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Alkol/Madde Kullanım Bozukluklarında Şiddet ve İntiharın Nörobiyolojik Temelleri

Year 2022, Volume: 14 Issue: 2, 264 - 275, 30.06.2022
https://doi.org/10.18863/pgy.998217

Abstract

Alkol ve madde kullanım bozukluklarında hem intihar davranışı riski hem de şiddet davranışı riski artmaktadır. Ayrıca, alkol ve madde kullanım bozukluklarının dünya genelinde artan intihar ve şiddet yaygınlığına önemli ölçüde katkıda bulunduğu ileri sürülmektedir. Bu nedenlerle intihar, şiddet ve bağımlılık kavramlarından oluşan sorunlar sarmalının küresel ölçekte çözüm beklediği düşünülmektedir. Bu problemlerle başa çıkmak için altta yatan nörobiyolojik mekanizmaların keşfi gereklidir. İntihar, şiddet ve bağımlılık davranışlarını anlamada nörobiyolojik mekanizmaların önemi daha önceki araştırmalarda ortaya konulmuştur. Özellikle son zamanlarda yapılan çalışmalar, bu üç durumun birbiriyle ilişkili genetik, epigenetik ve nörobiyolojik temellere sahip olabileceğine dair bazı kanıtlar göstermiştir. Bu nedenle bu derlemede alkol ve madde kullanım bozuklukları ile ilgili güncel nörobiyolojik araştırmaların yanı sıra intihar ve şiddet davranışları ile ilgili bilimsel yazın bir arada sunulacaktır.

