tw Teasdale, Strandberg-Larsen K (2014) Prenatal exposure to alcohol, and gender diferences on child mental health at age 7 years. J Epidemiol Commun Health; 68(3):224–232. https://doi.org/10.1136/Jech-2013-202956
  • Nielsen PR, Benros ME, Dalsgaard S (2017) Associations between autoimmune diseases and attention-deficit/hyperactivity disorder: a nationwide study. J Am Acad Child Adolesc Psychiatry; 56(3):234–240.e1. https://doi.org/10.1016/j.jaac.2016.12.010
  • Nomura Y, Marks DJ, Grossman B, Yoon M, Loudon H, Stone J, et al (2012) Exposure to gestational diabetes mellitus and low socioeconomic status: effects on neurocognitive development and risk of attention-deficit/hyperactivity disorder in offspring. Arch Pediatr Adolesc Med;166(4):337–343.
  • Oades RD, Myint AM, Dauvermann MR, Schimmelmann BG, Schwarz MJ (2010) Attention-deficit hyperactivity disorder (ADHD) and glial integrity: an exploration of associations of cytokines and kynurenine metabolites with symptoms and attention. Behav Brain Funct; 6, 32. [PubMed: 20534153]
  • Okano L, Ji Y, Riley AW, Wang X (2019) Maternal psychosocial stress and children's ADHD diagnosis: a prospective birth cohort study. J Psychosom Obstet Gynaecol. Sep;40(3):217-225. doi: 10.1080/0167482X.2018.1468434. Epub 2018 May 23. PMID: 29790815; PMCID: PMC6251762.
  • Oldenburg KS, O’Shea TM, Fry RC (2020) Genetic and epigenetic factors and early life inflammation as predictors of neurodevelopmental outcomes. In Seminars in Fetal and Neonatal Medicine; (p. 101115).
  • Ornoy A, Reece EA, Pavlinkova G, Kappen C, Miller RK (2015) Effect of maternal diabetes on the embryo, fetus, and children: congenital anomalies, genetic and epigenetic changes and developmental outcomes. Birth Defects Res C Embryo Today;105(1):53–72.
  • Oudin A, Frondelius K, Haglund N, Källén K, Forsberg B, Gustafsson P, et al (2019) Prenatal exposure to air pollution as a potential risk factor for autism and ADHD. Environ Int. Dec;133(Pt A):105149. doi: 10.1016/j.envint.2019.105149. Epub 2019 Oct 16. PMID: 31629172.
  • Önder A, Gizli Çoban Ö, Sürer Adanır A (2020) Elevated neutrophil-to-lymphocyte ratio in children and adolescents with attention-deficit/hyperactivity disorder. International Journal of Psychiatry in Clinical Practice; 1-6.
  • Pagliaccio D, Herbstman JB, Perera F, Tang D, Goldsmith J, Peterson BS, et al (2020) Prenatal exposure to polycyclic aromatic hydrocarbons modifies the effects of early life stress on attention and Thought Problems in late childhood. J Child Psychol Psychiatry. Jan 7:10.1111/jcpp.13189. doi: 10.1111/jcpp.13189. Epub ahead of print. PMID: 31907931; PMCID: PMC7338249.
  • Pagnin D, Zamboni Grecco ML, Furtado EF (2019) Prenatal alcohol use as a risk for attention-deficit/hyperactivity disorder. Eur Arch Psychiatry Clin Neurosci. Sep;269(6):681-687. doi: 10.1007/s00406-018-0946-7. Epub 2018 Oct 23. PMID: 30353263.
  • Perera FP, Chang HW, Tang D, Roen EL, Herbstman J, Margolis A, et al (2014) Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. PLoS One. Nov 5;9(11):e111670. doi: 10.1371/journal.pone.0111670. PMID: 25372862; PMCID: PMC4221082.
