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Serum Selenium and Copper Levels in Children with Simple Febrile Seizure and Viral Infections

Year 2014, Volume: 2 Issue: 1, - , 23.03.2014
https://doi.org/10.21765/pprjournal.219196

Abstract

Purpose: Trace elements are essential for a healthy nervous system. Their levels are shown to be affected in both viral infections and febrile seizures. The aim of this study is to evaluate the serum selenium and copper levels in children with febrile seizures and viral infection.

Method: This study consisted of 40 patients with simple febrile seizures and viral infection (study group) and 40 patients with fever and viral infection (control group). Serum samples were collected for selenium and copper from the study group within one hour following seizure. The serum samples were measured and compared.

Results: Serum selenium levels were significantly lower in the simple febrile seizure group (p=0.043). There was no significant relation between selenium and copper levels with age, sex, body mass index, degree of fever or duration of febrile seizure.  

Conclusion: Significantly decreased levels of selenium in children with simple febrile seizures may be the result of oxidative damage and the activation of antioxidant defense mechanisms. The lower serum levels of selenium in patients with SFS may trigger FS or may contribute to its recurrence. Further studies are required to assess selenium levels comparing simple and recurrent febrile seizures.

 

References

  • Chung S. Febrile seizures. Korean J Pediatr 2014;57:384-95.
  • Verity CM, Greenwood R, Golding J. Long-term intellectual and behavioral outcomes of children with febrile convulsions. N Engl J Med 1998;338:1723-8.
  • Kolfen W, Pehle K, Konig S. Is the long-term outcome of children following febrile convulsions favorable? Dev Med Child Neurol 1998;40:667-71.
  • Norgaard M, Ehrenstein V, Mahon BE, Nielsen GL, Rothman KJ, Sorensen HT. Febrile seizures and cognitive function in young adult life: a prevalence study in Danish conscripts. J
  • Pediatr 2009;155:404-9.
  • Seven M, Basaran SY, Cengiz M, Unal S, Yuksel A. Deficiency of selenium and zinc as a causative factor for idiopathic intractable epilepsy. Epilepsy Res 2013;104:35-9.
  • Pillai R, Uyehara-Lock JH, Bellinger FP. Selenium and selenoprotein function in brain disorders. IUBMB Life 2014;66:229-39.
  • Amiri M, Farzin L, Moassesi ME, Sajadi F. Serum trace element levels in febrile convulsion.Biol Trace Elem Res 2010;135:38-44.
  • Abuhandan M, Solmaz A, Geter S, Kaya C, Guzel B, Yetkin I, Koca B. Evaluation of selenium levels and mean platelet volume in patients with simple febrile convulsion.Iran J Pediatr 2014;24:401-5.
  • Mahyar A, Ayazi P, Fallahi M, Javadi A. Correlation between serum selenium level and febrile seizures. Pediatr Neurol 2010;43:331-4.
  • Erkekoğlu P, Aşçı A, Ceyhan M, Kızılgün M, Schweizer U, Ataş C, Kara A, Koçer Giray B. Selenium levels, selenoenzyme activities and oxidant/antioxidant parameters in H1N1- infected children. Turk J Pediatr 2013;55:271-82.
  • Sammalkorpi K, Valtonen V, Alfthan G, Aro A, Huttunen J. Serum selenium in acute infections. Infection. 1988;16:222-4.
  • Fang LQ, Goeijenbier M, Zuo SQ, Wang LP, Liang S, Klein SL, Li XL, Liu K, Liang L, Gong P, Glass GE, van Gorp E, Richardus JH, Ma JQ, Cao WC, de Vlas SJ. The association between hantavirus infection and selenium deficiency in mainland China. Viruses 2015; 20:333- 51.
  • Beck MA, Levander OA, Handy J. Selenium deficiency and viral infection. J Nutr 2003; 133: 1463-1467.