References

  • Aharonovich E, Hasin DS, Brooks AC, Liu X, Bisaga A, Nunes EV (2006) Cognitive deficits predict low treatment retention in cocaine dependent patients. Drug Alcohol Depend, 81:313-322.
  • Amin F, Davidson M, Davis KL (1992) Homovanillic acid measurement in clinical research: a review of methodology. Schizophr Bull, 18:123-48.
  • APA (2013) Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM 5). Washington, DC, American Psychiatric Association.
  • Arango V, Underwood MD, Mann JJ (1996) Fewer pigmented locus coeruleus neurons in suicide victims: preliminary results. Biol Psychiatry, 39:112-120.
  • Arseneault L, Moffitt TE, Caspi A, Taylor PJ, Silva PA (2000) Mental disorders and violence in a total birth cohort: results from the Dunedin Study. Arch Gen Psychiatry, 57:979-986.
  • Aydın M, Hacımusalar Y, Hocaoğlu Ç (2019) İntihar Davranışının Nörobiyolojisi. Psikiyatride Güncel Yaklaşımlar, 11:1-23.
  • Bagge CL, Littlefield AK, Conner KR, Schumacher JA, Lee HJ (2014) Near-term predictors of the intensity of suicidal ideation: an examination of the 24 h prior to a recent suicide attempt. J Affect Disord, 165:53-58.
  • Berrocoso E, Sánchez-Blázquez P, Garzón J, Mico JA (2009) Opiates as antidepressants. Curr Pharm Des 15:1612-1622.
  • Blonigen D, Krueger R (2005) Human quantitative genetics of aggression. In Biology of Aggression. (Ed Nelson R). Oxford, Oxford University Press: 20-36.
  • Bolla KI, Eldreth DA, London ED, Kiehl KA, Mouratidis M, Contoreggi C et al. (2003) Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task. Neuroimage, 19:1085-1094.
  • Borges G, Bagge CL, Cherpitel CJ, Conner KR, Orozco R, Rossow I (2017) A meta-analysis of acute use of alcohol and the risk of suicide attempt. Psychol Med, 47:949-957.
  • Brent DA, Mann JJ (2005). Family genetic studies, suicide, and suicidal behavior. Am J Med Genet C Semin Med Genet,133c:13-24.
  • Brent DA, Melhem N (2008) Familial transmission of suicidal behavior. Psychiatr Clin North Am, 31:157-177.
  • Brienza RS, Stein MD, Chen M, Gogineni A, Sobota M, Maksad J et al. (2000) Depression among needle exchange program and methadone maintenance clients. J Subst Abuse Treat, 18:331-337.
  • Broerman R (2017) Diathesis-Stress Model. Encyclopedia of Personality and Individual Differences. (Eds Zeigler-Hill V, Shackelford TK). Cham, Springer International Publishing: 1-3.
  • Buttenschøn HN, Flint TJ, Foldager L, Qin P, Christoffersen S, Hansen NF et al. (2013) An association study of suicide and candidate genes in the serotonergic system. J Affect Disord, 148:291-298.
  • Cacciola JS, Alterman AI, Rutherford MJ, McKay JR, Mulvaney FD (2001) The relationship of psychiatric comorbidity to treatment outcomes in methadone maintained patients. Drug Alcohol Depend, 61:271-280.
  • Cam O, Bilge A (2013) The process of stigmatization, attitude, and belief about mental illness and patient in Turkey: a systematic review. Journal of Psychiatric Nursing, 4:91-102.
  • Castillo-Carniglia A, Keyes KM, Hasin DS, Cerdá M (2019) Psychiatric comorbidities in alcohol use disorder. Lancet Psychiatry, 6:1068-1080.
  • Cheung S, Woo J, Maes MS, Zai CC (2020) Suicide epigenetics, a review of recent progress. J Affect Disord, 265:423-438.
  • Chiaruttini C, Vicario A, Li Z, Baj G, Braiuca P, Wu Y et al. (2009) Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation. Proc Natl Acad Sci U S A, 106:16481-16486.
  • Corrigan PW, Watson AC (2005) Findings from the National Comorbidity Survey on the frequency of violent behavior in individuals with psychiatric disorders. Psychiatry Res, 136:153-162.
  • Cosgrove KP, Tellez-Jacques K, Pittman B, Petrakis I, Baldwin RM, Tamagnan G et al. (2010) Dopamine and serotonin transporter availability in chronic heroin users: a [¹²³I]β-CIT SPECT imaging study. Psychiatry Res, 184:192-195.
  • Craig IW, Halton KE (2009) Genetics of human aggressive behaviour. Hum Genet, 126:101-113.
  • Çinik E, Güçlü O, Şenormancı Ö, Aydin E, Erkiran M, Erkmen H (2015) Şizofreni hastalarında madde kullanımının suç ve şiddet özelliklerine etkisi. Anadolu Psikiyatri Dergisi, 16:104-112.
  • Depue RA, Spoont MR (1986) Conceptualizing a serotonin trait. A behavioral dimension of constraint. Ann N Y Acad Sci, 487:47-62.
  • Elizabeth Sublette M, Carballo JJ, Moreno CC, Galfalvy HC, Brent DA, Birmaher B et al. (2009) Substance use disorders and suicide attempts in bipolar subtypes. J Psychiatr Res, 43:230-238.
  • Eronen M, Hakola P, Tiihonen J (1996) Factors associated with homicide recidivism in a 13-year sample of homicide offenders in Finland. Psychiatr Serv, 47:403-406.
  • Esang M, Ahmed S (2018) A Closer Look at Substance Use and Suicide. Am J Psychiatry Resid J, 13:6-8.
  • Everitt BJ, Belin D, Economidou D, Pelloux Y, Dalley JW, Robbins TW (2008) Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos Trans R Soc Lond B Biol Sci, 363:3125-3135.
  • Fazel S, Gulati G, Linsell L, Geddes JR, Grann M (2009) Schizophrenia and violence: systematic review and meta-analysis. PLoS Med, 6:e1000120.
  • Fernández-Montalvo J, López-Goñi JJ, Arteaga A (2012) Violent behaviors in drug addiction: differential profiles of drug-addicted patients with and without violence problems. J Interpers Violence, 27:142-157.
  • Fitzgerald ML, Kassir SA, Underwood MD, Bakalian MJ, Mann JJ, Arango V (2017) Dysregulation of Striatal Dopamine Receptor Binding in Suicide. Neuropsychopharmacology, 42:974-982.
  • Fu LP, Bi GH, Zou ZT, Wang Y, Ye EM, Ma L et al. (2008) Impaired response inhibition function in abstinent heroin dependents: an fMRI study. Neurosci Lett, 438:322-326.
  • Garno JL, Gunawardane N, Goldberg JF (2008) Predictors of trait aggression in bipolar disorder. Bipolar Disord, 10:285-292.
  • Geniş B, Coşar B (2018) Psikiyatrik Hastalıklar ve Şiddet, Ankara, Nobel Kitabevi.
  • Gorwood P, Batel P, Adès J, Hamon M, Boni C (2000) Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior. Biol Psychiatry, 48:259-264.
  • Grant BF, Chou SP, Saha TD, Pickering RP, Kerridge BT, Ruan WJ et al. (2017) Prevalence of 12-Month Alcohol Use, High-Risk Drinking, and DSM-IV Alcohol Use Disorder in the United States, 2001-2002 to 2012-2013: Results From the National Epidemiologic Survey on Alcohol and Related Conditions. JAMA Psychiatry, 74:911-923.
