Metoksimetiltrifenilfosfonyum Klorür Tek Kristalinde Oluşturulan Yapısal Bozukluğun Elektron Paramanyetik Rezonans ile Tespiti
Year 2023,
, 457 - 468, 27.03.2023
Ali Cengiz Çalışkan
,
Betül Çalışkan
Abstract
Metoksimetiltrifenilfosfonyum klorür (MOMTPPC) tek kristalleri Elektron Paramanyetik Rezonans (EPR) spektroskopi yöntemi ile analiz edilmiştir. MOMTPPC tek kristalleri, 60Co- kaynağı ile ışınlanarak paramanyetik bozukluklar oluşturulmuştur. MOMTPPC tek kristallerinin EPR spektrumları, 120 K sıcaklıkta üç dik eksen etrafında belirli açılarda döndürülerek EPR spektrumları alınmıştır. MOMTPPC'de ışınlama etkisiyle oluşan radikalin yapısı, EPR spektrumlarının detaylı incelenmesi ile elde edilmiştir. Radyasyonun etkisiyle C20-H24 bağı kopmuş ve bir paramanyetik merkez oluşmuştur. Kimyasal bağın kopması sonucu oluşan radikalin eşleşmemiş elektronunun C20 atomu üzerinde bulunduğu belirlenmiştir. Radyasyon hasar merkezine ait anizotropik g-faktörü ve aşırı ince yapı çiftlenim sabitleri belirlenmiştir. Spektroskopik yarılma faktörünün izotropik değeri g = 2,00764 olarak elde edilirken, aşırı ince yapı sabitlerinin izotropik değerleri ise sırasıyla, 〖(a_H)〗_α = 2,010 mT, 〖(a_P)〗_β = 3,196 mT ve 〖(a_(C_6 H_5 ))〗_γ= 〖(a_fenil)〗_γ = 0,472 mT olarak hesaplanmıştır. EPR parametrelerine ait yön kosinüsleri elde edilmiştir. Ayrıca, simülasyon çalışmaları ile deneysel verilerimizin doğruluğu desteklenmiştir.
Supporting Institution
Pamukkale Üniversitesi-BAP
Project Number
The BAP of Pamukkale University [grant number 2012FBE037].
Thanks
2012FBE037 numaralı projeye desteklerinden dolayı Pamukkale Üniversitesi Bilimsel Araştırma Projeleri Birimi’ne teşekkür ederiz.
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Detection of Structural Defect in Methoxymethyltriphenylphosphonium Chloride Single Crystal by Electron Paramagnetic Resonance
Year 2023,
, 457 - 468, 27.03.2023
Ali Cengiz Çalışkan
,
Betül Çalışkan
Abstract
Single crystals of methoxymethyltriphenylphosphonium chloride (MOMTPPC) were analyzed by Electron Paramagnetic Resonance (EPR) spectroscopy method. Gamma radiation from 60Co was used to create paramagnetic defects in MOMTPPC single crystal. EPR spectra of MOMTPPC single crystals were obtained at 120 K temperature by rotating around three orthogonal axes. The structure of the radical formed by the irradiation effect in MOMTPPC was found by detailed examination of the EPR spectra. With the effect of radiation, the C20-H24 bond was broken and a paramagnetic center was formed. It has been determined that the unpaired electron of the radical formed as a result of the breaking of the chemical bond is located mainly on the C20 atom. The anisotropic g-factor and hyperfine coupling constants of the radiation damage center were determined. While the isotropic value of the spectroscopic splitting factor is obtained as g = 2.00764, the isotropic values of the hyperfine structure constants are 〖(a_H)〗_α = 2.010 mT, 〖(a_P)〗_β = 3.196 mT and 〖(a_(C_6 H_5 ))〗_γ= 〖(a_fenil)〗_γ = 0.472 mT. Direction cosines of EPR parameters were obtained. Simulation was also carried out to prove the accuracy of our experimental data.
Project Number
The BAP of Pamukkale University [grant number 2012FBE037].
References
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- [26] Zheng Y., Ji S., Tomaselli E., Ernest C., Freiji and Liu S., ‘‘Effect of co-ligands on chemical and biological properties of 99mTc(III) complexes [99mTc(L)(CDO)(CDOH)2BMe] (L = Cl, F, SCN and N3; CDOH2 = cyclohexanedione dioxime)’’, Nucl. Med. Biol., 41(10): 813-824, (2014).
- [27] Haslop A., Wells L., Gee A., Plisson C. and Long N., ‘‘One-pot multi-tracer synthesis of novel 18F-labeled PET imaging agents’’, Mol. Pharm., 11(11): 3818-3822, (2014).
- [28] Kim D. Y., Kim H. S., Jang H. Y., Kim J. H., Bom H. S. and Min J. J., ‘‘Comparison of the cardiac microPET images obtained using [18F]FPTP and [13N]NH3 in rat myocardial infarction models’’, ACS Med. Chem. Lett., 5(10): 1124-1128, (2014).
- [29] Liu S., Li D., Shan H., Gabbai F. P., Li Z. and Conti P. S., ‘‘Evaluation of ¹⁸F-labeled BODIPY dye as potential PET agents for myocardial perfusion imaging’’, Nucl. Med. Biol., 41(1): 120-126, (2014).
- [30] Maddahi J. and Packard R. R. S., ‘‘Cardiac PET perfusion tracers: Current status and future directions’’, Semin. Nucl. Med., 44(5): 333-343, (2014).
- [31] Neves A. A. and Brindle K. M., ‘‘Imaging cell death’’, J. Nucl. Med., 55(1): 1-4, (2014).
- [32] Ravert H. T., Holt D. P. and Dannals R. F., ‘‘A microwave radiosynthesis of the 4‐[18F]‐fluorobenzyltriphenylphosphonium ion’’, J. Labelled Cmpd. Radiopharm., 57(12): 695-698, (2014).
- [33] Yeo D. C., Wiraja C., Mantalaris A. and Xu C., ‘‘Nanosensors for regenerative medicine’’, J. Biomed. Nanotechnol., 10(10): 2722-2746, (2014).
- [34] Zhao G., Yu Y. M., Shoup T. M., Elmaleh D. R., Bonab A. A., Tompkins R. G. and Fischman A. J., ‘‘Membrane potential-dependent uptake of 18F-triphenylphosphonium-a new voltage sensor as an imaging agent for detecting burn-induced apoptosis’’, J. Surg. Res., 188(2): 473-479, (2014).
- [35] Zhao Z., Yu Q., Mou T., Liu C., Yang W., Fang W., Peng C., Lu J., Liu Y. and Zhang X., ‘‘Highly efficient one-pot labeling of new phosphonium cations with fluorine-18 as potential PET agents for myocardial perfusion imaging’’, Mol. Pharm., 11(11): 3823-3831, (2014).
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