  • Broome CS, McArdle F, Kyle JA, Andrews F, Lowe NM, Hart CA, Arthur JR, Jackson MJ. An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status. Am J Clin Nutr 2004; 80: 154-162.
  • Khoshdel A, Parvin N, Abbasi M. Selenium and leptin levels in febrile seizure: a case-control study in children. Korean J Pediatr 2013;56:80-5.
  • Patel N, Ram D, Swiderska N, Mewasingh LD, Newton RW, Offringa M. Febrile seizures. BMJ. 2015;18:4240.
  • Saad K, Hammad E, Hassan AF, Badry R. Trace element, oxidant, and antioxidant enzyme values in blood of children with refractory epilepsy. Int J Neurosci. 2014;124:181-6.
  • Sobaniec W, Solowiej E, Kulak W, Bockowski L, Smigielska-Kuzia J, Artemowicz B. Evaluation of the influence of antiepileptic therapy on antioxidant enzyme activity and lipid peroxidation in erythrocytes of children with epilepsy. J Child Neurol 2006;21: 558-62.
  • Chen J, Berry MJ. Selenium and selenoproteins in the brain and brain disease. Journal of Neurochemistry 2003;86:1-12.
  • Schweizer U, Brauer AU, Kohrle J, Nitsch R, Savaskan NE. Selenium and brain function: a poorly recognized liaison. Brain Research Reviews 2004;45:164-178.
  • Savaskan NE, Bräuer AU, Kühbacher M, Eyüpoglu IY, Kyriakopoulos A, Ninnemann O, Behne D, Nitsch R. Selenium deficiency increases susceptibility to glutamate-induced excitotoxicity. FASEB J. 2003;17:112-4.
  • Ashrafi MR, Shabanian R, Abbaskhanian A, Nasirian A, Ghofrani M, Mohammadi M, Zamani GR, Kayhanidoost Z, Ebrahimi S, Pourpak Z. Selenium and intractable epilepsy: is there any correlation? Pediatr Neurol 2007;36:25-29
  • Harthill M. Review: micronutrient selenium deficiency influences evolution of some viral
  • infectious diseases. Biol Trace Elem Res 2011; 143: 1325-1336.
  • Sheridan PA(1), Zhong N, Carlson BA, Perella CM, Hatfield DL, Beck MA.Decreased selenoprotein expression alters the immune response during influenza virus infection in mice. J Nutr 2007; 137: 1466-1471.
  • Bendich A. Physiological role of antioxidants in the immune system. J Dairy Sci 1993; 76: 2789-2794.
  • Nelson HK, Shi Q, Van Dael P, et al. Host nutritional selenium status as a driving force for influenza virus mutations. FASEB J 2001; 15: 1846-1848.
  • Mathie A, Sutton GL, Clarke CE, et al. Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability. Pharmacol Ther. 2006;111:567-583.
  • Schlief ML, Craig AM, Gitlin JD. NMDA receptor activation mediates copper homeostasis in hippocampal neurons. J Neurosci 2005;25:239-246.
  • Saghazadeh A, Mahmoudi M, Meysamie A, Gharedaghi M, Zamponi GW, Rezaei N.Possible role of trace elements in epilepsy and febrile seizures: a meta-analysis. Nutr Rev 2015;73:760-79.
  • Hincal F, Başaran N, Yetgin S, Gökmen O. Selenium status in Turkey. II. Serum selenium concentration in healthy residents of different ages in Ankara. J Trace Elem Electrolytes Health Dis. 1994;8:9-12
  • Weber GF, Maertens P, Meng XZ, Pippenger CE. Glutathione peroxidase deficiency and childhood seizures. Lancet 1991;337, 1443.1444
  • Ramaekers VT, Calomme M, Vanden Berghe D, Makropoulos W. Selenium deficiency triggering intractable seizures. Neuropediatrics 1994; 25, 217.223

Viral Enfeksiyonu ve Basit Febril Konvülziyonu Olan Çocuklarda Serum Selenyum ve Bakır Düzeyleri

Year 2014, Volume: 2 Issue: 1, - , 23.03.2014
https://doi.org/10.21765/pprjournal.219196

Abstract

Amaç:  Sağlıklı bir sinir sistemi için eser elementler son derece önemlidir. Eser elementlerin düzeyi viral enfeksiyonlar ve ateşli nöbetler sırasında değişiklik gösterir. Bu çalışmanın amacı febril nöbet ve viral enfeksiyonu olan çocukların serum selenyum ve bakır düzeylerini belirlemektir.