  • Gray NS, Taylor J, Snowden RJ (2011) Predicting violence using structured professional judgment in patients with different mental and behavioral disorders. Psychiatry Res, 187:248-253.
  • Gruber SA, Silveri M, Yurgelun-Todd DA (2007) Neuropsychological consequences of opiate use. Neuropsychol Rev, 17:299-315.
  • Guy N, Newton-Howes G, Ford H, Williman J, Foulds J (2018) The prevalence of comorbid alcohol use disorder in the presence of personality disorder: Systematic review and explanatory modelling. Personal Ment Health, 12:216-228.
  • Hedegaard H, Curtin SC, Warner M (2020) Increase in Suicide Mortality in the United States, 1999-2018. NCHS Data Brief, 362:1-8.
  • Heim C, Nemeroff CB (2001) The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry, 49:1023-1039.
  • Hernandez G, Hamdani S, Rajabi H, Conover K, Stewart J, Arvanitogiannis A et al. (2006) Prolonged rewarding stimulation of the rat medial forebrain bundle: neurochemical and behavioral consequences. Behav Neurosci, 120:888-904.
  • Hurd YL, Herman MM, Hyde TM, Bigelow LB, Weinberger DR, Kleinman JE (1997) Prodynorphin mRNA expression is increased in the patch vs matrix compartment of the caudate nucleus in suicide subjects. Mol Psychiatry, 2:495-500.
  • Ieong HF, Yuan Z (2017) Resting-State Neuroimaging and Neuropsychological Findings in Opioid Use Disorder during Abstinence: A Review. Front Hum Neurosci, 11:1-12.
  • İnandı T, Özer C, Akdemir A, Akoğlu S, Babayiğit C, Turhan E, Sangün Ö (2009) Hatay’da Lise Öğrencilerinde Madde Kullanımı, Bazı Psikolojik Özellikler ve Şiddet: Kesitsel Bir Çalışma. Trakya Univ Tip Fak Derg, 26:189-196.
  • Jacobs DG, Baldessarini RJ, Conwell Y, Fawcett JA, Horton L, Meltzer H et al. (2010) Assessment and treatment of patients with suicidal behaviors. APA Practice Guidelines, 1-183.
  • Jokinen J, Nordström A-L, Nordström P (2009) Cerebrospinal fluid monoamine metabolites and suicide. Nord J Psychiatry, 63:276-279.
  • Joyal CC, Putkonen A, Mancini-Marïe A, Hodgins S, Kononen M, Boulay L et al. (2007) Violent persons with schizophrenia and comorbid disorders: a functional magnetic resonance imaging study. Schizophr Res, 91:97-102.
  • Keller S, Sarchiapone M, Zarrilli F, Videtic A, Ferraro A, Carli V et al. (2010) Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Arch Gen Psychiatry, 67:258-267.
  • Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L et al. (2001) Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology, 24:561-567.
  • Koob G, Kreek MJ (2007) Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry, 164:1149-1159.
  • Koob GF, Simon EJ (2009) The Neurobiology of Addiction: Where We Have Been and Where We Are Going. J Drug Issues, 39:115-132.
  • Koob GF, Volkow ND (2010) Neurocircuitry of addiction. Neuropsychopharmacology, 35: 217-238.
  • Koob GF, Volkow ND (2016) Neurobiology of addiction: a neurocircuitry analysis. Lancet Psychiatry, 3:760-773.
  • Krug EG, Mercy JA, Dahlberg LL, Zwi AB (2002) The world report on violence and health. Lancet, 360:1083-1088.
  • Kundakovic M, Gudsnuk K, Herbstman JB, Tang D, Perera FP, Champagne FA (2015) DNA methylation of BDNF as a biomarker of early-life adversity. Proc Natl Acad Sci U S A, 112:6807-6813.
  • Lindqvist P, Allebeck P (1990) Schizophrenia and crime. A longitudinal follow-up of 644 schizophrenics in Stockholm. Br J Psychiatry, 157:345-350.
  • Lutz PE, Gross JA, Dhir SK, Maussion G, Yang J, Bramoulle A et al. (2018) Epigenetic Regulation of the Kappa Opioid Receptor by Child Abuse. Biol Psychiatry, 84:751-761.
  • Mann JJ (2003) Neurobiology of suicidal behaviour. Nature Reviews Neuroscience, 4:819-828.
  • Marshall BDL, Fairbairn N, Li K, Wood E, Kerr T (2008) Physical violence among a prospective cohort of injection drug users: a gender-focused approach. Drug Alcohol Depend, 97:237-246.
  • Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y et al. (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science, 302:890-893.
  • McGowan PO, Szyf M (2010) The epigenetics of social adversity in early life: Implications for mental health outcomes. Neurobiol Dis, 39:66-72.
  • McGuffin P, Perroud N, Uher R, Butler A, Aitchison KJ, Craig I et al. (2010) The genetics of affective disorder and suicide. Eur Psychiatry, 25:275-277.
  • Melis M, Spiga S, Diana M (2005) The dopamine hypothesis of drug addiction: hypodopaminergic state. Int Rev Neurobiol, 63:101-154.
  • Nestler EJ (2005) Is there a common molecular pathway for addiction? Nature neuroscience, 8:1445-1449.
  • Nobile B, Lutz PE, Olie E, Courtet P (2020) The Role of Opiates in Social Pain and Suicidal Behavior. Curr Top Behav Neurosci, 46:197-210.
  • O'Connor DB, Ferguson E, Green JA, O'Carroll RE, O'Connor RC (2016) Cortisol levels and suicidal behavior: A meta-analysis. Psychoneuroendocrinology, 63:370-379.
  • O'Connor DB, Gartland N, O'Connor RC (2020) Stress, cortisol and suicide risk. Int Rev Neurobiol, 152:101-130.
  • Oliveira SL, Pillat MM, Cheffer A, Lameu C, Schwindt TT, Ulrich H (2013) Functions of neurotrophins and growth factors in neurogenesis and brain repair. Cytometry A, 83:76-89.
  • Özalp E (2009) İntihar Davranışının Genetiği. Turk Psikiyatri Derg, 20:85-93.
  • Özer Ü, Yıldırım EA, Erkoç ŞN (2015) Major Depresyon Olgularında İntihar Düşünce ve Davranışının Bağlanma Biçimi ile İlişkisi. Arch Neuropsychiatr, 52: 283-288.
  • Pardini DA, Raine A, Erickson K, Loeber R (2014) Lower amygdala volume in men is associated with childhood aggression, early psychopathic traits, and future violence. Biol Psychiatry, 75:73-80.
  • Peng S, Li W, Lv L, Zhang Z, Zhan X (2018) BDNF as a biomarker in diagnosis and evaluation of treatment for schizophrenia and depression. Discov Med, 26:127-136.
  • Phelps EA (2006) Emotion and cognition: insights from studies of the human amygdala. Annu Rev Psychol, 57:27-53.
  • Phillips J, Carpenter KM, Nunes EV (2004) Suicide risk in depressed methadone-maintained patients: associations with clinical and demographic characteristics. Am J Addict, 13:327-332.