  • Perera FP, Wheelock K, Wang Y, Tang D, Margolis AE, Badia G, et al (2018) Combined effects of prenatal exposure to polycyclic aromatic hydrocarbons and material hardship on child ADHD behavior problems. Environ Res. Jan; 160:506-513. doi: 10.1016/j.envres.2017.09.002. Epub 2017 Oct 4. PMID: 28987706; PMCID: PMC5724364.
  • Peterson BS, Rauh VA, Bansal R, Hao X, Toth Z, Nati G, et al (2015) Effects of prenatal exposure to air pollutants (polycyclic aromatic hydrocarbons) on the development of brain white matter, cognition, and behavior in later childhood. JAMA Psychiatry. Jun;72(6):531-40. doi: 10.1001/jamapsychiatry.2015.57. Erratum in: JAMA Psychiatry. 2015 Jun;72(6):625. PMID: 25807066; PMCID: PMC4456286.
  • Pineles BL, Park E, Samet JM (2014) Systematic review and meta-analysis of miscarriage and maternal exposure to tobacco smoke during pregnancy. Am J Epidemiol;179(7):807–823
  • Popova S, Lange S, Shield K, Mihic A, Ae Chudley, Ra Mukherjee, et al (2016) Comorbidity of fetal alcohol spectrum disorder: a systematic review and meta-analysis. Lancet; 387(10022):9
  • Rzehak P, Saffery R, Reischl E, Covic M, Wahl S, Grote V, et al (2016) European Childhood Obesity Trial Study group. Maternal smoking during pregnancy and DNA-methylation in children at age 5.5 years: epigenomewide- analysis in the European Childhood Obesity Project (CHOP)-study. PLoS One;11(5): e0155554
  • San Martin Porter M, Maravilla JC, Betts KS, Alati R (2019) Low-moderate prenatal alcohol exposure and offspring attention-deficit hyperactivity disorder (ADHD): systematic review and meta-analysis. Arch Gynecol Obstet. Aug;300(2):269-277. doi: 10.1007/s00404-019-05204-x. Epub 2019
  • Sanchez CE, Barry C, Sabhlok A, Russell K, Majors A, Kollins SH, et al (2018) Maternal pre-pregnancy obesity and child neurodevelopmental outcomes: a meta-analysis. Obes Rev;19:464-84.
  • Say GN, Karabekiroğlu K, Babadağı Z, Yüce M (2016) Maternal stress and perinatal features in autism and attention deficit/hyperactivity disorder. Pediatr Int. Apr;58(4):265-9. doi: 10.1111/ped.12822. Epub 2016 Feb 2. PMID: 26338105.
  • Sayal K, Es Draper, Fraser R, Barrow M, Smith Gd, Gray R (2013) Light drinking in pregnancy and mid-childhood mental health and learning outcomes. Arch Dis Child Fetal Neonatal Ed; 98(2):107–111. https://doi.org/10.1111/Acer.12214
  • Schans JV, Çiçek R, de Vries TW, Hak E, Hoekstra PJ (2017) Association of atopic diseases and attention-deficit/hyperactivity disorder: a systematic review and meta-analyses. Neurosci Biobehav Rev; 74(Pt A):139–148. https://doi.org/10.1016/j.neubiorev.2017.01.011
  • Segman RH, Meltzer A, Gross-Tsur V, Kosov A, Frisch A, Inbar E, et al (2002) Preferential transmission of interleukin-1 receptor antagonist alleles in attention deficit hyperactivity disorder. Molecular psychiatry;7(1), 72-74.
  • Shao S, Wang J, Huang K, Wang S, Liu H, Wan S, et al (2020) Prenatal pregnancy-related anxiety predicts boys' ADHD symptoms via placental C-reactive protein. Psychoneuroendocrinology. Oct;120:104797. doi: 10.1016/j.psyneuen.2020.104797. Epub 2020 Jul 11. PMID: 32682173.