Gereç yöntem: Basit febril konvülziyon geçiren ve viral enfeksiyonu saptanan 40 çocuk çalışmaya alındı. Kontrol grubu olarak ise ateşi ve viral enfeksiyonu olup nöbet geçirmeyen 40 çocuk seçildi. Her iki gruptan alınan serum örnekleri ölçüldü ve karşılaştırıldı.

Bulgular: Basit febril konvülziyon grubunda serum selenyum düzeyleri istatistiksel anlamlı olarak düşük bulundu( p=0.043). Selenyum ve bakır düzeyleri ile yaş, cinsiyet, vücut kitle indeksi, nöbet süresi ve ateş yüksekliği arasında ilişki saptanmadı.

Sonuç: Basit febril konvülziyon geçiren çocuklarda selenyum düzeyinin düşük olması oksidatif hasar ve antioksidan savunma mekanizmalarının aktifleşmesine bağlı olabilir. Selenyum düzeyindeki anlamlı düşüklük febril nöbetleri başlatabileceği gibi nöbetin tekrarlamasına da neden olabilir. Basit ve tekrarlayan febril nöbetlerde selenyum düzeyini araştıran çalışmalara ihtiyaç vardır.

 

Anahtar kelimeler: Febril konvülziyon, selenyum, bakır, çocuk 

References

  • Chung S. Febrile seizures. Korean J Pediatr 2014;57:384-95.
  • Verity CM, Greenwood R, Golding J. Long-term intellectual and behavioral outcomes of children with febrile convulsions. N Engl J Med 1998;338:1723-8.
  • Kolfen W, Pehle K, Konig S. Is the long-term outcome of children following febrile convulsions favorable? Dev Med Child Neurol 1998;40:667-71.
  • Norgaard M, Ehrenstein V, Mahon BE, Nielsen GL, Rothman KJ, Sorensen HT. Febrile seizures and cognitive function in young adult life: a prevalence study in Danish conscripts. J
  • Pediatr 2009;155:404-9.
  • Seven M, Basaran SY, Cengiz M, Unal S, Yuksel A. Deficiency of selenium and zinc as a causative factor for idiopathic intractable epilepsy. Epilepsy Res 2013;104:35-9.
  • Pillai R, Uyehara-Lock JH, Bellinger FP. Selenium and selenoprotein function in brain disorders. IUBMB Life 2014;66:229-39.
  • Amiri M, Farzin L, Moassesi ME, Sajadi F. Serum trace element levels in febrile convulsion.Biol Trace Elem Res 2010;135:38-44.
  • Abuhandan M, Solmaz A, Geter S, Kaya C, Guzel B, Yetkin I, Koca B. Evaluation of selenium levels and mean platelet volume in patients with simple febrile convulsion.Iran J Pediatr 2014;24:401-5.
  • Mahyar A, Ayazi P, Fallahi M, Javadi A. Correlation between serum selenium level and febrile seizures. Pediatr Neurol 2010;43:331-4.
  • Erkekoğlu P, Aşçı A, Ceyhan M, Kızılgün M, Schweizer U, Ataş C, Kara A, Koçer Giray B. Selenium levels, selenoenzyme activities and oxidant/antioxidant parameters in H1N1- infected children. Turk J Pediatr 2013;55:271-82.
  • Sammalkorpi K, Valtonen V, Alfthan G, Aro A, Huttunen J. Serum selenium in acute infections. Infection. 1988;16:222-4.
  • Fang LQ, Goeijenbier M, Zuo SQ, Wang LP, Liang S, Klein SL, Li XL, Liu K, Liang L, Gong P, Glass GE, van Gorp E, Richardus JH, Ma JQ, Cao WC, de Vlas SJ. The association between hantavirus infection and selenium deficiency in mainland China. Viruses 2015; 20:333- 51.
  • Beck MA, Levander OA, Handy J. Selenium deficiency and viral infection. J Nutr 2003; 133: 1463-1467.
  • Broome CS, McArdle F, Kyle JA, Andrews F, Lowe NM, Hart CA, Arthur JR, Jackson MJ. An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status. Am J Clin Nutr 2004; 80: 154-162.