  • Pietrzak RH, Naganawa M, Huang Y, Corsi-Travali S, Zheng MQ, Stein MB et al. (2014) Association of In Vivo κ-Opioid Receptor Availability and the Transdiagnostic Dimensional Expression of Trauma-Related Psychopathology. JAMA Psychiatry, 71:1262-1270.
  • Pitchot W, Reggers J, Pinto E, Hansenne M, Fuchs S, Pirard S et al. (2001) Reduced dopaminergic activity in depressed suicides. Psychoneuroendocrinology, 26:331-335.
  • Placidi GP, Oquendo MA, Malone KM, Huang YY, Ellis SP, Mann JJ (2001) Aggressivity, suicide attempts, and depression: relationship to cerebrospinal fluid monoamine metabolite levels. Biol Psychiatry, 50:783-791.
  • Pompili M, Serafini G, Innamorati M, Dominici G, Ferracuti S, Kotzalidis GD et al. (2010) Suicidal behavior and alcohol abuse. Int J Environ Res Public Health, 7:1392-1431.
  • Puhalla AA, Berman ME, Coccaro EF, Fahlgren MK, McCloskey MS (2020) History of childhood abuse and alcohol use disorder: Relationship with intermittent explosive disorder and intoxicated aggression frequency. J Psychiatr Res, 125:38-44.
  • Pulay AJ, Dawson DA, Hasin DS, Goldstein RB, Ruan WJ, Pickering RP et al. (2008) Violent behavior and DSM-IV psychiatric disorders: results from the national epidemiologic survey on alcohol and related conditions. J Clin Psychiatry, 69:12-22.
  • Quanbeck CD, Stone DC, McDermott BE, Boone K, Scott CL, Frye MA (2005) Relationship between criminal arrest and community treatment history among patients with bipolar disorder. Psychiatr Serv, 56:847-852.
  • Ramstedt M (2001) Alcohol and suicide in 14 European countries. Addiction, 96:59-75.
  • Rizk MM, Herzog S, Dugad S, Stanley B (2021) Suicide Risk and Addiction: The Impact of Alcohol and Opioid Use Disorders. Curr Addict Rep, 1-14.
  • Roy A (2002) Characteristics of opiate dependent patients who attempt suicide. J Clin Psychiatry, 63:403-407.
  • Roy A (2009) Characteristics of cocaine dependent patients who attempt suicide. Arch Suicide Res, 13:46-51.
  • Roy A (2010) Risk factors for attempting suicide in heroin addicts. Suicide Life Threat Behav, 40:416-420.
  • Sander T, Harms H, Lesch KP, Dufeu P, Kuhn S, Hoehe M et al. (1997) Association analysis of a regulatory variation of the serotonin transporter gene with severe alcohol dependence. Alcohol Clin Exp Res, 21:1356-1359.
  • Sansone RA, Whitecar P, Wiederman MW (2009) The prevalence of childhood trauma among those seeking buprenorphine treatment. J Addict Dis, 28:64-67.
  • Secunda SK, Cross CK, Koslow S, Katz MM, Kocsis J, Maas JW et al. (1986) Biochemistry and suicidal behavior in depressed patients. Biol Psychiatry, 21:756-767.
  • Schulteis G, Ahmed SH, Morse AC, Koob GF, Everitt BJ (2000) Conditioning and opiate withdrawal. Nature, 405:1013-1014.
  • Shiels MS, Tatalovich Z, Chen Y, Haozous EA, Hartge P, Nápoles AM et al. (2020) Trends in Mortality From Drug Poisonings, Suicide, and Alcohol-Induced Deaths in the United States From 2000 to 2017. JAMA Network Open, 3:e2016217-e2016217.
  • Shurman J, Koob GF, Gutstein HB (2010) Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain. Pain Med, 11:1092-1098.
  • Sopromadze S, Tsiskaridze A (2018) Violent Behavior. Neurologic-Psychiatric Syndromes in Focus. Part II. In From Psychiatry to Neurology (Eds Bogousslavsky J): 106-121. Basel, Karger.
  • Stanley B, Michel CA, Galfalvy HC, Keilp JG, Rizk MM, Richardson-Vejlgaard R et al. (2019) Suicidal subtypes, stress responsivity and impulsive aggression. Psychiatry Res, 280: 112486.
  • Steinert T, Wiebe C, Gebhardt RP (1999) Aggressive behavior against self and others among first-admission patients with schizophrenia. Psychiatr Serv, 50: 85-90.
  • Stoffel BCMM, Henrique PKF, Flavio P, Lisia vD, Olivier SMF, Tatiana HL et al. (2019) Crack users and violence. What is the relationship between trauma, antisocial personality disorder and posttraumatic stress disorder?. Addict Behav, 98:106012.
  • Sullivan LE, Fiellin DA, O'Connor PG (2005) The prevalence and impact of alcohol problems in major depression: a systematic review. Am J Med, 118:330-341.
  • Swanson JW, Holzer CE, Ganju VK, Jono RT (1990) Violence and psychiatric disorder in the community: evidence from the Epidemiologic Catchment Area surveys. Hosp Community Psychiatry, 41: 761-770.
  • Torrey EF (1994) Violent behavior by individuals with serious mental illness. Hosp Community Psychiatry, 45: 653-662.
  • Türkmen SN, Epsoylu H (2019) Madde kullanım varlığının, suç işleyen ve işlemeyen hastalarda suç ve şiddet özelliklerine etkisi. STED/Sürekli Tıp Eğitimi Dergisi, 28: 108-113.
  • Underwood MD, Mann JJ, Arango V (2004) Serotonergic and noradrenergic neurobiology of alcoholic suicide. Alcohol Clin Exp Res, 28:57-69.
  • van Heeringen C, Bijttebier S, Godfrin K (2011) Suicidal brains: a review of functional and structural brain studies in association with suicidal behaviour. Neurosci Biobehav Rev, 35: 688-698.
  • van Heeringen K, Mann JJ (2014) The neurobiology of suicide. Lancet Psychiatry, 1: 63-72.
  • van Praag HM, Asnis GM, Kahn RS, Brown SL, Korn M, Friedman JM et al. (1990) Monoamines and abnormal behaviour. A multi-aminergic perspective. Br J Psychiatry, 157: 723-734.
  • Volavka J, Laska E, Baker S, Meisner M, Czobor P, Krivelevich I (1997) History of violent behaviour and schizophrenia in different cultures. Analyses based on the WHO study on Determinants of Outcome of Severe Mental Disorders. Br J Psychiatry, 171:9-14.
  • Wagner G, Schultz CC, Koch K, Schachtzabel C, Sauer H, Schlösser RG (2012) Prefrontal cortical thickness in depressed patients with high-risk for suicidal behavior. J Psychiatr Res, 46: 1449-1455.
  • Welch KA, Carson A, Lawrie SM (2013) Brain structure in adolescents and young adults with alcohol problems: systematic review of imaging studies. Alcohol Alcohol, 48: 433-444.
  • Yüksel N (2001) İntiharın Nörobiyolojisi. Journal of Clinical Psychiatry, 4:5-15.
  • Zatti C, Rosa V, Barros A, Valdivia L, Calegaro VC, Freitas LH et al. (2017) Childhood trauma and suicide attempt: A meta-analysis of longitudinal studies from the last decade. Psychiatry Res, 256: 353-358.