  • Skogheim TS, Villanger GD, Weyde KVF, Engel SM, Surén P, Øie MG, et al (2020) Prenatal exposure to perfluoroalkyl substances and associations with symptoms of attention-deficit/hyperactivity disorder and cognitive functions in preschool children. Int J Hyg Environ Health. Jan;223(1):80-92. doi: 10.1016/j.ijheh.2019.10.003. Epub 2019 Oct 22. PMID: 31653559; PMCID: PMC6922090.
  • Sourander A, Sucksdorff M, Chudal R, Surcel HM, Hinkka-Yli-Salomäki S, Gyllenberg D, et al (2019) Prenatal Cotinine Levels and ADHD Among Offspring. Pediatrics. Mar;143(3):e20183144. doi: 10.1542/peds.2018-3144. PMID: 30804074; PMCID: PMC6398365.
  • Terasaki LS, Schwarz JM (2016) Effects of Moderate Prenatal Alcohol Exposure during Early Gestation in Rats on Inflammation across the Maternal-Fetal-Immune Interface and Later-Life Immune Function in the Offspring. J Neuroimmune Pharmacol, 11(4), 680–692. [PubMed: 27318824]
  • Tong VT, Althabe F, Alemán A, Johnson CC, Dietz PM, Berrueta M, et al (2015) Prenatal Tobacco Cessation Intervention Collaborative. Accuracy of self-reported smoking cessation during pregnancy. Acta Obstet Gynecol Scand;94(1):106–111
  • Toto M, Margari F, Simone M, Craig F, Petruzzelli MG, Tafuri S, et al (2015) Antibasal Ganglia Antibodies and Antistreptolysin O in Noncomorbid ADHD. Journal of attention disorders; 19(11), 965–970. [PubMed: 22956712]
  • Verlaet AA, Noriega DB, Hermans N, Savelkoul HF (2014) Nutrition, immunological mechanisms and dietary immunomodulation in ADHD. European child & adolescent psychiatry, 23(7), 519-529.
  • Werenberg Dreier J, Nybo Andersen AE, Hvolby A, Garne E, Andersen PK, Berg-Beckhoff G (2016) Fever and infections in pregnancy and risk of attention deficit/hyperactivity disorder in the offspring. J Child Psychol Psychiatry; 57(4):540–548.https://doi.org/10.1111/jcpp.12480
  • Xiang AH, Orcid Id, Wang X, Martinez MP, Getahun D, Page KA, et al (2018) Maternal gestational diabetes mellitus, type 1 diabetes, and type 2 diabetes during pregnancy and risk of ADHD in offspring. Diabetes Care;41(12):2502-8.
  • Yolton K, Cornelius M, Ornoy A, Mcgough J, Makris S, Schantz S (2014) Exposure to neurotoxicants and the development of attention defcit hyperactivity disorder and its related behaviors in childhood. Neurotoxicol Teratol; 44:30–45. https://doi. org/10.1016/J.Ntt.2014.05.003 10.
  • Zhang X, Li X, Jing Y, Fang X, Zhang X, Lei B, et al (2017) Transplacental transfer of polycyclic aromatic hydrocarbons in paired samples of maternal serum, umbilical cord serum, and placenta in Shanghai, China. Environ Pollut. Mar;222:267-275. doi: 10.1016/j.envpol.2016.12.046. Epub 2016 Dec 24. PMID: 28024810.
There are 97 citations in total.

Details

Primary Language Turkish
Subjects Psychiatry
Journal Section Review
Authors

Canan Kuygun Karcı 0000-0002-9355-9449

Publication Date September 30, 2021
Acceptance Date December 24, 2020
Published in Issue Year 2021 Volume: 13 Issue: 3

Cite

AMA Kuygun Karcı C. Prenatal Enflamasyon ve Dikkat Eksikliği Hiperaktivite Bozukluğu İlişkisi. Psikiyatride Güncel Yaklaşımlar - Current Approaches in Psychiatry. September 2021;13(3):478-489. doi:10.18863/pgy.811846

Creative Commons License
Psikiyatride Güncel Yaklaşımlar - Current Approaches in Psychiatry is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.