  • Khoshdel A, Parvin N, Abbasi M. Selenium and leptin levels in febrile seizure: a case-control study in children. Korean J Pediatr 2013;56:80-5.
  • Patel N, Ram D, Swiderska N, Mewasingh LD, Newton RW, Offringa M. Febrile seizures. BMJ. 2015;18:4240.
  • Saad K, Hammad E, Hassan AF, Badry R. Trace element, oxidant, and antioxidant enzyme values in blood of children with refractory epilepsy. Int J Neurosci. 2014;124:181-6.
  • Sobaniec W, Solowiej E, Kulak W, Bockowski L, Smigielska-Kuzia J, Artemowicz B. Evaluation of the influence of antiepileptic therapy on antioxidant enzyme activity and lipid peroxidation in erythrocytes of children with epilepsy. J Child Neurol 2006;21: 558-62.
  • Chen J, Berry MJ. Selenium and selenoproteins in the brain and brain disease. Journal of Neurochemistry 2003;86:1-12.
  • Schweizer U, Brauer AU, Kohrle J, Nitsch R, Savaskan NE. Selenium and brain function: a poorly recognized liaison. Brain Research Reviews 2004;45:164-178.
  • Savaskan NE, Bräuer AU, Kühbacher M, Eyüpoglu IY, Kyriakopoulos A, Ninnemann O, Behne D, Nitsch R. Selenium deficiency increases susceptibility to glutamate-induced excitotoxicity. FASEB J. 2003;17:112-4.
  • Ashrafi MR, Shabanian R, Abbaskhanian A, Nasirian A, Ghofrani M, Mohammadi M, Zamani GR, Kayhanidoost Z, Ebrahimi S, Pourpak Z. Selenium and intractable epilepsy: is there any correlation? Pediatr Neurol 2007;36:25-29
  • Harthill M. Review: micronutrient selenium deficiency influences evolution of some viral
  • infectious diseases. Biol Trace Elem Res 2011; 143: 1325-1336.
  • Sheridan PA(1), Zhong N, Carlson BA, Perella CM, Hatfield DL, Beck MA.Decreased selenoprotein expression alters the immune response during influenza virus infection in mice. J Nutr 2007; 137: 1466-1471.
  • Bendich A. Physiological role of antioxidants in the immune system. J Dairy Sci 1993; 76: 2789-2794.
  • Nelson HK, Shi Q, Van Dael P, et al. Host nutritional selenium status as a driving force for influenza virus mutations. FASEB J 2001; 15: 1846-1848.
  • Mathie A, Sutton GL, Clarke CE, et al. Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability. Pharmacol Ther. 2006;111:567-583.
  • Schlief ML, Craig AM, Gitlin JD. NMDA receptor activation mediates copper homeostasis in hippocampal neurons. J Neurosci 2005;25:239-246.
  • Saghazadeh A, Mahmoudi M, Meysamie A, Gharedaghi M, Zamponi GW, Rezaei N.Possible role of trace elements in epilepsy and febrile seizures: a meta-analysis. Nutr Rev 2015;73:760-79.
  • Hincal F, Başaran N, Yetgin S, Gökmen O. Selenium status in Turkey. II. Serum selenium concentration in healthy residents of different ages in Ankara. J Trace Elem Electrolytes Health Dis. 1994;8:9-12
  • Weber GF, Maertens P, Meng XZ, Pippenger CE. Glutathione peroxidase deficiency and childhood seizures. Lancet 1991;337, 1443.1444
  • Ramaekers VT, Calomme M, Vanden Berghe D, Makropoulos W. Selenium deficiency triggering intractable seizures. Neuropediatrics 1994; 25, 217.223

Details

Primary Language English
Journal Section Original Articles
Authors

Oya BALCİ

Deniz YILMAZ

Publication Date March 23, 2014
Published in Issue Year 2014 Volume: 2 Issue: 1

Cite

Vancouver BALCİ O, YILMAZ D. Serum Selenium and Copper Levels in Children with Simple Febrile Seizure and Viral Infections. pediatr pract res. 2014;2(1).