Neurobiological Basis of Violence and Suicide in Alcohol/Substance Use Disorders

Year 2022, Volume: 14 Issue: 2, 264 - 275, 30.06.2022
https://doi.org/10.18863/pgy.998217

Abstract

Both the risk of suicidal and violent behaviours increases in alcohol and substance use disorders. Besides, it's proposed that alcohol and substance use disorders significantly contribute to the increasing prevalence of suicide and violence worldwide. For these reasons, it is thought that the spiral of problems consisting of the concepts of suicide, violence, and addiction awaits a solution on a global scale. The discovery of the underlying neurobiological mechanisms is required to deal with these problems. Previous research has revealed the importance of neurobiological mechanisms in understanding suicidal, violent, and addictive behaviours. Especially recent studies have shown some evidence that these three conditions have some related genetic, epigenetic, and neurobiological bases. Therefore, besides the current neurobiological research on alcohol and substance use disorders, scientific literature related to suicidal and violent behaviours will be presented in this review altogether.

References

  • Aharonovich E, Hasin DS, Brooks AC, Liu X, Bisaga A, Nunes EV (2006) Cognitive deficits predict low treatment retention in cocaine dependent patients. Drug Alcohol Depend, 81:313-322.
  • Amin F, Davidson M, Davis KL (1992) Homovanillic acid measurement in clinical research: a review of methodology. Schizophr Bull, 18:123-48.
  • APA (2013) Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM 5). Washington, DC, American Psychiatric Association.
  • Arango V, Underwood MD, Mann JJ (1996) Fewer pigmented locus coeruleus neurons in suicide victims: preliminary results. Biol Psychiatry, 39:112-120.
  • Arseneault L, Moffitt TE, Caspi A, Taylor PJ, Silva PA (2000) Mental disorders and violence in a total birth cohort: results from the Dunedin Study. Arch Gen Psychiatry, 57:979-986.
  • Aydın M, Hacımusalar Y, Hocaoğlu Ç (2019) İntihar Davranışının Nörobiyolojisi. Psikiyatride Güncel Yaklaşımlar, 11:1-23.
  • Bagge CL, Littlefield AK, Conner KR, Schumacher JA, Lee HJ (2014) Near-term predictors of the intensity of suicidal ideation: an examination of the 24 h prior to a recent suicide attempt. J Affect Disord, 165:53-58.
  • Berrocoso E, Sánchez-Blázquez P, Garzón J, Mico JA (2009) Opiates as antidepressants. Curr Pharm Des 15:1612-1622.
  • Blonigen D, Krueger R (2005) Human quantitative genetics of aggression. In Biology of Aggression. (Ed Nelson R). Oxford, Oxford University Press: 20-36.
  • Bolla KI, Eldreth DA, London ED, Kiehl KA, Mouratidis M, Contoreggi C et al. (2003) Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task. Neuroimage, 19:1085-1094.
  • Borges G, Bagge CL, Cherpitel CJ, Conner KR, Orozco R, Rossow I (2017) A meta-analysis of acute use of alcohol and the risk of suicide attempt. Psychol Med, 47:949-957.
  • Brent DA, Mann JJ (2005). Family genetic studies, suicide, and suicidal behavior. Am J Med Genet C Semin Med Genet,133c:13-24.
  • Brent DA, Melhem N (2008) Familial transmission of suicidal behavior. Psychiatr Clin North Am, 31:157-177.
  • Brienza RS, Stein MD, Chen M, Gogineni A, Sobota M, Maksad J et al. (2000) Depression among needle exchange program and methadone maintenance clients. J Subst Abuse Treat, 18:331-337.
  • Broerman R (2017) Diathesis-Stress Model. Encyclopedia of Personality and Individual Differences. (Eds Zeigler-Hill V, Shackelford TK). Cham, Springer International Publishing: 1-3.
  • Buttenschøn HN, Flint TJ, Foldager L, Qin P, Christoffersen S, Hansen NF et al. (2013) An association study of suicide and candidate genes in the serotonergic system. J Affect Disord, 148:291-298.
  • Cacciola JS, Alterman AI, Rutherford MJ, McKay JR, Mulvaney FD (2001) The relationship of psychiatric comorbidity to treatment outcomes in methadone maintained patients. Drug Alcohol Depend, 61:271-280.
  • Cam O, Bilge A (2013) The process of stigmatization, attitude, and belief about mental illness and patient in Turkey: a systematic review. Journal of Psychiatric Nursing, 4:91-102.
  • Castillo-Carniglia A, Keyes KM, Hasin DS, Cerdá M (2019) Psychiatric comorbidities in alcohol use disorder. Lancet Psychiatry, 6:1068-1080.
  • Cheung S, Woo J, Maes MS, Zai CC (2020) Suicide epigenetics, a review of recent progress. J Affect Disord, 265:423-438.
  • Chiaruttini C, Vicario A, Li Z, Baj G, Braiuca P, Wu Y et al. (2009) Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation. Proc Natl Acad Sci U S A, 106:16481-16486.
  • Corrigan PW, Watson AC (2005) Findings from the National Comorbidity Survey on the frequency of violent behavior in individuals with psychiatric disorders. Psychiatry Res, 136:153-162.
  • Cosgrove KP, Tellez-Jacques K, Pittman B, Petrakis I, Baldwin RM, Tamagnan G et al. (2010) Dopamine and serotonin transporter availability in chronic heroin users: a [¹²³I]β-CIT SPECT imaging study. Psychiatry Res, 184:192-195.
