İnek Dokularının 635 nm'deki Optik Özelliklerinin Araştırılması: Toplayıcı Küre Ölçümleri ve Monte Carlo Simülasyonları

Year 2025, EARLY VIEW, 1 - 1

Halil Arslan , Abdulrahman Alsheikh

https://doi.org/10.2339/politeknik.1649712

Abstract

Biyolojik dokuların optik özelliklerinin bilinmesi, fototerapi, lazer cerrahisi ve biyomedikal görüntüleme gibi ışık tabanlı tıbbi uygulamaları optimize etmek için önemlidir. Bu çalışmada, inekten alınan kas, kalp, beyin, böbrek ve yağ dokularının 635 nm'deki soğurma katsayısı (μₐ) ve indirgenmiş saçılma katsayısı (μₛ′) değerleri, entegre küre sistemi ve Ters Ekleme-Katlama (IAD) yöntemi kullanılarak belirlendi. Deneysel sonuçlar, ışığın doku modelleri içindeki yayılımını modellemek ve optik doz dağılımlarını belirlemek için MCML simülasyonlarında giriş parametreleri olarak kullanıldı. Farklı doku türlerinin optik özelliklerinin farklı olduğu, beyin ve yağ dokularının görece yüksek saçılma katsayıları nedeniyle daha düşük penetrasyon derinlikleri görülmüştür. Deney ve Monte Carlo simülasyonlarının birlikte kullanıldığı bu çalışmada literatürle uyumlu sonuçlar elde edilmiştir.

Keywords

Doku , Toplayıcı Küre Sistemi , IAD , Monte Carlo Simülasyonu

Investigation of the Optical Properties of Bovine Tissues at 635 nm: Integrating Sphere Measurements and Monte Carlo Simulations

Abstract

Understanding the optical properties of biological tissues is essential for optimizing light-based medical applications such as phototherapy, laser surgery, and biomedical imaging. In this study, the absorption coefficient (μₐ) and reduced scattering coefficient (μₛ′) of bovine muscle, heart, brain, kidney and fat tissues were determined at 635 nm using an integrating sphere system and Inverse Adding-Doubling (IAD) method. The experimental results were then used as input parameters for Monte Carlo (MCML) simulations to model light propagation and determine fluence rate distributions within the tissue models. The results demonstrated significant variations in optical properties across different types of tissue, with brain and fat tissues exhibiting lower penetration depths due to higher scattering coefficients. The findings align with previous literature while providing a more comprehensive evaluation through the integration of experimental and computational approaches.

Keywords

Tissue , Integrating Sphere System , IAD , Monte Carlo Simulation

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