  • Craig IW, Halton KE (2009) Genetics of human aggressive behaviour. Hum Genet, 126:101-113.
  • Çinik E, Güçlü O, Şenormancı Ö, Aydin E, Erkiran M, Erkmen H (2015) Şizofreni hastalarında madde kullanımının suç ve şiddet özelliklerine etkisi. Anadolu Psikiyatri Dergisi, 16:104-112.
  • Depue RA, Spoont MR (1986) Conceptualizing a serotonin trait. A behavioral dimension of constraint. Ann N Y Acad Sci, 487:47-62.
  • Elizabeth Sublette M, Carballo JJ, Moreno CC, Galfalvy HC, Brent DA, Birmaher B et al. (2009) Substance use disorders and suicide attempts in bipolar subtypes. J Psychiatr Res, 43:230-238.
  • Eronen M, Hakola P, Tiihonen J (1996) Factors associated with homicide recidivism in a 13-year sample of homicide offenders in Finland. Psychiatr Serv, 47:403-406.
  • Esang M, Ahmed S (2018) A Closer Look at Substance Use and Suicide. Am J Psychiatry Resid J, 13:6-8.
  • Everitt BJ, Belin D, Economidou D, Pelloux Y, Dalley JW, Robbins TW (2008) Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos Trans R Soc Lond B Biol Sci, 363:3125-3135.
  • Fazel S, Gulati G, Linsell L, Geddes JR, Grann M (2009) Schizophrenia and violence: systematic review and meta-analysis. PLoS Med, 6:e1000120.
  • Fernández-Montalvo J, López-Goñi JJ, Arteaga A (2012) Violent behaviors in drug addiction: differential profiles of drug-addicted patients with and without violence problems. J Interpers Violence, 27:142-157.
  • Fitzgerald ML, Kassir SA, Underwood MD, Bakalian MJ, Mann JJ, Arango V (2017) Dysregulation of Striatal Dopamine Receptor Binding in Suicide. Neuropsychopharmacology, 42:974-982.
  • Fu LP, Bi GH, Zou ZT, Wang Y, Ye EM, Ma L et al. (2008) Impaired response inhibition function in abstinent heroin dependents: an fMRI study. Neurosci Lett, 438:322-326.
  • Garno JL, Gunawardane N, Goldberg JF (2008) Predictors of trait aggression in bipolar disorder. Bipolar Disord, 10:285-292.
  • Geniş B, Coşar B (2018) Psikiyatrik Hastalıklar ve Şiddet, Ankara, Nobel Kitabevi.
  • Gorwood P, Batel P, Adès J, Hamon M, Boni C (2000) Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior. Biol Psychiatry, 48:259-264.
  • Grant BF, Chou SP, Saha TD, Pickering RP, Kerridge BT, Ruan WJ et al. (2017) Prevalence of 12-Month Alcohol Use, High-Risk Drinking, and DSM-IV Alcohol Use Disorder in the United States, 2001-2002 to 2012-2013: Results From the National Epidemiologic Survey on Alcohol and Related Conditions. JAMA Psychiatry, 74:911-923.
  • Gray NS, Taylor J, Snowden RJ (2011) Predicting violence using structured professional judgment in patients with different mental and behavioral disorders. Psychiatry Res, 187:248-253.
  • Gruber SA, Silveri M, Yurgelun-Todd DA (2007) Neuropsychological consequences of opiate use. Neuropsychol Rev, 17:299-315.
  • Guy N, Newton-Howes G, Ford H, Williman J, Foulds J (2018) The prevalence of comorbid alcohol use disorder in the presence of personality disorder: Systematic review and explanatory modelling. Personal Ment Health, 12:216-228.
  • Hedegaard H, Curtin SC, Warner M (2020) Increase in Suicide Mortality in the United States, 1999-2018. NCHS Data Brief, 362:1-8.
  • Heim C, Nemeroff CB (2001) The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry, 49:1023-1039.
  • Hernandez G, Hamdani S, Rajabi H, Conover K, Stewart J, Arvanitogiannis A et al. (2006) Prolonged rewarding stimulation of the rat medial forebrain bundle: neurochemical and behavioral consequences. Behav Neurosci, 120:888-904.
  • Hurd YL, Herman MM, Hyde TM, Bigelow LB, Weinberger DR, Kleinman JE (1997) Prodynorphin mRNA expression is increased in the patch vs matrix compartment of the caudate nucleus in suicide subjects. Mol Psychiatry, 2:495-500.
  • Ieong HF, Yuan Z (2017) Resting-State Neuroimaging and Neuropsychological Findings in Opioid Use Disorder during Abstinence: A Review. Front Hum Neurosci, 11:1-12.
  • İnandı T, Özer C, Akdemir A, Akoğlu S, Babayiğit C, Turhan E, Sangün Ö (2009) Hatay’da Lise Öğrencilerinde Madde Kullanımı, Bazı Psikolojik Özellikler ve Şiddet: Kesitsel Bir Çalışma. Trakya Univ Tip Fak Derg, 26:189-196.
  • Jacobs DG, Baldessarini RJ, Conwell Y, Fawcett JA, Horton L, Meltzer H et al. (2010) Assessment and treatment of patients with suicidal behaviors. APA Practice Guidelines, 1-183.
  • Jokinen J, Nordström A-L, Nordström P (2009) Cerebrospinal fluid monoamine metabolites and suicide. Nord J Psychiatry, 63:276-279.
  • Joyal CC, Putkonen A, Mancini-Marïe A, Hodgins S, Kononen M, Boulay L et al. (2007) Violent persons with schizophrenia and comorbid disorders: a functional magnetic resonance imaging study. Schizophr Res, 91:97-102.
  • Keller S, Sarchiapone M, Zarrilli F, Videtic A, Ferraro A, Carli V et al. (2010) Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Arch Gen Psychiatry, 67:258-267.
  • Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L et al. (2001) Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology, 24:561-567.
  • Koob G, Kreek MJ (2007) Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry, 164:1149-1159.
  • Koob GF, Simon EJ (2009) The Neurobiology of Addiction: Where We Have Been and Where We Are Going. J Drug Issues, 39:115-132.
  • Koob GF, Volkow ND (2010) Neurocircuitry of addiction. Neuropsychopharmacology, 35: 217-238.
  • Koob GF, Volkow ND (2016) Neurobiology of addiction: a neurocircuitry analysis. Lancet Psychiatry, 3:760-773.
  • Krug EG, Mercy JA, Dahlberg LL, Zwi AB (2002) The world report on violence and health. Lancet, 360:1083-1088.
  • Kundakovic M, Gudsnuk K, Herbstman JB, Tang D, Perera FP, Champagne FA (2015) DNA methylation of BDNF as a biomarker of early-life adversity. Proc Natl Acad Sci U S A, 112:6807-6813.
  • Lindqvist P, Allebeck P (1990) Schizophrenia and crime. A longitudinal follow-up of 644 schizophrenics in Stockholm. Br J Psychiatry, 157:345-350.
  • Lutz PE, Gross JA, Dhir SK, Maussion G, Yang J, Bramoulle A et al. (2018) Epigenetic Regulation of the Kappa Opioid Receptor by Child Abuse. Biol Psychiatry, 84:751-761.
  • Mann JJ (2003) Neurobiology of suicidal behaviour. Nature Reviews Neuroscience, 4:819-828.
  • Marshall BDL, Fairbairn N, Li K, Wood E, Kerr T (2008) Physical violence among a prospective cohort of injection drug users: a gender-focused approach. Drug Alcohol Depend, 97:237-246.
  • Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y et al. (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science, 302:890-893.
  • McGowan PO, Szyf M (2010) The epigenetics of social adversity in early life: Implications for mental health outcomes. Neurobiol Dis, 39:66-72.
  • McGuffin P, Perroud N, Uher R, Butler A, Aitchison KJ, Craig I et al. (2010) The genetics of affective disorder and suicide. Eur Psychiatry, 25:275-277.
  • Melis M, Spiga S, Diana M (2005) The dopamine hypothesis of drug addiction: hypodopaminergic state. Int Rev Neurobiol, 63:101-154.
  • Nestler EJ (2005) Is there a common molecular pathway for addiction? Nature neuroscience, 8:1445-1449.
  • Nobile B, Lutz PE, Olie E, Courtet P (2020) The Role of Opiates in Social Pain and Suicidal Behavior. Curr Top Behav Neurosci, 46:197-210.
  • O'Connor DB, Ferguson E, Green JA, O'Carroll RE, O'Connor RC (2016) Cortisol levels and suicidal behavior: A meta-analysis. Psychoneuroendocrinology, 63:370-379.
  • O'Connor DB, Gartland N, O'Connor RC (2020) Stress, cortisol and suicide risk. Int Rev Neurobiol, 152:101-130.
  • Oliveira SL, Pillat MM, Cheffer A, Lameu C, Schwindt TT, Ulrich H (2013) Functions of neurotrophins and growth factors in neurogenesis and brain repair. Cytometry A, 83:76-89.
  • Özalp E (2009) İntihar Davranışının Genetiği. Turk Psikiyatri Derg, 20:85-93.
  • Özer Ü, Yıldırım EA, Erkoç ŞN (2015) Major Depresyon Olgularında İntihar Düşünce ve Davranışının Bağlanma Biçimi ile İlişkisi. Arch Neuropsychiatr, 52: 283-288.
  • Pardini DA, Raine A, Erickson K, Loeber R (2014) Lower amygdala volume in men is associated with childhood aggression, early psychopathic traits, and future violence. Biol Psychiatry, 75:73-80.
  • Peng S, Li W, Lv L, Zhang Z, Zhan X (2018) BDNF as a biomarker in diagnosis and evaluation of treatment for schizophrenia and depression. Discov Med, 26:127-136.
  • Phelps EA (2006) Emotion and cognition: insights from studies of the human amygdala. Annu Rev Psychol, 57:27-53.
  • Phillips J, Carpenter KM, Nunes EV (2004) Suicide risk in depressed methadone-maintained patients: associations with clinical and demographic characteristics. Am J Addict, 13:327-332.
  • Pietrzak RH, Naganawa M, Huang Y, Corsi-Travali S, Zheng MQ, Stein MB et al. (2014) Association of In Vivo κ-Opioid Receptor Availability and the Transdiagnostic Dimensional Expression of Trauma-Related Psychopathology. JAMA Psychiatry, 71:1262-1270.
  • Pitchot W, Reggers J, Pinto E, Hansenne M, Fuchs S, Pirard S et al. (2001) Reduced dopaminergic activity in depressed suicides. Psychoneuroendocrinology, 26:331-335.
  • Placidi GP, Oquendo MA, Malone KM, Huang YY, Ellis SP, Mann JJ (2001) Aggressivity, suicide attempts, and depression: relationship to cerebrospinal fluid monoamine metabolite levels. Biol Psychiatry, 50:783-791.
  • Pompili M, Serafini G, Innamorati M, Dominici G, Ferracuti S, Kotzalidis GD et al. (2010) Suicidal behavior and alcohol abuse. Int J Environ Res Public Health, 7:1392-1431.
  • Puhalla AA, Berman ME, Coccaro EF, Fahlgren MK, McCloskey MS (2020) History of childhood abuse and alcohol use disorder: Relationship with intermittent explosive disorder and intoxicated aggression frequency. J Psychiatr Res, 125:38-44.
  • Pulay AJ, Dawson DA, Hasin DS, Goldstein RB, Ruan WJ, Pickering RP et al. (2008) Violent behavior and DSM-IV psychiatric disorders: results from the national epidemiologic survey on alcohol and related conditions. J Clin Psychiatry, 69:12-22.
  • Quanbeck CD, Stone DC, McDermott BE, Boone K, Scott CL, Frye MA (2005) Relationship between criminal arrest and community treatment history among patients with bipolar disorder. Psychiatr Serv, 56:847-852.
  • Ramstedt M (2001) Alcohol and suicide in 14 European countries. Addiction, 96:59-75.
  • Rizk MM, Herzog S, Dugad S, Stanley B (2021) Suicide Risk and Addiction: The Impact of Alcohol and Opioid Use Disorders. Curr Addict Rep, 1-14.
  • Roy A (2002) Characteristics of opiate dependent patients who attempt suicide. J Clin Psychiatry, 63:403-407.
  • Roy A (2009) Characteristics of cocaine dependent patients who attempt suicide. Arch Suicide Res, 13:46-51.
  • Roy A (2010) Risk factors for attempting suicide in heroin addicts. Suicide Life Threat Behav, 40:416-420.
  • Sander T, Harms H, Lesch KP, Dufeu P, Kuhn S, Hoehe M et al. (1997) Association analysis of a regulatory variation of the serotonin transporter gene with severe alcohol dependence. Alcohol Clin Exp Res, 21:1356-1359.
  • Sansone RA, Whitecar P, Wiederman MW (2009) The prevalence of childhood trauma among those seeking buprenorphine treatment. J Addict Dis, 28:64-67.
  • Secunda SK, Cross CK, Koslow S, Katz MM, Kocsis J, Maas JW et al. (1986) Biochemistry and suicidal behavior in depressed patients. Biol Psychiatry, 21:756-767.
  • Schulteis G, Ahmed SH, Morse AC, Koob GF, Everitt BJ (2000) Conditioning and opiate withdrawal. Nature, 405:1013-1014.
  • Shiels MS, Tatalovich Z, Chen Y, Haozous EA, Hartge P, Nápoles AM et al. (2020) Trends in Mortality From Drug Poisonings, Suicide, and Alcohol-Induced Deaths in the United States From 2000 to 2017. JAMA Network Open, 3:e2016217-e2016217.
  • Shurman J, Koob GF, Gutstein HB (2010) Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain. Pain Med, 11:1092-1098.
  • Sopromadze S, Tsiskaridze A (2018) Violent Behavior. Neurologic-Psychiatric Syndromes in Focus. Part II. In From Psychiatry to Neurology (Eds Bogousslavsky J): 106-121. Basel, Karger.
  • Stanley B, Michel CA, Galfalvy HC, Keilp JG, Rizk MM, Richardson-Vejlgaard R et al. (2019) Suicidal subtypes, stress responsivity and impulsive aggression. Psychiatry Res, 280: 112486.
  • Steinert T, Wiebe C, Gebhardt RP (1999) Aggressive behavior against self and others among first-admission patients with schizophrenia. Psychiatr Serv, 50: 85-90.
  • Stoffel BCMM, Henrique PKF, Flavio P, Lisia vD, Olivier SMF, Tatiana HL et al. (2019) Crack users and violence. What is the relationship between trauma, antisocial personality disorder and posttraumatic stress disorder?. Addict Behav, 98:106012.
  • Sullivan LE, Fiellin DA, O'Connor PG (2005) The prevalence and impact of alcohol problems in major depression: a systematic review. Am J Med, 118:330-341.
  • Swanson JW, Holzer CE, Ganju VK, Jono RT (1990) Violence and psychiatric disorder in the community: evidence from the Epidemiologic Catchment Area surveys. Hosp Community Psychiatry, 41: 761-770.
  • Torrey EF (1994) Violent behavior by individuals with serious mental illness. Hosp Community Psychiatry, 45: 653-662.
  • Türkmen SN, Epsoylu H (2019) Madde kullanım varlığının, suç işleyen ve işlemeyen hastalarda suç ve şiddet özelliklerine etkisi. STED/Sürekli Tıp Eğitimi Dergisi, 28: 108-113.
  • Underwood MD, Mann JJ, Arango V (2004) Serotonergic and noradrenergic neurobiology of alcoholic suicide. Alcohol Clin Exp Res, 28:57-69.
  • van Heeringen C, Bijttebier S, Godfrin K (2011) Suicidal brains: a review of functional and structural brain studies in association with suicidal behaviour. Neurosci Biobehav Rev, 35: 688-698.
  • van Heeringen K, Mann JJ (2014) The neurobiology of suicide. Lancet Psychiatry, 1: 63-72.
  • van Praag HM, Asnis GM, Kahn RS, Brown SL, Korn M, Friedman JM et al. (1990) Monoamines and abnormal behaviour. A multi-aminergic perspective. Br J Psychiatry, 157: 723-734.
  • Volavka J, Laska E, Baker S, Meisner M, Czobor P, Krivelevich I (1997) History of violent behaviour and schizophrenia in different cultures. Analyses based on the WHO study on Determinants of Outcome of Severe Mental Disorders. Br J Psychiatry, 171:9-14.
  • Wagner G, Schultz CC, Koch K, Schachtzabel C, Sauer H, Schlösser RG (2012) Prefrontal cortical thickness in depressed patients with high-risk for suicidal behavior. J Psychiatr Res, 46: 1449-1455.
  • Welch KA, Carson A, Lawrie SM (2013) Brain structure in adolescents and young adults with alcohol problems: systematic review of imaging studies. Alcohol Alcohol, 48: 433-444.
  • Yüksel N (2001) İntiharın Nörobiyolojisi. Journal of Clinical Psychiatry, 4:5-15.
  • Zatti C, Rosa V, Barros A, Valdivia L, Calegaro VC, Freitas LH et al. (2017) Childhood trauma and suicide attempt: A meta-analysis of longitudinal studies from the last decade. Psychiatry Res, 256: 353-358.
There are 112 citations in total.

Details

Primary Language Turkish
Subjects Psychiatry
Journal Section Review
Authors

Bahadır Geniş 0000-0001-8541-7670

Ferit Sahin 0000-0003-2686-3990

Nermin Gürhan 0000-0002-3472-7115

Publication Date June 30, 2022
Acceptance Date December 1, 2021
Published in Issue Year 2022 Volume: 14 Issue: 2

Cite

AMA Geniş B, Sahin F, Gürhan N. Alkol/Madde Kullanım Bozukluklarında Şiddet ve İntiharın Nörobiyolojik Temelleri. Psikiyatride Güncel Yaklaşımlar - Current Approaches in Psychiatry. June 2022;14(2):264-275. doi:10.18863/pgy.998217

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